CN103974965B - 唾液酸类似物 - Google Patents
唾液酸类似物 Download PDFInfo
- Publication number
- CN103974965B CN103974965B CN201280052218.0A CN201280052218A CN103974965B CN 103974965 B CN103974965 B CN 103974965B CN 201280052218 A CN201280052218 A CN 201280052218A CN 103974965 B CN103974965 B CN 103974965B
- Authority
- CN
- China
- Prior art keywords
- compound
- structural formula
- pharmaceutically acceptable
- group
- sialic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550610P | 2011-10-24 | 2011-10-24 | |
| US61/550,610 | 2011-10-24 | ||
| PCT/US2012/061737 WO2013063149A1 (en) | 2011-10-24 | 2012-10-24 | Sialic acid analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103974965A CN103974965A (zh) | 2014-08-06 |
| CN103974965B true CN103974965B (zh) | 2019-09-24 |
Family
ID=48168447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280052218.0A Active CN103974965B (zh) | 2011-10-24 | 2012-10-24 | 唾液酸类似物 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US8840926B2 (enExample) |
| EP (1) | EP2771348B1 (enExample) |
| JP (1) | JP6196224B2 (enExample) |
| KR (1) | KR102049214B1 (enExample) |
| CN (1) | CN103974965B (enExample) |
| AU (1) | AU2012328874B2 (enExample) |
| BR (1) | BR112014009760B1 (enExample) |
| CA (1) | CA2849114C (enExample) |
| ES (1) | ES2807890T3 (enExample) |
| HK (1) | HK1201067A1 (enExample) |
| IL (1) | IL231714B (enExample) |
| MX (1) | MX347541B (enExample) |
| WO (1) | WO2013063149A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9241896B2 (en) | 2008-12-19 | 2016-01-26 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| BR112013000776A2 (pt) | 2010-07-13 | 2016-05-24 | Ultragenyx Pharmaceutical Inc | método e formulação para tratamento de deficiência de ácido siálico |
| WO2013063149A1 (en) | 2011-10-24 | 2013-05-02 | Ultragenyx Pharmaceutical, Inc. | Sialic acid analogs |
| CN104271125A (zh) * | 2012-01-18 | 2015-01-07 | 奥特吉尼克斯制药公司 | 用于治疗唾液酸缺乏的方法和制剂 |
| WO2017048817A1 (en) | 2015-09-14 | 2017-03-23 | Ultragenyx Pharmaceutical Inc. | Crystal forms of sialic acid or salt or solvate thereof |
| CN121079430A (zh) * | 2023-02-17 | 2025-12-05 | 奥特吉尼克斯制药公司 | 唾液酸衍生物的结晶形式及其使用方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6168418A (ja) | 1984-09-11 | 1986-04-08 | Kanto Ishi Pharma Co Ltd | 去痰薬 |
| JPS63139193A (ja) * | 1986-11-28 | 1988-06-10 | Mect Corp | シアル酸誘導体１，７−ラクトン |
| US6156544A (en) | 1993-06-09 | 2000-12-05 | Glaxo Group Limited | Process for the preparation of N-acetylneuraminic acid |
| CA2215978A1 (en) | 1995-04-04 | 1996-10-10 | Wound Healing Of Oklahoma | Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant |
| US5624677A (en) | 1995-06-13 | 1997-04-29 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| WO1999052931A1 (fr) | 1998-04-10 | 1999-10-21 | Mitsubishi Chemical Corporation | Dispersion solide contenant un derive d'acide sialique |
| KR20030006721A (ko) | 2001-07-14 | 2003-01-23 | 삼성전자 주식회사 | 리소그라피 시스템 및 이를 이용한 레티클 표면의 파티클제거방법 |
| BR0311978A (pt) | 2002-06-21 | 2005-03-22 | Novo Nordisk Healthcare Ag | Preparação, método para preparar a mesma, formulação farmacêutica, métodos para tratar de uma sìndrome responsiva ao fator vii, para prevenir hemorragias indesejáveis, para prevenir coagulação sanguìnea indesejável e para prevenir as reações mediadas pelo fator tecidual, e, uso de uma preparação |
| US7238677B2 (en) | 2003-03-28 | 2007-07-03 | Kimberly-Clark Worldwide, Inc. | Prevention of urogenital infections |
| AU2004296404A1 (en) * | 2003-12-09 | 2005-06-23 | Spherics, Inc. | Bioadhesive polymers with catechol functionality |
| KR101202607B1 (ko) | 2005-03-03 | 2012-11-20 | 마나테크 인코포레이티드 | 영양 보조제의 조절된 방출을 위한 방법 및 조성물 |
| WO2007103286A2 (en) * | 2006-03-02 | 2007-09-13 | Spherics, Inc. | Rate-controlled bioadhesive oral dosage formulations |
| US9744137B2 (en) * | 2006-08-31 | 2017-08-29 | Supernus Pharmaceuticals, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| WO2008150477A2 (en) | 2007-05-31 | 2008-12-11 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health | N-acetyl mannosamine as a therapeutic agent |
| CA2698108A1 (en) | 2007-08-27 | 2009-03-12 | Massachusetts Institute Of Technology | Bi-functional polymer-attached inhibitors of influenza virus |
| WO2009137827A2 (en) | 2008-05-09 | 2009-11-12 | Tiara Pharmaceuticals, Inc. | Controlled release of n-acetylcysteine (nac) for reduction of systemic and/or vascular inflammation |
| KR101116864B1 (ko) | 2008-08-01 | 2012-02-29 | 주식회사 베네비오 | 고지혈증, 지방간 또는 비만의 예방 또는 치료용 조성물 |
| US9241896B2 (en) | 2008-12-19 | 2016-01-26 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| US20100160363A1 (en) | 2008-12-19 | 2010-06-24 | Aaipharma Services Corp. | Extended-release pharmaceutical formulations |
| US20100159001A1 (en) | 2008-12-19 | 2010-06-24 | Cardinal John R | Extended-Release Pharmaceutical Formulations |
| JP5626734B2 (ja) * | 2009-05-15 | 2014-11-19 | 公益財団法人ヒューマンサイエンス振興財団 | Ｇｎｅタンパク質の機能低下に起因する疾患の治療用医薬剤、食品組成物 |
| BR112013000776A2 (pt) | 2010-07-13 | 2016-05-24 | Ultragenyx Pharmaceutical Inc | método e formulação para tratamento de deficiência de ácido siálico |
| WO2013063149A1 (en) | 2011-10-24 | 2013-05-02 | Ultragenyx Pharmaceutical, Inc. | Sialic acid analogs |
| CN104271125A (zh) | 2012-01-18 | 2015-01-07 | 奥特吉尼克斯制药公司 | 用于治疗唾液酸缺乏的方法和制剂 |
| EP3252065B1 (en) | 2015-01-28 | 2020-01-08 | Kyowa Hakko Bio Co., Ltd. | Crystal of ammonium n-acetylneuraminate anhydrate, and process for producing same |
| WO2017048817A1 (en) | 2015-09-14 | 2017-03-23 | Ultragenyx Pharmaceutical Inc. | Crystal forms of sialic acid or salt or solvate thereof |
-
2012
- 2012-10-24 WO PCT/US2012/061737 patent/WO2013063149A1/en not_active Ceased
- 2012-10-24 CA CA2849114A patent/CA2849114C/en active Active
- 2012-10-24 JP JP2014537380A patent/JP6196224B2/ja active Active
- 2012-10-24 KR KR1020147013997A patent/KR102049214B1/ko active Active
- 2012-10-24 HK HK15101526.4A patent/HK1201067A1/xx unknown
- 2012-10-24 US US13/659,550 patent/US8840926B2/en active Active
- 2012-10-24 CN CN201280052218.0A patent/CN103974965B/zh active Active
- 2012-10-24 ES ES12843460T patent/ES2807890T3/es active Active
- 2012-10-24 MX MX2014004928A patent/MX347541B/es active IP Right Grant
- 2012-10-24 AU AU2012328874A patent/AU2012328874B2/en active Active
- 2012-10-24 BR BR112014009760-7A patent/BR112014009760B1/pt active IP Right Grant
- 2012-10-24 EP EP12843460.2A patent/EP2771348B1/en active Active
-
2014
- 2014-03-26 IL IL231714A patent/IL231714B/en active IP Right Grant
- 2014-08-15 US US14/461,295 patent/US9221858B2/en active Active
-
2015
- 2015-11-18 US US14/944,779 patent/US10065981B2/en active Active
-
2018
- 2018-07-31 US US16/050,343 patent/US10457701B2/en active Active
-
2019
- 2019-09-16 US US16/571,589 patent/US10889607B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20160297846A1 (en) | 2016-10-13 |
| AU2012328874B2 (en) | 2017-08-31 |
| US20200131215A1 (en) | 2020-04-30 |
| MX347541B (es) | 2017-04-28 |
| BR112014009760A2 (pt) | 2017-04-18 |
| US8840926B2 (en) | 2014-09-23 |
| JP2014530882A (ja) | 2014-11-20 |
| JP6196224B2 (ja) | 2017-09-13 |
| EP2771348A1 (en) | 2014-09-03 |
| MX2014004928A (es) | 2014-11-10 |
| KR102049214B1 (ko) | 2019-11-28 |
| US9221858B2 (en) | 2015-12-29 |
| CA2849114C (en) | 2020-12-15 |
| US20130122094A1 (en) | 2013-05-16 |
| CN103974965A (zh) | 2014-08-06 |
| WO2013063149A1 (en) | 2013-05-02 |
| CA2849114A1 (en) | 2013-05-02 |
| US20150038693A1 (en) | 2015-02-05 |
| KR20140084277A (ko) | 2014-07-04 |
| US10889607B2 (en) | 2021-01-12 |
| ES2807890T3 (es) | 2021-02-24 |
| US10457701B2 (en) | 2019-10-29 |
| AU2012328874A1 (en) | 2014-04-10 |
| BR112014009760B1 (pt) | 2022-11-29 |
| EP2771348A4 (en) | 2015-09-09 |
| BR112014009760A8 (pt) | 2018-01-16 |
| IL231714B (en) | 2018-10-31 |
| IL231714A0 (en) | 2014-05-28 |
| US20190127409A1 (en) | 2019-05-02 |
| US10065981B2 (en) | 2018-09-04 |
| EP2771348B1 (en) | 2020-05-20 |
| HK1201067A1 (en) | 2015-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |