JP6188960B2 - ブレクスピプラゾール、重要な中間体およびその塩の製造方法 - Google Patents
ブレクスピプラゾール、重要な中間体およびその塩の製造方法 Download PDFInfo
- Publication number
- JP6188960B2 JP6188960B2 JP2016548404A JP2016548404A JP6188960B2 JP 6188960 B2 JP6188960 B2 JP 6188960B2 JP 2016548404 A JP2016548404 A JP 2016548404A JP 2016548404 A JP2016548404 A JP 2016548404A JP 6188960 B2 JP6188960 B2 JP 6188960B2
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- JP
- Japan
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- reaction
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *c1cc(c(N2CCN(*)CC2)ccc2)c2[s]1 Chemical compound *c1cc(c(N2CCN(*)CC2)ccc2)c2[s]1 0.000 description 4
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310493206.8 | 2013-10-18 | ||
| CN201310493206.8A CN104557896A (zh) | 2013-10-18 | 2013-10-18 | 布瑞哌唑、其关键中间体及其盐的制备方法 |
| PCT/CN2014/000921 WO2015054976A1 (zh) | 2013-10-18 | 2014-10-20 | 布瑞哌唑、其关键中间体及其盐的制备方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535081A JP2016535081A (ja) | 2016-11-10 |
| JP2016535081A5 JP2016535081A5 (enExample) | 2017-08-03 |
| JP6188960B2 true JP6188960B2 (ja) | 2017-08-30 |
Family
ID=52827618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016548404A Active JP6188960B2 (ja) | 2013-10-18 | 2014-10-20 | ブレクスピプラゾール、重要な中間体およびその塩の製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10100044B2 (enExample) |
| EP (1) | EP3059237A4 (enExample) |
| JP (1) | JP6188960B2 (enExample) |
| CN (2) | CN104557896A (enExample) |
| WO (1) | WO2015054976A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105732572A (zh) * | 2014-12-10 | 2016-07-06 | 苏州鹏旭医药科技有限公司 | 一种Brexpiprazole中间体的制备方法及Brexpiprazole中间体 |
| CN105985314A (zh) * | 2015-02-05 | 2016-10-05 | 苏州旺山旺水生物医药有限公司 | 布瑞哌唑类似物的制备方法 |
| CN104844586A (zh) * | 2015-04-16 | 2015-08-19 | 重庆医药工业研究院有限责任公司 | 一种依匹哌唑无定型物及其制备方法 |
| CN104829588B (zh) * | 2015-04-30 | 2017-03-29 | 苏州苏旺森生物医药科技有限公司 | 一种苯并[b]噻吩的制备方法及其中间体 |
| CN105061414B (zh) * | 2015-07-21 | 2019-01-01 | 杭州新博思生物医药有限公司 | 一锅法制备Brexpiprazole |
| WO2017025987A1 (en) * | 2015-08-11 | 2017-02-16 | Mylan Laboratories Limited | Process for the preparation of brexpiprazole |
| EP3150591A1 (en) | 2015-10-02 | 2017-04-05 | Crystal Pharma S.A.U | Process and intermediates for the preparation of benzo[b]thiophene compounds |
| WO2017078621A1 (en) * | 2015-11-03 | 2017-05-11 | Scinopharm Taiwan, Ltd. | Processes for preparing brexpiprazole |
| CN105461704A (zh) * | 2015-12-15 | 2016-04-06 | 南京艾德凯腾生物医药有限责任公司 | 一种依匹哌唑的制备方法 |
| US10464931B2 (en) | 2015-12-28 | 2019-11-05 | Honour (R&D) | Process for the preparation of Quinolin-2(1H)-one derivatives |
| CN106938982A (zh) * | 2016-01-05 | 2017-07-11 | 连云港皓海医药科技有限公司 | 布瑞哌唑的制备方法及用于制备布瑞哌唑的化合物 |
| CN105399736B (zh) * | 2016-01-07 | 2018-10-19 | 安徽省逸欣铭医药科技有限公司 | 一种依匹哌唑新的制备方法 |
| US20170320862A1 (en) | 2016-05-03 | 2017-11-09 | Cadila Healthcare Limited | Process for the preparation of brexpiprazole and intermediates thereof |
| CN106645494B (zh) * | 2016-12-29 | 2019-09-06 | 成都百裕制药股份有限公司 | 依匹哌唑起始物料有关物质的检测方法 |
| WO2020087031A1 (en) | 2018-10-26 | 2020-04-30 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| CN109694343B (zh) * | 2018-12-19 | 2020-07-28 | 帕潘纳(北京)科技有限公司 | 一种杂环羧酸类化合物的脱羧方法 |
| CN110483476B (zh) * | 2019-08-15 | 2020-11-27 | 绍兴文理学院 | 一种催化法制备苯并硒吩类化合物的工艺 |
| CN110483475B (zh) * | 2019-08-15 | 2020-11-27 | 绍兴文理学院 | 一种氧化银催化法制备苯并噻吩类化合物的方法 |
| CN111423452B (zh) * | 2020-03-26 | 2023-08-22 | 江西青峰药业有限公司 | 瑞卢戈利的中间体及其制备方法和应用 |
| CN115894435B (zh) * | 2022-11-14 | 2024-11-22 | 山东厚德精诚药业有限公司 | 一种1-(苯并[b]噻吩-4-基)哌嗪盐酸盐的合成方法 |
| CN116969960A (zh) * | 2023-07-25 | 2023-10-31 | 乳源东阳光药业有限公司 | 酪氨酸激酶抑制剂的中间体的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4977154A (en) * | 1985-12-12 | 1990-12-11 | Warner-Lambert Company | 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents |
| US5436246A (en) * | 1992-09-17 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | Serotonin receptor agents |
| MX2007001106A (es) * | 2004-07-28 | 2007-03-15 | Glaxo Group Ltd | Derivados de piperazina utiles para el tratamiento de trastornos gastrointestinales. |
| JP4315393B2 (ja) * | 2005-04-14 | 2009-08-19 | 大塚製薬株式会社 | 複素環化合物 |
| TWI320783B (en) * | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| JP4540700B2 (ja) * | 2006-10-13 | 2010-09-08 | 大塚製薬株式会社 | 医薬 |
| JP2011136906A (ja) * | 2008-04-18 | 2011-07-14 | Otsuka Pharmaceut Co Ltd | 複素環化合物 |
| KR101911121B1 (ko) * | 2011-07-28 | 2018-10-23 | 오쓰까 세이야꾸 가부시키가이샤 | 벤조［ｂ］티오펜 화합물의 제조 방법 |
| CN104892589A (zh) * | 2014-03-07 | 2015-09-09 | 中国科学院上海药物研究所 | 一类杂环化合物、其制备方法和用途 |
-
2013
- 2013-10-18 CN CN201310493206.8A patent/CN104557896A/zh active Pending
-
2014
- 2014-10-20 WO PCT/CN2014/000921 patent/WO2015054976A1/zh not_active Ceased
- 2014-10-20 US US15/030,331 patent/US10100044B2/en not_active Expired - Fee Related
- 2014-10-20 CN CN201480039363.4A patent/CN105473579B/zh active Active
- 2014-10-20 JP JP2016548404A patent/JP6188960B2/ja active Active
- 2014-10-20 EP EP14854084.2A patent/EP3059237A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN104557896A (zh) | 2015-04-29 |
| CN105473579B (zh) | 2018-04-13 |
| EP3059237A1 (en) | 2016-08-24 |
| CN105473579A (zh) | 2016-04-06 |
| EP3059237A4 (en) | 2016-08-24 |
| JP2016535081A (ja) | 2016-11-10 |
| WO2015054976A1 (zh) | 2015-04-23 |
| US20160272624A1 (en) | 2016-09-22 |
| US10100044B2 (en) | 2018-10-16 |
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