JP6251682B2 - メラノーマ治療の治療の組み合わせ及び方法 - Google Patents

メラノーマ治療の治療の組み合わせ及び方法 Download PDF

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Publication number
JP6251682B2
JP6251682B2 JP2014538892A JP2014538892A JP6251682B2 JP 6251682 B2 JP6251682 B2 JP 6251682B2 JP 2014538892 A JP2014538892 A JP 2014538892A JP 2014538892 A JP2014538892 A JP 2014538892A JP 6251682 B2 JP6251682 B2 JP 6251682B2
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antibody
seq
etbr
mpk
inhibitor
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Expired - Fee Related
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Japanese (ja)
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JP2014532648A5 (enrdf_load_stackoverflow
JP2014532648A (ja
Inventor
ポール ポラキス，
ポール ポラキス，
ジョティー アスンディ，
ジョティー アスンディ，
スザンナ クラーク，
スザンナ クラーク，
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Genentech Inc
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Genentech Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2014538892A 2011-10-28 2012-10-24 メラノーマ治療の治療の組み合わせ及び方法 Expired - Fee Related JP6251682B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161552893P 2011-10-28 2011-10-28
US61/552,893 2011-10-28
US201261678978P 2012-08-02 2012-08-02
US61/678,978 2012-08-02
PCT/US2012/061533 WO2013063001A1 (en) 2011-10-28 2012-10-24 Therapeutic combinations and methods of treating melanoma

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017161010A Division JP2018027948A (ja) 2011-10-28 2017-08-24 メラノーマ治療の治療の組み合わせ及び方法

Publications (3)

Publication Number Publication Date
JP2014532648A JP2014532648A (ja) 2014-12-08
JP2014532648A5 JP2014532648A5 (enrdf_load_stackoverflow) 2015-12-17
JP6251682B2 true JP6251682B2 (ja) 2017-12-20

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JP2014538892A Expired - Fee Related JP6251682B2 (ja) 2011-10-28 2012-10-24 メラノーマ治療の治療の組み合わせ及び方法
JP2017161010A Withdrawn JP2018027948A (ja) 2011-10-28 2017-08-24 メラノーマ治療の治療の組み合わせ及び方法

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EP (1) EP2776051A4 (enrdf_load_stackoverflow)
JP (2) JP6251682B2 (enrdf_load_stackoverflow)
KR (1) KR20140097205A (enrdf_load_stackoverflow)
CN (1) CN104039340B (enrdf_load_stackoverflow)
AR (1) AR088509A1 (enrdf_load_stackoverflow)
AU (1) AU2012328980A1 (enrdf_load_stackoverflow)
BR (1) BR112014009953A2 (enrdf_load_stackoverflow)
CA (1) CA2850034A1 (enrdf_load_stackoverflow)
CL (1) CL2014001092A1 (enrdf_load_stackoverflow)
CO (1) CO7151543A2 (enrdf_load_stackoverflow)
EA (1) EA201490879A1 (enrdf_load_stackoverflow)
IL (1) IL232135A0 (enrdf_load_stackoverflow)
IN (1) IN2014CN03062A (enrdf_load_stackoverflow)
MX (1) MX2014004991A (enrdf_load_stackoverflow)
PE (1) PE20142312A1 (enrdf_load_stackoverflow)
PH (1) PH12014500925A1 (enrdf_load_stackoverflow)
SG (1) SG11201401815XA (enrdf_load_stackoverflow)
TW (1) TW201325613A (enrdf_load_stackoverflow)
WO (1) WO2013063001A1 (enrdf_load_stackoverflow)

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WO2016011160A1 (en) 2014-07-15 2016-01-21 Genentech, Inc. Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors
WO2016055907A1 (en) * 2014-10-10 2016-04-14 Pfizer Inc. Synergistic auristatin combinations
CN108025035B (zh) * 2015-08-03 2023-06-13 Enb治疗公司 用于治疗与etbr激活相关的癌症的组合物和方法
FR3053042B1 (fr) 2016-06-24 2018-08-10 Commissariat A L'energie Atomique Et Aux Energies Alternatives Anticorps dirige contre le sous-type b des recepteurs aux endothelines et ses utilisations
WO2018134254A1 (en) 2017-01-17 2018-07-26 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
WO2024209089A1 (en) 2023-04-07 2024-10-10 Commissariat A L'energie Atomique Et Aux Energies Alternatives Use of antibody against the endothelin receptor b for diagnostic and therapeutic applications
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FR3155709A1 (fr) * 2023-11-27 2025-05-30 Skymab Biotherapeutics Conjugue anticorps-medicament et ses utilisations

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MX2014004991A (es) 2014-05-22
CO7151543A2 (es) 2014-12-29
CL2014001092A1 (es) 2014-07-25
CN104039340B (zh) 2017-04-05
JP2014532648A (ja) 2014-12-08
PH12014500925A1 (en) 2014-06-09
TW201325613A (zh) 2013-07-01
AR088509A1 (es) 2014-06-11
JP2018027948A (ja) 2018-02-22
KR20140097205A (ko) 2014-08-06
WO2013063001A1 (en) 2013-05-02
SG11201401815XA (en) 2014-05-29
CN104039340A (zh) 2014-09-10
IL232135A0 (en) 2014-05-28
PE20142312A1 (es) 2015-01-25
EP2776051A4 (en) 2015-06-17
IN2014CN03062A (enrdf_load_stackoverflow) 2015-07-31
EP2776051A1 (en) 2014-09-17
CA2850034A1 (en) 2013-05-02
AU2012328980A1 (en) 2014-04-24
BR112014009953A2 (pt) 2017-12-05

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