CN105980388B - 化合物 - Google Patents

化合物 Download PDF

Info

Publication number
CN105980388B
CN105980388B CN201580006294.1A CN201580006294A CN105980388B CN 105980388 B CN105980388 B CN 105980388B CN 201580006294 A CN201580006294 A CN 201580006294A CN 105980388 B CN105980388 B CN 105980388B
Authority
CN
China
Prior art keywords
pyrrolo
amino
pyrimidine
base
ketone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201580006294.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN105980388A (zh
Inventor
丁晓
刘谦
龙凯
桑迎霞
L.P.斯塔西
万泽红
徐琼峰
C.M.埃奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Intellectual Property Development Ltd
Original Assignee
GlaxoSmithKline Intellectual Property Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Intellectual Property Development Ltd filed Critical GlaxoSmithKline Intellectual Property Development Ltd
Publication of CN105980388A publication Critical patent/CN105980388A/zh
Application granted granted Critical
Publication of CN105980388B publication Critical patent/CN105980388B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201580006294.1A 2014-01-29 2015-01-28 化合物 Expired - Fee Related CN105980388B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2014/000140 2014-01-29
CN2014000140 2014-01-29
PCT/CN2015/000054 WO2015113451A1 (en) 2014-01-29 2015-01-28 Compounds

Publications (2)

Publication Number Publication Date
CN105980388A CN105980388A (zh) 2016-09-28
CN105980388B true CN105980388B (zh) 2018-01-16

Family

ID=53756223

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580006294.1A Expired - Fee Related CN105980388B (zh) 2014-01-29 2015-01-28 化合物

Country Status (9)

Country Link
US (1) US9815841B2 (enExample)
EP (1) EP3099694B1 (enExample)
JP (1) JP6474826B2 (enExample)
CN (1) CN105980388B (enExample)
AU (2) AU2015210554A1 (enExample)
CA (1) CA2937430A1 (enExample)
ES (1) ES2717757T3 (enExample)
RU (1) RU2016134751A (enExample)
WO (1) WO2015113451A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20161443A1 (es) 2014-01-29 2017-01-06 Glaxosmithkline Ip Dev Ltd Compuestos
EP3778605A3 (en) * 2015-02-13 2021-03-10 Dana Farber Cancer Institute, Inc. Lrrk2 inhibitors and methods of making and using the same
JP2018537502A (ja) 2015-12-16 2018-12-20 サウザーン リサーチ インスチチュート ピロロピリミジン化合物、キナーゼｌｒｒｋ２阻害剤としての使用、及びその調製方法
CA3049820A1 (en) 2017-01-25 2018-08-02 Glaxosmithkline Intellectual Property Development Limited Compounds for inhibiting lrrk2 kinase activity
CN110248936A (zh) * 2017-01-25 2019-09-17 葛兰素史密斯克莱知识产权发展有限公司 化合物
KR20180097162A (ko) * 2017-02-22 2018-08-30 국립암센터 피롤로-피리미딘 유도체 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물
AU2018239798B2 (en) 2017-03-23 2020-08-27 Daegu Gyeongbuk Institute Of Science And Technology Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
CA3168211A1 (en) 2019-01-18 2020-07-23 Voronoi Co., Ltd. Pyrrolopyridine derivative and use thereof for preventing or treating protein kinase related disease
CN113614086A (zh) * 2019-01-18 2021-11-05 沃若诺伊公司 吡咯并嘧啶衍生物以及包含其作为活性成分的用于预防或治疗蛋白激酶相关的疾病的药物组合物
CZ308800B6 (cs) * 2019-02-12 2021-05-26 Univerzita Palackého v Olomouci Heterocyklické dusíkaté deriváty purinu, farmaceutické přípravky obsahující tyto deriváty a jejich použití při neuroprotekci
EP3968990A4 (en) * 2019-05-16 2023-06-07 Dana-Farber Cancer Institute, Inc. WILD-TYPE PYRROLOPYRIMIDINE INHIBITORS AND MUTANT FORMS OF LRRK2
CN111205216B (zh) * 2020-03-11 2022-03-29 连云港恒运药业有限公司 一种制备沙格列汀的方法
KR20230091150A (ko) * 2020-10-29 2023-06-22 수저우 야바오 파마슈티걸 알앤디 컴퍼니 리미티드 치환된 디아릴아민 화합물 및 이의 약학적 조성물, 제조 방법과 용도
KR20220081631A (ko) 2020-12-09 2022-06-16 보로노이 주식회사 염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도
WO2022155419A1 (en) * 2021-01-15 2022-07-21 ESCAPE Bio, Inc. Indazoles and azaindazoles as lrrk2 inhibitors
AU2022246081A1 (en) 2021-03-23 2023-10-12 Halia Therapeutics, Inc. Pyrimidine derivatives useful as lrrk2 kinase inhibitors
WO2023073013A1 (en) 2021-10-27 2023-05-04 H. Lundbeck A/S Lrrk2 inhibitors
CN115108991B (zh) * 2022-06-30 2023-05-05 南京理工大学 一种硝仿基吡唑起爆药及其制备方法
TW202412777A (zh) 2022-09-15 2024-04-01 丹麥商Ｈ 朗德貝克公司 富白胺酸重複激酶2（lrrk2）抑制劑

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005028480A2 (en) 2003-09-03 2005-03-31 Neurogen Corporation 5-aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds
GB0420719D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
WO2006050076A1 (en) 2004-10-29 2006-05-11 Janssen Pharmaceutica, N.V. Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
WO2007042298A1 (en) * 2005-10-13 2007-04-19 Glaxo Group Limited Pyrrolopyrimidine derivatives as syk inhibitors
WO2007125405A2 (en) 2006-05-01 2007-11-08 Pfizer Products Inc. Substituted 2-amino-fused heterocyclic compounds
WO2009036066A1 (en) 2007-09-10 2009-03-19 Curis, Inc. Vegfr inhibitors containing a zinc binding moiety
US9315449B2 (en) 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
US8158636B2 (en) 2008-05-19 2012-04-17 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2009143404A1 (en) 2008-05-23 2009-11-26 Wyeth Piperazine metabotropic glutamate receptor 5 (mglur5) negative allosteric modulators for anxiety/depression
US9908884B2 (en) 2009-05-05 2018-03-06 Dana-Farber Cancer Institute, Inc. EGFR inhibitors and methods of treating disorders
BR112012006859A2 (pt) 2009-09-29 2019-09-24 Glaxo Group Ltd compostos
MX2012014158A (es) * 2010-06-04 2013-02-07 Hoffmann La Roche Derivados de aminopirimidina como moduladores de proteina cinasa rica repeticiones leucina 2 (lrrk2).
WO2011153553A2 (en) 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
WO2012009258A2 (en) 2010-07-13 2012-01-19 Edward Roberts Peptidomimetic galanin receptor modulators
WO2012045195A1 (en) * 2010-10-09 2012-04-12 Abbott Laboratories Pyrrolopyrimidines as fak and alk inhibiters for treatment of cancers and other diseases
CN103298474B (zh) 2010-11-10 2016-06-29 无限药品股份有限公司 杂环化合物及其用途
PH12013500880A1 (en) 2010-11-10 2013-07-01 Hoffmann La Roche Pyrazole aminopyrimidine derivatives as lrrk2 modulators
JP5937102B2 (ja) 2010-12-14 2016-06-22 エレクトロフォレティクス リミテッド カゼインキナーゼ１デルタ（ｃｋ１デルタ）阻害剤
CA2831634C (en) * 2011-04-21 2019-11-12 Origenis Gmbh Pyrazolo [4,3-d] pyrimidines useful as kinase inhibitors
AU2012311184A1 (en) 2011-09-22 2014-03-06 Pfizer Inc. Pyrrolopyrimidine and purine derivatives
BR112014012822A8 (pt) 2011-11-30 2017-07-11 Hoffmann La Roche Radioligantes rotulados com flúor-18 e carbono-11 para imagiologia por tomografia por emissão de pósitrons (pet) para lrrk2
GB201204985D0 (en) * 2012-03-21 2012-05-02 Genentech Inc Compounds
JP6218808B2 (ja) 2012-05-03 2017-10-25 ジェネンテック， インコーポレイテッド Ｌｒｒｋ２モジュレ−タ−としてのピラゾ−ルアミノピリミジン誘導体
KR102091895B1 (ko) 2012-05-03 2020-04-14 제넨테크, 인크. 파킨슨병의 치료에 사용하기 위한 lrrk2 조절제로서의 피라졸 아미노피리미딘 유도체
MD20140130A2 (ro) 2012-06-29 2015-04-30 Pfizer Inc. 4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2
PE20161443A1 (es) 2014-01-29 2017-01-06 Glaxosmithkline Ip Dev Ltd Compuestos

Also Published As

Publication number Publication date
US20170022204A1 (en) 2017-01-26
AU2015210554A1 (en) 2016-07-07
WO2015113451A1 (en) 2015-08-06
US9815841B2 (en) 2017-11-14
JP2017504635A (ja) 2017-02-09
CN105980388A (zh) 2016-09-28
AU2018200271A1 (en) 2018-02-01
JP6474826B2 (ja) 2019-02-27
EP3099694B1 (en) 2019-01-16
RU2016134751A (ru) 2018-03-02
ES2717757T3 (es) 2019-06-25
EP3099694A4 (en) 2017-06-14
CA2937430A1 (en) 2015-08-06
EP3099694A1 (en) 2016-12-07

Similar Documents

Publication Publication Date Title
CN105980388B (zh) 化合物
TWI801372B (zh) 作為a2a抑制劑的硫胺甲酸酯衍生物以及用於癌症治療的方法
JP6745824B2 (ja) 複素環化合物
JP6832342B2 (ja) 複素環化合物
KR101792837B1 (ko) 키나아제 억제제로서 사용을 위한 이미다조피라진
JP2020526543A (ja) ロイシンリッチリピートキナーゼ２の阻害剤
CN110678467B (zh) 治疗化合物和组合物及其使用方法
WO2018030466A1 (ja) 複素環化合物
CN110678472B (zh) 作为a2a抑制剂的2-氧代噻唑衍生物和用于治疗癌症的化合物
WO2018137607A1 (en) Compounds
EP3630766A1 (en) Therapeutic compounds and compositions, and methods of use thereof
CN1842529A (zh) 用作蛋白激酶抑制剂的化合物和组合物
CA2871453A1 (en) Quinazolinedione derivative
KR20160106623A (ko) 화합물
CN114008050B (zh) Jak激酶的吡唑并嘧啶芳基醚抑制剂及其用途
CN111587250A (zh) 作为jak抑制剂的吡唑并嘧啶化合物
HK40091436A (zh) 作为a2a抑制剂的2-氧代噻唑衍生物和用於治疗癌症的化合物
HK40089309A (zh) 作为a2a抑制剂的2-氧代噻唑衍生物和用於治疗癌症的化合物
AU2022209175A9 (en) Indole derivatives as kinase inhibitors
HK40019825A (en) Therapeutic compounds and compositions, and methods of use thereof
HK40029259A (en) Pyrazolopyrimidine compounds as jak inhibitors
HK40019824B (en) Therapeutic compounds and compositions, and methods of use thereof
HK40019824A (en) Therapeutic compounds and compositions, and methods of use thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180116

Termination date: 20190128