ES2972523T3 - Composición para el tratamiento del disco intervertebral - Google Patents

Composición para el tratamiento del disco intervertebral Download PDF

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Publication number
ES2972523T3
ES2972523T3 ES17769650T ES17769650T ES2972523T3 ES 2972523 T3 ES2972523 T3 ES 2972523T3 ES 17769650 T ES17769650 T ES 17769650T ES 17769650 T ES17769650 T ES 17769650T ES 2972523 T3 ES2972523 T3 ES 2972523T3
Authority
ES
Spain
Prior art keywords
composition
nucleus pulposus
intervertebral disc
filling
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17769650T
Other languages
English (en)
Spanish (es)
Inventor
Hideki Sudo
Takeru TSUJIMOTO
Norimasa Iwasaki
Satoshi Shimizu
Mitsuko Isaji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hokkaido University NUC
Mochida Pharmaceutical Co Ltd
Original Assignee
Hokkaido University NUC
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokkaido University NUC, Mochida Pharmaceutical Co Ltd filed Critical Hokkaido University NUC
Application granted granted Critical
Publication of ES2972523T3 publication Critical patent/ES2972523T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444—Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Prostheses (AREA)
ES17769650T 2016-03-23 2017-01-27 Composición para el tratamiento del disco intervertebral Active ES2972523T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016058396 2016-03-23
PCT/JP2017/002925 WO2017163603A1 (ja) 2016-03-23 2017-01-27 椎間板治療用組成物

Publications (1)

Publication Number Publication Date
ES2972523T3 true ES2972523T3 (es) 2024-06-13

Family

ID=59901106

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17769650T Active ES2972523T3 (es) 2016-03-23 2017-01-27 Composición para el tratamiento del disco intervertebral

Country Status (8)

Country Link
US (1) US12478636B2 (enExample)
EP (2) EP3434291B1 (enExample)
JP (5) JP6487110B2 (enExample)
CN (1) CN109069692A (enExample)
BR (2) BR122021024709B1 (enExample)
CA (1) CA3018152A1 (enExample)
ES (1) ES2972523T3 (enExample)
WO (1) WO2017163603A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3593807B1 (en) 2017-03-07 2023-09-06 Mochida Pharmaceutical Co., Ltd. Alginate liquid formulation
WO2019151444A1 (ja) * 2018-01-31 2019-08-08 国立大学法人神戸大学 椎間板変性の治療剤および椎間板細胞培養材
JP7404228B2 (ja) 2018-03-22 2023-12-25 持田製薬株式会社 非ステロイド性抗炎症性化合物結合アルギン酸誘導体
CN113195083B (zh) * 2018-12-26 2022-12-27 东丽株式会社 多孔膜、复合膜和多孔膜的制造方法
EP4072608A1 (en) 2019-12-12 2022-10-19 Instituto de Engenharia Biomédica (INEB) Fetal decellularized nucleus pulposus material and methods for obtaining pharmaceutic compositions to be used in the treatment of intervertebral disc degeneration and back pain
EP4074349A4 (en) * 2020-01-14 2024-02-07 Mochida Pharmaceutical Co., Ltd. COMBINATION AND METHOD FOR TREATING SUBJECTS WITH ALGIC ACID SALT
US20230080690A1 (en) * 2020-01-17 2023-03-16 National University Corporation Hokkaido University Cartilage damage treatment material utilizing bone marrow fluid
JP7761941B2 (ja) * 2020-11-01 2025-10-29 日本全薬工業株式会社 脊髄損傷の治療剤
JPWO2022102093A1 (enExample) * 2020-11-13 2022-05-19
US20240100099A1 (en) * 2021-01-29 2024-03-28 National University Corporation Hokkaido University Composition for regeneration of intervertebral disc
CN116115824B (zh) * 2022-10-04 2025-08-26 奥美医疗用品股份有限公司 一种注射型髓核修复产品及其制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589591A (en) 1986-07-03 1996-12-31 Advanced Magnetics, Inc. Endotoxin-free polysaccharides
WO1993013136A1 (en) 1991-12-20 1993-07-08 Howmedica Inc. Ultra-pure polysaccharide materials for medical use
AU2621295A (en) * 1994-05-24 1995-12-18 Smith & Nephew Plc Intervertebral disc implant
JPH08269102A (ja) 1995-03-30 1996-10-15 Shiseido Co Ltd エンドトキシンフリーのβ１，３−グルカン及びその製造法並びに医療用ゲル素材
JPH09324001A (ja) 1996-04-02 1997-12-16 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸ナトリウムの精製法
JPH11253547A (ja) * 1998-03-11 1999-09-21 Kunio Ishikawa 細胞遮断膜
EP1135418A1 (en) 1998-11-13 2001-09-26 CP Kelco U.S., Inc. Biopolymer salts with low endotoxin levels, biopolymer compositions thereof and methods of making the same
US20030069639A1 (en) 2001-04-14 2003-04-10 Tom Sander Methods and compositions for repair or replacement of joints and soft tissues
EP1448089A4 (en) 2001-11-01 2008-06-04 Spine Wave Inc DEVICES AND METHODS FOR SPINACH RECOVERY
JP2005036036A (ja) 2003-07-16 2005-02-10 Tanabe Seiyaku Co Ltd エンドトキシン除去方法
US7938818B2 (en) 2005-05-03 2011-05-10 Yeung Jeffrey E Alleviate back pain by increasing pH of the disc
JP2008543449A (ja) * 2005-06-17 2008-12-04 アボット・ラボラトリーズ 変性脊椎疾患の改良型治療方法
ITPI20050071A1 (it) * 2005-06-20 2006-12-21 Giuseppe Calvosa Composizione biocompatibile per la sostituzione/rigenerazione di tessuti
US8506633B2 (en) 2005-12-27 2013-08-13 Warsaw Orthopedic, Inc. Rehydration and restoration of intervertebral discs with polyelectrolytes
MX2009008760A (es) 2007-02-21 2009-08-27 Mochida Pharm Co Ltd Composicion para el tratamiento de enfermedades del cartilago.
EP2082755A1 (de) 2008-01-16 2009-07-29 CellMed AG Monolithische in-situ vernetzte Alginatimplantate
US20140213524A1 (en) 2011-08-23 2014-07-31 National University Corporation Hokkaido University Composition for regeneration of cartilage
CN108135928B (zh) * 2015-09-07 2021-06-08 持田制药株式会社 藻酸冻结干燥制剂
JP6196283B2 (ja) 2015-12-10 2017-09-13 トヨタ自動車株式会社 燃料電池用電極、燃料電池用電極の製造方法、固体高分子形燃料電池、および触媒インクの製造方法
WO2018159768A1 (ja) 2017-03-02 2018-09-07 持田製薬株式会社 線維軟骨組織損傷治療用組成物

Also Published As

Publication number Publication date
CA3018152A1 (en) 2017-09-28
JP2021154163A (ja) 2021-10-07
JP6907254B2 (ja) 2021-07-21
JP2019088900A (ja) 2019-06-13
EP4374886A1 (en) 2024-05-29
JPWO2017163603A1 (ja) 2019-01-31
EP3434291A4 (en) 2019-10-23
EP3434291A1 (en) 2019-01-30
US12478636B2 (en) 2025-11-25
BR122021024709B1 (pt) 2023-01-03
EP3434291B1 (en) 2023-11-29
WO2017163603A1 (ja) 2017-09-28
JP6487110B2 (ja) 2019-03-20
JP7314207B2 (ja) 2023-07-25
JP2023134610A (ja) 2023-09-27
CN109069692A (zh) 2018-12-21
JP2025160358A (ja) 2025-10-22
US20200289547A1 (en) 2020-09-17
BR112018069060A2 (pt) 2019-01-29

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