JP6244004B2 - 酸素センサ - Google Patents
酸素センサ Download PDFInfo
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- JP6244004B2 JP6244004B2 JP2016502074A JP2016502074A JP6244004B2 JP 6244004 B2 JP6244004 B2 JP 6244004B2 JP 2016502074 A JP2016502074 A JP 2016502074A JP 2016502074 A JP2016502074 A JP 2016502074A JP 6244004 B2 JP6244004 B2 JP 6244004B2
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- sensor
- tissue
- polymer
- oxidase
- compound
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Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10010272B2 (en) | 2010-05-27 | 2018-07-03 | Profusa, Inc. | Tissue-integrating electronic apparatus |
| KR101690535B1 (ko) | 2010-10-06 | 2017-01-09 | 프로퓨사 인코퍼레이티드 | 조직-일체화 센서 |
| WO2014011724A1 (en) * | 2012-07-10 | 2014-01-16 | The General Hospital Corporation | System and method for monitoring and treating a surface of a subject |
| US10045722B2 (en) | 2013-03-14 | 2018-08-14 | Profusa, Inc. | Method and device for correcting optical signals |
| AU2014274784B2 (en) | 2013-06-06 | 2018-12-06 | Profusa, Inc. | Apparatus and methods for detecting optical signals from implanted sensors |
| JP2017528572A (ja) * | 2014-09-15 | 2017-09-28 | クロックス テクノロジーズ インコーポレイテッドＫｌｏｘ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． | 放射性高分子マトリクス |
| US10695000B2 (en) * | 2015-09-02 | 2020-06-30 | Metronom Health, Inc. | Systems and methods for continuous health monitoring using an opto-enzymatic analyte sensor |
| DE102015014526A1 (de) | 2015-11-11 | 2017-05-11 | Giesecke & Devrient Gmbh | Sicherheitspigment, lumineszierendes Polymerharz und Verfahren zum Herstellen desselben |
| WO2017100680A1 (en) * | 2015-12-09 | 2017-06-15 | The Texas A&M University System | Implantable biosensors |
| US10324058B2 (en) * | 2016-04-28 | 2019-06-18 | Medtronic Minimed, Inc. | In-situ chemistry stack for continuous glucose sensors |
| WO2017210841A1 (en) * | 2016-06-06 | 2017-12-14 | University Of Washington | Nanoparticle transducer sensors and methods of use thereof |
| US10662333B2 (en) | 2016-06-17 | 2020-05-26 | Profusa, Inc. | NIR long lifetime indicator molecule |
| EP3500168B1 (en) * | 2016-08-22 | 2021-06-23 | Ramot at Tel-Aviv University Ltd. | System for subcutaneous bioanalyte sensing |
| CA3034347A1 (en) | 2016-08-22 | 2018-03-01 | Fernando Patolsky | Methods and systems for detecting bioanalytes |
| CN110352036B (zh) | 2016-12-21 | 2022-11-15 | 普罗菲尤萨股份有限公司 | 可聚合的近红外染料 |
| CN108968976B (zh) | 2017-05-31 | 2022-09-13 | 心脏起搏器股份公司 | 具有化学传感器的植入式医疗设备 |
| WO2019006400A1 (en) | 2017-06-29 | 2019-01-03 | Profusa, Inc. | FABRIC INTEGRATION SENSORS FOR DETECTION OF MULTIPLE ANALYTES |
| WO2019023093A1 (en) | 2017-07-26 | 2019-01-31 | Cardiac Pacemakers, Inc. | SYSTEMS AND METHODS FOR POSTURE DISAMBIGULATION |
| CN109381195B (zh) | 2017-08-10 | 2023-01-10 | 心脏起搏器股份公司 | 包括电解质传感器融合的系统和方法 |
| CN109419515B (zh) | 2017-08-23 | 2023-03-24 | 心脏起搏器股份公司 | 具有分级激活的可植入化学传感器 |
| CN109864746B (zh) * | 2017-12-01 | 2023-09-29 | 心脏起搏器股份公司 | 用于医学装置的多模式分析物传感器 |
| CN109864747B (zh) * | 2017-12-05 | 2023-08-25 | 心脏起搏器股份公司 | 多模式分析物传感器光电子接口 |
| US11534503B2 (en) | 2017-12-28 | 2022-12-27 | Profusa, Inc. | Oxidase-based sensors and methods of using |
| CA3087231A1 (en) * | 2017-12-28 | 2019-07-04 | Profusa, Inc. | System and method for analyzing biochemical sensor data |
| CN112601491B (zh) | 2018-06-27 | 2025-08-19 | 普罗菲尤萨股份有限公司 | 近红外葡萄糖传感器 |
| KR20210027392A (ko) | 2018-06-29 | 2021-03-10 | 프로퓨사 인코퍼레이티드 | 적층형 센서들 및 사용 방법들 |
| CN109035688B (zh) * | 2018-08-06 | 2021-01-08 | 山东师范大学 | 基于磷光的氧浓度声光报警器 |
| WO2020037269A2 (en) * | 2018-08-17 | 2020-02-20 | The Regents Of The University Of California | Composite matrix for analyte biosensors |
| GB2577770B (en) * | 2019-07-25 | 2020-10-21 | Oxford Optronix Solutions Ltd | Method for detection of bacteria |
| WO2021035047A1 (en) | 2019-08-20 | 2021-02-25 | Profusa, Inc. | Optical filter device, system, and method for improved optical rejection of out-of-band wavelengths |
| US11998330B2 (en) * | 2021-01-29 | 2024-06-04 | Medtronic Minimed, Inc. | Interference rejection membranes useful with analyte sensors |
| JP7678137B2 (ja) | 2021-04-19 | 2025-05-15 | ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド | 電気化学分析物バイオセンサ、関連する組成物ならびにそれらの製造及び使用方法 |
| WO2023172612A2 (en) * | 2022-03-08 | 2023-09-14 | Trustees Of Tufts College | Silk chromophore composite materials for in situ oxygen sensing |
| US20250067712A1 (en) * | 2023-07-18 | 2025-02-27 | Mohamed Magdy Ibrahim | Oxygen Sensing Composition and Method of Use |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5220036A (en) * | 1985-12-16 | 1993-06-15 | Polaroid Corporation | Thiolactone dye precursors |
| DK576187D0 (da) | 1987-11-03 | 1987-11-03 | Radiometer As | Fremgangsmaade til bestemmelse af oxygenkoncentration |
| US5242835A (en) * | 1987-11-03 | 1993-09-07 | Radiometer A/S | Method and apparatus for determining the concentration of oxygen |
| US4925268A (en) | 1988-07-25 | 1990-05-15 | Abbott Laboratories | Fiber-optic physiological probes |
| US6362175B1 (en) * | 1991-09-20 | 2002-03-26 | The Trustees Of The University Of Pennsylvania | Porphyrin compounds for imaging tissue oxygen |
| JP2533430B2 (ja) | 1992-03-24 | 1996-09-11 | 三ツ星ベルト株式会社 | 色素分子を分散させたポリアミド複合物とその製造方法 |
| US5487885A (en) * | 1992-12-21 | 1996-01-30 | Biophysica, Inc. | Sunblocking polymers and their formulation |
| US5837865A (en) * | 1993-10-15 | 1998-11-17 | Trustees Of The University Of Pennsylvania | Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen |
| JP2883824B2 (ja) | 1993-11-07 | 1999-04-19 | 科学技術振興事業団 | ボロン酸基を有する発蛍光性化合物 |
| JP3321288B2 (ja) | 1994-04-25 | 2002-09-03 | 日本ペイント株式会社 | 近赤外光重合性組成物 |
| CA2235738C (en) | 1995-11-22 | 2005-07-26 | Minimed, Inc. | Detection of biological molecules using chemical amplification and optical sensors |
| AU3769597A (en) | 1996-07-22 | 1998-02-10 | Novartis Ag | Process for the preparation of platinum or palladium benzoporphyrins and platinum or palladium cyclohexenoporphyrins, intermediates, and an oxygen sensor comprising platinum or palladium cyclohexenoporphyrin |
| US6274086B1 (en) * | 1996-12-16 | 2001-08-14 | The Trustees Of The University Of Pennsylvania | Apparatus for non-invasive imaging oxygen distribution in multi-dimensions |
| US6485703B1 (en) | 1998-07-31 | 2002-11-26 | The Texas A&M University System | Compositions and methods for analyte detection |
| US6013122A (en) | 1998-08-18 | 2000-01-11 | Option Technologies, Inc. | Tattoo inks |
| KR100753184B1 (ko) | 1999-01-25 | 2007-08-30 | 내셔날 쥬이쉬 메디칼 앤드 리서치 센터 | 치환된 포르피린 |
| US6858403B2 (en) | 1999-05-11 | 2005-02-22 | M-Biotech, Inc. | Polymer matrix containing catalase co-immobilized with analytic enzyme that generates hydrogen peroxide |
| US6366793B1 (en) | 1999-09-10 | 2002-04-02 | Beckman Coulter, Inc. | Minimally invasive methods for measuring analtes in vivo |
| US6682938B1 (en) | 1999-09-15 | 2004-01-27 | The Regents Of The University Of California | Glucose sensing molecules having selected fluorescent properties |
| CA2415338C (en) | 2000-08-04 | 2012-10-23 | Sensors For Medicine And Science, Inc. | Detection of analytes in aqueous environments |
| GB0025147D0 (en) | 2000-10-13 | 2000-11-29 | Torsana Diabetes Diagnostics A | Optical sensor for in situ measurement of analytes |
| EP1221465A1 (en) | 2001-01-03 | 2002-07-10 | Innosense S.r.l. | Symmetric, monofunctionalised polymethine dyes labelling reagents |
| US20020127626A1 (en) | 2001-01-05 | 2002-09-12 | Sensors For Medicine And Science, Inc. | Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone |
| US6800451B2 (en) | 2001-01-05 | 2004-10-05 | Sensors For Medicine And Science, Inc. | Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone |
| US20020119581A1 (en) | 2001-01-05 | 2002-08-29 | Daniloff George Y. | Detection of analytes |
| JP2003261464A (ja) | 2002-03-07 | 2003-09-16 | Fuji Photo Film Co Ltd | 近赤外蛍光造影剤および蛍光造影法 |
| AU2003220547A1 (en) | 2003-03-28 | 2004-11-23 | Terumo Corporation Of Japan | Solid-phase saccharide sensing compounds |
| AU2004233805B2 (en) | 2003-04-25 | 2007-06-21 | Kos Life Sciences, Inc. | Formation of strong superporous hydrogels |
| US7358094B2 (en) | 2003-05-01 | 2008-04-15 | Bell Michael L | Sensor system for saccharides |
| US7972628B2 (en) | 2003-10-01 | 2011-07-05 | University Of Washington | Porous biomaterials |
| WO2005065241A2 (en) | 2003-12-24 | 2005-07-21 | Argose, Inc. | Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors |
| AU2005245996A1 (en) | 2004-05-21 | 2005-12-01 | Atonomics A/S | Surface acoustic wave sensor comprising a hydrogel |
| DE602005000858T2 (de) | 2004-07-23 | 2008-01-17 | Terumo K.K. | Saccharid-messender fluoreszierender Monomer, Saccharid-messende fluoreszierende Sensor-Substanz und implantierbarer, Saccharid-messender Sensor |
| JP4691333B2 (ja) | 2004-07-23 | 2011-06-01 | テルモ株式会社 | 糖類測定用蛍光モノマー化合物、糖類測定用蛍光センサー物質および体内埋め込み用の糖類測定用センサー |
| JP4691345B2 (ja) | 2004-10-07 | 2011-06-01 | テルモ株式会社 | 糖類測定用蛍光モノマー化合物、糖類測定用蛍光センサー物質および体内埋め込み用の糖類測定用センサー |
| US20070036682A1 (en) | 2005-08-15 | 2007-02-15 | Honeywell International Inc. | Microoptic glucose detector |
| JP5106397B2 (ja) | 2005-09-02 | 2012-12-26 | ビセン メディカル， インコーポレイテッド | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 |
| GB0522796D0 (en) | 2005-11-08 | 2005-12-14 | Smart Holograms Ltd | Novel boronate complex and its use in a glucose sensor |
| JP5159778B2 (ja) | 2006-07-25 | 2013-03-13 | グルメトリックス，インコーポレイテッド | グルコース検知における使用のための蛍光色素 |
| GB0615211D0 (en) | 2006-07-31 | 2006-09-06 | Ge Healthcare Uk Ltd | Asymmetric flouro-substituted polymethine dyes |
| DK2099807T3 (da) | 2006-11-30 | 2014-01-27 | Senseonics Inc | Oxidationsresistente indikatormolekyler |
| US8785624B2 (en) * | 2007-06-13 | 2014-07-22 | University Of Southern California | Organic photosensitive optoelectronic devices with nonplanar porphyrins |
| GB0906318D0 (en) | 2009-04-09 | 2009-05-20 | Glysure Ltd | Fluorophore and fluorescent sensor compound containing same |
| US9517023B2 (en) * | 2009-06-01 | 2016-12-13 | Profusa, Inc. | Method and system for directing a localized biological response to an implant |
| EP2526103B1 (en) | 2010-01-22 | 2016-05-04 | Council of Scientific & Industrial Research | A process for the preparation of novel porphyrin derivatives and their use as pdt agents and fluorescence probes |
| EP2528918B1 (en) | 2010-01-29 | 2014-09-10 | Nerviano Medical Sciences S.r.l. | 6,7-dihydroimidazo[1,5-a]pyrazin-8(5h)-one derivatives as protein kinase modulators |
| FR2958557B1 (fr) | 2010-04-07 | 2014-10-31 | Centre Nat Rech Scient | Procede de traitement d'effluents comprenant des composes halogenes |
| DE112011101279T5 (de) | 2010-04-07 | 2013-03-14 | Cornell University | Kovalente organische Gerüste und Verfahren zu deren Herstellung |
| US10010272B2 (en) | 2010-05-27 | 2018-07-03 | Profusa, Inc. | Tissue-integrating electronic apparatus |
| WO2012027593A1 (en) | 2010-08-25 | 2012-03-01 | The University Of South Dakota | Electron-deficient fluorous porphyrins and methods of making and their use in organic solar cells |
| EP2614684B1 (en) | 2010-09-10 | 2015-07-01 | University Of Southern California | Broadly absorbing metalloporphyrin-based multichromophoric arrays for triplet harvesting |
| KR101690535B1 (ko) | 2010-10-06 | 2017-01-09 | 프로퓨사 인코퍼레이티드 | 조직-일체화 센서 |
| EP2658924B1 (en) | 2010-12-28 | 2017-05-10 | Dura Chemicals, Inc. | Additives for curable liquid compositions |
| US9250246B2 (en) | 2011-06-29 | 2016-02-02 | Portland State University | Near-infrared fluorescent dyes with large stokes shifts |
| WO2013006160A1 (en) | 2011-07-01 | 2013-01-10 | Empire Technology Development Llc | Paraben derivatives for preserving cellulosic materials |
| US9469941B2 (en) | 2011-07-01 | 2016-10-18 | Empire Technology Development Llc | Paraben derivatives for preserving cellulosic materials |
| WO2013019722A1 (en) | 2011-08-01 | 2013-02-07 | Massachusetts Institute Of Technology | Photoluminescent nanostructure-based sensors |
| JP2013103094A (ja) | 2011-11-16 | 2013-05-30 | Sony Corp | 測定装置、測定方法、プログラム及び記録媒体 |
| US20140072515A9 (en) | 2012-03-02 | 2014-03-13 | Greg Hermanson | Cyanine compounds |
| CN102735667B (zh) | 2012-06-28 | 2014-05-21 | 南京大学 | 基于氟硼二吡咯-苯硼酸的荧光传感膜及其制备方法和应用 |
| EP2895202A1 (en) | 2012-09-13 | 2015-07-22 | Ben-Gurion University Of The Negev Research And Development Authority | Diagnostic agents with enhanced sensitivity/specificity |
| US20140088383A1 (en) | 2012-09-14 | 2014-03-27 | Senseonics, Incorporated | Integrated catalytic protection of oxidation sensitive materials |
| EP3636653A1 (en) | 2013-01-07 | 2020-04-15 | The University of Tokyo | Asymmetrical si rhodamine and rhodol synthesis |
| JP6244004B2 (ja) | 2013-03-14 | 2017-12-06 | プロフサ，インコーポレイテッド | 酸素センサ |
| US10045722B2 (en) | 2013-03-14 | 2018-08-14 | Profusa, Inc. | Method and device for correcting optical signals |
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| JOP20190161A1 (ar) | 2016-12-27 | 2017-06-16 | Profusa Inc | مستشعرات جلوكوز بطيف قريب من الأشعة تحت الحمراء |
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-
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018051333A (ja) * | 2013-03-14 | 2018-04-05 | プロフサ，インコーポレイテッド | 酸素センサ |
| JP2020072650A (ja) * | 2013-03-14 | 2020-05-14 | プロフサ，インコーポレイテッド | 酸素センサ |
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