JP6479800B2 - ピロリジン誘導体の経口製剤 - Google Patents

ピロリジン誘導体の経口製剤 Download PDF

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JP6479800B2
JP6479800B2 JP2016534249A JP2016534249A JP6479800B2 JP 6479800 B2 JP6479800 B2 JP 6479800B2 JP 2016534249 A JP2016534249 A JP 2016534249A JP 2016534249 A JP2016534249 A JP 2016534249A JP 6479800 B2 JP6479800 B2 JP 6479800B2
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methyl
biphenyl
carbonyl
hydroxymethyl
pyrrolidin
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Japanese (ja)
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JP2016540758A (ja
Inventor
ショレ、アンドレ
ポール、オリヴィエ
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オブセヴァ エス．エー．
オブセヴァ エス．エー．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
JP2016534249A 2013-12-17 2014-12-15 ピロリジン誘導体の経口製剤 Active JP6479800B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13197606.0 2013-12-17
EP13197606.0A EP2886107A1 (en) 2013-12-17 2013-12-17 Oral formulations of pyrrolydine derivatives
PCT/EP2014/077767 WO2015091365A1 (en) 2013-12-17 2014-12-15 Oral formulations of pyrrolidine derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019019345A Division JP2019108336A (ja) 2013-12-17 2019-02-06 ピロリジン誘導体の経口製剤

Publications (2)

Publication Number Publication Date
JP2016540758A JP2016540758A (ja) 2016-12-28
JP6479800B2 true JP6479800B2 (ja) 2019-03-06

Family

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Family Applications (2)

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JP2016534249A Active JP6479800B2 (ja) 2013-12-17 2014-12-15 ピロリジン誘導体の経口製剤
JP2019019345A Pending JP2019108336A (ja) 2013-12-17 2019-02-06 ピロリジン誘導体の経口製剤

Family Applications After (1)

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JP2019019345A Pending JP2019108336A (ja) 2013-12-17 2019-02-06 ピロリジン誘導体の経口製剤

Country Status (19)

Country Link
US (5) US20170065556A1 (OSRAM)
EP (4) EP2886107A1 (OSRAM)
JP (2) JP6479800B2 (OSRAM)
KR (1) KR102350156B1 (OSRAM)
CN (2) CN110960495B (OSRAM)
AU (1) AU2014364962B2 (OSRAM)
CA (1) CA2931592C (OSRAM)
CY (1) CY1119728T1 (OSRAM)
DK (1) DK3082773T3 (OSRAM)
EA (2) EA031530B1 (OSRAM)
ES (2) ES2654927T3 (OSRAM)
HK (1) HK1249050B (OSRAM)
HU (1) HUE035212T2 (OSRAM)
IL (2) IL245855B (OSRAM)
MX (2) MX363697B (OSRAM)
PT (1) PT3082773T (OSRAM)
SI (1) SI3082773T1 (OSRAM)
UA (1) UA116824C2 (OSRAM)
WO (1) WO2015091365A1 (OSRAM)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
US20220218680A1 (en) * 2019-06-14 2022-07-14 Kalvista Pharmaceuticals Limited Treatments of hereditary angioedema

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EP3753921A1 (en) 2014-07-02 2020-12-23 ObsEva S.A. Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime useful in methods of treating conditions related to the ot-r activity
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EP4025207A1 (en) * 2019-09-03 2022-07-13 ObsEva S.A. Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
AU2021218895A1 (en) 2020-02-10 2022-09-15 ObsEva S.A. Biomarkers for oxytocin receptor antagonist therapy
SMT202200411T1 (it) 2020-05-18 2022-11-18 Orexo Ab Nuova composizione farmaceutica per il rilascio controllato di farmaci
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GB202117016D0 (en) 2021-11-25 2022-01-12 Orexo Ab New pharmaceutical device

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EP2886107A1 (en) * 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
EP3753921A1 (en) 2014-07-02 2020-12-23 ObsEva S.A. Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime useful in methods of treating conditions related to the ot-r activity
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220218680A1 (en) * 2019-06-14 2022-07-14 Kalvista Pharmaceuticals Limited Treatments of hereditary angioedema

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Publication number Publication date
IL245855A0 (en) 2016-07-31
KR102350156B1 (ko) 2022-01-11
CA2931592C (en) 2021-12-07
MX363697B (es) 2019-03-29
CN110960495A (zh) 2020-04-07
US20170065556A1 (en) 2017-03-09
HUE035212T2 (en) 2018-05-02
US20150164859A1 (en) 2015-06-18
EA201892033A2 (ru) 2019-02-28
JP2016540758A (ja) 2016-12-28
US9962367B2 (en) 2018-05-08
JP2019108336A (ja) 2019-07-04
EA201892033A3 (ru) 2019-03-29
US10478420B2 (en) 2019-11-19
CN110960495B (zh) 2022-05-10
EP3266449A1 (en) 2018-01-10
HK1249050B (en) 2020-01-17
CN106029057A (zh) 2016-10-12
US11419851B2 (en) 2022-08-23
WO2015091365A1 (en) 2015-06-25
IL245855B (en) 2019-02-28
SI3082773T1 (en) 2018-02-28
ES2726730T3 (es) 2019-10-08
EP3494967A1 (en) 2019-06-12
EA201691061A1 (ru) 2016-11-30
EP2886107A1 (en) 2015-06-24
EP3082773B1 (en) 2017-10-04
ES2654927T3 (es) 2018-02-15
MX2016007930A (es) 2016-09-19
AU2014364962A1 (en) 2016-07-28
MX2019003598A (es) 2019-07-15
AU2014364962B2 (en) 2020-03-26
EA031530B1 (ru) 2019-01-31
IL264259A (en) 2019-02-28
CY1119728T1 (el) 2018-06-27
DK3082773T3 (en) 2018-01-08
US20180311211A1 (en) 2018-11-01
US20230226021A1 (en) 2023-07-20
UA116824C2 (uk) 2018-05-10
PT3082773T (pt) 2018-01-09
US20200281892A1 (en) 2020-09-10
KR20160097359A (ko) 2016-08-17
CN106029057B (zh) 2019-09-03
CA2931592A1 (en) 2015-06-25
EP3082773A1 (en) 2016-10-26
EP3266449B1 (en) 2019-02-27

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