CA2906574C - Imageable embolic microsphere - Google Patents

Imageable embolic microsphere Download PDF

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Publication number
CA2906574C
CA2906574C CA2906574A CA2906574A CA2906574C CA 2906574 C CA2906574 C CA 2906574C CA 2906574 A CA2906574 A CA 2906574A CA 2906574 A CA2906574 A CA 2906574A CA 2906574 C CA2906574 C CA 2906574C
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CA
Canada
Prior art keywords
beads
iodinated
alcohol
microspheres
activated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2906574A
Other languages
English (en)
French (fr)
Other versions
CA2906574A1 (en
Inventor
Matthew R. Dreher
Bradford J. Wood
Ayele H. Negussie
Andrew Lennard Lewis
Yiqing Tang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Medical Device Ltd
National Institutes of Health NIH
Original Assignee
Biocompatibles UK Ltd
National Institutes of Health NIH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles UK Ltd, National Institutes of Health NIH filed Critical Biocompatibles UK Ltd
Publication of CA2906574A1 publication Critical patent/CA2906574A1/en
Application granted granted Critical
Publication of CA2906574C publication Critical patent/CA2906574C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F116/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F116/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F116/04—Acyclic compounds
    • C08F116/06—Polyvinyl alcohol ; Vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
CA2906574A 2013-03-15 2014-03-14 Imageable embolic microsphere Active CA2906574C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361790373P 2013-03-15 2013-03-15
US61/790,373 2013-03-15
PCT/US2014/027395 WO2014152488A2 (en) 2013-03-15 2014-03-14 Imageable embolic microsphere

Publications (2)

Publication Number Publication Date
CA2906574A1 CA2906574A1 (en) 2014-09-25
CA2906574C true CA2906574C (en) 2021-08-31

Family

ID=50631039

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2906574A Active CA2906574C (en) 2013-03-15 2014-03-14 Imageable embolic microsphere

Country Status (8)

Country Link
US (3) US10307493B2 (https=)
EP (1) EP2968618B1 (https=)
JP (3) JP6420817B2 (https=)
KR (1) KR20160032000A (https=)
CN (2) CN117982687A (https=)
CA (1) CA2906574C (https=)
HK (1) HK1220119A1 (https=)
WO (1) WO2014152488A2 (https=)

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CN118743779A (zh) * 2021-11-12 2024-10-08 重庆百迈腾世医药科技有限公司 基于活性金属微球的复合栓塞剂、制备方法及其应用
CN114057600B (zh) * 2021-12-02 2024-02-02 上海汇禾医疗科技股份有限公司 一种可x射线显影分子、载药栓塞微球及其制备方法
CN114344554A (zh) * 2022-02-11 2022-04-15 上海益思妙医疗器械有限公司 一种peg化合物作为制备栓塞剂的应用
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Also Published As

Publication number Publication date
CA2906574A1 (en) 2014-09-25
WO2014152488A8 (en) 2014-12-04
JP2019023221A (ja) 2019-02-14
US10307493B2 (en) 2019-06-04
CN117982687A (zh) 2024-05-07
US20200155711A1 (en) 2020-05-21
JP2020079313A (ja) 2020-05-28
JP6420817B2 (ja) 2018-11-07
US20190328908A1 (en) 2019-10-31
WO2014152488A2 (en) 2014-09-25
CN105517580A (zh) 2016-04-20
KR20160032000A (ko) 2016-03-23
JP6723312B2 (ja) 2020-07-15
JP2016515158A (ja) 2016-05-26
JP6983930B2 (ja) 2021-12-17
EP2968618A2 (en) 2016-01-20
US11672876B2 (en) 2023-06-13
WO2014152488A3 (en) 2015-03-05
EP2968618B1 (en) 2021-02-17
HK1220119A1 (zh) 2017-04-28
US20160030602A1 (en) 2016-02-04

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