JP6420817B2 - 結像可能な塞栓性微小球 - Google Patents

結像可能な塞栓性微小球 Download PDF

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Publication number
JP6420817B2
JP6420817B2 JP2016502420A JP2016502420A JP6420817B2 JP 6420817 B2 JP6420817 B2 JP 6420817B2 JP 2016502420 A JP2016502420 A JP 2016502420A JP 2016502420 A JP2016502420 A JP 2016502420A JP 6420817 B2 JP6420817 B2 JP 6420817B2
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beads
radiopaque
iodinated
hydrogel beads
radiopaque hydrogel
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JP2016515158A (ja
JP2016515158A5 (https=
Inventor
ドレハー，マシュー，アール．
ウッド，ブラッドフォード，ジェイ．
ネグシー，アエレ，エイチ．
ルイス，アンドリュー，レナード
タン，イーキン
Original Assignee
バイオコンパティブルズ ユーケー リミテッド
バイオコンパティブルズ ユーケー リミテッド
ザ ユナイテッド ステイツ オブ アメリカ，アズ レプリゼンティッド バイ ザ ナショナル インスティテューツ オブ ヘルス，ア コンポーネント オブ ザ ユナイテッド ステイツ デパートメント オブ ヘルス アンド ヒューマン サービシズ
ザ ユナイテッド ステイツ オブ アメリカ，アズ レプリゼンティッド バイ ザ ナショナル インスティテューツ オブ ヘルス，ア コンポーネント オブ ザ ユナイテッド ステイツ デパートメント オブ ヘルス アンド ヒューマン サービシズ
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Application filed by バイオコンパティブルズ ユーケー リミテッド, バイオコンパティブルズ ユーケー リミテッド, ザ ユナイテッド ステイツ オブ アメリカ，アズ レプリゼンティッド バイ ザ ナショナル インスティテューツ オブ ヘルス，ア コンポーネント オブ ザ ユナイテッド ステイツ デパートメント オブ ヘルス アンド ヒューマン サービシズ, ザ ユナイテッド ステイツ オブ アメリカ，アズ レプリゼンティッド バイ ザ ナショナル インスティテューツ オブ ヘルス，ア コンポーネント オブ ザ ユナイテッド ステイツ デパートメント オブ ヘルス アンド ヒューマン サービシズ filed Critical バイオコンパティブルズ ユーケー リミテッド
Publication of JP2016515158A publication Critical patent/JP2016515158A/ja
Publication of JP2016515158A5 publication Critical patent/JP2016515158A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F116/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F116/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F116/04—Acyclic compounds
    • C08F116/06—Polyvinyl alcohol ; Vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
JP2016502420A 2013-03-15 2014-03-14 結像可能な塞栓性微小球 Active JP6420817B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361790373P 2013-03-15 2013-03-15
US61/790,373 2013-03-15
PCT/US2014/027395 WO2014152488A2 (en) 2013-03-15 2014-03-14 Imageable embolic microsphere

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018193368A Division JP6723312B2 (ja) 2013-03-15 2018-10-12 結像可能な塞栓性微小球

Publications (3)

Publication Number Publication Date
JP2016515158A JP2016515158A (ja) 2016-05-26
JP2016515158A5 JP2016515158A5 (https=) 2017-04-20
JP6420817B2 true JP6420817B2 (ja) 2018-11-07

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JP2016502420A Active JP6420817B2 (ja) 2013-03-15 2014-03-14 結像可能な塞栓性微小球
JP2018193368A Active JP6723312B2 (ja) 2013-03-15 2018-10-12 結像可能な塞栓性微小球
JP2020031965A Active JP6983930B2 (ja) 2013-03-15 2020-02-27 結像可能な塞栓性微小球

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JP2020031965A Active JP6983930B2 (ja) 2013-03-15 2020-02-27 結像可能な塞栓性微小球

Country Status (8)

Country Link
US (3) US10307493B2 (https=)
EP (1) EP2968618B1 (https=)
JP (3) JP6420817B2 (https=)
KR (1) KR20160032000A (https=)
CN (2) CN117982687A (https=)
CA (1) CA2906574C (https=)
HK (1) HK1220119A1 (https=)
WO (1) WO2014152488A2 (https=)

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CN114057600B (zh) * 2021-12-02 2024-02-02 上海汇禾医疗科技股份有限公司 一种可x射线显影分子、载药栓塞微球及其制备方法
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CA2906574A1 (en) 2014-09-25
WO2014152488A8 (en) 2014-12-04
JP2019023221A (ja) 2019-02-14
US10307493B2 (en) 2019-06-04
CN117982687A (zh) 2024-05-07
US20200155711A1 (en) 2020-05-21
JP2020079313A (ja) 2020-05-28
US20190328908A1 (en) 2019-10-31
WO2014152488A2 (en) 2014-09-25
CN105517580A (zh) 2016-04-20
CA2906574C (en) 2021-08-31
KR20160032000A (ko) 2016-03-23
JP6723312B2 (ja) 2020-07-15
JP2016515158A (ja) 2016-05-26
JP6983930B2 (ja) 2021-12-17
EP2968618A2 (en) 2016-01-20
US11672876B2 (en) 2023-06-13
WO2014152488A3 (en) 2015-03-05
EP2968618B1 (en) 2021-02-17
HK1220119A1 (zh) 2017-04-28
US20160030602A1 (en) 2016-02-04

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