JP6309892B2 - 薬剤と有機溶媒と親油性膏体基剤と粉体を配合した貼付製剤組成物 - Google Patents

薬剤と有機溶媒と親油性膏体基剤と粉体を配合した貼付製剤組成物 Download PDF

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JP6309892B2
JP6309892B2 JP2014521482A JP2014521482A JP6309892B2 JP 6309892 B2 JP6309892 B2 JP 6309892B2 JP 2014521482 A JP2014521482 A JP 2014521482A JP 2014521482 A JP2014521482 A JP 2014521482A JP 6309892 B2 JP6309892 B2 JP 6309892B2
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powder
drug solution
acid
drug
ionic liquid
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JPWO2013191187A1 (ja
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濱本　英利
英利 濱本
勝弘 山中
勝弘 山中
高広 谷本
高広 谷本
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MedRx Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014521482A 2012-06-20 2013-06-18 薬剤と有機溶媒と親油性膏体基剤と粉体を配合した貼付製剤組成物 Active JP6309892B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012139215 2012-06-20
JP2012139215 2012-06-20
PCT/JP2013/066765 WO2013191187A1 (ja) 2012-06-20 2013-06-18 薬剤と有機溶媒と親油性膏体基剤と粉体を配合した貼付製剤組成物

Publications (2)

Publication Number Publication Date
JPWO2013191187A1 JPWO2013191187A1 (ja) 2016-05-26
JP6309892B2 true JP6309892B2 (ja) 2018-04-11

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ID=49768781

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JP2014521482A Active JP6309892B2 (ja) 2012-06-20 2013-06-18 薬剤と有機溶媒と親油性膏体基剤と粉体を配合した貼付製剤組成物

Country Status (16)

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US (2) US10543275B2 (enExample)
EP (1) EP2865376B2 (enExample)
JP (1) JP6309892B2 (enExample)
CN (3) CN110693859A (enExample)
AU (1) AU2013278403B2 (enExample)
BR (1) BR112014031701A2 (enExample)
CA (1) CA2875454C (enExample)
DK (1) DK2865376T4 (enExample)
ES (1) ES2738303T5 (enExample)
HU (1) HUE045479T2 (enExample)
IN (1) IN2014DN10706A (enExample)
PL (1) PL2865376T5 (enExample)
PT (1) PT2865376T (enExample)
SI (1) SI2865376T1 (enExample)
TR (1) TR201911328T4 (enExample)
WO (1) WO2013191187A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105744931B (zh) * 2013-09-11 2020-03-10 美德阿利克斯株式会社 用于胶带制剂中的膏体基质材料的新型组合物
CN103830206B (zh) * 2014-02-26 2016-08-31 上海现代药物制剂工程研究中心有限公司 阿戈美拉汀三维网状立体构型的透皮给药制剂及制备方法
MX2016011152A (es) * 2014-02-27 2016-12-09 Medrx Co Ltd Parche transdermico que contiene pramipexol para tratamiento de enfermedad neurodegenerativa.
WO2016109483A1 (en) * 2014-12-30 2016-07-07 Noven Pharmaceuticals, Inc. Transdermal drug delivery systems for agomelatine
CN107427509B (zh) * 2015-08-29 2021-06-15 美德阿利克斯株式会社 含有碱性药物和山梨酸的经皮吸收组成物
WO2017037812A1 (ja) * 2015-08-29 2017-03-09 株式会社メドレックス 酸捕捉剤を含有する貼付製剤
US10016502B2 (en) 2015-08-29 2018-07-10 Medrx Co., Ltd Patch preparation containing an acid scavenger
US20170273974A1 (en) 2016-03-24 2017-09-28 Medrx Co., Ltd Patch preparations with misuse prevention features
JPWO2017164084A1 (ja) * 2016-03-24 2019-02-07 株式会社 メドレックス 誤用防止特性を有する貼付製剤
WO2018088303A1 (ja) * 2016-11-09 2018-05-17 株式会社クラレ 粘着シート、絆創膏及びこれらの製造方法
US20220016061A1 (en) * 2018-10-04 2022-01-20 Medrx Co., Ltd. Preparation Stabilized by Means of Nonaqueous Solvent
CN116887815A (zh) * 2021-02-12 2023-10-13 美德阿利克斯株式会社 难吸收性药物的吸收性得到改善的组合物
JP7179212B1 (ja) 2022-05-02 2022-11-28 久光製薬株式会社 リドカイン含有貼付剤

Family Cites Families (20)

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Publication number Priority date Publication date Assignee Title
JP3144895B2 (ja) * 1992-06-30 2001-03-12 積水化学工業株式会社 医療用粘着テープもしくはシート
JPH06145050A (ja) 1992-11-11 1994-05-24 Sekisui Chem Co Ltd 貼付剤の製造方法
JPH07145047A (ja) * 1993-11-25 1995-06-06 Sekisui Chem Co Ltd 局所麻酔用経皮吸収テープ
JPH0827003A (ja) * 1994-07-22 1996-01-30 Sekisui Chem Co Ltd 経皮吸収製剤
JPH09169636A (ja) * 1995-06-12 1997-06-30 Sekisui Chem Co Ltd 貼付剤
JPH09136834A (ja) * 1995-11-14 1997-05-27 Sekisui Chem Co Ltd 経皮吸収貼付剤
JP4648518B2 (ja) * 2000-06-01 2011-03-09 帝國製薬株式会社 ４−ビフェニル酢酸含有貼付剤
DE10033853A1 (de) 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
US6503532B1 (en) * 2001-04-13 2003-01-07 Murty Pharmaceuticals, Inc. Pharmaceutical composition containing tetrahydrocannabinol and a transdermal/transcutaneous delivery method thereof
JP4758101B2 (ja) * 2002-09-13 2011-08-24 久光製薬株式会社 貼付剤
KR20120035220A (ko) * 2003-01-22 2012-04-13 센주 세이야꾸 가부시키가이샤 안질환 치료용 경피 흡수형 제제, 그 사용, 및 안질환 치료약의 눈의 국소 조직으로의 이행 방법
US8080261B2 (en) * 2004-09-30 2011-12-20 Teikoku Pharma Usa, Inc. 1-chloro-2,4-dinitrobenzene non-aqueous gel compositions and methods for using the same
JP4148988B2 (ja) * 2006-09-11 2008-09-10 積水化学工業株式会社 貼付剤
US20090317452A1 (en) 2006-09-11 2009-12-24 Sekisui Chemical Co. Td. Transdermal patch
CN103239721B (zh) * 2007-11-22 2016-03-16 美德阿利克斯株式会社 包括基于脂肪酸的离子型液体作为活性成分的外用制剂组合物
WO2009110351A1 (ja) 2008-03-03 2009-09-11 久光製薬株式会社 経皮吸収製剤
JP4822032B2 (ja) 2009-01-08 2011-11-24 タイヨーエレック株式会社 組合せ式遊技機
WO2010113225A1 (en) * 2009-03-30 2010-10-07 Yutoku Pharmaceutical Industries Co., Ltd. Riluzole-containing transdermal patch
DE102009022915A1 (de) * 2009-05-27 2010-12-09 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit gesteuertem Wirkstofffluss
JP2011074035A (ja) 2009-09-30 2011-04-14 Sekisui Medical Co Ltd 貼付剤

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Publication number Publication date
IN2014DN10706A (enExample) 2015-09-04
ES2738303T3 (es) 2020-01-21
CA2875454A1 (en) 2013-12-27
TR201911328T4 (tr) 2019-08-21
US10543275B2 (en) 2020-01-28
SI2865376T1 (sl) 2019-11-29
EP2865376A4 (en) 2015-11-18
DK2865376T3 (da) 2019-08-12
EP2865376A1 (en) 2015-04-29
US20150174249A1 (en) 2015-06-25
EP2865376B2 (en) 2022-05-11
CN110693859A (zh) 2020-01-17
US20190388544A1 (en) 2019-12-26
PL2865376T3 (pl) 2019-12-31
DK2865376T4 (da) 2022-07-18
AU2013278403B2 (en) 2018-02-01
ES2738303T5 (es) 2022-09-12
CA2875454C (en) 2021-02-16
CN104363900A (zh) 2015-02-18
EP2865376B1 (en) 2019-06-05
WO2013191187A1 (ja) 2013-12-27
CN108553452A (zh) 2018-09-21
AU2013278403A1 (en) 2015-01-22
PL2865376T5 (pl) 2023-01-09
JPWO2013191187A1 (ja) 2016-05-26
US12016924B2 (en) 2024-06-25
PT2865376T (pt) 2019-08-26
HUE045479T2 (hu) 2019-12-30
BR112014031701A2 (pt) 2017-06-27

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