CN105143216B - 抗菌双芳香族衍生物 - Google Patents
抗菌双芳香族衍生物 Download PDFInfo
- Publication number
- CN105143216B CN105143216B CN201480022059.9A CN201480022059A CN105143216B CN 105143216 B CN105143216 B CN 105143216B CN 201480022059 A CN201480022059 A CN 201480022059A CN 105143216 B CN105143216 B CN 105143216B
- Authority
- CN
- China
- Prior art keywords
- oxo
- pyrido
- ethyl
- methoxy
- oxazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(CC*)(CCCCC1)OC2OC2N1C(*=C(C*C1)NC1=O)=CC Chemical compound CC(CC*)(CCCCC1)OC2OC2N1C(*=C(C*C1)NC1=O)=CC 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2013053021 | 2013-04-16 | ||
| IBPCT/IB2013/053021 | 2013-04-16 | ||
| PCT/IB2014/060724 WO2014170821A1 (en) | 2013-04-16 | 2014-04-15 | Antibacterial biaromatic derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105143216A CN105143216A (zh) | 2015-12-09 |
| CN105143216B true CN105143216B (zh) | 2018-04-13 |
Family
ID=50639826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480022059.9A Expired - Fee Related CN105143216B (zh) | 2013-04-16 | 2014-04-15 | 抗菌双芳香族衍生物 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9527867B2 (https=) |
| EP (1) | EP2986607B1 (https=) |
| JP (1) | JP6375365B2 (https=) |
| KR (1) | KR20150143720A (https=) |
| CN (1) | CN105143216B (https=) |
| AR (1) | AR095884A1 (https=) |
| AU (1) | AU2014255326B2 (https=) |
| BR (1) | BR112015026261A8 (https=) |
| CA (1) | CA2907832A1 (https=) |
| CL (1) | CL2015003019A1 (https=) |
| EA (1) | EA029361B1 (https=) |
| ES (1) | ES2640482T3 (https=) |
| HK (1) | HK1221459A1 (https=) |
| MA (1) | MA38588B1 (https=) |
| MX (1) | MX362338B (https=) |
| PH (1) | PH12015502411A1 (https=) |
| PL (1) | PL2986607T3 (https=) |
| SA (1) | SA515361261B1 (https=) |
| SG (1) | SG11201508479RA (https=) |
| TW (1) | TWI631119B (https=) |
| WO (1) | WO2014170821A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2344495T3 (en) | 2008-10-07 | 2015-02-02 | Actelion Pharmaceuticals Ltd | TRICYCLIC OXAZOLIDINON ANTIBIOTIC COMPOUNDS |
| AR102256A1 (es) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| TW201722965A (zh) | 2015-08-16 | 2017-07-01 | 葛蘭素史密斯克藍智慧財產發展有限公司 | 用於抗菌應用之化合物 |
| JP2019513700A (ja) | 2016-03-16 | 2019-05-30 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 殺有害生物剤及び植物保護剤としてのｎ−（シアノベンジル）−６−（シクロプロピル−カルボニルアミノ）−４−（フェニル）−ピリジン−２−カルボキサミド誘導体及び関連する化合物 |
| AR108108A1 (es) | 2016-04-14 | 2018-07-18 | Idorsia Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos con sustitución de oxetan-3-iloxi |
| GB2550437B (en) * | 2016-05-20 | 2021-06-23 | Bugworks Res Inc | Heterocyclic compounds useful as anti-bacterial agents and method for production |
| TW201833120A (zh) * | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| EP3284739A1 (de) | 2017-07-19 | 2018-02-21 | Bayer CropScience Aktiengesellschaft | Substituierte (het)arylverbindungen als schädlingsbekämpfungsmittel |
| CN111527093B (zh) * | 2017-11-29 | 2023-06-09 | 巴格沃克斯研究有限公司 | 抗菌杂环化合物及其合成 |
| PE20211089A1 (es) | 2018-08-13 | 2021-06-14 | Hoffmann La Roche | Nuevos compuestos heterociclicos como inhibidores de la monoacilglicerol lipasa |
| WO2020104494A1 (en) | 2018-11-22 | 2020-05-28 | F. Hoffmann-La Roche Ag | New heterocyclic compounds |
| CN114269755A (zh) | 2019-09-12 | 2022-04-01 | 豪夫迈·罗氏有限公司 | 作为magl抑制剂的4,4a,5,7,8,8a-六吡啶并[4,3-b][1,4]噁嗪-3-酮化合物 |
| CN115298176A (zh) * | 2020-03-24 | 2022-11-04 | 豪夫迈·罗氏有限公司 | 化合物以及它们在治疗细菌感染中的用途 |
| CN115785718B (zh) * | 2022-11-25 | 2023-08-22 | 四川大学 | 一种多基底表面的金属配位抗菌涂层及其制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010015985A1 (en) * | 2008-08-04 | 2010-02-11 | Actelion Pharmaceuticals Ltd | Tricyclic alkylaminomethyloxazolidinone derivatives |
| CN101657450A (zh) * | 2007-04-11 | 2010-02-24 | 埃科特莱茵药品有限公司 | 噁唑烷酮抗生素衍生物 |
| CN102164915A (zh) * | 2008-10-10 | 2011-08-24 | 埃科特莱茵药品有限公司 | 作为抗菌剂的2-苯并噻吩基-和2-萘基-噁唑烷酮及其氮杂等排体类似物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0297042A1 (de) | 1987-06-23 | 1988-12-28 | Ciba-Geigy Ag | Substituierte Penem-Verbindungen |
| DE19802239A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
| WO2001030782A2 (en) | 1999-10-29 | 2001-05-03 | Syngenta Participations Ag | Novel herbicides |
| US7205321B2 (en) | 2001-11-15 | 2007-04-17 | Eli Lilly And Company | Peroxisome proliferator activated receptor alpha agonists |
| TW200406413A (en) | 2002-06-26 | 2004-05-01 | Glaxo Group Ltd | Compounds |
| WO2006102674A2 (en) | 2005-03-24 | 2006-09-28 | Microbia, Inc. | Diphenylheterocycle cholesterol absorption inhibitors |
| TW200734311A (en) | 2005-11-21 | 2007-09-16 | Astrazeneca Ab | New compounds |
| JPWO2008120655A1 (ja) | 2007-03-30 | 2010-07-15 | 株式会社医薬分子設計研究所 | Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有するオキサゾリジノン誘導体 |
| RU2493147C2 (ru) | 2007-12-20 | 2013-09-20 | Фарма Мар, С.А. | Противоопухолевые соединения |
| ES2411930T3 (es) | 2008-02-20 | 2013-07-09 | Actelion Pharmaceuticals Ltd. | Compuestos antibióticos azatricíclicos |
| KR101592046B1 (ko) | 2008-02-22 | 2016-02-05 | 액테리온 파마슈티칼 리미티드 | 옥사졸리디논 유도체 |
| DK2344495T3 (en) | 2008-10-07 | 2015-02-02 | Actelion Pharmaceuticals Ltd | TRICYCLIC OXAZOLIDINON ANTIBIOTIC COMPOUNDS |
| SG11201401710PA (en) | 2011-11-08 | 2014-09-26 | Actelion Pharmaceuticals Ltd | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
-
2014
- 2014-04-15 KR KR1020157032552A patent/KR20150143720A/ko not_active Abandoned
- 2014-04-15 TW TW103113729A patent/TWI631119B/zh not_active IP Right Cessation
- 2014-04-15 HK HK16109490.8A patent/HK1221459A1/zh unknown
- 2014-04-15 PL PL14721539T patent/PL2986607T3/pl unknown
- 2014-04-15 MX MX2015014576A patent/MX362338B/es active IP Right Grant
- 2014-04-15 CA CA2907832A patent/CA2907832A1/en not_active Abandoned
- 2014-04-15 US US14/784,602 patent/US9527867B2/en not_active Expired - Fee Related
- 2014-04-15 WO PCT/IB2014/060724 patent/WO2014170821A1/en not_active Ceased
- 2014-04-15 BR BR112015026261A patent/BR112015026261A8/pt not_active Application Discontinuation
- 2014-04-15 JP JP2016508263A patent/JP6375365B2/ja not_active Expired - Fee Related
- 2014-04-15 EA EA201501025A patent/EA029361B1/ru not_active IP Right Cessation
- 2014-04-15 AU AU2014255326A patent/AU2014255326B2/en not_active Ceased
- 2014-04-15 ES ES14721539.6T patent/ES2640482T3/es active Active
- 2014-04-15 SG SG11201508479RA patent/SG11201508479RA/en unknown
- 2014-04-15 MA MA38588A patent/MA38588B1/fr unknown
- 2014-04-15 EP EP14721539.6A patent/EP2986607B1/en not_active Not-in-force
- 2014-04-15 CN CN201480022059.9A patent/CN105143216B/zh not_active Expired - Fee Related
- 2014-04-16 AR ARP140101625A patent/AR095884A1/es unknown
-
2015
- 2015-10-04 SA SA515361261A patent/SA515361261B1/ar unknown
- 2015-10-09 CL CL2015003019A patent/CL2015003019A1/es unknown
- 2015-10-16 PH PH12015502411A patent/PH12015502411A1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101657450A (zh) * | 2007-04-11 | 2010-02-24 | 埃科特莱茵药品有限公司 | 噁唑烷酮抗生素衍生物 |
| WO2010015985A1 (en) * | 2008-08-04 | 2010-02-11 | Actelion Pharmaceuticals Ltd | Tricyclic alkylaminomethyloxazolidinone derivatives |
| CN102164915A (zh) * | 2008-10-10 | 2011-08-24 | 埃科特莱茵药品有限公司 | 作为抗菌剂的2-苯并噻吩基-和2-萘基-噁唑烷酮及其氮杂等排体类似物 |
Also Published As
| Publication number | Publication date |
|---|---|
| TWI631119B (zh) | 2018-08-01 |
| EA029361B1 (ru) | 2018-03-30 |
| JP2016516805A (ja) | 2016-06-09 |
| ES2640482T3 (es) | 2017-11-03 |
| HK1221459A1 (zh) | 2017-06-02 |
| MA38588A1 (fr) | 2017-05-31 |
| WO2014170821A1 (en) | 2014-10-23 |
| EP2986607A1 (en) | 2016-02-24 |
| SA515361261B1 (ar) | 2016-06-15 |
| KR20150143720A (ko) | 2015-12-23 |
| SG11201508479RA (en) | 2015-11-27 |
| AR095884A1 (es) | 2015-11-18 |
| AU2014255326A1 (en) | 2015-11-26 |
| MX362338B (es) | 2019-01-11 |
| EP2986607B1 (en) | 2017-06-14 |
| BR112015026261A2 (pt) | 2017-07-25 |
| US20160075722A1 (en) | 2016-03-17 |
| PL2986607T3 (pl) | 2017-11-30 |
| MX2015014576A (es) | 2016-03-04 |
| AU2014255326B2 (en) | 2018-09-13 |
| EA201501025A1 (ru) | 2016-08-31 |
| TW201516043A (zh) | 2015-05-01 |
| US9527867B2 (en) | 2016-12-27 |
| CL2015003019A1 (es) | 2016-09-30 |
| MA38588B1 (fr) | 2018-04-30 |
| CA2907832A1 (en) | 2014-10-23 |
| BR112015026261A8 (pt) | 2017-12-26 |
| JP6375365B2 (ja) | 2018-08-15 |
| CN105143216A (zh) | 2015-12-09 |
| PH12015502411A1 (en) | 2016-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20171123 Address after: Swiss A Skei Weil Applicant after: Aidu West Pharmaceutical Co. Ltd. Address before: Swiss A Skei Weil Applicant before: Actelion Pharmaceuticals Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180413 Termination date: 20210415 |