JP6196224B2 - シアル酸類似体 - Google Patents
シアル酸類似体 Download PDFInfo
- Publication number
- JP6196224B2 JP6196224B2 JP2014537380A JP2014537380A JP6196224B2 JP 6196224 B2 JP6196224 B2 JP 6196224B2 JP 2014537380 A JP2014537380 A JP 2014537380A JP 2014537380 A JP2014537380 A JP 2014537380A JP 6196224 B2 JP6196224 B2 JP 6196224B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- structural formula
- hydrogen
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Physical Education & Sports Medicine (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550610P | 2011-10-24 | 2011-10-24 | |
| US61/550,610 | 2011-10-24 | ||
| PCT/US2012/061737 WO2013063149A1 (en) | 2011-10-24 | 2012-10-24 | Sialic acid analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530882A JP2014530882A (ja) | 2014-11-20 |
| JP2014530882A5 JP2014530882A5 (enExample) | 2015-09-10 |
| JP6196224B2 true JP6196224B2 (ja) | 2017-09-13 |
Family
ID=48168447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537380A Active JP6196224B2 (ja) | 2011-10-24 | 2012-10-24 | シアル酸類似体 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US8840926B2 (enExample) |
| EP (1) | EP2771348B1 (enExample) |
| JP (1) | JP6196224B2 (enExample) |
| KR (1) | KR102049214B1 (enExample) |
| CN (1) | CN103974965B (enExample) |
| AU (1) | AU2012328874B2 (enExample) |
| BR (1) | BR112014009760B1 (enExample) |
| CA (1) | CA2849114C (enExample) |
| ES (1) | ES2807890T3 (enExample) |
| HK (1) | HK1201067A1 (enExample) |
| IL (1) | IL231714B (enExample) |
| MX (1) | MX347541B (enExample) |
| WO (1) | WO2013063149A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9241896B2 (en) | 2008-12-19 | 2016-01-26 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| BR112013000776A2 (pt) | 2010-07-13 | 2016-05-24 | Ultragenyx Pharmaceutical Inc | método e formulação para tratamento de deficiência de ácido siálico |
| KR102049214B1 (ko) | 2011-10-24 | 2019-11-28 | 울트라제닉스 파마수티컬 인코포레이티드 | 시알산 유사체 |
| KR20150000872A (ko) * | 2012-01-18 | 2015-01-05 | 울트라제닉스 파마수티컬 인코포레이티드 | 시알산 결핍을 치료하기 위한 방법 및 제형 |
| US10385085B2 (en) | 2015-09-14 | 2019-08-20 | Ultragenyx Pharmaceutical Inc. | Crystal forms of sialic acid or salt or solvate thereof |
| CN121079430A (zh) * | 2023-02-17 | 2025-12-05 | 奥特吉尼克斯制药公司 | 唾液酸衍生物的结晶形式及其使用方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6168418A (ja) | 1984-09-11 | 1986-04-08 | Kanto Ishi Pharma Co Ltd | 去痰薬 |
| JPS63139193A (ja) * | 1986-11-28 | 1988-06-10 | Mect Corp | シアル酸誘導体１，７−ラクトン |
| US6156544A (en) | 1993-06-09 | 2000-12-05 | Glaxo Group Limited | Process for the preparation of N-acetylneuraminic acid |
| CN1090022C (zh) | 1995-04-04 | 2002-09-04 | 俄克拉荷马创伤治疗所 | 通过光动力疗法与免疫佐剂联合应用治疗癌症 |
| US5624677A (en) | 1995-06-13 | 1997-04-29 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| CA2328085C (en) | 1998-04-10 | 2006-08-22 | Mitsubishi Chemical Corporation | Solid dispersion containing sialic acid derivative |
| KR20030006721A (ko) | 2001-07-14 | 2003-01-23 | 삼성전자 주식회사 | 리소그라피 시스템 및 이를 이용한 레티클 표면의 파티클제거방법 |
| CN1671420A (zh) | 2002-06-21 | 2005-09-21 | 诺和诺德医疗保健公司 | Peg化因子ⅶ糖型 |
| US7238677B2 (en) | 2003-03-28 | 2007-07-03 | Kimberly-Clark Worldwide, Inc. | Prevention of urogenital infections |
| AU2004296404A1 (en) * | 2003-12-09 | 2005-06-23 | Spherics, Inc. | Bioadhesive polymers with catechol functionality |
| JP2008535787A (ja) | 2005-03-03 | 2008-09-04 | マナテク・インコーポレーテツド | 栄養補助剤の改変された放出のための方法及び組成物 |
| EP2086515A2 (en) * | 2006-03-02 | 2009-08-12 | Vaunnex, Inc. | Rate-controlled bioadhesive oral dosage formulations |
| WO2008027557A2 (en) * | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| CA2903133C (en) | 2007-05-31 | 2021-10-19 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health | N-acetyl mannosamine or derivatives thereof for use in treating a kidney disorder in a mammal |
| JP2010537997A (ja) | 2007-08-27 | 2010-12-09 | マサチューセッツ インスティテュート オブ テクノロジー | 二機能性ポリマーに結合させたインフルエンザウイルス阻害剤 |
| CN102316730A (zh) | 2008-05-09 | 2012-01-11 | 天雅瑞药业有限公司 | 用于减轻全身性炎症和/或血管炎症的n-乙酰半胱氨酸(nac)的控释 |
| KR101116864B1 (ko) | 2008-08-01 | 2012-02-29 | 주식회사 베네비오 | 고지혈증, 지방간 또는 비만의 예방 또는 치료용 조성물 |
| US20100160363A1 (en) | 2008-12-19 | 2010-06-24 | Aaipharma Services Corp. | Extended-release pharmaceutical formulations |
| US9241896B2 (en) | 2008-12-19 | 2016-01-26 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| US20100159001A1 (en) | 2008-12-19 | 2010-06-24 | Cardinal John R | Extended-Release Pharmaceutical Formulations |
| KR20120023064A (ko) * | 2009-05-15 | 2012-03-12 | 자이단호진 휴먼 사이언스 신코우자이단 | Ｇｎｅ 단백질의 기능 저하에 기인하는 질환의 치료용 의약제, 식품 조성물 및 식품 첨가물 |
| BR112013000776A2 (pt) | 2010-07-13 | 2016-05-24 | Ultragenyx Pharmaceutical Inc | método e formulação para tratamento de deficiência de ácido siálico |
| KR102049214B1 (ko) | 2011-10-24 | 2019-11-28 | 울트라제닉스 파마수티컬 인코포레이티드 | 시알산 유사체 |
| KR20150000872A (ko) | 2012-01-18 | 2015-01-05 | 울트라제닉스 파마수티컬 인코포레이티드 | 시알산 결핍을 치료하기 위한 방법 및 제형 |
| ES2777838T3 (es) | 2015-01-28 | 2020-08-06 | Kyowa Hakko Bio Co Ltd | Cristal de anhidrato de N-acetilneuraminato de amonio y procedimiento para producir el mismo |
| US10385085B2 (en) | 2015-09-14 | 2019-08-20 | Ultragenyx Pharmaceutical Inc. | Crystal forms of sialic acid or salt or solvate thereof |
-
2012
- 2012-10-24 KR KR1020147013997A patent/KR102049214B1/ko active Active
- 2012-10-24 HK HK15101526.4A patent/HK1201067A1/xx unknown
- 2012-10-24 AU AU2012328874A patent/AU2012328874B2/en active Active
- 2012-10-24 MX MX2014004928A patent/MX347541B/es active IP Right Grant
- 2012-10-24 EP EP12843460.2A patent/EP2771348B1/en active Active
- 2012-10-24 ES ES12843460T patent/ES2807890T3/es active Active
- 2012-10-24 WO PCT/US2012/061737 patent/WO2013063149A1/en not_active Ceased
- 2012-10-24 CA CA2849114A patent/CA2849114C/en active Active
- 2012-10-24 US US13/659,550 patent/US8840926B2/en active Active
- 2012-10-24 BR BR112014009760-7A patent/BR112014009760B1/pt active IP Right Grant
- 2012-10-24 JP JP2014537380A patent/JP6196224B2/ja active Active
- 2012-10-24 CN CN201280052218.0A patent/CN103974965B/zh active Active
-
2014
- 2014-03-26 IL IL231714A patent/IL231714B/en active IP Right Grant
- 2014-08-15 US US14/461,295 patent/US9221858B2/en active Active
-
2015
- 2015-11-18 US US14/944,779 patent/US10065981B2/en active Active
-
2018
- 2018-07-31 US US16/050,343 patent/US10457701B2/en active Active
-
2019
- 2019-09-16 US US16/571,589 patent/US10889607B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014009760A2 (pt) | 2017-04-18 |
| US10065981B2 (en) | 2018-09-04 |
| EP2771348A4 (en) | 2015-09-09 |
| US20190127409A1 (en) | 2019-05-02 |
| CN103974965B (zh) | 2019-09-24 |
| IL231714A0 (en) | 2014-05-28 |
| EP2771348B1 (en) | 2020-05-20 |
| MX2014004928A (es) | 2014-11-10 |
| US20150038693A1 (en) | 2015-02-05 |
| CN103974965A (zh) | 2014-08-06 |
| AU2012328874A1 (en) | 2014-04-10 |
| BR112014009760A8 (pt) | 2018-01-16 |
| CA2849114C (en) | 2020-12-15 |
| EP2771348A1 (en) | 2014-09-03 |
| ES2807890T3 (es) | 2021-02-24 |
| US20200131215A1 (en) | 2020-04-30 |
| HK1201067A1 (en) | 2015-08-21 |
| US9221858B2 (en) | 2015-12-29 |
| US10889607B2 (en) | 2021-01-12 |
| US10457701B2 (en) | 2019-10-29 |
| JP2014530882A (ja) | 2014-11-20 |
| KR20140084277A (ko) | 2014-07-04 |
| US20130122094A1 (en) | 2013-05-16 |
| AU2012328874B2 (en) | 2017-08-31 |
| MX347541B (es) | 2017-04-28 |
| WO2013063149A1 (en) | 2013-05-02 |
| BR112014009760B1 (pt) | 2022-11-29 |
| CA2849114A1 (en) | 2013-05-02 |
| IL231714B (en) | 2018-10-31 |
| US8840926B2 (en) | 2014-09-23 |
| US20160297846A1 (en) | 2016-10-13 |
| KR102049214B1 (ko) | 2019-11-28 |
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