AU2012328874B2 - Sialic acid analogs - Google Patents

Sialic acid analogs Download PDF

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Publication number
AU2012328874B2
AU2012328874B2 AU2012328874A AU2012328874A AU2012328874B2 AU 2012328874 B2 AU2012328874 B2 AU 2012328874B2 AU 2012328874 A AU2012328874 A AU 2012328874A AU 2012328874 A AU2012328874 A AU 2012328874A AU 2012328874 B2 AU2012328874 B2 AU 2012328874B2
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Australia
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compound
hydrogen
optionally substituted
group
structural formula
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AU2012328874A
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AU2012328874A1 (en
Inventor
Steven Jungles
Emil Kakkis
He Zhao
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Ultragenyx Pharmaceutical Inc
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Ultragenyx Pharmaceutical Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/027—Keto-aldonic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2012328874A 2011-10-24 2012-10-24 Sialic acid analogs Active AU2012328874B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161550610P 2011-10-24 2011-10-24
US61/550,610 2011-10-24
PCT/US2012/061737 WO2013063149A1 (en) 2011-10-24 2012-10-24 Sialic acid analogs

Publications (2)

Publication Number Publication Date
AU2012328874A1 AU2012328874A1 (en) 2014-04-10
AU2012328874B2 true AU2012328874B2 (en) 2017-08-31

Family

ID=48168447

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012328874A Active AU2012328874B2 (en) 2011-10-24 2012-10-24 Sialic acid analogs

Country Status (13)

Country Link
US (5) US8840926B2 (enExample)
EP (1) EP2771348B1 (enExample)
JP (1) JP6196224B2 (enExample)
KR (1) KR102049214B1 (enExample)
CN (1) CN103974965B (enExample)
AU (1) AU2012328874B2 (enExample)
BR (1) BR112014009760B1 (enExample)
CA (1) CA2849114C (enExample)
ES (1) ES2807890T3 (enExample)
HK (1) HK1201067A1 (enExample)
IL (1) IL231714B (enExample)
MX (1) MX347541B (enExample)
WO (1) WO2013063149A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9241896B2 (en) 2008-12-19 2016-01-26 Ultragenyx Pharmaceutical Inc. Methods and formulations for treating sialic acid deficiencies
BR112013000776A2 (pt) 2010-07-13 2016-05-24 Ultragenyx Pharmaceutical Inc método e formulação para tratamento de deficiência de ácido siálico
KR102049214B1 (ko) 2011-10-24 2019-11-28 울트라제닉스 파마수티컬 인코포레이티드 시알산 유사체
KR20150000872A (ko) * 2012-01-18 2015-01-05 울트라제닉스 파마수티컬 인코포레이티드 시알산 결핍을 치료하기 위한 방법 및 제형
US10385085B2 (en) 2015-09-14 2019-08-20 Ultragenyx Pharmaceutical Inc. Crystal forms of sialic acid or salt or solvate thereof
CN121079430A (zh) * 2023-02-17 2025-12-05 奥特吉尼克斯制药公司 唾液酸衍生物的结晶形式及其使用方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20120264928A1 (en) * 2009-05-15 2012-10-18 Japan Health Sciences Foundation Therapeutic pharmaceutical agent for diseases associated with decrease in function of gne protein, food composition, and food additive

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JPS6168418A (ja) 1984-09-11 1986-04-08 Kanto Ishi Pharma Co Ltd 去痰薬
JPS63139193A (ja) * 1986-11-28 1988-06-10 Mect Corp シアル酸誘導体１，７−ラクトン
US6156544A (en) 1993-06-09 2000-12-05 Glaxo Group Limited Process for the preparation of N-acetylneuraminic acid
CN1090022C (zh) 1995-04-04 2002-09-04 俄克拉荷马创伤治疗所 通过光动力疗法与免疫佐剂联合应用治疗癌症
US5624677A (en) 1995-06-13 1997-04-29 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
CA2328085C (en) 1998-04-10 2006-08-22 Mitsubishi Chemical Corporation Solid dispersion containing sialic acid derivative
KR20030006721A (ko) 2001-07-14 2003-01-23 삼성전자 주식회사 리소그라피 시스템 및 이를 이용한 레티클 표면의 파티클제거방법
CN1671420A (zh) 2002-06-21 2005-09-21 诺和诺德医疗保健公司 Peg化因子ⅶ糖型
US7238677B2 (en) 2003-03-28 2007-07-03 Kimberly-Clark Worldwide, Inc. Prevention of urogenital infections
AU2004296404A1 (en) * 2003-12-09 2005-06-23 Spherics, Inc. Bioadhesive polymers with catechol functionality
JP2008535787A (ja) 2005-03-03 2008-09-04 マナテク・インコーポレーテツド 栄養補助剤の改変された放出のための方法及び組成物
EP2086515A2 (en) * 2006-03-02 2009-08-12 Vaunnex, Inc. Rate-controlled bioadhesive oral dosage formulations
WO2008027557A2 (en) * 2006-08-31 2008-03-06 Spherics, Inc. Topiramate compositions and methods of enhancing its bioavailability
CA2903133C (en) 2007-05-31 2021-10-19 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health N-acetyl mannosamine or derivatives thereof for use in treating a kidney disorder in a mammal
JP2010537997A (ja) 2007-08-27 2010-12-09 マサチューセッツ インスティテュート オブ テクノロジー 二機能性ポリマーに結合させたインフルエンザウイルス阻害剤
CN102316730A (zh) 2008-05-09 2012-01-11 天雅瑞药业有限公司 用于减轻全身性炎症和/或血管炎症的n-乙酰半胱氨酸(nac)的控释
KR101116864B1 (ko) 2008-08-01 2012-02-29 주식회사 베네비오 고지혈증, 지방간 또는 비만의 예방 또는 치료용 조성물
US20100160363A1 (en) 2008-12-19 2010-06-24 Aaipharma Services Corp. Extended-release pharmaceutical formulations
US9241896B2 (en) 2008-12-19 2016-01-26 Ultragenyx Pharmaceutical Inc. Methods and formulations for treating sialic acid deficiencies
US20100159001A1 (en) 2008-12-19 2010-06-24 Cardinal John R Extended-Release Pharmaceutical Formulations
BR112013000776A2 (pt) 2010-07-13 2016-05-24 Ultragenyx Pharmaceutical Inc método e formulação para tratamento de deficiência de ácido siálico
KR102049214B1 (ko) 2011-10-24 2019-11-28 울트라제닉스 파마수티컬 인코포레이티드 시알산 유사체
KR20150000872A (ko) 2012-01-18 2015-01-05 울트라제닉스 파마수티컬 인코포레이티드 시알산 결핍을 치료하기 위한 방법 및 제형
ES2777838T3 (es) 2015-01-28 2020-08-06 Kyowa Hakko Bio Co Ltd Cristal de anhidrato de N-acetilneuraminato de amonio y procedimiento para producir el mismo
US10385085B2 (en) 2015-09-14 2019-08-20 Ultragenyx Pharmaceutical Inc. Crystal forms of sialic acid or salt or solvate thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120264928A1 (en) * 2009-05-15 2012-10-18 Japan Health Sciences Foundation Therapeutic pharmaceutical agent for diseases associated with decrease in function of gne protein, food composition, and food additive

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry, 1998, Vol. 6, pages 1283-1292. *
CAS Registry Number 1053644-78-2; STN Entry Date 28 September 2008 *
COLOMBO, R. et al., "The first synthesis of N-acetylneuraminic acid 1,7-lactone", Chemical Communications, 2008, pages 5517-5519. *
HORN, E. et al., "Investigation into an efficient synthesis of 2,3-dehydro-N-acetyl neuraminic acid leads to three decarboxylated sialic acid dimers", Carbohydrate Research, 2008, Vol. 343, pages 936-940. *
LIU, J. L-C. et al., "Overproduction of CMP-Sialic Acid Synthetase for Organic Synthesis", 1992, Vol. 114, pages 3901-3910. *
OTEKE, C. et al., "Viersatile Bisynthetic Engineering of Sialic Acid in Living Cells Using Syhthetic Sialic Acid Analogues". J. Biol. Chem. 2002, Vol. 277, No. 8, pages 6688-6695 *
PubChem CID 440962; Entry Date 24 June 2005; N-acetylneuraminic acid 9-phosphate. *
REZENDE, M. C. et al., "A facile route to 9-phosphorylated neuraminic acid derivatives", Synthetic Communications, 1998, Vol. 28, No. 23, pages 4393-4400. *
SATO, S. et al., "Studies on Sialic Acids. XIV. Lactone Derivatives of N-Acetylneuraminic Acid", Chemical and Pharmaceutical Bulletin, 1988, Vol. 36, No. 12, pages 4678-4688. *

Also Published As

Publication number Publication date
BR112014009760A2 (pt) 2017-04-18
US10065981B2 (en) 2018-09-04
EP2771348A4 (en) 2015-09-09
US20190127409A1 (en) 2019-05-02
CN103974965B (zh) 2019-09-24
IL231714A0 (en) 2014-05-28
EP2771348B1 (en) 2020-05-20
MX2014004928A (es) 2014-11-10
US20150038693A1 (en) 2015-02-05
CN103974965A (zh) 2014-08-06
AU2012328874A1 (en) 2014-04-10
BR112014009760A8 (pt) 2018-01-16
CA2849114C (en) 2020-12-15
EP2771348A1 (en) 2014-09-03
ES2807890T3 (es) 2021-02-24
US20200131215A1 (en) 2020-04-30
HK1201067A1 (en) 2015-08-21
US9221858B2 (en) 2015-12-29
US10889607B2 (en) 2021-01-12
US10457701B2 (en) 2019-10-29
JP2014530882A (ja) 2014-11-20
KR20140084277A (ko) 2014-07-04
US20130122094A1 (en) 2013-05-16
MX347541B (es) 2017-04-28
WO2013063149A1 (en) 2013-05-02
BR112014009760B1 (pt) 2022-11-29
CA2849114A1 (en) 2013-05-02
IL231714B (en) 2018-10-31
US8840926B2 (en) 2014-09-23
US20160297846A1 (en) 2016-10-13
KR102049214B1 (ko) 2019-11-28
JP6196224B2 (ja) 2017-09-13

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