JP6293127B2 - 未分化細胞の選択的阻害剤 - Google Patents

未分化細胞の選択的阻害剤 Download PDF

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JP6293127B2
JP6293127B2 JP2015513349A JP2015513349A JP6293127B2 JP 6293127 B2 JP6293127 B2 JP 6293127B2 JP 2015513349 A JP2015513349 A JP 2015513349A JP 2015513349 A JP2015513349 A JP 2015513349A JP 6293127 B2 JP6293127 B2 JP 6293127B2
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cells
plurisin
undifferentiated
cell
cancer
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JP2015525207A (ja
JP2015525207A5 (enExample
Inventor
ウリ ベン−デイヴィッド，
ウリ ベン−デイヴィッド，
ニッシム ベンヴェニスティ，
ニッシム ベンヴェニスティ，
パヤル アロラ，
パヤル アロラ，
チン−フェン ガン，
チン−フェン ガン，
ラルフ ジェー． ガリッパ，
ラルフ ジェー． ガリッパ，
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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JP2015513349A 2012-05-22 2013-05-22 未分化細胞の選択的阻害剤 Expired - Fee Related JP6293127B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261650049P 2012-05-22 2012-05-22
US61/650,049 2012-05-22
US201261696387P 2012-09-04 2012-09-04
US61/696,387 2012-09-04
PCT/IL2013/050441 WO2013175474A2 (en) 2012-05-22 2013-05-22 Selective inhibitors of undifferentiated cells

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JP2015525207A JP2015525207A (ja) 2015-09-03
JP2015525207A5 JP2015525207A5 (enExample) 2016-07-07
JP6293127B2 true JP6293127B2 (ja) 2018-03-14

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US (3) US9456998B2 (enExample)
EP (1) EP2852387A2 (enExample)
JP (1) JP6293127B2 (enExample)
KR (1) KR20150013777A (enExample)
CN (1) CN104768549A (enExample)
BR (1) BR112014029365A2 (enExample)
CA (1) CA2873817A1 (enExample)
MX (1) MX2014014174A (enExample)
RU (1) RU2014149559A (enExample)
WO (1) WO2013175474A2 (enExample)

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MX2014014174A (es) 2012-05-22 2015-07-06 Hoffmann La Roche Inhibidores selectivos de celulas no diferenciadas.
CN103755618A (zh) * 2013-12-19 2014-04-30 南京农业大学 一种含n-取代苯肼的吡咯烷-2,4-二酮类化合物、制备方法及应用
WO2015112581A1 (en) 2014-01-21 2015-07-30 The Medical College Of Wisconsin, Inc. Methods for selective inhibition of pluripotent stem cells
US20180042925A1 (en) * 2015-03-04 2018-02-15 Children's Hospital Medical Center Methods for treating cancer
CA2986930C (en) 2015-06-24 2023-09-26 Duke University Chemical modulators of signaling pathways and therapeutic use
US11434472B2 (en) 2016-12-20 2022-09-06 Sumitomo Pharma Co., Ltd. Agent for removing undifferentiated iPS cells
MA47212A (fr) 2017-01-06 2019-11-13 Yumanity Therapeutics Inc Méthodes de traitement de troubles neurologiques
EP3634425A4 (en) * 2017-06-07 2021-04-07 Academia Sinica METHOD OF ELIMINATION OF UNDIFFERENTIATED PLURIPOTENT STEM CELLS
EP3480296A1 (en) 2017-11-06 2019-05-08 Universität zu Köln Diamines for use in the elimination of pluripotent stem cells
ES3043183T3 (en) 2018-03-23 2025-11-25 Janssen Pharmaceutica Nv Compounds and uses thereof
CN109402121A (zh) * 2018-12-11 2019-03-01 宁夏医科大学总医院 一种环状RNA hsa_circSCD_004及其特异性扩增引物和应用
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US9456998B2 (en) 2016-10-04
WO2013175474A3 (en) 2014-01-16
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WO2013175474A9 (en) 2014-03-13
BR112014029365A2 (pt) 2017-06-27
US20150148359A1 (en) 2015-05-28
RU2014149559A (ru) 2016-06-27
US20180153830A1 (en) 2018-06-07
US20170027890A1 (en) 2017-02-02
CA2873817A1 (en) 2013-11-28
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