JP6347793B2 - Bcl−2/Bcl−xL阻害薬およびそれを使用した治療方法 - Google Patents

Bcl−2/Bcl−xL阻害薬およびそれを使用した治療方法 Download PDF

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JP6347793B2
JP6347793B2 JP2015553788A JP2015553788A JP6347793B2 JP 6347793 B2 JP6347793 B2 JP 6347793B2 JP 2015553788 A JP2015553788 A JP 2015553788A JP 2015553788 A JP2015553788 A JP 2015553788A JP 6347793 B2 JP6347793 B2 JP 6347793B2
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JP2016506916A (ja
JP2016506916A5 (https=
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ワン,シャオメン
チェン,ジエンファン
マッカカーン,ドナ
バイ,ロンチュアン
リュー,リュー
サン,ドキシン
リー,シャオチン
アギラール,アンジェロ
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ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン
ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/30Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015553788A 2013-01-16 2014-01-15 Bcl−2/Bcl−xL阻害薬およびそれを使用した治療方法 Active JP6347793B2 (ja)

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US201361753066P 2013-01-16 2013-01-16
US61/753,066 2013-01-16
PCT/US2014/011571 WO2014113413A1 (en) 2013-01-16 2014-01-15 Bcl-2bcl-xl inhibitors and therapeutic methods using the same

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JP2016506916A JP2016506916A (ja) 2016-03-07
JP2016506916A5 JP2016506916A5 (https=) 2017-01-26
JP6347793B2 true JP6347793B2 (ja) 2018-06-27

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US (2) US9096625B2 (https=)
EP (2) EP3689886A1 (https=)
JP (1) JP6347793B2 (https=)
KR (2) KR102318204B1 (https=)
CN (3) CN110302205B (https=)
AU (1) AU2014207716B2 (https=)
CA (1) CA2897055C (https=)
ES (1) ES2819232T3 (https=)
HK (1) HK1219734A1 (https=)
NZ (1) NZ709635A (https=)
SG (1) SG11201505525UA (https=)
WO (1) WO2014113413A1 (https=)
ZA (1) ZA201504902B (https=)

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Publication number Publication date
ES2819232T3 (es) 2021-04-15
EP2945940A4 (en) 2016-07-06
KR20150104631A (ko) 2015-09-15
HK1219734A1 (zh) 2017-04-13
EP2945940B1 (en) 2020-07-15
WO2014113413A1 (en) 2014-07-24
US20140199234A1 (en) 2014-07-17
KR102318204B1 (ko) 2021-10-26
AU2014207716B2 (en) 2017-07-27
JP2016506916A (ja) 2016-03-07
EP3689886A1 (en) 2020-08-05
CA2897055A1 (en) 2014-07-24
CN110302205A (zh) 2019-10-08
SG11201505525UA (en) 2015-08-28
CN110302205B (zh) 2020-06-09
EP2945940A1 (en) 2015-11-25
KR20210002126A (ko) 2021-01-06
CN105246882A (zh) 2016-01-13
AU2014207716A1 (en) 2015-07-23
US20150336994A1 (en) 2015-11-26
NZ709635A (en) 2019-10-25
CN110305162A (zh) 2019-10-08
KR102210316B1 (ko) 2021-01-29
CA2897055C (en) 2021-04-20
US9403856B2 (en) 2016-08-02
ZA201504902B (en) 2016-07-27
US9096625B2 (en) 2015-08-04

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