JP6373275B2 - 肺動脈高血圧症及び肺障害の治療に使用するための１，３‐ジヒドロイミダゾール‐２‐チオン誘導体 - Google Patents
肺動脈高血圧症及び肺障害の治療に使用するための１，３‐ジヒドロイミダゾール‐２‐チオン誘導体 Download PDFInfo
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- JP6373275B2 JP6373275B2 JP2015542997A JP2015542997A JP6373275B2 JP 6373275 B2 JP6373275 B2 JP 6373275B2 JP 2015542997 A JP2015542997 A JP 2015542997A JP 2015542997 A JP2015542997 A JP 2015542997A JP 6373275 B2 JP6373275 B2 JP 6373275B2
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- thione
- dihydroimidazol
- aminoethyl
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- 238000011282 treatment Methods 0.000 title claims description 42
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 title claims description 40
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- 208000019693 Lung disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 131
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- 150000003839 salts Chemical class 0.000 claims description 34
- -1 hydroxy, nitro, amino Chemical group 0.000 claims description 32
- 239000008194 pharmaceutical composition Substances 0.000 claims description 29
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 20
- CWWWTTYMUOYSQA-LLVKDONJSA-N 4-(2-aminoethyl)-3-[(3r)-6,8-difluoro-3,4-dihydro-2h-chromen-3-yl]-1h-imidazole-2-thione Chemical compound NCCC1=CNC(=S)N1[C@@H]1CC2=CC(F)=CC(F)=C2OC1 CWWWTTYMUOYSQA-LLVKDONJSA-N 0.000 claims description 19
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Landscapes
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- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201261726119P | 2012-11-14 | 2012-11-14 | |
| US61/726,119 | 2012-11-14 | ||
| PCT/PT2013/000065 WO2014077715A1 (en) | 2012-11-14 | 2013-11-14 | 1,3-dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury |
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| JP2016504286A JP2016504286A (ja) | 2016-02-12 |
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| JP6373275B2 true JP6373275B2 (ja) | 2018-08-15 |
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| EP (1) | EP2919780B1 (sr) |
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| SI (1) | SI2919780T1 (sr) |
| TR (1) | TR201815850T4 (sr) |
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| GB201810395D0 (en) * | 2018-06-25 | 2018-08-08 | Bial Portela & Ca Sa | Formulations comprising dopamine-beta-hydroxylase inhibitors and methods for their preparation |
| WO2021005623A1 (en) * | 2019-07-08 | 2021-01-14 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | A vaccine formulation for protection against enterotoxigenic e. coli (etec) and cholera |
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| TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| US7125904B2 (en) * | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
| US20040102361A1 (en) * | 2002-11-27 | 2004-05-27 | Frederic Bodin | Pharmaceutical composition for the treatment of pulmonary arterial hypertension |
| GB0600709D0 (en) | 2006-01-13 | 2006-02-22 | Portela & Ca Sa | Drug combinations |
| GB0610804D0 (en) * | 2006-05-31 | 2006-07-12 | Portela & Ca Sa | New crystal forms |
| GB0700635D0 (en) | 2007-01-12 | 2007-02-21 | Portela & Ca Sa | Therapy |
| EP2146707A2 (en) * | 2007-05-03 | 2010-01-27 | Abraxis BioScience, LLC | Methods and compositions for treating pulmonary hypertension |
| GB0708818D0 (en) * | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
| WO2009072915A1 (en) * | 2007-12-05 | 2009-06-11 | Bial - Portela & Ca., S.A. | New salts and crystal forms |
| BRPI0821970A2 (pt) | 2008-01-03 | 2015-06-23 | Biomarin Pharm Inc | Análogos de pterina para tratamento de condição responsiva a bh4 |
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| AR071632A1 (es) * | 2008-05-06 | 2010-06-30 | Bial Portela & Ca Sa | Proceso catalitico para hidrogenacion asimetrica en la sintesis de inhibidores de la dopamina-beta-hidroxilasa" |
| DE102008054205A1 (de) * | 2008-10-31 | 2010-05-06 | Bayer Schering Pharma Aktiengesellschaft | Verwendung von Helium-Sauerstoff-Gasgemischen zur Behandlung der pulmonalen arteriellen Hypertonie |
| JP6161538B2 (ja) * | 2010-12-22 | 2017-07-12 | バイアル−ポルテラ アンド シーエー，エス．エー． | 結晶形及びその製造方法 |
| ES2693025T3 (es) | 2012-11-14 | 2018-12-07 | Bial - Portela & Ca., S.A. | Derivados de 1,3-dihidroimidazol-2-tiona para su uso en el tratamiento de hipertensión arterial pulmonar y lesión pulmonar |
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