JP6236531B2 - ヒト耐虫遺伝子およびそれによりコードされた抗Ｃｒｙ１Ａｂ毒素イディオタイプ一本鎖抗体ならびに用途 - Google Patents

ヒト耐虫遺伝子およびそれによりコードされた抗Ｃｒｙ１Ａｂ毒素イディオタイプ一本鎖抗体ならびに用途 Download PDF

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JP6236531B2
JP6236531B2 JP2016535242A JP2016535242A JP6236531B2 JP 6236531 B2 JP6236531 B2 JP 6236531B2 JP 2016535242 A JP2016535242 A JP 2016535242A JP 2016535242 A JP2016535242 A JP 2016535242A JP 6236531 B2 JP6236531 B2 JP 6236531B2
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single chain
chain antibody
cry1ab toxin
cry1ab
antibody
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Japanese (ja)
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JP2017505109A (ja
JP2017505109A5 (enExample
Inventor
▲劉▼▲賢▼金
徐重新
▲張▼霄
▲劉▼媛
▲謝▼雅晶
▲張▼存政
余向▲陽▼
王冬▲蘭▼
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Jiangsu Academy of Agricultural Sciences
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Jiangsu Academy of Agricultural Sciences
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4233—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-bacterial Ig
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Catching Or Destruction (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2016535242A 2014-01-26 2015-01-09 ヒト耐虫遺伝子およびそれによりコードされた抗Ｃｒｙ１Ａｂ毒素イディオタイプ一本鎖抗体ならびに用途 Expired - Fee Related JP6236531B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410037000.9 2014-01-26
CN201410037000.9A CN103773774B (zh) 2014-01-26 2014-01-26 一种人源抗虫基因及其编码的抗Cry1Ab毒素独特型单链抗体与应用
PCT/CN2015/070420 WO2015109951A1 (zh) 2014-01-26 2015-01-09 一种人源抗虫基因及其编码的抗Cry1Ab毒素独特型单链抗体与应用

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JP2017505109A JP2017505109A (ja) 2017-02-16
JP2017505109A5 JP2017505109A5 (enExample) 2017-11-09
JP6236531B2 true JP6236531B2 (ja) 2017-11-22

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JP2016535242A Expired - Fee Related JP6236531B2 (ja) 2014-01-26 2015-01-09 ヒト耐虫遺伝子およびそれによりコードされた抗Ｃｒｙ１Ａｂ毒素イディオタイプ一本鎖抗体ならびに用途

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US (1) US9751952B2 (enExample)
EP (1) EP3098315B1 (enExample)
JP (1) JP6236531B2 (enExample)
CN (1) CN103773774B (enExample)
BR (1) BR112016016035B1 (enExample)
WO (1) WO2015109951A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103773775B (zh) 2014-01-26 2015-11-18 江苏省农业科学院 一种人源抗虫基因及其编码的抗Cry1B毒素独特型单链抗体与应用
CN103773774B (zh) 2014-01-26 2015-11-18 江苏省农业科学院 一种人源抗虫基因及其编码的抗Cry1Ab毒素独特型单链抗体与应用
CN104498501B (zh) * 2014-12-05 2017-07-18 江苏省农业科学院 一种人源杀虫基因及其编码杀虫肽与应用
CN104628852A (zh) * 2015-02-04 2015-05-20 东南大学 抗Cry1Ab毒素纳米抗体、其编码序列及应用
CN104926940B (zh) * 2015-06-15 2018-02-09 江苏省农业科学院 一种人源杀虫蛋白及其制备方法与应用
CN105131123B (zh) * 2015-09-16 2018-11-27 江苏省农业科学院 一种具有杀虫活性的牛源化改型抗体及其制备方法与应用
CN105085683B (zh) * 2015-09-16 2018-11-27 江苏省农业科学院 一种具有杀虫活性的猪源化改型抗体及其制备方法与应用
CN105777899B (zh) * 2016-04-25 2021-12-24 江苏省农业科学院 抗Bt Cry1Ab毒素单克隆抗体及产生该抗体的细胞株、制备方法与应用
CN108101970B (zh) * 2017-12-14 2021-02-26 江苏省农业科学院 基于抗独特型纳米抗体的Cry1Ab毒素模拟抗原及其应用
CN108997495B (zh) 2018-08-09 2020-08-07 江苏省农业科学院 一种改进的人源模拟Bt Cry杀虫蛋白功能效应物及其设计方法与应用
CN108997494B (zh) * 2018-08-09 2020-08-07 江苏省农业科学院 一种改进的人源模拟Bt Cry毒素蛋白功能效应物(GGCC)及其设计方法与应用
CN110294803B (zh) * 2019-05-27 2020-12-01 中国农业科学院植物保护研究所 Cry1Ah1蛋白的单克隆抗体及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006128569A2 (en) 2005-06-02 2006-12-07 Syngenta Participations Ag 1143-14a, insecticidal transgenic cotton expressing cry1ab
CN102964447A (zh) * 2012-06-29 2013-03-13 无锡福阳生物科技有限公司 一种Cry1Ab/Ac转基因成分配对单克隆抗体制备及检测方法
CN102936598B (zh) * 2012-11-21 2014-04-16 江苏省农业科学院 抗Cry1Ac毒素单链抗体的编码基因及免疫PCR检测方法
CN103773774B (zh) 2014-01-26 2015-11-18 江苏省农业科学院 一种人源抗虫基因及其编码的抗Cry1Ab毒素独特型单链抗体与应用

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Publication number Publication date
US9751952B2 (en) 2017-09-05
US20170044272A1 (en) 2017-02-16
BR112016016035B1 (pt) 2022-02-08
EP3098315A1 (en) 2016-11-30
EP3098315A4 (en) 2017-06-21
CN103773774A (zh) 2014-05-07
JP2017505109A (ja) 2017-02-16
WO2015109951A1 (zh) 2015-07-30
EP3098315B1 (en) 2018-10-03
BR112016016035A2 (pt) 2017-09-26
CN103773774B (zh) 2015-11-18
WO2015109951A8 (zh) 2015-10-29

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