EA201892033A2 - Лекарственные формы производных пирролидина для перорального введения - Google Patents

Лекарственные формы производных пирролидина для перорального введения

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Publication number
EA201892033A2
EA201892033A2 EA201892033A EA201892033A EA201892033A2 EA 201892033 A2 EA201892033 A2 EA 201892033A2 EA 201892033 A EA201892033 A EA 201892033A EA 201892033 A EA201892033 A EA 201892033A EA 201892033 A2 EA201892033 A2 EA 201892033A2
Authority
EA
Eurasian Patent Office
Prior art keywords
oral administration
dosage forms
drug forms
pyrrolidine derivatives
relates
Prior art date
Application number
EA201892033A
Other languages
English (en)
Other versions
EA201892033A3 (ru
Inventor
Андрэ Шолле
Оливье Поль
Original Assignee
Обсева С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Обсева С.А. filed Critical Обсева С.А.
Publication of EA201892033A2 publication Critical patent/EA201892033A2/ru
Publication of EA201892033A3 publication Critical patent/EA201892033A3/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)

Abstract

Настоящее изобретение относится к твердым лекарственным формам для перорального введения, содержащим соединение формулы (3Z,5S)-5-(гидроксиметил)-1-[(2'-метил-1,1'-бифенил-4-ил)карбонил]пирролидин-3-он-O-метилоксим и/или его активный метаболит, и применению указанных лекарственных форм для лечения и/или предотвращения преждевременных родов, недоношенности, дисменореи и нарушения имплантации эмбриона, вызванного маточными сокращениями. Настоящее изобретение также относится к способам получения указанных лекарственных форм.
EA201892033A 2013-12-17 2014-12-15 Лекарственные формы производных пирролидина для перорального введения EA201892033A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13197606.0A EP2886107A1 (en) 2013-12-17 2013-12-17 Oral formulations of pyrrolydine derivatives

Publications (2)

Publication Number Publication Date
EA201892033A2 true EA201892033A2 (ru) 2019-02-28
EA201892033A3 EA201892033A3 (ru) 2019-03-29

Family

ID=49765403

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201691061A EA031530B1 (ru) 2013-12-17 2014-12-15 ДИСПЕРГИРУЕМАЯ ТАБЛЕТКА ДЛЯ ПЕРОРАЛЬНОГО ВВЕДЕНИЯ, СОДЕРЖАЩАЯ (3Z,5S)-5-(ГИДРОКСИМЕТИЛ)-1-[(2'-МЕТИЛ-1,1'-БИФЕНИЛ-4-ИЛ)КАРБОНИЛ]ПИРРОЛИДИН-3-он-О-МЕТИЛОКСИМ
EA201892033A EA201892033A3 (ru) 2013-12-17 2014-12-15 Лекарственные формы производных пирролидина для перорального введения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201691061A EA031530B1 (ru) 2013-12-17 2014-12-15 ДИСПЕРГИРУЕМАЯ ТАБЛЕТКА ДЛЯ ПЕРОРАЛЬНОГО ВВЕДЕНИЯ, СОДЕРЖАЩАЯ (3Z,5S)-5-(ГИДРОКСИМЕТИЛ)-1-[(2'-МЕТИЛ-1,1'-БИФЕНИЛ-4-ИЛ)КАРБОНИЛ]ПИРРОЛИДИН-3-он-О-МЕТИЛОКСИМ

Country Status (19)

Country Link
US (5) US20170065556A1 (ru)
EP (4) EP2886107A1 (ru)
JP (2) JP6479800B2 (ru)
KR (1) KR102350156B1 (ru)
CN (2) CN110960495B (ru)
AU (1) AU2014364962B2 (ru)
CA (1) CA2931592C (ru)
CY (1) CY1119728T1 (ru)
DK (1) DK3082773T3 (ru)
EA (2) EA031530B1 (ru)
ES (2) ES2726730T3 (ru)
HK (1) HK1249050B (ru)
HU (1) HUE035212T2 (ru)
IL (2) IL245855B (ru)
MX (2) MX363697B (ru)
PT (1) PT3082773T (ru)
SI (1) SI3082773T1 (ru)
UA (1) UA116824C2 (ru)
WO (1) WO2015091365A1 (ru)

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EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
EA201891873A1 (ru) 2014-07-02 2019-04-30 Обсева Са Кристаллический о-метилоксим (3z,5s)-5-(гидроксиметил)-1-[(2'-метил-1,1'-бифенил-4-ил)карбонил]пирролидин-3-он, полезный в способах лечения состояний, связанных с активностью ot-r
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Also Published As

Publication number Publication date
HK1249050B (zh) 2020-01-17
SI3082773T1 (en) 2018-02-28
MX2016007930A (es) 2016-09-19
US9962367B2 (en) 2018-05-08
EA031530B1 (ru) 2019-01-31
AU2014364962A1 (en) 2016-07-28
EP3082773B1 (en) 2017-10-04
CN110960495B (zh) 2022-05-10
EA201892033A3 (ru) 2019-03-29
CY1119728T1 (el) 2018-06-27
US20200281892A1 (en) 2020-09-10
ES2654927T3 (es) 2018-02-15
CN106029057A (zh) 2016-10-12
EP3494967A1 (en) 2019-06-12
US20170065556A1 (en) 2017-03-09
JP2019108336A (ja) 2019-07-04
EP3082773A1 (en) 2016-10-26
AU2014364962B2 (en) 2020-03-26
MX2019003598A (es) 2019-07-15
KR102350156B1 (ko) 2022-01-11
ES2726730T3 (es) 2019-10-08
PT3082773T (pt) 2018-01-09
EP3266449B1 (en) 2019-02-27
IL245855B (en) 2019-02-28
JP6479800B2 (ja) 2019-03-06
IL264259A (en) 2019-02-28
MX363697B (es) 2019-03-29
CA2931592C (en) 2021-12-07
EP2886107A1 (en) 2015-06-24
KR20160097359A (ko) 2016-08-17
US11419851B2 (en) 2022-08-23
CA2931592A1 (en) 2015-06-25
DK3082773T3 (en) 2018-01-08
EP3266449A1 (en) 2018-01-10
US10478420B2 (en) 2019-11-19
EA201691061A1 (ru) 2016-11-30
WO2015091365A1 (en) 2015-06-25
UA116824C2 (uk) 2018-05-10
US20230226021A1 (en) 2023-07-20
US20150164859A1 (en) 2015-06-18
HUE035212T2 (en) 2018-05-02
IL245855A0 (en) 2016-07-31
JP2016540758A (ja) 2016-12-28
CN106029057B (zh) 2019-09-03
CN110960495A (zh) 2020-04-07
US20180311211A1 (en) 2018-11-01

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