JP6375365B2 - 抗菌活性を有する二芳香族誘導体 - Google Patents

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Publication number

JP6375365B2

JP6375365B2 JP2016508263A JP2016508263A JP6375365B2 JP 6375365 B2 JP6375365 B2 JP 6375365B2 JP 2016508263 A JP2016508263 A JP 2016508263A JP 2016508263 A JP2016508263 A JP 2016508263A JP 6375365 B2 JP6375365 B2 JP 6375365B2

Authority

JP

Japan

Prior art keywords

oxo

pyrido

oxazolidine

ethyl

methoxy

Prior art date

2013-04-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 230000000844 anti-bacterial effect Effects 0.000 title description 6
• 150000001875 compounds Chemical class 0.000 claims description 522
• 229910052757 nitrogen Inorganic materials 0.000 claims description 124
• -1 cyanomethoxy Chemical group 0.000 claims description 90
• 229910052770 Uranium Inorganic materials 0.000 claims description 78
• 150000003839 salts Chemical class 0.000 claims description 65
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 59
• 208000015181 infectious disease Diseases 0.000 claims description 35
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 32
• 125000003545 alkoxy group Chemical group 0.000 claims description 31
• 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims description 30
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 28
• 208000035143 Bacterial infection Diseases 0.000 claims description 27
• 208000022362 bacterial infectious disease Diseases 0.000 claims description 27
• 229910052736 halogen Inorganic materials 0.000 claims description 24
• 150000002367 halogens Chemical class 0.000 claims description 24
• 229910052720 vanadium Inorganic materials 0.000 claims description 18
• 239000003814 drug Substances 0.000 claims description 15
• 229910052717 sulfur Inorganic materials 0.000 claims description 15
• 241000191967 Staphylococcus aureus Species 0.000 claims description 14
• 229910052760 oxygen Inorganic materials 0.000 claims description 14
• 230000002265 prevention Effects 0.000 claims description 13
• 241000588626 Acinetobacter baumannii Species 0.000 claims description 11
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 10
• 206010035664 Pneumonia Diseases 0.000 claims description 6
• 239000004480 active ingredient Substances 0.000 claims description 6
• 239000008194 pharmaceutical composition Substances 0.000 claims description 6
• 150000003857 carboxamides Chemical class 0.000 claims description 5
• AISJUFSMNZRJOE-LJQANCHMSA-N (5r)-5-[2-[[3-(4-methoxypyrimidin-2-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC=NC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=N1 AISJUFSMNZRJOE-LJQANCHMSA-N 0.000 claims description 4
• 208000016604 Lyme disease Diseases 0.000 claims description 4
• 206010033078 Otitis media Diseases 0.000 claims description 4
• 206010057190 Respiratory tract infections Diseases 0.000 claims description 4
• MEXRMIQFQTWYNL-INIZCTEOSA-N (5S)-5-[2-[[2-hydroxy-3-(6-methoxypyridin-2-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4H-pyrido[3,2-b][1,4]thiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COc1cccc(n1)-c1cccc(CNCC[C@H]2CN(C(=O)O2)c2ccc3SCC(=O)Nc3n2)c1O MEXRMIQFQTWYNL-INIZCTEOSA-N 0.000 claims description 3
• BZQZJIWDDLWPMW-OAQYLSRUSA-N (5r)-5-[2-[[2-(3-methoxyphenyl)pyridin-4-yl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC=CC(C=2N=CC=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=2)=C1 BZQZJIWDDLWPMW-OAQYLSRUSA-N 0.000 claims description 3
• QJYDOVYCBCWLAT-OAQYLSRUSA-N (5r)-5-[2-[[2-fluoro-3-(3-methoxyphenyl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC=CC(C=2C(=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)F)=C1 QJYDOVYCBCWLAT-OAQYLSRUSA-N 0.000 claims description 3
• FERWCDLUVRRJOZ-LJQANCHMSA-N (5r)-5-[2-[[3-(2,6-dimethoxypyrimidin-4-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=NC(OC)=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=N1 FERWCDLUVRRJOZ-LJQANCHMSA-N 0.000 claims description 3
• MIOSSSWCJGTVJN-JOCHJYFZSA-N (5r)-5-[2-[[3-(3-hydroxy-5-methoxyphenyl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC(O)=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=C1 MIOSSSWCJGTVJN-JOCHJYFZSA-N 0.000 claims description 3
• ZWRZWEUTBNNRNO-HSZRJFAPSA-N (5r)-5-[2-[[3-(3-methoxyphenyl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=C1 ZWRZWEUTBNNRNO-HSZRJFAPSA-N 0.000 claims description 3
• FZPFIZMNVCWVTG-GOSISDBHSA-N (5r)-5-[2-[[3-(4,6-dimethoxy-1,3,5-triazin-2-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=NC(OC)=NC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=N1 FZPFIZMNVCWVTG-GOSISDBHSA-N 0.000 claims description 3
• DCTIIKWJNLWDTE-LJQANCHMSA-N (5r)-5-[2-[[3-(4,6-dimethoxypyrimidin-2-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC(OC)=NC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=N1 DCTIIKWJNLWDTE-LJQANCHMSA-N 0.000 claims description 3
• ZOHKBAOTZFSHFL-OAQYLSRUSA-N (5r)-5-[2-[[3-(4-hydroxy-3-methoxyphenyl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound C1=C(O)C(OC)=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=C1 ZOHKBAOTZFSHFL-OAQYLSRUSA-N 0.000 claims description 3
• JWUGLAQHBBEENX-HSZRJFAPSA-N (5r)-5-[2-[[3-(4-methoxyphenyl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound C1=CC(OC)=CC=C1C1=CC=CC(CNCC[C@H]2OC(=O)N(C2)C=2C=C3NC(=O)CSC3=CC=2)=C1 JWUGLAQHBBEENX-HSZRJFAPSA-N 0.000 claims description 3
• KMFLSVYXZRTXDK-OAQYLSRUSA-N (5r)-5-[2-[[3-(4-methoxypyridin-2-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC=NC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=C1 KMFLSVYXZRTXDK-OAQYLSRUSA-N 0.000 claims description 3
• LPVKQNNPHYBPTB-LJQANCHMSA-N (5r)-5-[2-[[3-(5-methoxypyridazin-3-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CN=NC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=C1 LPVKQNNPHYBPTB-LJQANCHMSA-N 0.000 claims description 3
• RMXHRIFHBCKLQJ-QGZVFWFLSA-N (5r)-5-[2-[[3-(5-methoxypyridazin-3-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-pyrido[3,2-b][1,4]thiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CN=NC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3N=C4NC(=O)CSC4=CC=3)C=CC=2)=C1 RMXHRIFHBCKLQJ-QGZVFWFLSA-N 0.000 claims description 3
• IYRBZBAACJLSFZ-OAQYLSRUSA-N (5r)-5-[2-[[3-(5-methoxypyridin-3-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CN=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=C1 IYRBZBAACJLSFZ-OAQYLSRUSA-N 0.000 claims description 3
• CXNDNFIGBVBVBB-LJQANCHMSA-N (5r)-5-[2-[[3-(6-methoxypyrazin-2-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CN=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=N1 CXNDNFIGBVBVBB-LJQANCHMSA-N 0.000 claims description 3
• YLGHLNHHFJLNTF-HXUWFJFHSA-N (5r)-5-[2-[[3-(6-methoxypyridin-2-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=N1 YLGHLNHHFJLNTF-HXUWFJFHSA-N 0.000 claims description 3
• IZICXEZTQTYHSJ-OAQYLSRUSA-N (5r)-5-[2-[[3-(6-methoxypyridin-3-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound C1=NC(OC)=CC=C1C1=CC=CC(CNCC[C@H]2OC(=O)N(C2)C=2C=C3NC(=O)CSC3=CC=2)=C1 IZICXEZTQTYHSJ-OAQYLSRUSA-N 0.000 claims description 3
• OVEBOTBLWDHUDS-LJQANCHMSA-N (5r)-5-[2-[[3-(6-methoxypyrimidin-4-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound C1=NC(OC)=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=N1 OVEBOTBLWDHUDS-LJQANCHMSA-N 0.000 claims description 3
• CVSXXHGSLPROKX-JOCHJYFZSA-N (5r)-5-[2-[[4-(3-methoxyphenyl)pyridin-2-yl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)N=CC=2)=C1 CVSXXHGSLPROKX-JOCHJYFZSA-N 0.000 claims description 3
• CWRBSKXWXCKQPP-OAQYLSRUSA-N (5r)-5-[2-[[4-fluoro-3-(3-methoxyphenyl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC=CC(C=2C(=CC=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=2)F)=C1 CWRBSKXWXCKQPP-OAQYLSRUSA-N 0.000 claims description 3
• AJXNBKZNHBFWRY-JOCHJYFZSA-N (5r)-5-[2-[[5-(3-methoxyphenyl)pyridin-3-yl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=NC=2)=C1 AJXNBKZNHBFWRY-JOCHJYFZSA-N 0.000 claims description 3
• UZGMKSJHKJANAC-OAQYLSRUSA-N (5r)-5-[2-[[6-(3-methoxyphenyl)pyridin-2-yl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC=CC(C=2N=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=C1 UZGMKSJHKJANAC-OAQYLSRUSA-N 0.000 claims description 3
• VKHARGSMFQTYRQ-GOSISDBHSA-N (5r)-5-[2-[[6-(6-methoxypyridin-2-yl)pyridin-2-yl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC=CC(C=2N=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=N1 VKHARGSMFQTYRQ-GOSISDBHSA-N 0.000 claims description 3
• RMXHRIFHBCKLQJ-KRWDZBQOSA-N (5s)-5-[2-[[3-(5-methoxypyridazin-3-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-pyrido[3,2-b][1,4]thiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CN=NC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)CSC4=CC=3)C=CC=2)=C1 RMXHRIFHBCKLQJ-KRWDZBQOSA-N 0.000 claims description 3
• YLGHLNHHFJLNTF-FQEVSTJZSA-N (5s)-5-[2-[[3-(6-methoxypyridin-2-yl)phenyl]methylamino]ethyl]-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one Chemical compound COC1=CC=CC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=N1 YLGHLNHHFJLNTF-FQEVSTJZSA-N 0.000 claims description 3
• QPPXQPRTOIOSAL-VWLOTQADSA-N 1-[[3-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]phenoxy]methyl]cyclobutane-1-carbonitrile Chemical compound C([C@@H]1OC(N(C1)C=1N=C2NC(=O)COC2=CC=1)=O)CNCC(C=1)=CC=CC=1C(C=1)=CC=CC=1OCC1(C#N)CCC1 QPPXQPRTOIOSAL-VWLOTQADSA-N 0.000 claims description 3
• YOEVPTGEJXKNBI-QFIPXVFZSA-N 2-[3-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]phenoxy]acetonitrile Chemical compound C([C@@H]1OC(N(C1)C=1N=C2NC(=O)COC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CC=CC(OCC#N)=C1 YOEVPTGEJXKNBI-QFIPXVFZSA-N 0.000 claims description 3
• IQENPUPMHASIGK-IBGZPJMESA-N 2-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]pyridine-3-carbonitrile Chemical compound C([C@@H]1OC(N(C1)C=1N=C2NC(=O)COC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=NC=CC=C1C#N IQENPUPMHASIGK-IBGZPJMESA-N 0.000 claims description 3
• USBBBUOTABHBED-OAQYLSRUSA-N 2-methoxy-4-[3-[[2-[(5r)-2-oxo-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzamide Chemical compound C1=C(C(N)=O)C(OC)=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=C1 USBBBUOTABHBED-OAQYLSRUSA-N 0.000 claims description 3
• SCMQCSCJUDHKDH-NRFANRHFSA-N 2-methoxy-4-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound C1=C(C#N)C(OC)=CC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CC=2)=C1 SCMQCSCJUDHKDH-NRFANRHFSA-N 0.000 claims description 3
• JMNIYDBAIJPBJX-OAQYLSRUSA-N 2-methoxy-6-[3-[[2-[(5r)-2-oxo-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]pyridine-4-carbonitrile Chemical compound COC1=CC(C#N)=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=N1 JMNIYDBAIJPBJX-OAQYLSRUSA-N 0.000 claims description 3
• QKFNGWFGHSTIRL-IBGZPJMESA-N 2-methoxy-6-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound COC1=CC=CC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CC=2)=C1C#N QKFNGWFGHSTIRL-IBGZPJMESA-N 0.000 claims description 3
• BYLFCHGSFPVZBN-HXUWFJFHSA-N 2-oxo-6-[3-[[2-[(5r)-2-oxo-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]-1h-pyridine-4-carbonitrile Chemical compound C([C@H]1OC(N(C1)C=1C=C2NC(=O)CSC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CC(C#N)=CC(=O)N1 BYLFCHGSFPVZBN-HXUWFJFHSA-N 0.000 claims description 3
• WDIMHTFBNRCXFU-HSZRJFAPSA-N 3-[3-[[2-[(5r)-2-oxo-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound C([C@H]1OC(N(C1)C=1C=C2NC(=O)CSC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CC=CC(C#N)=C1 WDIMHTFBNRCXFU-HSZRJFAPSA-N 0.000 claims description 3
• ZPBUSOWTNFZYQD-OAQYLSRUSA-N 3-[3-[[2-[(5r)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound C([C@H]1OC(N(C1)C=1N=C2NC(=O)COC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CC=CC(C#N)=C1 ZPBUSOWTNFZYQD-OAQYLSRUSA-N 0.000 claims description 3
• WDIMHTFBNRCXFU-QHCPKHFHSA-N 3-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound C([C@@H]1OC(N(C1)C=1C=C2NC(=O)CSC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CC=CC(C#N)=C1 WDIMHTFBNRCXFU-QHCPKHFHSA-N 0.000 claims description 3
• MJGAGEMSVCTFPW-QHCPKHFHSA-N 3-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-1,4-benzoxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound C([C@@H]1OC(N(C1)C=1C=C2NC(=O)COC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CC=CC(C#N)=C1 MJGAGEMSVCTFPW-QHCPKHFHSA-N 0.000 claims description 3
• ZPBUSOWTNFZYQD-NRFANRHFSA-N 3-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound C([C@@H]1OC(N(C1)C=1N=C2NC(=O)COC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CC=CC(C#N)=C1 ZPBUSOWTNFZYQD-NRFANRHFSA-N 0.000 claims description 3
• WFHFBOBRBKWDSV-SFHVURJKSA-N 3-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]pyridine-2-carbonitrile Chemical compound C([C@@H]1OC(N(C1)C=1N=C2NC(=O)COC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CC=CN=C1C#N WFHFBOBRBKWDSV-SFHVURJKSA-N 0.000 claims description 3
• UMYYTXWHPDZJNO-NRFANRHFSA-N 3-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]thiazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound C([C@@H]1OC(N(C1)C=1N=C2NC(=O)CSC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CC=CC(C#N)=C1 UMYYTXWHPDZJNO-NRFANRHFSA-N 0.000 claims description 3
• KAHFELSLQNZONT-UHFFFAOYSA-N 3-[3-[[2-[2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazol-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound N1=C2NC(=O)COC2=CC=C1N(C(O1)=O)C=C1CCNCC(C=1)=CC=CC=1C1=CC=CC(C#N)=C1 KAHFELSLQNZONT-UHFFFAOYSA-N 0.000 claims description 3
• SEVKZXVRKIZTQF-UHFFFAOYSA-N 3-[3-[[2-[5-oxo-4-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3,4-oxadiazol-2-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound N1=C2NC(=O)COC2=CC=C1N(C(O1)=O)N=C1CCNCC(C=1)=CC=CC=1C1=CC=CC(C#N)=C1 SEVKZXVRKIZTQF-UHFFFAOYSA-N 0.000 claims description 3
• NJYDVPNQSMTLTH-IBGZPJMESA-N 3-[4-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]pyridin-2-yl]benzonitrile Chemical compound C([C@@H]1OC(N(C1)C=1N=C2NC(=O)COC2=CC=1)=O)CNCC(C=1)=CC=NC=1C1=CC=CC(C#N)=C1 NJYDVPNQSMTLTH-IBGZPJMESA-N 0.000 claims description 3
• HWRVVYPJVZHVSY-UHFFFAOYSA-N 3-[4-[[2-[2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazol-5-yl]ethylamino]methyl]pyridin-2-yl]benzonitrile Chemical compound N1=C2NC(=O)COC2=CC=C1N(C(O1)=O)C=C1CCNCC(C=1)=CC=NC=1C1=CC=CC(C#N)=C1 HWRVVYPJVZHVSY-UHFFFAOYSA-N 0.000 claims description 3
• VCYXEHFSSZOSAR-HSZRJFAPSA-N 3-methoxy-5-[3-[[2-[(5r)-2-oxo-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound COC1=CC(C#N)=CC(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=C1 VCYXEHFSSZOSAR-HSZRJFAPSA-N 0.000 claims description 3
• UZLPLGGBEWMCLB-NRFANRHFSA-N 4-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound C([C@@H]1OC(N(C1)C=1N=C2NC(=O)COC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CC=C(C#N)C=C1 UZLPLGGBEWMCLB-NRFANRHFSA-N 0.000 claims description 3
• ZXUHIAVUAFBGAA-IBGZPJMESA-N 4-hydroxy-3-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound OC1=CC=C(C#N)C=C1C1=CC=CC(CNCC[C@@H]2OC(=O)N(C2)C=2N=C3NC(=O)COC3=CC=2)=C1 ZXUHIAVUAFBGAA-IBGZPJMESA-N 0.000 claims description 3
• CHKYIUIAQNEZKZ-LJQANCHMSA-N 4-hydroxy-3-[4-[[2-[(5R)-2-oxo-3-(3-oxo-4H-1,4-benzothiazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]pyridin-2-yl]benzonitrile Chemical compound Oc1ccc(cc1-c1cc(CNCC[C@@H]2CN(C(=O)O2)c2ccc3SCC(=O)Nc3c2)ccn1)C#N CHKYIUIAQNEZKZ-LJQANCHMSA-N 0.000 claims description 3
• NFXIVSWELWHTME-HSZRJFAPSA-N 4-methoxy-2-[3-[[2-[(5r)-2-oxo-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound COC1=CC=C(C#N)C(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3C=C4NC(=O)CSC4=CC=3)C=CC=2)=C1 NFXIVSWELWHTME-HSZRJFAPSA-N 0.000 claims description 3
• FZIFAWAATKRLMN-OAQYLSRUSA-N 4-methoxy-2-[3-[[2-[(5r)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound COC1=CC=C(C#N)C(C=2C=C(CNCC[C@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CC=2)=C1 FZIFAWAATKRLMN-OAQYLSRUSA-N 0.000 claims description 3
• FZIFAWAATKRLMN-NRFANRHFSA-N 4-methoxy-2-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound COC1=CC=C(C#N)C(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CC=2)=C1 FZIFAWAATKRLMN-NRFANRHFSA-N 0.000 claims description 3
• NGLUCDAVCQONCD-UHFFFAOYSA-N 4-methoxy-2-[3-[[2-[2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazol-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound COC1=CC=C(C#N)C(C=2C=C(CNCCC=3OC(=O)N(C=4N=C5NC(=O)COC5=CC=4)C=3)C=CC=2)=C1 NGLUCDAVCQONCD-UHFFFAOYSA-N 0.000 claims description 3
• WMXIPLUNDNMUIL-UHFFFAOYSA-N 4-methoxy-2-[3-[[2-[5-oxo-4-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3,4-oxadiazol-2-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound COC1=CC=C(C#N)C(C=2C=C(CNCCC=3OC(=O)N(C=4N=C5NC(=O)COC5=CC=4)N=3)C=CC=2)=C1 WMXIPLUNDNMUIL-UHFFFAOYSA-N 0.000 claims description 3
• UCKIAXRBTUIVDF-FQEVSTJZSA-N 4-methoxy-3-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]benzonitrile Chemical compound COC1=CC=C(C#N)C=C1C1=CC=CC(CNCC[C@@H]2OC(=O)N(C2)C=2N=C3NC(=O)COC3=CC=2)=C1 UCKIAXRBTUIVDF-FQEVSTJZSA-N 0.000 claims description 3
• OGXAWPGCPSKSEJ-IBGZPJMESA-N 5-[3-[[2-[(5S)-2-oxo-3-(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]pyridazine-3-carbonitrile Chemical compound O=C1O[C@@H](CCNCc2cccc(c2)-c2cnnc(c2)C#N)CN1c1ccc2OCC(=O)Nc2n1 OGXAWPGCPSKSEJ-IBGZPJMESA-N 0.000 claims description 3
• UKSXUFYFDFPHMD-JOCHJYFZSA-N 5-[3-[[2-[(5r)-2-oxo-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]pyridine-3-carbonitrile Chemical compound C([C@H]1OC(N(C1)C=1C=C2NC(=O)CSC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CN=CC(C#N)=C1 UKSXUFYFDFPHMD-JOCHJYFZSA-N 0.000 claims description 3
• BEOLIDREZGYMNM-KRWDZBQOSA-N 6-[(5S)-5-[2-[[2-hydroxy-3-(4-methoxypyridin-2-yl)phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound OC1=C(CNCC[C@H]2CN(C(O2)=O)C=2C=CC=3OCC(NC=3N=2)=O)C=CC=C1C1=NC=CC(=C1)OC BEOLIDREZGYMNM-KRWDZBQOSA-N 0.000 claims description 3
• YGGVWXQQJYLRNE-SFHVURJKSA-N 6-[(5S)-5-[2-[[2-hydroxy-3-(6-methoxypyridin-2-yl)phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4H-1,4-benzoxazin-3-one Chemical compound COc1cccc(n1)-c1cccc(CNCC[C@H]2CN(C(=O)O2)c2ccc3OCC(=O)Nc3c2)c1O YGGVWXQQJYLRNE-SFHVURJKSA-N 0.000 claims description 3
• JHONWRPDNDVKRT-INIZCTEOSA-N 6-[(5S)-5-[2-[[2-hydroxy-3-(6-methoxypyridin-2-yl)phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound OC1=C(CNCC[C@H]2CN(C(O2)=O)C=2C=CC=3OCC(NC=3N=2)=O)C=CC=C1C1=NC(=CC=C1)OC JHONWRPDNDVKRT-INIZCTEOSA-N 0.000 claims description 3
• ZHHLEJMUFOVXSY-KRWDZBQOSA-N 6-[(5S)-5-[2-[[4-hydroxy-3-(4-methoxypyridin-2-yl)phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound COc1ccnc(c1)-c1cc(CNCC[C@H]2CN(C(=O)O2)c2ccc3OCC(=O)Nc3n2)ccc1O ZHHLEJMUFOVXSY-KRWDZBQOSA-N 0.000 claims description 3
• HUMNTPGAPLHNPR-HNNXBMFYSA-N 6-[(5S)-5-[2-[[4-hydroxy-3-(5-methoxypyridazin-3-yl)phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound OC1=C(C=C(CNCC[C@H]2CN(C(O2)=O)C=2C=CC=3OCC(NC=3N=2)=O)C=C1)C=1N=NC=C(C=1)OC HUMNTPGAPLHNPR-HNNXBMFYSA-N 0.000 claims description 3
• ROJRSACABYSEHB-INIZCTEOSA-N 6-[(5S)-5-[2-[[4-hydroxy-3-(6-methoxypyridin-2-yl)phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4H-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound COc1cccc(n1)-c1cc(CNCC[C@H]2CN(C(=O)O2)c2ccc3OCC(=O)Nc3n2)ccc1O ROJRSACABYSEHB-INIZCTEOSA-N 0.000 claims description 3
• YXJHYAIZZALXBI-SFHVURJKSA-N 6-[(5s)-5-[2-[[2-(3-methoxyphenyl)pyrimidin-4-yl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound COC1=CC=CC(C=2N=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CN=2)=C1 YXJHYAIZZALXBI-SFHVURJKSA-N 0.000 claims description 3
• IJDWCSRMTFZMQR-INIZCTEOSA-N 6-[(5s)-5-[2-[[2-(6-methoxypyridin-2-yl)pyridin-4-yl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound COC1=CC=CC(C=2N=CC=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=2)=N1 IJDWCSRMTFZMQR-INIZCTEOSA-N 0.000 claims description 3
• YSKKPPFYLROHAY-FQEVSTJZSA-N 6-[(5s)-5-[2-[[3-(2,5-dimethoxyphenyl)phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound COC1=CC=C(OC)C(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CC=2)=C1 YSKKPPFYLROHAY-FQEVSTJZSA-N 0.000 claims description 3
• YCITVRROCMIVHA-FQEVSTJZSA-N 6-[(5s)-5-[2-[[3-(3,4-dimethoxyphenyl)phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC=CC(CNCC[C@@H]2OC(=O)N(C2)C=2N=C3NC(=O)COC3=CC=2)=C1 YCITVRROCMIVHA-FQEVSTJZSA-N 0.000 claims description 3
• YPANFOWCQUODJD-QFIPXVFZSA-N 6-[(5s)-5-[2-[[3-(3-ethoxyphenyl)phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound CCOC1=CC=CC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CC=2)=C1 YPANFOWCQUODJD-QFIPXVFZSA-N 0.000 claims description 3
• CTHWNRYVKFFKLB-NRFANRHFSA-N 6-[(5s)-5-[2-[[3-(3-methoxyphenyl)phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound COC1=CC=CC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CC=2)=C1 CTHWNRYVKFFKLB-NRFANRHFSA-N 0.000 claims description 3
• OFFZWRBRVNYNAY-IBGZPJMESA-N 6-[(5s)-5-[2-[[3-(5-methoxypyridazin-3-yl)phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-1,4-benzoxazin-3-one Chemical compound COC1=CN=NC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3C=C4NC(=O)COC4=CC=3)C=CC=2)=C1 OFFZWRBRVNYNAY-IBGZPJMESA-N 0.000 claims description 3
• JMJNEAMRFCRSPG-SFHVURJKSA-N 6-[(5s)-5-[2-[[3-(6-methoxypyridin-2-yl)phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound COC1=CC=CC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CC=2)=N1 JMJNEAMRFCRSPG-SFHVURJKSA-N 0.000 claims description 3
• SZQVVCZLKCXDQX-QHCPKHFHSA-N 6-[(5s)-5-[2-[[3-[3-(2-methoxyethoxy)phenyl]phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound COCCOC1=CC=CC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CC=2)=C1 SZQVVCZLKCXDQX-QHCPKHFHSA-N 0.000 claims description 3
• SZOSRVNQYGGEIM-QHCPKHFHSA-N 6-[(5s)-5-[2-[[3-[3-(3-hydroxypropoxy)phenyl]phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound OCCCOC1=CC=CC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CC=2)=C1 SZOSRVNQYGGEIM-QHCPKHFHSA-N 0.000 claims description 3
• CSFMYMOKYXJOKN-DEOSSOPVSA-N 6-[(5s)-5-[2-[[3-[3-(4-hydroxybutoxy)phenyl]phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound OCCCCOC1=CC=CC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CC=2)=C1 CSFMYMOKYXJOKN-DEOSSOPVSA-N 0.000 claims description 3
• JNRLAFVOGSWMDW-LBAQZLPGSA-N 6-[(5s)-5-[2-[[3-[6-(3-hydroxypyrrolidin-1-yl)pyridin-2-yl]phenyl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound C1C(O)CCN1C1=CC=CC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=CC=2)=N1 JNRLAFVOGSWMDW-LBAQZLPGSA-N 0.000 claims description 3
• HKXSHRGZBHLQJJ-IBGZPJMESA-N 6-[(5s)-5-[2-[[5-(3-methoxyphenyl)pyridazin-3-yl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound COC1=CC=CC(C=2C=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)N=NC=2)=C1 HKXSHRGZBHLQJJ-IBGZPJMESA-N 0.000 claims description 3
• UKYJHVANWPIMRQ-SFHVURJKSA-N 6-[(5s)-5-[2-[[6-(3-methoxyphenyl)pyrazin-2-yl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound COC1=CC=CC(C=2N=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=NC=2)=C1 UKYJHVANWPIMRQ-SFHVURJKSA-N 0.000 claims description 3
• JUDHTLKIWOUUBH-SFHVURJKSA-N 6-[(5s)-5-[2-[[6-(3-methoxyphenyl)pyridazin-4-yl]methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound COC1=CC=CC(C=2N=NC=C(CNCC[C@@H]3OC(=O)N(C3)C=3N=C4NC(=O)COC4=CC=3)C=2)=C1 JUDHTLKIWOUUBH-SFHVURJKSA-N 0.000 claims description 3
• SMKHTJKJAPOWDC-IBGZPJMESA-N 6-[2-hydroxy-3-[[2-[(5S)-2-oxo-3-(3-oxo-4H-1,4-benzoxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]pyridine-2-carbonitrile Chemical compound OC1=C(C=CC=C1CNCC[C@H]1CN(C(O1)=O)C=1C=CC2=C(NC(CO2)=O)C=1)C1=CC=CC(=N1)C#N SMKHTJKJAPOWDC-IBGZPJMESA-N 0.000 claims description 3
• PDOXRTNEFGGBSA-KRWDZBQOSA-N 6-[2-hydroxy-3-[[2-[(5S)-2-oxo-3-(3-oxo-4H-pyrido[3,2-b][1,4]thiazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]pyridine-2-carbonitrile Chemical compound OC1=C(C=CC=C1CNCC[C@H]1CN(C(O1)=O)C=1C=CC=2SCC(NC=2N=1)=O)C1=CC=CC(=N1)C#N PDOXRTNEFGGBSA-KRWDZBQOSA-N 0.000 claims description 3
• KYFKFYWCJMQFFL-UHFFFAOYSA-N 6-[2-hydroxy-3-[[2-[5-oxo-4-(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3,4-oxadiazol-2-yl]ethylamino]methyl]phenyl]pyridine-2-carbonitrile Chemical compound OC1=C(C=CC=C1CNCCC=1OC(N(N=1)C=1C=CC=2OCC(NC=2N=1)=O)=O)C1=CC=CC(=N1)C#N KYFKFYWCJMQFFL-UHFFFAOYSA-N 0.000 claims description 3
• KZFBURJMGDEUQJ-OAQYLSRUSA-N 6-[3-[[2-[(5r)-2-oxo-3-(3-oxo-4h-1,4-benzothiazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]pyridine-2-carbonitrile Chemical compound C([C@H]1OC(N(C1)C=1C=C2NC(=O)CSC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CC=CC(C#N)=N1 KZFBURJMGDEUQJ-OAQYLSRUSA-N 0.000 claims description 3
• ILIGGSOUVGCIER-SFHVURJKSA-N 6-[3-[[2-[(5s)-2-oxo-3-(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)-1,3-oxazolidin-5-yl]ethylamino]methyl]phenyl]pyridazine-4-carbonitrile Chemical compound C([C@@H]1OC(N(C1)C=1N=C2NC(=O)COC2=CC=1)=O)CNCC(C=1)=CC=CC=1C1=CC(C#N)=CN=N1 ILIGGSOUVGCIER-SFHVURJKSA-N 0.000 claims description 3
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