JP6343034B2 - ナフチリジンジオン誘導体 - Google Patents

ナフチリジンジオン誘導体 Download PDF

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Publication number
JP6343034B2
JP6343034B2 JP2016570886A JP2016570886A JP6343034B2 JP 6343034 B2 JP6343034 B2 JP 6343034B2 JP 2016570886 A JP2016570886 A JP 2016570886A JP 2016570886 A JP2016570886 A JP 2016570886A JP 6343034 B2 JP6343034 B2 JP 6343034B2
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JP
Japan
Prior art keywords
dione
naphthyridine
alkyl
cyclobutyl
isopropyl
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Expired - Fee Related
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JP2016570886A
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Japanese (ja)
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JP2017516821A (ja
Inventor
ラインハルト，ヨーガン
シュミーデベルク，ニコ
スパンカ，カーステン
Original Assignee
ノバルティス アーゲー
ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016570886A 2014-06-03 2015-06-02 ナフチリジンジオン誘導体 Expired - Fee Related JP6343034B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14170976 2014-06-03
EP14170976.6 2014-06-03
PCT/IB2015/054174 WO2015186063A1 (fr) 2014-06-03 2015-06-02 Dérivés de naphthyridinédione

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018095248A Division JP2018138609A (ja) 2014-06-03 2018-05-17 ナフチリジンジオン誘導体

Publications (2)

Publication Number Publication Date
JP2017516821A JP2017516821A (ja) 2017-06-22
JP6343034B2 true JP6343034B2 (ja) 2018-06-13

Family

ID=50841689

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016570886A Expired - Fee Related JP6343034B2 (ja) 2014-06-03 2015-06-02 ナフチリジンジオン誘導体
JP2018095248A Pending JP2018138609A (ja) 2014-06-03 2018-05-17 ナフチリジンジオン誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018095248A Pending JP2018138609A (ja) 2014-06-03 2018-05-17 ナフチリジンジオン誘導体

Country Status (28)

Country Link
US (2) US10138232B2 (fr)
EP (1) EP3152209B1 (fr)
JP (2) JP6343034B2 (fr)
KR (1) KR101905295B1 (fr)
CN (1) CN106459043B (fr)
AP (1) AP2016009545A0 (fr)
AR (1) AR100706A1 (fr)
AU (2) AU2015270125B2 (fr)
BR (1) BR112016027383A8 (fr)
CA (1) CA2950724A1 (fr)
CL (1) CL2016003081A1 (fr)
CR (1) CR20160565A (fr)
CU (1) CU24438B1 (fr)
EA (1) EA030374B1 (fr)
EC (1) ECSP16096831A (fr)
ES (1) ES2731802T3 (fr)
GT (1) GT201600252A (fr)
IL (1) IL248773B (fr)
MX (1) MX2016015856A (fr)
MY (1) MY178379A (fr)
PE (1) PE20170086A1 (fr)
PH (2) PH12016502293B1 (fr)
SG (1) SG11201609209YA (fr)
SV (1) SV2016005331A (fr)
TN (1) TN2016000490A1 (fr)
TW (1) TWI688565B (fr)
UY (1) UY36150A (fr)
WO (1) WO2015186063A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY178379A (en) 2014-06-03 2020-10-09 Novartis Ag Naphthyridinedione derivatives as suppressors of non-sense mutations
EP3152207B1 (fr) 2014-06-03 2019-05-08 Novartis AG Dérivés de pyridopyrimidinedione comme suppresseur de mutations non-sens
EP3152208B1 (fr) 2014-06-03 2019-05-08 Novartis AG Pyrimido [4,5-b]quinoline-4,5(3h, 10h)-diones comme suppresseur de mutations non-sens
WO2019225625A1 (fr) * 2018-05-23 2019-11-28 京都薬品工業株式会社 Inducteur de translecture et utilisation pharmaceutique associée
CN112424928A (zh) 2018-07-24 2021-02-26 索尼半导体解决方案公司 半导体装置

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2884170B2 (ja) 1989-08-24 1999-04-19 株式会社フジモト・ブラザーズ ５−デアザフラビン系化合物を有効成分とする制癌剤
JP2989871B2 (ja) * 1989-08-30 1999-12-13 大日本製薬株式会社 三環式化合物
DE4035479A1 (de) 1990-11-08 1992-05-14 Basf Ag Substituierte pyrido (2,3-d)pyrimidin-2,4(1h,3h)-dione
US5908930A (en) 1995-03-15 1999-06-01 Pfizer Inc. 5,10-dihydropyrimdo 4,5-b!quinolin-4(1H)-one tyrosine kinase inhibitors
US6016875A (en) * 1998-02-10 2000-01-25 Case Corporation Gain adaptation control for hydraulic systems
US6468990B1 (en) 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
WO2004006906A2 (fr) 2002-07-15 2004-01-22 Combinatorx, Incorporated Methodes de traitement de neoplasmes
CA2514733A1 (fr) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Compositions pharmaceutiques a base d'un co-cristal
ES2624610T3 (es) 2003-04-11 2017-07-17 Ptc Therapeutics, Inc. Compuestos de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
PL1773816T3 (pl) 2004-06-24 2015-06-30 Vertex Pharma Modulatory transporterów posiadających kasetę wiążącą ATP
CN101076703A (zh) * 2004-10-13 2007-11-21 Ptc医疗公司 用于无义抑制的化合物及其使用方法
ES2689539T3 (es) 2006-04-03 2018-11-14 Technion Research & Development Foundation Ltd. Aminoglucósidos novedosos y usos de los mismos en el tratamiento de trastornos genéticos
TW200819454A (en) 2006-08-23 2008-05-01 Neurogen Corp Haloalkyl-substituted pyrimidinone derivatives
WO2008147952A1 (fr) 2007-05-25 2008-12-04 Vertex Pharmaceuticals Incorporated Modulateurs de régulateur de conductance transmembranaire de fibrose cystique
JP2011507910A (ja) 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
EP2422817A1 (fr) 2010-07-29 2012-02-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Conjugués flavine-ligand d'acide nucléique
WO2012016930A1 (fr) 2010-08-05 2012-02-09 Universite De Droit Et Sante De Lille Composé utile pour le traitement de maladies médiées par une mutation non-sens et composition pharmaceutique comprenant ledit composé
EP2931282B1 (fr) * 2012-12-13 2018-10-31 Novartis AG Pyrimido [4,5-b]quinoline-4,5 (3h,10h)-diones utilisés en tant que suppresseurs de mutation non-sens
EP3152207B1 (fr) 2014-06-03 2019-05-08 Novartis AG Dérivés de pyridopyrimidinedione comme suppresseur de mutations non-sens
EP3152208B1 (fr) 2014-06-03 2019-05-08 Novartis AG Pyrimido [4,5-b]quinoline-4,5(3h, 10h)-diones comme suppresseur de mutations non-sens
MY178379A (en) 2014-06-03 2020-10-09 Novartis Ag Naphthyridinedione derivatives as suppressors of non-sense mutations

Also Published As

Publication number Publication date
MY178379A (en) 2020-10-09
AU2015270125A1 (en) 2016-11-24
EP3152209B1 (fr) 2019-03-20
CL2016003081A1 (es) 2017-06-09
IL248773A0 (en) 2017-01-31
JP2017516821A (ja) 2017-06-22
BR112016027383A8 (pt) 2021-07-20
AR100706A1 (es) 2016-10-26
CN106459043A (zh) 2017-02-22
AP2016009545A0 (en) 2016-11-30
AU2018200421A1 (en) 2018-02-08
WO2015186063A1 (fr) 2015-12-10
CA2950724A1 (fr) 2015-12-10
IL248773B (en) 2019-12-31
US20190248784A1 (en) 2019-08-15
CU20160182A7 (es) 2017-03-03
CU24438B1 (es) 2019-09-04
JP2018138609A (ja) 2018-09-06
SV2016005331A (es) 2018-08-20
CN106459043B (zh) 2018-12-28
TW201625610A (zh) 2016-07-16
UY36150A (es) 2016-01-29
ECSP16096831A (es) 2018-04-30
PH12016502293A1 (en) 2017-02-13
EA201692270A1 (ru) 2017-03-31
BR112016027383A2 (pt) 2017-08-15
PH12018501709A1 (en) 2019-08-14
KR101905295B1 (ko) 2018-10-05
EP3152209A1 (fr) 2017-04-12
PH12016502293B1 (en) 2017-02-13
EA030374B1 (ru) 2018-07-31
ES2731802T3 (es) 2019-11-19
MX2016015856A (es) 2017-04-25
PE20170086A1 (es) 2017-03-17
US10138232B2 (en) 2018-11-27
US20150344476A1 (en) 2015-12-03
SG11201609209YA (en) 2016-12-29
GT201600252A (es) 2018-12-18
TN2016000490A1 (en) 2018-04-04
KR20160148679A (ko) 2016-12-26
AU2015270125B2 (en) 2017-10-19
TWI688565B (zh) 2020-03-21
CR20160565A (es) 2017-03-10

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