JP6458322B2 - 粉末状ビタミンe製剤 - Google Patents
粉末状ビタミンe製剤 Download PDFInfo
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- JP6458322B2 JP6458322B2 JP2016512339A JP2016512339A JP6458322B2 JP 6458322 B2 JP6458322 B2 JP 6458322B2 JP 2016512339 A JP2016512339 A JP 2016512339A JP 2016512339 A JP2016512339 A JP 2016512339A JP 6458322 B2 JP6458322 B2 JP 6458322B2
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title description 40
- 229930003427 Vitamin E Natural products 0.000 title description 19
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 title description 19
- 229940046009 vitamin E Drugs 0.000 title description 19
- 235000019165 vitamin E Nutrition 0.000 title description 19
- 239000011709 vitamin E Substances 0.000 title description 19
- 238000002360 preparation method Methods 0.000 title description 5
- 239000000203 mixture Substances 0.000 claims description 152
- 229920002774 Maltodextrin Polymers 0.000 claims description 16
- 150000004676 glycans Chemical class 0.000 claims description 16
- 229920001282 polysaccharide Polymers 0.000 claims description 16
- 239000005017 polysaccharide Substances 0.000 claims description 16
- 239000005913 Maltodextrin Substances 0.000 claims description 14
- 229940035034 maltodextrin Drugs 0.000 claims description 14
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 13
- 150000002148 esters Chemical class 0.000 claims description 13
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 11
- 229940042585 tocopherol acetate Drugs 0.000 claims description 11
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 claims description 9
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 claims description 9
- 229920002472 Starch Polymers 0.000 claims description 9
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- 238000000034 method Methods 0.000 claims description 5
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- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 3
- 229920000881 Modified starch Polymers 0.000 claims description 3
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- 229920001213 Polysorbate 20 Polymers 0.000 claims description 3
- 229920001219 Polysorbate 40 Polymers 0.000 claims description 3
- 240000008042 Zea mays Species 0.000 claims description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 3
- 125000002947 alkylene group Chemical group 0.000 claims description 3
- 235000005822 corn Nutrition 0.000 claims description 3
- 125000001165 hydrophobic group Chemical group 0.000 claims description 3
- 235000019426 modified starch Nutrition 0.000 claims description 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 3
- -1 polyoxyethylene monooleate Polymers 0.000 claims description 2
- 235000013826 starch sodium octenyl succinate Nutrition 0.000 claims description 2
- 239000001334 starch sodium octenyl succinate Substances 0.000 claims description 2
- 229910000831 Steel Inorganic materials 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000010959 steel Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
- 229920002245 Dextrose equivalent Polymers 0.000 description 17
- 238000009472 formulation Methods 0.000 description 17
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
- 229940032147 starch Drugs 0.000 description 8
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- 235000010582 Pisum sativum Nutrition 0.000 description 5
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- 235000013305 food Nutrition 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000009928 pasteurization Methods 0.000 description 4
- 239000008121 dextrose Substances 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
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- 239000011550 stock solution Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 2
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- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 2
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- XDIYNQZUNSSENW-UUBOPVPUSA-N (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O XDIYNQZUNSSENW-UUBOPVPUSA-N 0.000 description 1
- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- GUOCOOQWZHQBJI-UHFFFAOYSA-N 4-oct-7-enoxy-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)OCCCCCCC=C GUOCOOQWZHQBJI-UHFFFAOYSA-N 0.000 description 1
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 1
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 240000004713 Pisum sativum Species 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
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- 229910052802 copper Inorganic materials 0.000 description 1
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- 238000002955 isolation Methods 0.000 description 1
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- 150000002772 monosaccharides Chemical class 0.000 description 1
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- 238000004448 titration Methods 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
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- 125000002640 tocopherol group Chemical class 0.000 description 1
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Classifications
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- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/594—Mixtures of polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Description
本発明に従う粉末状組成物の意外な1つの利点は、本組成物が粘着性でない(噴霧乾燥によって通常行われる乾燥プロセス中でも)ことである。本組成物は乾燥装置の壁にくっつかない。従って、製造中の材料の損失が低減されると共に、洗浄のための時間が短縮される。
(i)粉末状組成物の全重量に基づいて最大25重量%(wt−%)までのビタミンEと、
(ii)粉末状組成物の全重量に基づいて20〜50重量%の、20未満のDEを有する少なくとも1つのマルトデキストリンと、
(iii)粉末状組成物の全重量に基づいて20〜50重量%の少なくとも1つの修飾多糖と、
(iv)粉末状組成物の全重量に基づいて少なくとも5重量%の少なくとも1つのポリオキシエチレンソルビタンモノ脂肪酸エステルと
を含む粉末状組成物(I)に関する。
DEは、デンプンからデキストロースへの転化の度合いを表す。
デンプンはDE=0に近い。
グルコース/デキストロースは、DE=100(パーセント)である。
好ましくは、マルトデキストリンはトウモロコシ源またはエンドウ源、より好ましくはエンドウ源から得ることができる。
従って、本発明は組成物(IV)に関し、これは、マルトデキストリンがトウモロコシ源またはエンドウ源から得られる組成物(I)、(II)または(III)である。
従って、本発明は組成物(V)に関し、これは、マルトデキストリンがエンドウ源から得られる組成物(I)、(II)、(III)または(IV)である。
これらのマルトデキストリン類−特にエンドウ豆から得られるもの(ジャガイモ、小麦などのような他一般的な源とは対照的)−を使用する場合、製造プロセスは著しく改善される。
(式中、Stはデンプンであり、
Rはアルキレン基であり、R’は疎水性基である)
を有する組成物(I)、(II)、(III)、(IV)、(V)または(VI)である。
さらに、これらの透明飲料は、貯蔵の間、透明なままである(安定な透明飲料)。
これらの製剤は任意の形態であり得る。固体、液体またはゲル様。
より好ましいのは、少なくとも1つの粉末状組成物(I)、(II)、(III)、(IV)、(V)、(VI)、(VII)、(VIII)、(IX)、(X)、(XI)、(XII)、(XIII)、(XIV)、(XV)、(XVI)、(XVII)、(XVIII)および/または(XIX)を含む飲料である。
140gのCapsul HSおよび105gのKleptose Linecaps 17を1.5lの反応容器に入れ、室温で150gの脱イオン水中に分散させた。マイサーディスク(micer disk)(800rpm、d=6cm)を用いる攪拌下で温度を85℃まで上昇させた。溶液を60分間85℃に保持した。
56gの酢酸dl−アルファ−トコフェロールを65℃に予熱し、5〜10分以内に、マイサーディスク(8’500rpm)による均質化の下でCapsul HS、Kleptose Linecaps 17および水の混合物に添加した。同時に、51.5gの水を5〜10分以内にエマルションに添加した。このエマルションをマイサーディスク(8’500rpm)により85℃でさらに30分間均質化した。次に、36.8gのLamesorb SMO 20を65℃に予熱し、5分以内に均質化(マイサーディスク(8’500rpm))の下でエマルションに添加した。エマルション温度は85℃に保持した。次に、エマルションを85℃でさらに30分間均質化した(マイサーディスク、8’500rpm)。
攪拌(マイサーディスク、250rpm)下でエマルションを85℃でさらに30分間保持した。
メジアン粒径は100nm未満であった。
粉末状組成物は、3.1%の残留水分含量と共に得られた。内部相D[0,5]のサイズは93nmであった。
以下の表は組成物の成分の量を示す(値は、水を含まない水組成物に対して再計算される)。
実施例に従う粉末状組成物を以下の適用例において使用した。
適用例では、以下のフレーバー水の基本組成物を使用した。
以下の適用例の全てについて、1000ppmのビタミンE含量を有するストック溶液に対して実施例1の粉末状組成物を脱イオン水により希釈した。次にこのストック溶液を用いて、適用例のサンプルを作製した。全てのサンプルをガラスビン(200ml)に満たし、クラウンキャップでビンを密封した。
液体製剤の低温殺菌は水浴中で実行した。ビン(ガラスビン/200ml)を85℃の水浴に入れた。80℃に到達した後、サンプルをさらに1分間水浴中に入れたままにした。低温殺菌中の温度の管理のために、水および温度計を含有するリファレンスビンを使用した。低温殺菌の後、ビンを室温まで急速に冷却した(冷水を用いて)。
またサンプルをガラスビン(200ml)に満たし、クラウンキャップで密封した。サンプルを室温で2週間、1か月間、2か月間および3か月間貯蔵した。
濁度を3回測定した。
低温殺菌していない場合、NTUは約7(開始時および90日後)であり、低温殺菌製剤については、NTUは4(開始時および90日後)であった。
Claims (16)
- (i)粉末状組成物の全重量に基づいて5〜25重量%の酢酸dl−α−トコフェロールと、
(ii)粉末状組成物の全重量に基づいて20〜50重量%の、20未満のDEを有する少なくとも1つのマルトデキストリンと、
(iii)粉末状組成物の全重量に基づいて20〜50重量%の少なくとも1つの修飾多糖と、
(iv)粉末状組成物の全重量に基づいて少なくとも5重量%の少なくとも1つのポリオキシエチレンソルビタンモノ脂肪酸エステルと
を含む粉末状組成物。 - 前記マルトデキストリンが18未満のDEを有する、請求項1に記載の粉末状組成物。
- 前記マルトデキストリンがトウモロコシ源またはエンドウ源から得られる、請求項1に記載の粉末状組成物。
- 前記修飾多糖が加工デンプンである、請求項1〜3のいずれか一項に記載の粉末状組成物。
- 前記修飾多糖がオクテニルコハク酸デンプンナトリウムである、請求項1〜5のいずれか一項に記載の粉末状組成物。
- 前記ポリオキシエチレンソルビタンモノ脂肪酸エステルが、モノラウリン酸ポリオキシエチレン(20)ソルビタン、モノパルミチン酸ポリオキシエチレン(20)ソルビタン、モノステアリン酸ポリオキシエチレン(20)ソルビタンおよびモノオレイン酸ポリオキシエチレン(20)ソルビタンからなる群から選択される、請求項1〜6のいずれか一項に記載の粉末状組成物。
- 平均内部粒径(内部相)が70nm〜110nmである、請求項1〜7のいずれか一項に記載の粉末状組成物。
- 粉末状組成物の全重量に基づいて10〜20重量%の酢酸dl−α−トコフェロールを含む、請求項1〜8のいずれか一項に記載の粉末状組成物。
- 粉末状組成物の全重量に基づいて25〜45重量%の、20未満のDEを有する少なくとも1つのマルトデキストリンを含む、請求項1〜9のいずれか一項に記載の粉末状組成物。
- 粉末状組成物の全重量に基づいて25〜45重量%の、少なくとも1つの修飾多糖を含む、請求項1〜10のいずれか一項に記載の粉末状組成物。
- 粉末状組成物の全重量に基づいて5〜20重量%の、少なくとも1つのポリオキシエチレンソルビタンモノ脂肪酸エステルを含む、請求項1〜11のいずれか一項に記載の粉末状組成物。
- 前記粉末状組成物が噴霧乾燥される、請求項1〜12のいずれか一項に記載の粉末状組成物。
- 請求項1〜13のいずれか一項に記載の粉末状組成物のいずれかの、噴霧乾燥技術を用いた製造方法。
- 請求項1〜12のいずれか一項に記載の粉末状組成物の、液体製剤における使用。
- 請求項1〜13のいずれか一項に記載の粉末状組成物の少なくとも1つを含む液体製剤。
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EP13166666.1 | 2013-05-06 | ||
EP13166666 | 2013-05-06 | ||
PCT/EP2014/059207 WO2014180827A1 (en) | 2013-05-06 | 2014-05-06 | Powderous vitamin e formulation |
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EP (1) | EP2993995B1 (ja) |
JP (1) | JP6458322B2 (ja) |
KR (1) | KR102339146B1 (ja) |
CN (1) | CN105188415A (ja) |
BR (1) | BR112015027824B1 (ja) |
ES (1) | ES2676022T3 (ja) |
PL (1) | PL2993995T3 (ja) |
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CN106753786A (zh) * | 2017-02-22 | 2017-05-31 | 李峰 | 一种羧甲基化米糠多糖协同维生素e亚油酸酯缓释型植物油抗氧剂 |
WO2019089520A1 (en) * | 2017-10-31 | 2019-05-09 | Roquette America, Inc. | Method for the formulation of oil-soluble substances, and powders obtainable thereof |
EP3784054A1 (en) * | 2018-04-27 | 2021-03-03 | DSM IP Assets B.V. | Powderous composition comprising carotenoid and/or derivative thereof, d-glycose oligomers and modified polysaccharide as well as food, feed or personal care formulation comprising the composition |
JP7315287B2 (ja) * | 2018-04-27 | 2023-07-26 | ディーエスエム アイピー アセッツ ビー.ブイ. | 粉末状製剤 |
CN112040790A (zh) * | 2018-04-27 | 2020-12-04 | 帝斯曼知识产权资产管理有限公司 | 包含类胡萝卜素和/或其衍生物、d-葡萄糖低聚物和改性多糖的粉末组合物以及包含该组合物的食物、饲料或个人护理制剂 |
EP4291046A1 (en) * | 2021-02-10 | 2023-12-20 | DSM IP Assets B.V. | Powderous composition (i) |
US20240090550A1 (en) * | 2021-02-10 | 2024-03-21 | Dsm Ip Assets B.V. | Powderous composition(ii) |
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BR112015027824A2 (pt) | 2017-07-25 |
EP2993995B1 (en) | 2018-04-11 |
PL2993995T3 (pl) | 2018-08-31 |
BR112015027824B1 (pt) | 2021-06-08 |
US20160073667A1 (en) | 2016-03-17 |
TR201809166T4 (tr) | 2018-07-23 |
BR112015027824A8 (pt) | 2019-12-24 |
CN105188415A (zh) | 2015-12-23 |
KR20160008223A (ko) | 2016-01-21 |
JP2016522684A (ja) | 2016-08-04 |
KR102339146B1 (ko) | 2021-12-15 |
ES2676022T3 (es) | 2018-07-16 |
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US20210347961A1 (en) | 2021-11-11 |
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