HK1220119A1 - 可成像栓塞微球 - Google Patents

可成像栓塞微球 Download PDF

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Publication number
HK1220119A1
HK1220119A1 HK16108169.0A HK16108169A HK1220119A1 HK 1220119 A1 HK1220119 A1 HK 1220119A1 HK 16108169 A HK16108169 A HK 16108169A HK 1220119 A1 HK1220119 A1 HK 1220119A1
Authority
HK
Hong Kong
Prior art keywords
beads
imageable
polymer network
radiopaque
covalently
Prior art date
Application number
HK16108169.0A
Other languages
English (en)
Chinese (zh)
Inventor
Matthew R. Dreher
Bradford J. Wood
Ayele H. Negussie
Andrew Leonard Lewis
Yiqing Tang
Original Assignee
Matthew R. Dreher
Bradford J. Wood
Ayele H. Negussie
Andrew Leonard Lewis
Yiqing Tang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matthew R. Dreher, Bradford J. Wood, Ayele H. Negussie, Andrew Leonard Lewis, Yiqing Tang filed Critical Matthew R. Dreher
Publication of HK1220119A1 publication Critical patent/HK1220119A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F116/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F116/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F116/04—Acyclic compounds
    • C08F116/06—Polyvinyl alcohol ; Vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
HK16108169.0A 2013-03-15 2014-03-14 可成像栓塞微球 HK1220119A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361790373P 2013-03-15 2013-03-15
US61/790,373 2013-03-15
PCT/US2014/027395 WO2014152488A2 (en) 2013-03-15 2014-03-14 Imageable embolic microsphere

Publications (1)

Publication Number Publication Date
HK1220119A1 true HK1220119A1 (zh) 2017-04-28

Family

ID=50631039

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16108169.0A HK1220119A1 (zh) 2013-03-15 2014-03-14 可成像栓塞微球

Country Status (8)

Country Link
US (3) US10307493B2 (https=)
EP (1) EP2968618B1 (https=)
JP (3) JP6420817B2 (https=)
KR (1) KR20160032000A (https=)
CN (2) CN117982687A (https=)
CA (1) CA2906574C (https=)
HK (1) HK1220119A1 (https=)
WO (1) WO2014152488A2 (https=)

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CN107050501B (zh) * 2016-12-29 2020-09-15 苏州恒瑞迦俐生生物医药科技有限公司 一种可视化多羟基聚合体栓塞微球及其制备方法
CN106822983B (zh) * 2016-12-29 2020-09-15 苏州恒瑞迦俐生生物医药科技有限公司 一种用于微创介入疗法治疗肿瘤疾病的可显影栓塞微球及其制备方法
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CN108686259B (zh) * 2018-07-12 2020-11-24 中国人民解放军总医院 用于血管内栓塞x线下可显影的载药微球及其制备方法
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CN110628008B (zh) * 2019-06-25 2021-10-08 复旦大学 一种具有x-射线显影功能的含碘聚碳酸酯及其制备方法与应用
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CN112972754B (zh) * 2021-02-24 2022-07-19 苏州微尺度科技有限公司 一种可视化岩藻多糖栓塞微球及其制备方法
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CN118743779A (zh) * 2021-11-12 2024-10-08 重庆百迈腾世医药科技有限公司 基于活性金属微球的复合栓塞剂、制备方法及其应用
CN114057600B (zh) * 2021-12-02 2024-02-02 上海汇禾医疗科技股份有限公司 一种可x射线显影分子、载药栓塞微球及其制备方法
CN114344554A (zh) * 2022-02-11 2022-04-15 上海益思妙医疗器械有限公司 一种peg化合物作为制备栓塞剂的应用
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Also Published As

Publication number Publication date
CA2906574A1 (en) 2014-09-25
WO2014152488A8 (en) 2014-12-04
JP2019023221A (ja) 2019-02-14
US10307493B2 (en) 2019-06-04
CN117982687A (zh) 2024-05-07
US20200155711A1 (en) 2020-05-21
JP2020079313A (ja) 2020-05-28
JP6420817B2 (ja) 2018-11-07
US20190328908A1 (en) 2019-10-31
WO2014152488A2 (en) 2014-09-25
CN105517580A (zh) 2016-04-20
CA2906574C (en) 2021-08-31
KR20160032000A (ko) 2016-03-23
JP6723312B2 (ja) 2020-07-15
JP2016515158A (ja) 2016-05-26
JP6983930B2 (ja) 2021-12-17
EP2968618A2 (en) 2016-01-20
US11672876B2 (en) 2023-06-13
WO2014152488A3 (en) 2015-03-05
EP2968618B1 (en) 2021-02-17
US20160030602A1 (en) 2016-02-04

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