AU2012328874B2 - Sialic acid analogs - Google Patents
Sialic acid analogs Download PDFInfo
- Publication number
- AU2012328874B2 AU2012328874B2 AU2012328874A AU2012328874A AU2012328874B2 AU 2012328874 B2 AU2012328874 B2 AU 2012328874B2 AU 2012328874 A AU2012328874 A AU 2012328874A AU 2012328874 A AU2012328874 A AU 2012328874A AU 2012328874 B2 AU2012328874 B2 AU 2012328874B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- hydrogen
- optionally substituted
- group
- structural formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550610P | 2011-10-24 | 2011-10-24 | |
| US61/550,610 | 2011-10-24 | ||
| PCT/US2012/061737 WO2013063149A1 (en) | 2011-10-24 | 2012-10-24 | Sialic acid analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012328874A1 AU2012328874A1 (en) | 2014-04-10 |
| AU2012328874B2 true AU2012328874B2 (en) | 2017-08-31 |
Family
ID=48168447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012328874A Active AU2012328874B2 (en) | 2011-10-24 | 2012-10-24 | Sialic acid analogs |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US8840926B2 (enExample) |
| EP (1) | EP2771348B1 (enExample) |
| JP (1) | JP6196224B2 (enExample) |
| KR (1) | KR102049214B1 (enExample) |
| CN (1) | CN103974965B (enExample) |
| AU (1) | AU2012328874B2 (enExample) |
| BR (1) | BR112014009760B1 (enExample) |
| CA (1) | CA2849114C (enExample) |
| ES (1) | ES2807890T3 (enExample) |
| HK (1) | HK1201067A1 (enExample) |
| IL (1) | IL231714B (enExample) |
| MX (1) | MX347541B (enExample) |
| WO (1) | WO2013063149A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9241896B2 (en) | 2008-12-19 | 2016-01-26 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| KR20140003380A (ko) | 2010-07-13 | 2014-01-09 | 울트라제닉스 파마수티컬 인코포레이티드 | 시알산 결함 치료용 방법들 및 제형들 |
| AU2012328874B2 (en) | 2011-10-24 | 2017-08-31 | Ultragenyx Pharmaceutical Inc. | Sialic acid analogs |
| CN104271125A (zh) * | 2012-01-18 | 2015-01-07 | 奥特吉尼克斯制药公司 | 用于治疗唾液酸缺乏的方法和制剂 |
| AR106025A1 (es) | 2015-09-14 | 2017-12-06 | Ultragenyx Pharmaceutical Inc | Formas cristalinas de ácido siálico o una sal o solvato de este |
| EP4665860A1 (en) * | 2023-02-17 | 2025-12-24 | Ultragenyx Pharmaceutical Inc. | Crystalline forms of sialic acid derivatives and methods for their use |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120264928A1 (en) * | 2009-05-15 | 2012-10-18 | Japan Health Sciences Foundation | Therapeutic pharmaceutical agent for diseases associated with decrease in function of gne protein, food composition, and food additive |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6168418A (ja) | 1984-09-11 | 1986-04-08 | Kanto Ishi Pharma Co Ltd | 去痰薬 |
| JPS63139193A (ja) * | 1986-11-28 | 1988-06-10 | Mect Corp | シアル酸誘導体１，７−ラクトン |
| US6156544A (en) | 1993-06-09 | 2000-12-05 | Glaxo Group Limited | Process for the preparation of N-acetylneuraminic acid |
| WO1996031237A2 (en) | 1995-04-04 | 1996-10-10 | Wound Healing Of Oklahoma | Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant |
| US5624677A (en) | 1995-06-13 | 1997-04-29 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| WO1999052931A1 (fr) | 1998-04-10 | 1999-10-21 | Mitsubishi Chemical Corporation | Dispersion solide contenant un derive d'acide sialique |
| KR20030006721A (ko) | 2001-07-14 | 2003-01-23 | 삼성전자 주식회사 | 리소그라피 시스템 및 이를 이용한 레티클 표면의 파티클제거방법 |
| ES2363205T3 (es) | 2002-06-21 | 2011-07-26 | Novo Nordisk Health Care Ag | Glicoformas del factor vii pegilado. |
| US7238677B2 (en) | 2003-03-28 | 2007-07-03 | Kimberly-Clark Worldwide, Inc. | Prevention of urogenital infections |
| WO2005056708A2 (en) * | 2003-12-09 | 2005-06-23 | Spherics, Inc. | Bioadhesive polymers with catechol functionality |
| NZ561116A (en) | 2005-03-03 | 2010-02-26 | Mannatech Inc | Methods and compositions for modified release of nutritional supplements |
| WO2007103286A2 (en) * | 2006-03-02 | 2007-09-13 | Spherics, Inc. | Rate-controlled bioadhesive oral dosage formulations |
| WO2008027557A2 (en) * | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| CA2903133C (en) | 2007-05-31 | 2021-10-19 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health | N-acetyl mannosamine or derivatives thereof for use in treating a kidney disorder in a mammal |
| US20090081249A1 (en) | 2007-08-27 | 2009-03-26 | Massachusetts Institute Of Technology | Bi-Functional Polymer-Attached Inhibitors of Influenza Virus |
| CN102316730A (zh) | 2008-05-09 | 2012-01-11 | 天雅瑞药业有限公司 | 用于减轻全身性炎症和/或血管炎症的n-乙酰半胱氨酸(nac)的控释 |
| KR101116864B1 (ko) | 2008-08-01 | 2012-02-29 | 주식회사 베네비오 | 고지혈증, 지방간 또는 비만의 예방 또는 치료용 조성물 |
| US20100160363A1 (en) | 2008-12-19 | 2010-06-24 | Aaipharma Services Corp. | Extended-release pharmaceutical formulations |
| US9241896B2 (en) | 2008-12-19 | 2016-01-26 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| US20100159001A1 (en) | 2008-12-19 | 2010-06-24 | Cardinal John R | Extended-Release Pharmaceutical Formulations |
| KR20140003380A (ko) | 2010-07-13 | 2014-01-09 | 울트라제닉스 파마수티컬 인코포레이티드 | 시알산 결함 치료용 방법들 및 제형들 |
| AU2012328874B2 (en) | 2011-10-24 | 2017-08-31 | Ultragenyx Pharmaceutical Inc. | Sialic acid analogs |
| CN104271125A (zh) | 2012-01-18 | 2015-01-07 | 奥特吉尼克斯制药公司 | 用于治疗唾液酸缺乏的方法和制剂 |
| ES2777838T3 (es) | 2015-01-28 | 2020-08-06 | Kyowa Hakko Bio Co Ltd | Cristal de anhidrato de N-acetilneuraminato de amonio y procedimiento para producir el mismo |
| AR106025A1 (es) | 2015-09-14 | 2017-12-06 | Ultragenyx Pharmaceutical Inc | Formas cristalinas de ácido siálico o una sal o solvato de este |
-
2012
- 2012-10-24 AU AU2012328874A patent/AU2012328874B2/en active Active
- 2012-10-24 CN CN201280052218.0A patent/CN103974965B/zh active Active
- 2012-10-24 WO PCT/US2012/061737 patent/WO2013063149A1/en not_active Ceased
- 2012-10-24 US US13/659,550 patent/US8840926B2/en active Active
- 2012-10-24 EP EP12843460.2A patent/EP2771348B1/en active Active
- 2012-10-24 HK HK15101526.4A patent/HK1201067A1/xx unknown
- 2012-10-24 ES ES12843460T patent/ES2807890T3/es active Active
- 2012-10-24 KR KR1020147013997A patent/KR102049214B1/ko active Active
- 2012-10-24 CA CA2849114A patent/CA2849114C/en active Active
- 2012-10-24 MX MX2014004928A patent/MX347541B/es active IP Right Grant
- 2012-10-24 JP JP2014537380A patent/JP6196224B2/ja active Active
- 2012-10-24 BR BR112014009760-7A patent/BR112014009760B1/pt active IP Right Grant
-
2014
- 2014-03-26 IL IL231714A patent/IL231714B/en active IP Right Grant
- 2014-08-15 US US14/461,295 patent/US9221858B2/en active Active
-
2015
- 2015-11-18 US US14/944,779 patent/US10065981B2/en active Active
-
2018
- 2018-07-31 US US16/050,343 patent/US10457701B2/en active Active
-
2019
- 2019-09-16 US US16/571,589 patent/US10889607B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120264928A1 (en) * | 2009-05-15 | 2012-10-18 | Japan Health Sciences Foundation | Therapeutic pharmaceutical agent for diseases associated with decrease in function of gne protein, food composition, and food additive |
Non-Patent Citations (9)
| Title |
|---|
| Bioorganic & Medicinal Chemistry, 1998, Vol. 6, pages 1283-1292. * |
| CAS Registry Number 1053644-78-2; STN Entry Date 28 September 2008 * |
| COLOMBO, R. et al., "The first synthesis of N-acetylneuraminic acid 1,7-lactone", Chemical Communications, 2008, pages 5517-5519. * |
| HORN, E. et al., "Investigation into an efficient synthesis of 2,3-dehydro-N-acetyl neuraminic acid leads to three decarboxylated sialic acid dimers", Carbohydrate Research, 2008, Vol. 343, pages 936-940. * |
| LIU, J. L-C. et al., "Overproduction of CMP-Sialic Acid Synthetase for Organic Synthesis", 1992, Vol. 114, pages 3901-3910. * |
| OTEKE, C. et al., "Viersatile Bisynthetic Engineering of Sialic Acid in Living Cells Using Syhthetic Sialic Acid Analogues". J. Biol. Chem. 2002, Vol. 277, No. 8, pages 6688-6695 * |
| PubChem CID 440962; Entry Date 24 June 2005; N-acetylneuraminic acid 9-phosphate. * |
| REZENDE, M. C. et al., "A facile route to 9-phosphorylated neuraminic acid derivatives", Synthetic Communications, 1998, Vol. 28, No. 23, pages 4393-4400. * |
| SATO, S. et al., "Studies on Sialic Acids. XIV. Lactone Derivatives of N-Acetylneuraminic Acid", Chemical and Pharmaceutical Bulletin, 1988, Vol. 36, No. 12, pages 4678-4688. * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140084277A (ko) | 2014-07-04 |
| JP6196224B2 (ja) | 2017-09-13 |
| CN103974965B (zh) | 2019-09-24 |
| US9221858B2 (en) | 2015-12-29 |
| KR102049214B1 (ko) | 2019-11-28 |
| US8840926B2 (en) | 2014-09-23 |
| IL231714A0 (en) | 2014-05-28 |
| BR112014009760B1 (pt) | 2022-11-29 |
| EP2771348B1 (en) | 2020-05-20 |
| BR112014009760A2 (pt) | 2017-04-18 |
| US20200131215A1 (en) | 2020-04-30 |
| CN103974965A (zh) | 2014-08-06 |
| US10889607B2 (en) | 2021-01-12 |
| US10065981B2 (en) | 2018-09-04 |
| BR112014009760A8 (pt) | 2018-01-16 |
| CA2849114A1 (en) | 2013-05-02 |
| US20190127409A1 (en) | 2019-05-02 |
| ES2807890T3 (es) | 2021-02-24 |
| WO2013063149A1 (en) | 2013-05-02 |
| US20150038693A1 (en) | 2015-02-05 |
| CA2849114C (en) | 2020-12-15 |
| EP2771348A4 (en) | 2015-09-09 |
| MX2014004928A (es) | 2014-11-10 |
| IL231714B (en) | 2018-10-31 |
| US10457701B2 (en) | 2019-10-29 |
| JP2014530882A (ja) | 2014-11-20 |
| MX347541B (es) | 2017-04-28 |
| EP2771348A1 (en) | 2014-09-03 |
| US20130122094A1 (en) | 2013-05-16 |
| AU2012328874A1 (en) | 2014-04-10 |
| HK1201067A1 (en) | 2015-08-21 |
| US20160297846A1 (en) | 2016-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |