JP6189403B2 - 医薬品と一体化された摂取可能な事象マーカシステム - Google Patents
医薬品と一体化された摂取可能な事象マーカシステム Download PDFInfo
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Description
Claims (21)
- 薬剤を含む錠剤と、
上部及び底部を有し、前記錠剤に固定されたデバイスと
を備えた医薬品であって、
前記デバイスは、
中央のキャビティを画定する非導電性のスカート部と、
該スカート部により画定された前記キャビティに配置された制御部と
を備えており、該制御部は、前記制御部の両側に配置され前記制御部に電気的に接続された少なくとも2つの異質材料を含んでおり、該異質材料は、導電性流体に接すると、前記少なくとも2つの異質材料が前記制御部に電力を供給すべく前記導電性流体に溶解するにつれて前記少なくとも2つの異質材料間に電位差を生じさせ、前記デバイスが起動して、前記導電性流体に溶解して溶液の前記少なくとも2つの異質材料によって電流が生成され、
前記デバイスは、該デバイスを前記錠剤に固定すべく前記デバイスの前記底部に固定部分を更に備えており、
前記制御部は電力が供給されると、前記薬剤の放出を制御することを特徴とする医薬品。 - 前記デバイスの上部に配置された保護層を更に備えていることを特徴とする請求項1に記載の医薬品。
- 前記保護層の大きさは、前記スカート部の大きさと同一であり、前記保護層は、前記制御部の上部を覆っていることを特徴とする請求項2に記載の医薬品。
- 前記保護層は前記デバイスより大きく、前記保護層は、前記デバイスを周囲環境から密閉すべく前記錠剤の表面に固定されていることを特徴とする請求項2に記載の医薬品。
- 前記固定部分は、前記デバイスの前記底部の前記スカート部に配置された複数の接着点であることを特徴とする請求項2に記載の医薬品。
- 前記固定部分の大きさは、前記デバイスの大きさと同一であり、前記固定部分は前記デバイスの前記底部を覆っていることを特徴とする請求項5に記載の医薬品。
- 前記デバイスの前記底部に設けられており、前記デバイスと前記固定部分との間に配置された第2保護層を更に備えていることを特徴とする請求項2に記載の医薬品。
- 前記第2保護層の大きさは、前記スカート部の大きさと同一であり、前記第2保護層は前記制御部の底部を覆っていることを特徴とする請求項7に記載の医薬品。
- 前記固定部分は、前記第2保護層上に設けられており、前記デバイスの周りに配置された複数の接着点であることを特徴とする請求項7に記載の医薬品。
- 前記固定部分の大きさは、前記デバイスの大きさと同一であり、前記固定部分は前記第2保護層上に配置されていることを特徴とする請求項7に記載の医薬品。
- 前記スカート部は、複数の穴を画定しており、前記保護層及び前記第2保護層は前記穴を通して互いに接続されていることを特徴とする請求項7に記載の医薬品。
- 電子マーカを備えた薬剤用のタブレットであって、
薬剤を含む第1タブレット部分と、
高速溶解剤を含む第2タブレット部分と
を備えており、前記高速溶解剤及び薬剤は化学的に相溶性であり、前記第1タブレット部分及び前記第2タブレット部分は、前記電子マーカを保持するためのキャビティを画定しており、
前記電子マーカは、
中央のキャビティを画定する非導電性のスカート部と、
該スカート部により画定された前記キャビティ内に配置された制御部と
を備えており、該制御部は、前記スカート部により離れて配置された少なくとも2つの異質材料を含んでおり、該少なくとも2つの異質材料は部分電源を形成し、導電性流体に接すると、前記少なくとも2つの異質材料が前記制御部に電力を供給すべく前記導電性流体に溶解するにつれて前記少なくとも2つの異質材料間に電位差を生じさせ、前記電子マーカが起動して、前記導電性流体に溶解して溶液の前記少なくとも2つの異質材料によって電流が生成され、
前記電子マーカは、前記スカート部と前記制御部とを囲むポケットを画定する被覆体を更に備えており、該被覆体は前記制御部を周囲環境に接触させるべく溶解し、
前記制御部は電力が供給されると、前記薬剤の放出を制御することを特徴とするタブレット。 - カプセルの内部に配置されていることを特徴とする請求項12に記載のタブレット。
- 前記カプセルは第2薬剤で充填されていることを特徴とする請求項13に記載のタブレット。
- デバイスを備えた医薬品を製造するための方法であって、
薬剤を含む錠剤を製造するステップと、
タグ付錠剤を製造すべく、前記デバイスを接着部分により前記錠剤に固定するステップと、
前記タグ付錠剤の前記デバイスの上部に配置された保護層を用いて前記タグ付錠剤を保護して、前記医薬品を製造するステップと
を含み、
前記デバイスは、
中央のキャビティを画定する非導電性のスカート部と、
該スカート部により画定された前記キャビティに配置された制御部と
を備えており、該制御部は、前記制御部の両側に配置され前記制御部に電気的に接続された少なくとも2つの異質材料を含んでおり、該異質材料は、導電性流体に接すると、前記少なくとも2つの異質材料が前記制御部に電力を供給すべく前記導電性流体に溶解するにつれて前記少なくとも2つの異質材料間に電位差を生じさせ、前記デバイスが起動して、前記導電性流体に溶解して溶液の前記少なくとも2つの異質材料によって電流が生成され、
前記制御部は電力が供給されると、前記薬剤の放出を制御することを特徴とする方法。 - 前記保護層を前記デバイスと同一の大きさになるように切断するステップを更に含むことを特徴とする請求項15に記載の方法。
- 前記デバイスを周囲環境から密閉すべく前記保護層が前記錠剤の表面に固定され得るように、前記保護層を、前記デバイスより大きい大きさになるように切断するステップを更に含むことを特徴とする請求項15に記載の方法。
- 前記固定するステップでは、前記接着部分として複数の接着点を用い、該接着点を前記デバイスの底部に配置することを特徴とする請求項15に記載の方法。
- 前記固定するステップでは、前記接着部分として接着シートを用い、該接着シートの大きさを前記デバイスの大きさと同一にすることを特徴とする請求項15に記載の方法。
- 積層されたデバイスを備えた識別可能な薬剤タブレットを製造するための方法であって、
薬剤である原料粉末の第1部分を、加圧器ホイールにより画定されたキャビティに充填するステップと、
前記原料粉末の第1部分を圧縮して、第1タブレット部分を形成するステップと、
前記デバイスを、前記第1タブレット部分を含有する前記キャビティに挿入するステップと、
第2タブレット部分を形成する原料粉末の第2部分を前記キャビティに充填するステップと、
前記キャビティ内の内容物を押圧して、前記第1タブレット部分を前記第2タブレット部分に密閉し、識別可能な薬剤タブレットを製造するステップと
を含み、
前記デバイスは、
中央のキャビティを画定する非導電性のスカート部と、
該スカート部により画定された前記キャビティに配置された制御部と
を備えており、該制御部は、前記制御部の両側に配置され前記制御部に電気的に接続された少なくとも2つの異質材料を含んでおり、該異質材料は、導電性流体に接すると、前記少なくとも2つの異質材料が前記制御部に電力を供給すべく前記導電性流体に溶解するにつれて前記少なくとも2つの異質材料間に電位差を生じさせ、前記デバイスが起動して、前記導電性流体に溶解して溶液の前記少なくとも2つの異質材料によって電流が生成され、
前記制御部は電力が供給されると、前記薬剤の放出を制御することを特徴とする方法。 - 薬剤を含む錠剤と、
上部及び底部を有するデバイスと
を備えた医薬品であって、
前記デバイスは、該デバイスを前記錠剤に固定するために前記デバイスの前記底部に配置された固定部分を用いて前記錠剤に固定されており、保護層が、前記デバイスを環境から保護するために前記デバイスの上部に配置されており、
前記デバイスは、
中央のキャビティを画定する非導電性のスカート部と、
該スカート部により画定された前記キャビティに配置された制御部と
を備えており、該制御部は、前記制御部の両側に配置され前記制御部に電気的に接続された少なくとも2つの異質材料を含んでおり、該異質材料は、導電性流体に接すると、前記少なくとも2つの異質材料が前記制御部に電力を供給すべく前記導電性流体に溶解するにつれて前記少なくとも2つの異質材料間に電位差を生じさせ、前記デバイスが起動して、前記導電性流体に溶解して溶液の前記少なくとも2つの異質材料によって電流が生成され、
前記制御部は電力が供給されると、前記薬剤の放出を制御することを特徴とする医薬品。
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