KR20160032000A - 이미지화 가능한 색전성 마이크로스피어 - Google Patents

이미지화 가능한 색전성 마이크로스피어 Download PDF

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Publication number
KR20160032000A
KR20160032000A KR1020157028536A KR20157028536A KR20160032000A KR 20160032000 A KR20160032000 A KR 20160032000A KR 1020157028536 A KR1020157028536 A KR 1020157028536A KR 20157028536 A KR20157028536 A KR 20157028536A KR 20160032000 A KR20160032000 A KR 20160032000A
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KR
South Korea
Prior art keywords
hydrogel
beads
bead
activated
iodide
Prior art date
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Ceased
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KR1020157028536A
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English (en)
Korean (ko)
Inventor
매튜 알. 드레허
브래드포드 제이. 우드
에일 에이취. 네거시
앤드류 레오나르드 루이스
이큉 탕
Original Assignee
매튜 알. 드레허
이큉 탕
앤드류 레오나르드 루이스
브래드포드 제이. 우드
에일 에이취. 네거시
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Application filed by 매튜 알. 드레허, 이큉 탕, 앤드류 레오나르드 루이스, 브래드포드 제이. 우드, 에일 에이취. 네거시 filed Critical 매튜 알. 드레허
Publication of KR20160032000A publication Critical patent/KR20160032000A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F116/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F116/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F116/04—Acyclic compounds
    • C08F116/06—Polyvinyl alcohol ; Vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
KR1020157028536A 2013-03-15 2014-03-14 이미지화 가능한 색전성 마이크로스피어 Ceased KR20160032000A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361790373P 2013-03-15 2013-03-15
US61/790,373 2013-03-15
PCT/US2014/027395 WO2014152488A2 (en) 2013-03-15 2014-03-14 Imageable embolic microsphere

Publications (1)

Publication Number Publication Date
KR20160032000A true KR20160032000A (ko) 2016-03-23

Family

ID=50631039

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157028536A Ceased KR20160032000A (ko) 2013-03-15 2014-03-14 이미지화 가능한 색전성 마이크로스피어

Country Status (8)

Country Link
US (3) US10307493B2 (https=)
EP (1) EP2968618B1 (https=)
JP (3) JP6420817B2 (https=)
KR (1) KR20160032000A (https=)
CN (2) CN117982687A (https=)
CA (1) CA2906574C (https=)
HK (1) HK1220119A1 (https=)
WO (1) WO2014152488A2 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2485777B1 (en) 2009-10-06 2013-12-11 Regents of the University of Minnesota Bioresorbable embolization microspheres
EP3984556B8 (en) 2012-06-14 2025-07-09 Microvention, Inc. Polymeric treatment compositions
AU2013331439B2 (en) 2012-10-15 2016-05-12 Microvention, Inc. Polymeric treatment compositions
GB2521997A (en) 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
US10265423B2 (en) 2015-01-12 2019-04-23 Biosphere Medical, Inc. Radiopaque monomers, polymers, microspheres, and methods related thereto
US20190070332A1 (en) * 2016-03-14 2019-03-07 Biocompatibles Uk Limited Oily compositions
US10182979B2 (en) 2016-03-22 2019-01-22 Regents Of The University Of Minnesota Biodegradable microspheres
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
CN107050501B (zh) * 2016-12-29 2020-09-15 苏州恒瑞迦俐生生物医药科技有限公司 一种可视化多羟基聚合体栓塞微球及其制备方法
CN106822983B (zh) * 2016-12-29 2020-09-15 苏州恒瑞迦俐生生物医药科技有限公司 一种用于微创介入疗法治疗肿瘤疾病的可显影栓塞微球及其制备方法
JP6925014B2 (ja) 2017-02-15 2021-08-25 ドリームメディカルパートナーズ株式会社 塞栓材の製造方法
WO2019074965A1 (en) 2017-10-09 2019-04-18 Microvention, Inc. EMBOLIC RADIOACTIVE LIQUID
CN107854720B (zh) * 2017-12-28 2020-12-08 苏州恒瑞迦俐生生物医药科技有限公司 具有造影功能的可载药多羟基聚合物栓塞微球及其制备方法
GB201810788D0 (en) 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Biodegradable polymer
JP7322073B2 (ja) 2018-06-29 2023-08-07 バイオコンパティブルズ ユーケー リミテッド 放射線不透過性ポリマー
CN108686259B (zh) * 2018-07-12 2020-11-24 中国人民解放军总医院 用于血管内栓塞x线下可显影的载药微球及其制备方法
TW202031299A (zh) * 2018-11-13 2020-09-01 大陸商上海盛迪醫藥有限公司 一種聚合物及其組合物
CN110628008B (zh) * 2019-06-25 2021-10-08 复旦大学 一种具有x-射线显影功能的含碘聚碳酸酯及其制备方法与应用
GB201910286D0 (en) 2019-07-18 2019-09-04 Biocompatibles Uk Ltd Radiopaque polymers
EP4026859A4 (en) * 2019-09-05 2022-12-28 Dalian Heyuan Medical Equipments Co., Ltd. Poly[alpha-cyanoacrylate] hydrolyzate and preparation method and applicaiton thereof
CN112972754B (zh) * 2021-02-24 2022-07-19 苏州微尺度科技有限公司 一种可视化岩藻多糖栓塞微球及其制备方法
US20230037198A1 (en) * 2021-07-29 2023-02-02 Varian Medical Systems, Inc. Apparatuses and methods for producing embolic particles with activated loading sites
CN118743779A (zh) * 2021-11-12 2024-10-08 重庆百迈腾世医药科技有限公司 基于活性金属微球的复合栓塞剂、制备方法及其应用
CN114057600B (zh) * 2021-12-02 2024-02-02 上海汇禾医疗科技股份有限公司 一种可x射线显影分子、载药栓塞微球及其制备方法
CN114344554A (zh) * 2022-02-11 2022-04-15 上海益思妙医疗器械有限公司 一种peg化合物作为制备栓塞剂的应用
CN116059368B (zh) * 2022-07-20 2025-07-25 暨南大学 Smo抑制剂在制备预防、延缓或减轻动静脉内瘘通路狭窄的药物中的应用
EP4563569A1 (en) 2022-08-25 2025-06-04 Cardiolink Science (Shenzhen) Medical Technology Development Co., Ltd. Amide compound containing iodo aryl or iodo heteroaryl, and preparation method therefor and use thereof
CN116574060A (zh) * 2022-09-19 2023-08-11 科睿驰（深圳）医疗科技发展有限公司 X射线显影化合物及其制备方法、x射线显影栓塞材料及其制备方法
CN117323294B (zh) * 2023-09-25 2024-05-31 至微(深圳)医学科技有限公司 一种载药栓塞微球及其制备方法和应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2860986A (en) 1956-08-31 1958-11-18 Eastman Kodak Co Partially acetalized polyvinyl alcohol containing active halogen
US3840482A (en) 1971-09-13 1974-10-08 Ici Australia Ltd Process for curing poly(vinyl alcohol)matrix beads
US4406878A (en) 1978-08-02 1983-09-27 Eastman Kodak Company Iodinated contrast agent for radiography
US4306031A (en) 1979-08-14 1981-12-15 Mitsubishi Chemical Industries Limited Weakly acidic cation exchange resin and process for producing same
US5141739A (en) * 1986-07-03 1992-08-25 Advanced Magnetics, Inc. Delivery of x-ray contrast agents using receptor mediated endocytosis
JPH0656676B2 (ja) 1986-09-01 1994-07-27 ティアツク株式会社 記録再生装置
EP0391741B1 (en) 1989-04-06 1995-04-19 Merocel Corporation Polymeric broad-spectrum antimicrobial materials
DK0586524T3 (https=) 1991-06-03 1997-05-20 Nycomed Imaging As
JPH0656676A (ja) 1992-08-05 1994-03-01 Hori Shinichi 血管塞栓用懸濁液
US5330739A (en) 1992-12-04 1994-07-19 Sterling Winthrop Inc. Iodinated benzoyl acetals and ketals for x-ray imaging
TW272976B (https=) * 1993-08-06 1996-03-21 Ciba Geigy Ag
AU4566001A (en) 2000-03-13 2001-09-24 Biocure Inc Embolic compositions
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
CA2431662A1 (en) * 2000-12-31 2002-07-11 Amersham Biosciences Ab A method for the manufacture of compositions containing low concentrations of salts
US6911219B2 (en) 2001-09-27 2005-06-28 Surgica Corporation Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
US20040161466A1 (en) 2003-02-14 2004-08-19 Biocompatibles Uk Limited Chemoembolisation
CN103393605B (zh) 2003-02-12 2018-05-29 生物相容英国有限公司 用于实体瘤的化学栓塞治疗的组合物
US7201918B2 (en) 2004-11-16 2007-04-10 Microvention, Inc. Compositions, systems and methods for treatment of defects in blood vessels
US20060292077A1 (en) * 2005-03-18 2006-12-28 Zhao Jonathon Z Dendritic and star-shaped contrast agents for medical devices and bioabsorbable radiopaque bulk material and method for producing same
EP1810698A1 (en) * 2006-01-24 2007-07-25 Biocompatibles UK Limited Process for producing radiopaque embolic microspheres
CA2648243C (en) * 2006-04-11 2015-12-22 Shaker A. Mousa Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof
US8507639B2 (en) * 2006-09-11 2013-08-13 Boston Scientific Scimed, Inc. Radiopaque amide polymers and medical devices formed thereof
WO2008039827A2 (en) 2006-09-26 2008-04-03 Aeris Therapeutics, Inc. Polymer systems for lung volume reduction therapy
WO2008059835A1 (en) * 2006-11-16 2008-05-22 Japan Health Sciences Foundation Metal chelate complex, proton relaxation rate enhancing agent and mri contrast agent
JP2010526914A (ja) 2007-05-11 2010-08-05 エアリス セラピューティクス エルエルシー 架橋した非天然ポリマーを用いる肺容量減少療法
EP1992371A1 (de) 2007-05-15 2008-11-19 Occlutech GmbH Bioresorbierbare röntgenopake Polymermaterialien und daraus hergestellte Occlussionsinstrumente
JP2010534563A (ja) 2007-07-24 2010-11-11 ネクスバイオ，インク． マイクロ粒子の作製のための技術
WO2009018280A2 (en) 2007-07-30 2009-02-05 Auspex Pharamaceuticals, Inc. Substituted indoles
EP2090592A1 (en) * 2007-07-31 2009-08-19 OctoPlus Sciences B.V. Biodegradable hydrogels based on click chemistry
WO2009086098A1 (en) * 2007-12-28 2009-07-09 Boston Scientific Scimed, Inc. Porous microparticles for injection and processes for forming the same
US20090269390A1 (en) * 2008-04-25 2009-10-29 Medtronic, Inc. Medical devices, polymers, compositions, and methods for delivering a haloacetate
WO2009134344A1 (en) 2008-04-28 2009-11-05 Surmodics, Inc. POLY-α(1→4)GLUCOPYRANOSE-BASED MATRICES WITH HYDRAZIDE CROSSLINKING
ITRM20080636A1 (it) * 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
US8383161B2 (en) 2009-12-15 2013-02-26 Incept, Llc Radioopaque covalently crosslinked hydrogel particle implants
EP2365009A1 (en) * 2010-03-10 2011-09-14 Universite Claude Bernard Lyon 1 (UCBL) Radiopaque, non-biodegradable, water-insoluble iodinated benzyl ethers of poly(vinyl alcohol), preparation method thereof, injectable embolizing compositions containing thereof and use thereof
ES2368307B1 (es) 2010-04-28 2012-10-17 Universidade De Santiago De Compostela Hidrogeles elaborados a base de polímeros aniónicos de origen natural.
KR20130124322A (ko) 2010-09-29 2013-11-13 사이언 카디오-바스큘라, 인크. 미소구의 가공 방법, 이에 의해 가공된 미소구, 및 그의 용도
CN103249436B (zh) * 2010-12-09 2015-09-30 东丽株式会社 生物降解性颗粒、血管栓塞材料及生物降解性颗粒的制造方法
US9910037B2 (en) 2013-03-15 2018-03-06 Iris International, Inc. Conjugation of multiple vancomycin molecules on a polyvinyl alcohol backbone for the capture of microorganisms
JP6506230B2 (ja) 2016-09-28 2019-04-24 Ｎｅｃプラットフォームズ株式会社 音声無音検知装置、音声無音検知方法、音声無音検知プログラム、及び音声無音検知システム

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CA2906574A1 (en) 2014-09-25
WO2014152488A8 (en) 2014-12-04
JP2019023221A (ja) 2019-02-14
US10307493B2 (en) 2019-06-04
CN117982687A (zh) 2024-05-07
US20200155711A1 (en) 2020-05-21
JP2020079313A (ja) 2020-05-28
JP6420817B2 (ja) 2018-11-07
US20190328908A1 (en) 2019-10-31
WO2014152488A2 (en) 2014-09-25
CN105517580A (zh) 2016-04-20
CA2906574C (en) 2021-08-31
JP6723312B2 (ja) 2020-07-15
JP2016515158A (ja) 2016-05-26
JP6983930B2 (ja) 2021-12-17
EP2968618A2 (en) 2016-01-20
US11672876B2 (en) 2023-06-13
WO2014152488A3 (en) 2015-03-05
EP2968618B1 (en) 2021-02-17
HK1220119A1 (zh) 2017-04-28
US20160030602A1 (en) 2016-02-04

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