JP6293127B2 - 未分化細胞の選択的阻害剤 - Google Patents

未分化細胞の選択的阻害剤 Download PDF

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JP6293127B2
JP6293127B2 JP2015513349A JP2015513349A JP6293127B2 JP 6293127 B2 JP6293127 B2 JP 6293127B2 JP 2015513349 A JP2015513349 A JP 2015513349A JP 2015513349 A JP2015513349 A JP 2015513349A JP 6293127 B2 JP6293127 B2 JP 6293127B2
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cells
plurisin
undifferentiated
cell
cancer
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JP2015525207A5 (enExample
JP2015525207A (ja
Inventor
ウリ ベン−デイヴィッド，
ウリ ベン−デイヴィッド，
ニッシム ベンヴェニスティ，
ニッシム ベンヴェニスティ，
パヤル アロラ，
パヤル アロラ，
チン−フェン ガン，
チン−フェン ガン，
ラルフ ジェー． ガリッパ，
ラルフ ジェー． ガリッパ，
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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JP2015513349A 2012-05-22 2013-05-22 未分化細胞の選択的阻害剤 Expired - Fee Related JP6293127B2 (ja)

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US201261650049P 2012-05-22 2012-05-22
US61/650,049 2012-05-22
US201261696387P 2012-09-04 2012-09-04
US61/696,387 2012-09-04
PCT/IL2013/050441 WO2013175474A2 (en) 2012-05-22 2013-05-22 Selective inhibitors of undifferentiated cells

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JP6293127B2 (ja) 2012-05-22 2018-03-14 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド 未分化細胞の選択的阻害剤
CN103755618A (zh) * 2013-12-19 2014-04-30 南京农业大学 一种含n-取代苯肼的吡咯烷-2,4-二酮类化合物、制备方法及应用
US10316287B2 (en) 2014-01-21 2019-06-11 The Medical College Of Wisconsin, Inc. Methods for selective inhibition of pluripotent stem cells
WO2016141299A1 (en) * 2015-03-04 2016-09-09 Children's Hospital Medical Center Methods for treating cancer
CA2986930C (en) 2015-06-24 2023-09-26 Duke University Chemical modulators of signaling pathways and therapeutic use
JP7123809B2 (ja) 2016-12-20 2022-08-23 住友ファーマ株式会社 未分化ｉＰＳ細胞の除去剤
JP2020514293A (ja) 2017-01-06 2020-05-21 ユマニティ セラピューティクス，インコーポレーテッド 神経障害を治療する方法
EP3634425A4 (en) * 2017-06-07 2021-04-07 Academia Sinica METHOD OF ELIMINATION OF UNDIFFERENTIATED PLURIPOTENT STEM CELLS
EP3480296A1 (en) 2017-11-06 2019-05-08 Universität zu Köln Diamines for use in the elimination of pluripotent stem cells
EP3768269B1 (en) 2018-03-23 2025-08-20 Janssen Pharmaceutica NV Compounds and uses thereof
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