JP6336435B2 - 動物モデルおよび治療用分子 - Google Patents

動物モデルおよび治療用分子 Download PDF

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JP6336435B2
JP6336435B2 JP2015502439A JP2015502439A JP6336435B2 JP 6336435 B2 JP6336435 B2 JP 6336435B2 JP 2015502439 A JP2015502439 A JP 2015502439A JP 2015502439 A JP2015502439 A JP 2015502439A JP 6336435 B2 JP6336435 B2 JP 6336435B2
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human
mouse
endogenous
cell
light chain
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JP2015512634A (ja
JP2015512634A5 (en:Method
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アラン・ブラッドリー
イー−チャン・リー
キ・リアン
ウェイ・ワン
ドミニク・スペンスベルガー
フイ・リウ
ジャスパー・クルブ
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カイマブ・リミテッド
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
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    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
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    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2207/00—Modified animals
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/35—Valency
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2015502439A 2012-03-28 2013-03-18 動物モデルおよび治療用分子 Active JP6336435B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13/433,084 2012-03-28
US13/433,084 US9445581B2 (en) 2012-03-28 2012-03-28 Animal models and therapeutic molecules
US13/434,361 US9253965B2 (en) 2012-03-28 2012-03-29 Animal models and therapeutic molecules
US13/434,361 2012-03-29
PCT/GB2013/050682 WO2013144566A2 (en) 2012-03-28 2013-03-18 Animal models and therapeutic molecules

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JP2018088749A Division JP2018119012A (ja) 2012-03-28 2018-05-02 動物モデルおよび治療用分子

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JP2015512634A JP2015512634A (ja) 2015-04-30
JP2015512634A5 JP2015512634A5 (en:Method) 2016-05-19
JP6336435B2 true JP6336435B2 (ja) 2018-06-06

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JP2018088749A Pending JP2018119012A (ja) 2012-03-28 2018-05-02 動物モデルおよび治療用分子
JP2020129123A Pending JP2020176140A (ja) 2012-03-28 2020-07-30 動物モデルおよび治療用分子
JP2022177513A Active JP7475415B2 (ja) 2012-03-28 2022-11-04 動物モデルおよび治療用分子

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JP2020129123A Pending JP2020176140A (ja) 2012-03-28 2020-07-30 動物モデルおよび治療用分子
JP2022177513A Active JP7475415B2 (ja) 2012-03-28 2022-11-04 動物モデルおよび治療用分子

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US (7) US9253965B2 (en:Method)
EP (3) EP2785845A2 (en:Method)
JP (4) JP6336435B2 (en:Method)
CN (1) CN104334732B (en:Method)
AU (1) AU2013239501B2 (en:Method)
CA (1) CA2867530A1 (en:Method)
DK (1) DK2831244T3 (en:Method)
ES (1) ES2979344T3 (en:Method)
IN (1) IN2014MN01879A (en:Method)
NZ (1) NZ629202A (en:Method)
SG (1) SG11201405058WA (en:Method)
WO (2) WO2013061098A2 (en:Method)

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