JP6474826B2 - 化合物 - Google Patents

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Publication number

JP6474826B2

JP6474826B2 JP2016549113A JP2016549113A JP6474826B2 JP 6474826 B2 JP6474826 B2 JP 6474826B2 JP 2016549113 A JP2016549113 A JP 2016549113A JP 2016549113 A JP2016549113 A JP 2016549113A JP 6474826 B2 JP6474826 B2 JP 6474826B2

Authority

JP

Japan

Prior art keywords

amino

pyrrolo

ethoxy

methanone

pyrimidin

Prior art date

2014-01-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 150000001875 compounds Chemical class 0.000 title claims description 293
• 150000003839 salts Chemical class 0.000 claims description 121
• -1 -CH 2 -OCH 3 Chemical group 0.000 claims description 94
• 208000018737 Parkinson disease Diseases 0.000 claims description 56
• 238000011282 treatment Methods 0.000 claims description 53
• 125000000217 alkyl group Chemical group 0.000 claims description 44
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 40
• 229910052739 hydrogen Inorganic materials 0.000 claims description 35
• WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims description 32
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 32
• 229910052757 nitrogen Inorganic materials 0.000 claims description 31
• 125000001424 substituent group Chemical group 0.000 claims description 27
• 125000003545 alkoxy group Chemical group 0.000 claims description 26
• 125000000623 heterocyclic group Chemical group 0.000 claims description 25
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 24
• 239000008194 pharmaceutical composition Substances 0.000 claims description 21
• 229910052799 carbon Inorganic materials 0.000 claims description 16
• 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims description 8
• FOYGUIORMIFUDH-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-[1-(methoxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CC3(CC3C1)COC)OC)NC=C2 FOYGUIORMIFUDH-UHFFFAOYSA-N 0.000 claims description 7
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 6
• WMLSHPWNBDRREK-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-[1-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CC3(CC3C1)CO)OC)NC=C2 WMLSHPWNBDRREK-UHFFFAOYSA-N 0.000 claims description 6
• 229910052731 fluorine Inorganic materials 0.000 claims description 6
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 6
• 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims description 6
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
• PBUIMZPVMYITCU-UHFFFAOYSA-N 4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-N-(2-hydroxy-2-methylpropyl)-3-methoxybenzamide Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C(=O)NCC(C)(C)O)C=C1)OC)NC=C2 PBUIMZPVMYITCU-UHFFFAOYSA-N 0.000 claims description 4
• LUQLXJIECULYHR-UHFFFAOYSA-N 4-ethoxy-2-[2-methoxy-4-(morpholine-4-carbonyl)anilino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CCOCC1)OC)NC=C2C#N LUQLXJIECULYHR-UHFFFAOYSA-N 0.000 claims description 4
• BVYHOSMEELUDJT-UHFFFAOYSA-N 4-ethoxy-2-[4-(4-fluoropiperidine-1-carbonyl)-2-methoxyanilino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CCC(CC1)F)OC)NC=C2C#N BVYHOSMEELUDJT-UHFFFAOYSA-N 0.000 claims description 4
• TYCYMJJYDKBBBY-UHFFFAOYSA-N 4-ethoxy-2-[4-(morpholine-4-carbonyl)-2-propan-2-yloxyanilino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CCOCC1)OC(C)C)NC=C2C#N TYCYMJJYDKBBBY-UHFFFAOYSA-N 0.000 claims description 4
• UBWYHVLVWQGUPH-UHFFFAOYSA-N 6-azaspiro[2.5]octan-6-yl-[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CCC3(CC3)CC1)OC)NC=C2 UBWYHVLVWQGUPH-UHFFFAOYSA-N 0.000 claims description 4
• MYHCTEBMNDXARD-KEYYUXOJSA-N C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C(=O)N3[C@H]4C[C@H]4C[C@H]3C#N)C=C1)OC)NC=C2 Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C(=O)N3[C@H]4C[C@H]4C[C@H]3C#N)C=C1)OC)NC=C2 MYHCTEBMNDXARD-KEYYUXOJSA-N 0.000 claims description 4
• DBMBMBNEFVQIKO-INIZCTEOSA-N C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1C[C@H]3N(CC1)CCC3)OC)NC=C2 Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1C[C@H]3N(CC1)CCC3)OC)NC=C2 DBMBMBNEFVQIKO-INIZCTEOSA-N 0.000 claims description 4
• YXDXETXIHNPNDD-UHFFFAOYSA-N C(C)OC=1C2=C(N=C(N=1)NC1=CC=C(C=C1)C(=O)N1CCOCC1)NC=C2 Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=CC=C(C=C1)C(=O)N1CCOCC1)NC=C2 YXDXETXIHNPNDD-UHFFFAOYSA-N 0.000 claims description 4
• BETIDOFKGOTVIM-UHFFFAOYSA-N C1(CC1)COC1=C2C(=NC(=N1)NC1=C(C=C(C=C1)C(=O)N1CCOCC1)OC)NN=C2 Chemical compound C1(CC1)COC1=C2C(=NC(=N1)NC1=C(C=C(C=C1)C(=O)N1CCOCC1)OC)NN=C2 BETIDOFKGOTVIM-UHFFFAOYSA-N 0.000 claims description 4
• DZCANEMNEGXZGF-CQSZACIVSA-N C[C@H]1N(CCN(C1)C)C(=O)C1=CC(=C(C=C1)NC=1N=C(C2=C(N=1)NC=C2)OCC)OC Chemical compound C[C@H]1N(CCN(C1)C)C(=O)C1=CC(=C(C=C1)NC=1N=C(C2=C(N=1)NC=C2)OCC)OC DZCANEMNEGXZGF-CQSZACIVSA-N 0.000 claims description 4
• DZCANEMNEGXZGF-AWEZNQCLSA-N [(2S)-2,4-dimethylpiperazin-1-yl]-[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]methanone Chemical compound C[C@@H]1N(CCN(C1)C)C(=O)C1=CC(=C(C=C1)NC=1N=C(C2=C(N=1)NC=C2)OCC)OC DZCANEMNEGXZGF-AWEZNQCLSA-N 0.000 claims description 4
• SMNTVQSPZMHDKB-CQSZACIVSA-N [(3R)-3,4-dimethylpiperazin-1-yl]-[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]methanone Chemical compound C[C@@H]1CN(CCN1C)C(=O)C1=CC(=C(C=C1)NC=1N=C(C2=C(N=1)NC=C2)OCC)OC SMNTVQSPZMHDKB-CQSZACIVSA-N 0.000 claims description 4
• SMNTVQSPZMHDKB-AWEZNQCLSA-N [(3S)-3,4-dimethylpiperazin-1-yl]-[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]methanone Chemical compound C[C@H]1CN(CCN1C)C(=O)C1=CC(=C(C=C1)NC=1N=C(C2=C(N=1)NC=C2)OCC)OC SMNTVQSPZMHDKB-AWEZNQCLSA-N 0.000 claims description 4
• DBMBMBNEFVQIKO-MRXNPFEDSA-N [(8aR)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]methanone Chemical compound [H][C@]12CCCN1CCN(C2)C(=O)C1=CC=C(NC2=NC(OCC)=C3C=CNC3=N2)C(OC)=C1 DBMBMBNEFVQIKO-MRXNPFEDSA-N 0.000 claims description 4
• DAKMZXFFGKUYMB-UHFFFAOYSA-N [3-(cyclopropylmethoxy)-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone Chemical compound C1(CC1)COC=1C=C(C=CC=1NC=1N=C(C2=C(N=1)NC=C2)OCC)C(=O)N1CCN(CC1)C DAKMZXFFGKUYMB-UHFFFAOYSA-N 0.000 claims description 4
• HOJVIDJOKDJWHI-UHFFFAOYSA-N [3-(difluoromethoxy)-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone Chemical compound FC(OC=1C=C(C=CC=1NC=1N=C(C2=C(N=1)NC=C2)OCC)C(=O)N1CCN(CC1)C)F HOJVIDJOKDJWHI-UHFFFAOYSA-N 0.000 claims description 4
• CJWBQHYSPLMYLF-UHFFFAOYSA-N [3-(dimethylamino)-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-morpholin-4-ylmethanone Chemical compound CN(C=1C=C(C=CC=1NC=1N=C(C2=C(N=1)NC=C2)OCC)C(=O)N1CCOCC1)C CJWBQHYSPLMYLF-UHFFFAOYSA-N 0.000 claims description 4
• PKPHXFLUJZRNMC-UHFFFAOYSA-N [3-chloro-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone Chemical compound ClC=1C=C(C=CC=1NC=1N=C(C2=C(N=1)NC=C2)OCC)C(=O)N1CCN(CC1)C PKPHXFLUJZRNMC-UHFFFAOYSA-N 0.000 claims description 4
• RXEIMTCOCBLPMN-UHFFFAOYSA-N [3-ethoxy-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone Chemical compound C(C)OC=1C=C(C=CC=1NC=1N=C(C2=C(N=1)NC=C2)OCC)C(=O)N1CCN(CC1)C RXEIMTCOCBLPMN-UHFFFAOYSA-N 0.000 claims description 4
• XCQZSMPJFKRMEC-UHFFFAOYSA-N [3-ethoxy-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-morpholin-4-ylmethanone Chemical compound C(C)OC=1C=C(C=CC=1NC=1N=C(C2=C(N=1)NC=C2)OCC)C(=O)N1CCOCC1 XCQZSMPJFKRMEC-UHFFFAOYSA-N 0.000 claims description 4
• HDISHNLOAWOBSV-UHFFFAOYSA-N [4-[(4-ethoxy-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Chemical compound C(C)OC1=C2C(=NC(=N1)NC1=C(C=C(C=C1)C(=O)N1CCOCC1)OC)NN=C2 HDISHNLOAWOBSV-UHFFFAOYSA-N 0.000 claims description 4
• PYUPIQNHSCPYNV-UHFFFAOYSA-N [4-[(4-ethoxy-3-methyl-2H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Chemical compound C(C)OC1=C2C(=NC(=N1)NC1=C(C=C(C=C1)C(=O)N1CCOCC1)OC)NN=C2C PYUPIQNHSCPYNV-UHFFFAOYSA-N 0.000 claims description 4
• UAEGPEVKKDUSGO-UHFFFAOYSA-N [4-[(4-ethoxy-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CCOCC1)OC)NC=C2C UAEGPEVKKDUSGO-UHFFFAOYSA-N 0.000 claims description 4
• MLCOBAYMDQFCEL-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-2-fluoro-5-methoxyphenyl]-(4-methylpiperazin-1-yl)methanone Chemical compound CCOC1=C2C=CNC2=NC(NC2=C(OC)C=C(C(=O)N3CCN(C)CC3)C(F)=C2)=N1 MLCOBAYMDQFCEL-UHFFFAOYSA-N 0.000 claims description 4
• XHNVLJKSFBTDET-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=CC(=C(C=C1OC)C(=O)N1CCOCC1)F)NC=C2 XHNVLJKSFBTDET-UHFFFAOYSA-N 0.000 claims description 4
• ILDNJYDWDJSMJE-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-2-methoxyphenyl]-morpholin-4-ylmethanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=CC(=C(C=C1)C(=O)N1CCOCC1)OC)NC=C2 ILDNJYDWDJSMJE-UHFFFAOYSA-N 0.000 claims description 4
• SYEFRJQQUWYFPO-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxy-2-methylphenyl]-morpholin-4-ylmethanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C(=C(C=C1)C(=O)N1CCOCC1)C)OC)NC=C2 SYEFRJQQUWYFPO-UHFFFAOYSA-N 0.000 claims description 4
• PNSIDIFOMRFWKN-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(1,3-oxazolidin-3-yl)methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1COCC1)OC)NC=C2 PNSIDIFOMRFWKN-UHFFFAOYSA-N 0.000 claims description 4
• XKTIZOAXSZOWSA-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(2-methyl-2,7-diazaspiro[3.5]nonan-7-yl)methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CCC3(CN(C3)C)CC1)OC)NC=C2 XKTIZOAXSZOWSA-UHFFFAOYSA-N 0.000 claims description 4
• DTAQNJRTPPUJGH-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CC3(COC3)C1)OC)NC=C2 DTAQNJRTPPUJGH-UHFFFAOYSA-N 0.000 claims description 4
• KIOSBYAHAHZRJR-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(2-oxa-7-azaspiro[3.4]octan-7-yl)methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CC3(COC3)CC1)OC)NC=C2 KIOSBYAHAHZRJR-UHFFFAOYSA-N 0.000 claims description 4
• ZENWLKYAFZOJLJ-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(2-oxa-8-azaspiro[3.5]nonan-8-yl)methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CC3(COC3)CCC1)OC)NC=C2 ZENWLKYAFZOJLJ-UHFFFAOYSA-N 0.000 claims description 4
• PMUOXSQEEBYJKS-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(4-fluoropiperidin-1-yl)methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CCC(CC1)F)OC)NC=C2 PMUOXSQEEBYJKS-UHFFFAOYSA-N 0.000 claims description 4
• OSKFNUPAFGHESE-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(4-methylpiperazin-1-yl)methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CCN(CC1)C)OC)NC=C2 OSKFNUPAFGHESE-UHFFFAOYSA-N 0.000 claims description 4
• MHQJXVQYHJEGQK-OAHLLOKOSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1[C@H](CCC1)COC)OC)NC=C2 MHQJXVQYHJEGQK-OAHLLOKOSA-N 0.000 claims description 4
• LMFRLKQMMLEFRK-ZDUSSCGKSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-[(3S)-3-methylmorpholin-4-yl]methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1[C@H](COCC1)C)OC)NC=C2 LMFRLKQMMLEFRK-ZDUSSCGKSA-N 0.000 claims description 4
• ALDNPHAMSBJPMR-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CCC(CC1)N1CCN(CC1)C)OC)NC=C2 ALDNPHAMSBJPMR-UHFFFAOYSA-N 0.000 claims description 4
• RKCPDXVXZIFUQT-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-[7-(hydroxymethyl)-6-azaspiro[2.5]octan-6-yl]methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1C(CC3(CC3)CC1)CO)OC)NC=C2 RKCPDXVXZIFUQT-UHFFFAOYSA-N 0.000 claims description 4
• OTTOCUYGSZUQOI-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CCOCC1)OC)NC=C2 OTTOCUYGSZUQOI-UHFFFAOYSA-N 0.000 claims description 4
• LABPCPFLOINJNJ-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-propan-2-yloxyphenyl]-(4-methylpiperazin-1-yl)methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CCN(CC1)C)OC(C)C)NC=C2 LABPCPFLOINJNJ-UHFFFAOYSA-N 0.000 claims description 4
• JNEYRGCOLYRABZ-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-propan-2-yloxyphenyl]-morpholin-4-ylmethanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=C(C=C(C=C1)C(=O)N1CCOCC1)OC(C)C)NC=C2 JNEYRGCOLYRABZ-UHFFFAOYSA-N 0.000 claims description 4
• LDUCAMLWRFAGCU-UHFFFAOYSA-N [4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone Chemical compound C(C)OC=1C2=C(N=C(N=1)NC1=CC=C(C=C1)C(=O)N1CCN(CC1)C)NC=C2 LDUCAMLWRFAGCU-UHFFFAOYSA-N 0.000 claims description 4
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