HK1219734A1 - 抑制劑和使用所述抑制劑的治療方法 - Google Patents
抑制劑和使用所述抑制劑的治療方法Info
- Publication number
- HK1219734A1 HK1219734A1 HK16107756.1A HK16107756A HK1219734A1 HK 1219734 A1 HK1219734 A1 HK 1219734A1 HK 16107756 A HK16107756 A HK 16107756A HK 1219734 A1 HK1219734 A1 HK 1219734A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- bcl
- 2bcl
- inhibitors
- same
- therapeutic methods
- Prior art date
Links
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 title 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361753066P | 2013-01-16 | 2013-01-16 | |
PCT/US2014/011571 WO2014113413A1 (en) | 2013-01-16 | 2014-01-15 | Bcl-2bcl-xl inhibitors and therapeutic methods using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1219734A1 true HK1219734A1 (zh) | 2017-04-13 |
Family
ID=51165292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16107756.1A HK1219734A1 (zh) | 2013-01-16 | 2016-07-05 | 抑制劑和使用所述抑制劑的治療方法 |
Country Status (13)
Country | Link |
---|---|
US (2) | US9096625B2 (zh) |
EP (2) | EP3689886A1 (zh) |
JP (1) | JP6347793B2 (zh) |
KR (2) | KR102318204B1 (zh) |
CN (3) | CN105246882A (zh) |
AU (1) | AU2014207716B2 (zh) |
CA (1) | CA2897055C (zh) |
ES (1) | ES2819232T3 (zh) |
HK (1) | HK1219734A1 (zh) |
NZ (1) | NZ709635A (zh) |
SG (1) | SG11201505525UA (zh) |
WO (1) | WO2014113413A1 (zh) |
ZA (1) | ZA201504902B (zh) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ709635A (en) * | 2013-01-16 | 2019-10-25 | Univ Michigan | Bcl-2bcl-xl inhibitors and therapeutic methods using the same |
CA2939121C (en) | 2014-01-28 | 2020-11-24 | Mayo Foundation For Medical Education And Research | Effective treatment of osteoarthritis, pulmonary disease, ophthalmic disease, and atherosclerosis by removing senescent cells at the site of the disease |
EP3139942B1 (en) | 2014-05-05 | 2019-12-18 | Bioventures, Llc | COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS |
EP3177144A4 (en) | 2014-07-22 | 2018-01-24 | Bioventures, LLC. | Compositions and methods for selectively depleting senescent cells |
US20180000816A1 (en) * | 2015-02-06 | 2018-01-04 | Unity Biotechnology, Inc. | Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions |
CN108025006A (zh) * | 2015-02-06 | 2018-05-11 | 尤尼蒂生物技术公司 | 化合物及在治疗衰老相关病症中的用途 |
US11111259B2 (en) | 2015-12-18 | 2021-09-07 | Unity Biotechnology, Inc. | Acylsulfonamide derivatives for treating senescence-associated diseases and disorders |
US11135198B2 (en) | 2016-03-28 | 2021-10-05 | Presage Biosciences, Inc. | Pharmaceutical combinations for the treatment of cancer |
JP6936498B2 (ja) * | 2016-04-21 | 2021-09-15 | バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーBioVentures, LLC | 抗アポトーシス性Bcl−2ファミリータンパク質の分解を誘導する化合物及びその使用 |
CN106177955B (zh) * | 2016-08-18 | 2018-03-16 | 广州威溶特医药科技有限公司 | Bcl‑xL抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用 |
WO2018098534A1 (en) * | 2016-12-02 | 2018-06-07 | Garvan Institute Of Medical Research | Methods of treating cancer and reagents thereof |
WO2019033122A1 (en) * | 2017-08-11 | 2019-02-14 | Unity Biotechnology, Inc. | TREATMENT OF PULMONARY DISEASES USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS |
US20200354336A9 (en) * | 2017-08-11 | 2020-11-12 | Unity Biotechnology, Inc. | Treatment of Lung Diseases Using Pharmaceutical Agents that Eliminate Senescent Cells |
CN111372598A (zh) * | 2017-08-11 | 2020-07-03 | 联合生物科技公司 | 使用消除衰老细胞的药剂治疗诸如黄斑变性,青光眼,和糖尿病性视网膜病变等眼科状况 |
US10588916B2 (en) | 2017-10-31 | 2020-03-17 | Unity Biotechnology, Inc. | Technology to inhibit vascular changes that lead to vision loss in the eye |
EP3548504B1 (en) | 2017-12-30 | 2021-07-21 | Unity Biotechnology, Inc. | Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer |
CA3087262A1 (en) | 2018-01-10 | 2019-07-18 | Recurium Ip Holdings, Llc | Benzamide compounds |
WO2019144117A1 (en) * | 2018-01-22 | 2019-07-25 | Bioventures, Llc | Bcl-2 proteins degraders for cancer treatment |
CN117683029A (zh) | 2018-04-29 | 2024-03-12 | 百济神州有限公司 | Bcl-2抑制剂 |
US10738042B2 (en) | 2018-04-30 | 2020-08-11 | Unity Biotechnology, Inc. | Phosphonamidates that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
CA3056878C (en) | 2018-04-30 | 2021-03-30 | Unity Biotechnology | Phospholidines that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
CN110662752B (zh) | 2018-04-30 | 2022-01-14 | 尤尼蒂生物技术公司 | 用于临床管理由衰老细胞引起或介导的病症以及治疗癌症的Bcl家族拮抗剂磷杂环化合物 |
US10717722B2 (en) | 2018-06-13 | 2020-07-21 | Unity Biotechnology, Inc. | Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
CN110772640B (zh) | 2018-07-31 | 2023-02-03 | 苏州亚盛药业有限公司 | Bcl-2抑制剂与利妥昔单抗和/或苯达莫司汀或与CHOP联合的协同抗肿瘤作用 |
CN114522167A (zh) * | 2018-07-31 | 2022-05-24 | 苏州亚盛药业有限公司 | Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途 |
AU2019314819A1 (en) | 2018-07-31 | 2020-10-22 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of Bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
WO2020024976A1 (en) * | 2018-07-31 | 2020-02-06 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination of bcl-2/bcl-xl inhibitors and chemotherapeutic agent and use thereof |
US11491168B2 (en) | 2018-07-31 | 2022-11-08 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination of Bcl-2/Bcl-xL inhibitors and chemotherapeutic agent and use thereof |
AU2019314624B2 (en) | 2018-07-31 | 2022-03-03 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of Bcl-2 inhibitor and MDM2 inhibitor and use thereof in the prevention and/or treatment of diseases |
WO2020041406A1 (en) | 2018-08-22 | 2020-02-27 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
US11872237B2 (en) * | 2018-12-28 | 2024-01-16 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical composition and preparation method thereof |
CN111410650B (zh) * | 2019-01-04 | 2020-12-08 | 苏州亚盛药业有限公司 | 制备磺胺类药物的方法 |
WO2020140956A1 (en) * | 2019-01-04 | 2020-07-09 | Ascentage Pharma (Suzhou) Co., Ltd. | Process for preparing sulfonamide compounds |
TWI770503B (zh) * | 2019-05-13 | 2022-07-11 | 大陸商蘇州亞盛藥業有限公司 | 用於預測bcl-2/bcl-xl抑制劑對癌症的功效的方法和組合物 |
TW202114692A (zh) * | 2019-07-02 | 2021-04-16 | 大陸商蘇州亞盛藥業有限公司 | 一種含有mTOR抑制劑的藥物組合及其應用 |
CN112294966B (zh) * | 2019-07-31 | 2021-12-17 | 苏州亚盛药业有限公司 | Bcl-2/Bcl-xL抑制剂与化疗药的组合产品及其在预防和/或治疗疾病中的用途 |
US20220372042A1 (en) | 2019-10-03 | 2022-11-24 | Newave Pharmaceutical Inc. | Condensed heterocycles as bcl-2 inhibitors |
CN112707900B (zh) * | 2019-10-24 | 2022-06-10 | 上海科技大学 | 蛋白降解剂及其在疾病治疗中的应用 |
TW202134239A (zh) * | 2019-11-27 | 2021-09-16 | 大陸商蘇州亞盛藥業有限公司 | 用於預測靶向細胞凋亡途徑的化合物的抗癌功效的方法和組合物 |
EP4069233A4 (en) * | 2019-12-04 | 2024-03-13 | Ascentage Pharma Suzhou Co Ltd | PHARMACEUTICAL COMBINATION AND USE THEREOF |
WO2021119439A1 (en) * | 2019-12-11 | 2021-06-17 | The Regents Of The University Of Michigan | Compositions and methods for systemic delivery of bcl-2 and bcl-xl antagonists |
CN113350281B (zh) * | 2020-03-02 | 2023-08-15 | 苏州亚盛药业有限公司 | 载药聚合物胶束及其制剂和制备方法 |
US20220296557A1 (en) * | 2020-04-10 | 2022-09-22 | Ascentage Pharma (Suzhou) Co., Ltd. | Combinations of bcl-2/bcl-xl inhibitors and related uses |
WO2021233948A1 (en) | 2020-05-19 | 2021-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to treat a pathogen lung infection |
WO2022008464A1 (en) | 2020-07-06 | 2022-01-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination of antineoplastic antibiotics and bcl-2 inhibitors for the treatment of npm-1-driven acute myeloid leukemia (aml) |
CN113929715A (zh) * | 2020-07-13 | 2022-01-14 | 苏州亚盛药业有限公司 | Bcl-2/Bcl-xL抑制剂化合物或其盐的结晶形式或无定形形式 |
CN114053288A (zh) * | 2020-07-31 | 2022-02-18 | 苏州亚盛药业有限公司 | 肺部疾病治疗的组合物和方法 |
WO2022099431A1 (en) * | 2020-11-10 | 2022-05-19 | Unity Biotechnology, Inc. | Crystalline solid meglumine salt inhibitor of bcl and methods of making and using same |
WO2022111647A1 (en) * | 2020-11-27 | 2022-06-02 | Ascentage Pharma (Suzhou) Co., Ltd. | Formulation combination containing freeze-dried formulation and reconstituted solvent, preparation method and application thereof |
CN117957018A (zh) | 2021-08-02 | 2024-04-30 | 苏州亚盛药业有限公司 | 一种药物组合及其用途 |
WO2024027706A1 (en) * | 2022-08-02 | 2024-02-08 | Beijing Neox Biotech Limited | Bcl-xl degrading compounds |
WO2024051741A1 (zh) * | 2022-09-06 | 2024-03-14 | 西藏海思科制药有限公司 | 一种抑制Bcl-2或Bcl-xL的化合物及其在医药上的应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7432304B2 (en) | 2001-05-30 | 2008-10-07 | The Regents Of The University Of Michigan | Small molecule antagonists of Bcl-2 family proteins |
US7973161B2 (en) * | 2003-11-13 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
KR20070046180A (ko) | 2004-08-20 | 2007-05-02 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 항세포사멸 bcl-2군 구성원의 소분자 억제제 및 이의용도 |
CA2606147C (en) | 2005-05-12 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
US20070197532A1 (en) | 2005-11-18 | 2007-08-23 | Cao Sheldon X | Glucokinase activators |
WO2008030836A2 (en) * | 2006-09-05 | 2008-03-13 | Abbott Laboratories | Bcl inhibitors treating platelet excess |
MX2011000738A (es) | 2008-07-24 | 2011-02-23 | Nerviano Medical Sciences Srl | 3,4-diarilpirazoles como inhibidoers de proteina cinasa. |
US20100278921A1 (en) | 2009-04-30 | 2010-11-04 | Fischer Cristina M | Solid oral formulation of abt-263 |
TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
EP2668180B1 (en) * | 2011-01-25 | 2018-08-01 | The Regents of The University of Michigan | Bcl-2/bcl-xl inhibitors for use in the treatment of cancer |
NZ709635A (en) * | 2013-01-16 | 2019-10-25 | Univ Michigan | Bcl-2bcl-xl inhibitors and therapeutic methods using the same |
-
2014
- 2014-01-15 NZ NZ70963514A patent/NZ709635A/en unknown
- 2014-01-15 ES ES14741180T patent/ES2819232T3/es active Active
- 2014-01-15 US US14/155,809 patent/US9096625B2/en active Active
- 2014-01-15 CN CN201480015733.0A patent/CN105246882A/zh active Pending
- 2014-01-15 EP EP20163914.3A patent/EP3689886A1/en not_active Withdrawn
- 2014-01-15 CN CN201910634723.XA patent/CN110305162A/zh active Pending
- 2014-01-15 CA CA2897055A patent/CA2897055C/en active Active
- 2014-01-15 AU AU2014207716A patent/AU2014207716B2/en active Active
- 2014-01-15 JP JP2015553788A patent/JP6347793B2/ja active Active
- 2014-01-15 WO PCT/US2014/011571 patent/WO2014113413A1/en active Application Filing
- 2014-01-15 SG SG11201505525UA patent/SG11201505525UA/en unknown
- 2014-01-15 CN CN201910634742.2A patent/CN110302205B/zh active Active
- 2014-01-15 KR KR1020207037597A patent/KR102318204B1/ko active IP Right Grant
- 2014-01-15 EP EP14741180.5A patent/EP2945940B1/en active Active
- 2014-01-15 KR KR1020157021823A patent/KR102210316B1/ko active IP Right Grant
-
2015
- 2015-07-08 ZA ZA2015/04902A patent/ZA201504902B/en unknown
- 2015-08-03 US US14/816,191 patent/US9403856B2/en active Active
-
2016
- 2016-07-05 HK HK16107756.1A patent/HK1219734A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU2014207716B2 (en) | 2017-07-27 |
EP3689886A1 (en) | 2020-08-05 |
US9403856B2 (en) | 2016-08-02 |
US9096625B2 (en) | 2015-08-04 |
CA2897055C (en) | 2021-04-20 |
WO2014113413A1 (en) | 2014-07-24 |
NZ709635A (en) | 2019-10-25 |
JP6347793B2 (ja) | 2018-06-27 |
AU2014207716A1 (en) | 2015-07-23 |
JP2016506916A (ja) | 2016-03-07 |
ZA201504902B (en) | 2016-07-27 |
CN110302205B (zh) | 2020-06-09 |
US20140199234A1 (en) | 2014-07-17 |
KR102318204B1 (ko) | 2021-10-26 |
EP2945940B1 (en) | 2020-07-15 |
KR102210316B1 (ko) | 2021-01-29 |
US20150336994A1 (en) | 2015-11-26 |
KR20150104631A (ko) | 2015-09-15 |
CA2897055A1 (en) | 2014-07-24 |
CN110302205A (zh) | 2019-10-08 |
KR20210002126A (ko) | 2021-01-06 |
EP2945940A1 (en) | 2015-11-25 |
ES2819232T3 (es) | 2021-04-15 |
CN110305162A (zh) | 2019-10-08 |
SG11201505525UA (en) | 2015-08-28 |
CN105246882A (zh) | 2016-01-13 |
EP2945940A4 (en) | 2016-07-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1219734A1 (zh) | 抑制劑和使用所述抑制劑的治療方法 | |
IL267681B (en) | Selective grp94 inhibitors and their uses | |
HK1226301A1 (zh) | 修飾的治療劑及其組合物 | |
ZA201305571B (en) | Bcl-2/bcl-xl inhibitors and therapeutic methods using the same | |
HK1222778A1 (zh) | 醫用裝置及使用該醫用裝置的方法 | |
EP2970312A4 (en) | BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THEM | |
HK1254296A1 (zh) | 治療性化合物和其用途 | |
GB201320729D0 (en) | Therapeutic compounds and their use | |
EP3060159A4 (en) | Intra-oral light-therapy apparatuses and methods for their use | |
IL286759A (en) | Therapeutic methods and preparations | |
HK1217092A1 (zh) | 治療性化合物及其用途 | |
GB201301626D0 (en) | Composition comprising 15-OHEPA and methods of using the same | |
IL244214A0 (en) | Thienopiperidine derivative and its use | |
HRP20190219T1 (hr) | Spojevi za tretman pretilosti i postupci za njihovu uporabu | |
EP2976091C0 (de) | Antioxidativ wirksame zusammensetzung und deren verwendung | |
GB201311361D0 (en) | Compounds and their therapeutic use | |
GB201308736D0 (en) | Compounds and their therapeutic use | |
GB201307082D0 (en) | Pharmaceutical composition comprising 15-HETrE and methods of using the same | |
GB201308753D0 (en) | Compounds and their use in therapy | |
EP3055286A4 (en) | 4-methylsulfonyl-2-butenenitrile and its pharmaceutical use | |
EP3071207A4 (en) | Libido-enhancing therapeutic and use | |
GB201317804D0 (en) | Therapeutic compounds and their use | |
GB201316173D0 (en) | Compounds and their therapeutic use | |
GB201307677D0 (en) | Compounds and their therapeutic use | |
GB201319255D0 (en) | Therapeutic compositions and methods |