JP6153866B2 - 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ - Google Patents

迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ Download PDF

Info

Publication number
JP6153866B2
JP6153866B2 JP2013512140A JP2013512140A JP6153866B2 JP 6153866 B2 JP6153866 B2 JP 6153866B2 JP 2013512140 A JP2013512140 A JP 2013512140A JP 2013512140 A JP2013512140 A JP 2013512140A JP 6153866 B2 JP6153866 B2 JP 6153866B2
Authority
JP
Japan
Prior art keywords
seq
type
nucleic acid
sample
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2013512140A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013534810A5 (OSRAM
JP2013534810A (ja
Inventor
マロニー,リチャード
キュウ,ピーター
Original Assignee
キアゲン ガイサーズバーグ アイエヌシー.
キアゲン ガイサーズバーグ アイエヌシー.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by キアゲン ガイサーズバーグ アイエヌシー., キアゲン ガイサーズバーグ アイエヌシー. filed Critical キアゲン ガイサーズバーグ アイエヌシー.
Publication of JP2013534810A publication Critical patent/JP2013534810A/ja
Publication of JP2013534810A5 publication Critical patent/JP2013534810A5/ja
Application granted granted Critical
Publication of JP6153866B2 publication Critical patent/JP6153866B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/708Specific hybridization probes for papilloma

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nuclear Medicine (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2013512140A 2010-05-25 2011-05-24 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ Expired - Fee Related JP6153866B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34794110P 2010-05-25 2010-05-25
US61/347,941 2010-05-25
PCT/US2011/037684 WO2011149897A1 (en) 2010-05-25 2011-05-24 Fast results hybrid capture assay and associated strategically-truncated probes

Publications (3)

Publication Number Publication Date
JP2013534810A JP2013534810A (ja) 2013-09-09
JP2013534810A5 JP2013534810A5 (OSRAM) 2014-05-29
JP6153866B2 true JP6153866B2 (ja) 2017-06-28

Family

ID=44275651

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013512140A Expired - Fee Related JP6153866B2 (ja) 2010-05-25 2011-05-24 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ

Country Status (6)

Country Link
US (1) US9376727B2 (OSRAM)
EP (1) EP2576840B1 (OSRAM)
JP (1) JP6153866B2 (OSRAM)
AU (1) AU2011258501B2 (OSRAM)
CA (1) CA2799205A1 (OSRAM)
WO (1) WO2011149897A1 (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062546A1 (en) * 2008-10-27 2010-06-03 Qiagen Gaithersburg Inc. Fast results hybrid capture assay on an automated platform
AU2011210734B2 (en) * 2010-01-29 2017-02-09 Qiagen Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
CN105368982B (zh) 2014-08-28 2019-01-29 杭州德同生物技术有限公司 一种高危型人乳头瘤病毒检测及分型方法
AU2020205142A1 (en) * 2019-01-03 2021-06-03 Hangzhou New Horizon Health Technology Co. Ltd. Compositions and methods for detecting human papillomavirus

Family Cites Families (223)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732847A (en) 1981-06-09 1988-03-22 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
FI63596C (fi) 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4486536A (en) 1982-05-28 1984-12-04 Smithkline Diagnostics, Inc. Specimen slide for occult blood testing
US4865980A (en) 1982-12-29 1989-09-12 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
US5288611A (en) 1983-01-10 1994-02-22 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
JPS60501339A (ja) 1983-01-10 1985-08-22 ジエン−プロ−ブ インコ−ポレィテッド 生物を検出、同定又は定量する方法およびキット
US5200313A (en) 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
EP0144914A3 (en) 1983-12-12 1986-08-13 Miles Inc. Hybridization assay employing labeled pairs of hybrid binding reagents
US4743535A (en) 1984-11-07 1988-05-10 Miles Inc. Hybridization assay employing labeled probe and anti-hybrid
US7138505B1 (en) 1984-01-12 2006-11-21 Novartis Vaccines And Diagnostics, Inc. Factor VIII:C nucleic acid molecules
FI71768C (fi) 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
CA1260372A (en) 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
CA1253777A (en) 1984-06-01 1989-05-09 Robert J. Carrico Nucleic acid hybridization assay employing immobilized rna probes
US4563417A (en) 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4689294A (en) 1984-11-19 1987-08-25 Miles Laboratories, Inc. Enhancement of hybridization of nucleic acids by anionic polymers
CA1276575C (fr) 1984-11-30 1990-11-20 Sylvie Beaudenon Sondes a papillomavirus et procede de diagnostic in vitro d'infections a papillomavirus
US5876922A (en) 1985-07-31 1999-03-02 Institute Pasteur Papillomavirus probe and a process for in vitro diagnosis of papillomavirus infections
US5411857A (en) 1985-07-31 1995-05-02 Institut Nationale De La Sante Probes for papillomaviruses and an in vitro diagnostic procedure for papilloma infections
US4751177A (en) 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
IL79112A (en) 1985-06-13 1992-01-15 Abbott Lab Method for the isolation of a nucleic acid sequence and kit for performing a hybridization assay
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
DE3779175D1 (de) 1986-03-21 1992-06-25 Pasteur Institut Bestimmte, von einem papillomavirus-genom abgeleitete dns-sequenzen, deren anwendungen fuer in vitro-diagnostische zwecke und die herstellung von antigenzusammensetzungen.
US5750338A (en) 1986-10-23 1998-05-12 Amoco Corporation Target and background capture methods with amplification for affinity assays
AU616646B2 (en) 1986-11-24 1991-11-07 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
AU619170B2 (en) 1987-01-09 1992-01-23 Abbott Laboratories Diagnostic assays using nucleic acid probes
DE3853678T2 (de) 1987-02-26 1995-08-31 Univ Sydney Verfahren zum nachweis des karzinogenen menschlichen papillomavirus.
AU601021B2 (en) 1987-03-11 1990-08-30 Molecular Diagnostics, Inc. Assay for necleic acid sequences in a sample
IL85551A0 (en) 1987-04-01 1988-08-31 Miles Inc Rapid hybridization assay and reagent system used therein
DE3722968A1 (de) 1987-07-11 1989-01-19 Behringwerke Ag Humaner papillomvirus typ 41, seine dna und die dafuer kodierenden proteine
US5656731A (en) 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
EP0333465B1 (en) 1988-03-18 1994-07-13 Baylor College Of Medicine Mutation detection by competitive oligonucleotide priming
US5374524A (en) 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
FR2632956B2 (fr) 1988-05-13 1991-07-12 Pasteur Institut Sondes a papillomavirus hpv49, hpv50, hpv54, hpv55; produits genetiquement et immunologiquement lies a ce papillomavirus hpv49, hpv50, hpv54, hpv55; procede de diagnostic in vitro d'infections a papillomavirus et d'immunisation in vivo contre ces papillomavirus
NO165894C (no) 1988-05-24 1991-04-24 Gunnar Paulsen Analysemetode for gener.
DE3826793A1 (de) 1988-08-06 1990-03-08 Behringwerke Ag Humaner papillomvirus typ 57, seine dna und die davon kodierten proteine
US5639871A (en) 1988-09-09 1997-06-17 Roche Molecular Systems, Inc. Detection of human papillomavirus by the polymerase chain reaction
US5182377A (en) 1988-09-09 1993-01-26 Hoffmann-La Roche Inc. Probes for detection of human papillomavirus
US5447839A (en) 1988-09-09 1995-09-05 Hoffmann-La Roche Inc. Detection of human papillomavirus by the polymerase chain reaction
ATE168724T1 (de) 1988-09-29 1998-08-15 Chiron Corp Nachweis eines polynukleotids durch ersätzung einer kette an einer fangsonde
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5077192A (en) 1988-10-25 1991-12-31 The General Hospital Corporation Method of detecting antigenic, nucleic acid-containing macromolecular entities
CA1339729C (en) 1988-10-26 1998-03-17 Wayne D. Lancaster Human papillomavirus type 52 dna sequences and methods for employing thesame
DE3838269A1 (de) 1988-11-11 1990-05-17 Behringwerke Ag Nachweis humaner papillomavirus dna und ihrer expression in zervix-abstrichen
CA2049043A1 (en) 1989-03-10 1990-09-11 Mark L. Collins Immobilized oligo-nucleotide probes and uses therefor
US5106727A (en) 1989-04-27 1992-04-21 Life Technologies, Inc. Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers
US5863717A (en) 1989-11-03 1999-01-26 Abbott Laboratories Use of conserved oligonucleotide primers to amplify human papillomavirus DNA sequences
US5580970A (en) 1989-12-01 1996-12-03 Amoco Corporation Detection of HPV transcripts
JPH05501650A (ja) 1989-12-01 1993-04-02 バイシス・インコーポレーテツド Hpv転写物の検出
US5756282A (en) 1989-12-04 1998-05-26 Isis Pharmaceuticals, Inc. Oligonucleotides for the diagnosis of papillomavirus
US5811232A (en) 1989-12-04 1998-09-22 Isis Pharmaceuticals, Inc. Oligonucleotides for Papillomavirus
US6174870B1 (en) 1989-12-04 2001-01-16 Isis Pharmaceuticals, Inc. Antisense oligonucleotide inhibition of papillomavirus
NL9000134A (nl) 1990-01-19 1991-08-16 Stichting Res Fonds Pathologie Primers en werkwijze voor het detecteren van humaan papilloma virus genotypen m.b.v. pcr.
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
CA2039517C (en) 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US5695926A (en) 1990-06-11 1997-12-09 Bio Merieux Sandwich hybridization assays using very short capture probes noncovalently bound to a hydrophobic support
GB9015845D0 (en) 1990-07-19 1990-09-05 Emery Vincent C Diagnostic method
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5484699A (en) 1990-09-28 1996-01-16 Abbott Laboratories Nucleotide sequences useful as type specific probes, PCR primers and LCR probes for the amplification and detection of human papilloma virus, and related kits and methods
WO1992008808A1 (en) 1990-11-14 1992-05-29 Siska Diagnostics, Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
US6582908B2 (en) * 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
EP0566670A4 (en) 1990-12-17 1993-12-08 Idexx Laboratories, Inc. Nucleic acid sequence detection by triple helix formation
FR2670797A1 (fr) * 1990-12-20 1992-06-26 Pasteur Institut Sequences d'adn determinees derivees du genome du papillomavirus hpv39, application de ces sequences au diagnostic in vitro d'infection par ce papillomavirus, et a la production de composition immunogene.
US5219990A (en) 1991-01-28 1993-06-15 Biogen, Inc. Papillomavirus e2 trans-activation repressors
GB9105383D0 (en) 1991-03-14 1991-05-01 Immunology Ltd An immunotherapeutic for cervical cancer
FR2678284B1 (fr) 1991-06-28 1993-10-08 Pasteur Institut Sequences d'adn derivees du genome du papillomavirus hpv42, application de ces sequences au diagnostic in vitro d'infection par ce papillomavirus et a la production de compositions immunogenes.
DE122007000023I1 (de) 1991-07-19 2007-08-09 Univ Queensland St Lucia Impfsstoff gegen Humanes Papillomavirus (typ 18)
US5543294A (en) 1991-07-19 1996-08-06 The Trustees Of Columbia University In The City Of New York Polymerase chain reaction/restriction fragment length polymorphism method for the detection and typing of myobacteria
US5346811A (en) 1991-07-22 1994-09-13 Cerveceria Polar Method and products for human papillomavirus detection
US5556748A (en) 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
JP3091492B2 (ja) 1991-11-14 2000-09-25 ダイジーン ダイアグノスティクス,インコーポレイテッド 非放射性ハイブリダイゼーションアッセイおよびキット
US5981179A (en) 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5506105A (en) 1991-12-10 1996-04-09 Dade International Inc. In situ assay of amplified intracellular mRNA targets
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5437951A (en) 1992-09-03 1995-08-01 The United States Of America As Represented By The Department Of Health And Human Services Self-assembling recombinant papillomavirus capsid proteins
FI951192L (fi) 1992-09-15 1995-03-14 Dow Chemical Co Kestomuovien iskumodifiointi
DE69327454T2 (de) 1992-10-09 2000-05-11 Vysis, Inc. Analytisches verfahren
JP3778925B2 (ja) 1993-01-15 2006-05-24 ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク 高感度核酸サンドイッチハイブリダイゼーション検定法及びキット
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6495676B1 (en) 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
KR100189229B1 (ko) 1993-07-23 1999-06-01 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 핵산 증폭을 강화하는 방법
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
US5679509A (en) 1993-09-28 1997-10-21 University Of New Mexico Methods and a diagnostic aid for distinguishing a subset of HPV that is associated with an increased risk of developing cervical dysplasia and cervical cancer
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
DK145493D0 (da) 1993-12-23 1993-12-23 Dako As Antistof
AUPM358894A0 (en) 1994-01-31 1994-02-24 Csl Limited Modified papilloma virus l2 protein and vlps formed therefrom
IL112636A0 (en) 1994-02-14 1995-05-26 Macfarlane Burnet Ctre Med Res Non-pathogenic strains of hiv-1
AU685233B2 (en) 1994-02-21 1998-01-15 Stichting Researchfonds Pathologie Human papilloma virus detection in a nucleic acid amplification process using general primers
DE4415743C2 (de) 1994-05-04 1996-10-10 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
AUPM566794A0 (en) 1994-05-17 1994-06-09 University Of Queensland, The Process and product
US6045995A (en) 1994-08-24 2000-04-04 Isis Pharmaceuticals, Inc. Capillary electrophoretic detection of nucleic acids
US5622822A (en) 1994-09-13 1997-04-22 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using polyethyleneimine and an anionic phosphate ester surfactant and amplification of same
US5582988A (en) 1994-09-15 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same
NZ293461A (en) 1994-09-22 1998-04-27 Merck & Co Inc Dna encoding human papillomavirus type 6a, compounds derived therefrom
JP3093116B2 (ja) 1994-09-30 2000-10-03 株式会社豊田中央研究所 核酸検出方法
GB9420146D0 (en) 1994-10-06 1994-11-23 Cancer Res Campaign Tech Papillomavirus vaccine
US6057099A (en) 1994-12-02 2000-05-02 Intelligene Ltd. Detection of nucleic acid sequences
US20030104361A1 (en) 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
US5731153A (en) 1996-08-26 1998-03-24 The Regents Of The University Of California Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions
US5888724A (en) 1995-02-17 1999-03-30 The Trustees Of Columbia University In The City Of New York Detection of high oncogenic-risk papilloma virus in high grade cervical lesions and cancers by a PCR/ELISA assay
DE19506561C1 (de) 1995-02-24 1996-10-10 Deutsches Krebsforsch Verfahren zur Früherkennung von HPV-assoziierten Karzinomen bzw. von hochgradigen, durch HPV-verursachten Dysplasien
US5820870A (en) 1995-03-22 1998-10-13 Merck & Co., Inc. Recombinant human papillomavirus type 18 vaccine
US5840306A (en) 1995-03-22 1998-11-24 Merck & Co., Inc. DNA encoding human papillomavirus type 18
IL117591A0 (en) 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
US6509149B2 (en) 1995-06-06 2003-01-21 Hybridon, Inc. HPV-specific oligonucleotides
US6458940B2 (en) 1995-06-06 2002-10-01 Hybridon, Inc. HPV-specific oligonucleotides
EP0832280A2 (en) 1995-06-07 1998-04-01 Abbott Laboratories Probe masking method of reducing background in an amplification reaction
DE19526386C1 (de) 1995-07-19 1997-01-02 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
FR2737502B1 (fr) 1995-07-31 1997-10-24 Genset Sa Procede de detection d'acides nucleiques utilisant des sondes nucleotidiques permettant a la fois une capture specifique et une detection
AU726047B2 (en) 1995-11-15 2000-10-26 Gen-Probe Incorporated Nucleic acid probes complementary to human papillomavirus nucleic acid and related methods and kits
US5888736A (en) 1995-12-22 1999-03-30 Visible Genetics, Inc. Method, compositions and kit for detection and identification of microorganisms
EP2574617B1 (en) 1996-02-09 2016-04-20 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US5981173A (en) 1996-02-14 1999-11-09 Institut Pasteur Genital human papillomavirus type 68a (HPV-68a), related to the potentially oncogenic HPV-39
US6511805B1 (en) 1996-03-15 2003-01-28 The Penn State Research Foundation Methods for detecting papillomavirus DNA in blood plasma and serum
US6214555B1 (en) 1996-05-01 2001-04-10 Visible Genetics Inc. Method compositions and kit for detection
WO1998001148A1 (en) 1996-07-09 1998-01-15 President And Fellows Of Harvard College Use of papillomavirus e2 protein in treating papillomavirus-infected cells and compositions containing the protein
US6218105B1 (en) 1996-07-19 2001-04-17 Kathleen S. Hall High throughput papilloma virus in vitro infectivity assay
US5853993A (en) 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
US6265154B1 (en) 1996-10-25 2001-07-24 Abbott Laboratories Nucleic acid primers and probes for detecting oncogenic human papillomaviruses
US6117631A (en) 1996-10-29 2000-09-12 Polyprobe, Inc. Detection of antigens via oligonucleotide antibody conjugates
GB9624165D0 (en) 1996-11-19 1997-01-08 Amdex A S Use of nucleic acids bound to carrier macromolecules
DE19648962C1 (de) 1996-11-26 1998-02-26 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
US6388065B1 (en) 1996-11-27 2002-05-14 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts DNA for evaluating the progression potential of cervical lesions
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
US20020034737A1 (en) 1997-03-04 2002-03-21 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
DE19712541C1 (de) 1997-03-25 1998-11-05 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
US5843995A (en) 1997-07-07 1998-12-01 University Of Medicine And Dentistry Of New Jersey Inhibition of HIV-1 replication using oligocarbamate derivatives
DE19735118C1 (de) 1997-08-13 1998-08-13 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
WO1999014377A2 (en) 1997-09-16 1999-03-25 Innogenetics N.V. Detection and identification of human papillomavirus by pcr and type-specific reverse hybridization
US6013258A (en) 1997-10-09 2000-01-11 Zycos Inc. Immunogenic peptides from the HPV E7 protein
AU1232099A (en) 1997-11-04 1999-05-24 Roche Diagnostics Gmbh Specific and sensitive method for detecting nucleic acids
BR9814271A (pt) 1997-12-12 2001-03-20 Digene Corp Determinação de doenças relacionadas com o vìrus do papiloma humano
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
EP1600512B1 (en) 1997-12-22 2008-05-28 Hitachi Chemical Co., Ltd. mRNA purification on microplates
JP2002517981A (ja) 1998-01-13 2002-06-25 ビオヒプ テヒノロギース ゲゼルシャフト ミット ベシュレンクテル ハフツング 核酸配列を検出するための方法
US7399589B2 (en) 1998-02-06 2008-07-15 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US5994079A (en) 1998-02-06 1999-11-30 Digene Corporation Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function
US6686151B1 (en) 1998-02-06 2004-02-03 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
CA2229955C (en) 1998-02-20 2003-12-09 Medigene Gmbh Papilloma virus capsomere vaccine formulations and methods of use
US20020039584A1 (en) 1998-02-20 2002-04-04 Medigene Ag Papilloma virus capsomere vaccine formulations and methods of use
ES2212251T3 (es) 1998-03-23 2004-07-16 Spal S.R.L. Ventilador de flujo axial.
US6183956B1 (en) 1998-03-31 2001-02-06 Tularik, Incorporated High throughput in vitro screening assays for transcription modulators
US6045993A (en) 1998-05-30 2000-04-04 Visible Genetics Inc. Method, reagent and kit for genotyping of human papillomavirus
US6284532B1 (en) 1998-08-17 2001-09-04 Indiana University Purified human papillomavirus
DE19840263C1 (de) 1998-09-03 2000-05-25 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
AU766403C (en) 1998-09-04 2004-05-27 Aventis Pasteur Limited Treatment of cervical cancer
US7569344B2 (en) 1998-10-26 2009-08-04 Ventana Medical Systems, Inc. Detection of human papilloma virus in papanicolaou (Pap) smears
US6951722B2 (en) 1999-03-19 2005-10-04 Takara Bio Inc. Method for amplifying nucleic acid sequence
WO2000060116A1 (en) 1999-04-02 2000-10-12 Tropix, Inc. High throughput and high sensitivity detection assays
US20010055766A1 (en) 1999-04-02 2001-12-27 Alexander Aristarkhov Immunosorbant assay using branched bis-biotin/avidin/multiple label complex as a detection reagent
HK1039940B (en) 1999-04-07 2010-08-27 Sankyo Company, Limited Amine derivatives
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US6420106B1 (en) 1999-06-09 2002-07-16 Quantovir Ab Method and kit for early cancer prediction
US6200746B1 (en) 1999-08-25 2001-03-13 Pharmacia & Upjohn Company Methods of identifying anti-viral agents
US7001995B1 (en) 1999-08-25 2006-02-21 Merck & Co., Inc. Synthetic human papillomavirus genes
US20060275784A1 (en) * 1999-10-26 2006-12-07 Ventana Medical Systems, Inc. Detection of Human Papilloma Virus in Papanicolaou (Pap) Smears
US6893819B1 (en) 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
DE10009143B4 (de) 2000-02-26 2012-04-26 Eberhard-Karls-Universität Tübingen Universitätsklinikum Nachweis von Humanen Papillomviren
KR100382703B1 (ko) 2000-03-15 2003-05-09 주식회사 바이오메드랩 인유두종바이러스의 유전형 진단키트 및 상기 진단키트의제조방법
US6936443B2 (en) 2000-04-03 2005-08-30 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
US7510834B2 (en) 2000-04-13 2009-03-31 Hidetoshi Inoko Gene mapping method using microsatellite genetic polymorphism markers
AU2001274869A1 (en) 2000-05-20 2001-12-03 The Regents Of The University Of Michigan Method of producing a dna library using positional amplification
US6331423B1 (en) 2000-06-01 2001-12-18 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
JP2003535600A (ja) 2000-06-02 2003-12-02 バイエル コーポレイション インサイチュ分枝dnaハイブリダイゼーションを用いた高感度遺伝子検出および位置決定
US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
WO2002010449A2 (en) 2000-07-28 2002-02-07 Compugen Inc. Oligonucleotide library for detecting rna transcripts and splice variants that populate a transcriptome
US6329152B1 (en) 2000-11-30 2001-12-11 Bruce K. Patterson Process for detecting low abundance RNA in intact cells
AU2002226053A1 (en) 2000-12-12 2002-06-24 Invitrogen Corporation Compositions and methods for the release of nucleic acid molecules from solid matrices
WO2002066993A1 (en) 2001-02-16 2002-08-29 Cortex Biochem, Inc. Magnetic isolation and purification of nucleic acids
US6670150B1 (en) 2001-05-10 2003-12-30 Applera Corporation Isolated human receptor proteins, nucleic acid molecules encoding human receptor proteins, and uses thereof
US6884605B2 (en) 2001-08-09 2005-04-26 Board Of Trustees Of The University Of Arkansas Compositions, methods and products comprising human papillomavirus for detecting and treating a cancer
EP1806410A3 (en) 2001-08-23 2007-10-24 Merck & Co., Inc. Fluorescent multiplex HPV PCR assays using multiple fluorophores
KR100452163B1 (ko) 2001-09-14 2004-10-12 주식회사 바이오메드랩 인유두종 바이러스의 감염을 진단하기 위한 유전형 분석키트
US20050032105A1 (en) 2001-10-12 2005-02-10 Bair Robert Jackson Compositions and methods for using a solid support to purify DNA
US6977148B2 (en) 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
DK1463839T3 (da) 2002-01-07 2007-07-02 Norchip As Fremgangsmåde til detektering af human papillomavirus mRNA
AU2003217413A1 (en) 2002-02-14 2003-09-04 Novavax, Inc. Method for isolation and purification of expressed gene products in vitro
HUP0200981A3 (en) 2002-03-14 2004-06-28 Genoid Kft Pcr reactions with hybridizing probes using primers with broad genotype-specificity for detection of human papilloma-viruses and typing amplificates by using specifically hybridizing oligonucleotides
ES2305483T3 (es) 2002-04-16 2008-11-01 Autogenomics, Inc. Deteccion del virus del papiloma humano mediante microarrays (chips) de adn.
DE60326449D1 (de) 2002-05-17 2009-04-16 Univ Cape Town Chimere human papilloma virus 16 l1 proteine, welche ein l2 peptid enthalten, damit hergestellte virus-ähnliche partikel und methode zur herstellung der partikel
JP2005537028A (ja) 2002-06-26 2005-12-08 ザ ペン ステート リサーチ ファウンデーション ヒト乳頭腫ウイルス感染症を治療する方法及び材料
SE0202896D0 (sv) 2002-10-01 2002-10-01 Quantovir Ab Method for estimating the risk of carcinoma development
PT1553966E (pt) 2002-10-03 2012-10-22 Wyeth Corp Péptidos de fusão que compreendem os polipéptidos e7 e e6 do vírus do papiloma humano e as composições imunogénicas dos mesmos
CN101405404A (zh) 2002-12-31 2009-04-08 迈特默菲公司 用于推断牛的性状的组合物、方法和系统
NZ542246A (en) 2003-03-24 2007-12-21 Merck & Co Inc Optimized expression of HPV 31 L1 yeast
ES2384170T3 (es) 2003-04-04 2012-07-02 F. Hoffmann-La Roche Ag Sistema mejorado de PCR multicolor a tiempo real
US7129260B2 (en) 2003-06-02 2006-10-31 Abbott Laboratories Isoindolinone kinase inhibitors
US20040248107A1 (en) 2003-06-09 2004-12-09 Sokolova Irina A. Detection of high grade dysplasia in cervical cells
CA2531105C (en) 2003-07-05 2015-03-17 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
ATE289685T1 (de) 2003-08-25 2005-03-15 Mtm Lab Ag Verfahren zum nachweis von karzinomen in solubilisierten zervikalen körperproben
WO2005030041A2 (en) 2003-09-25 2005-04-07 Third Wave Technologies, Inc. Detection of hpv
MY140664A (en) 2003-09-29 2010-01-15 Merck Sharp & Dohme Optimized expression of hpv 45 l1 in yeast
WO2005033333A2 (en) * 2003-10-07 2005-04-14 Dako Denmark A/S Methods and compositions for the diagnosis of cancer
US8012944B2 (en) 2003-10-30 2011-09-06 Pharmascience Inc. Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
MY139500A (en) 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
JP2005243132A (ja) 2004-02-26 2005-09-08 Renesas Technology Corp 半導体装置
US7700103B2 (en) 2004-03-24 2010-04-20 Merck & Co., Inc. Optimized expression of HPV 52 L1 in yeast
CN1690223B (zh) 2004-04-27 2010-05-05 亚能生物技术(深圳)有限公司 人乳头瘤病毒分型基因芯片检测系统
US7482142B1 (en) 2004-05-07 2009-01-27 Roche Molecular Systems, Inc. High-risk human papillomavirus detection
ES2521115T3 (es) 2004-09-30 2014-11-12 Epigenomics Ag Método para proveer fragmentos de ADN derivados de una muestra archivada
US7670774B2 (en) 2004-10-04 2010-03-02 Goodgene Inc. Probe of human papillomavirus and DNA chip comprising the same
US7354719B2 (en) 2004-12-08 2008-04-08 Gen-Probe Incorporated Detection of nucleic acids from multiple types of human papillomaviruses
AU2006205638A1 (en) 2005-01-14 2006-07-20 The Regents Of The University Of Michigan Systems, methods, and compositions for detection of human papilloma virus in biological samples
US20060240449A1 (en) 2005-01-19 2006-10-26 Mcglennen Ronald C Methods and compositions for preparation of biological samples
US7524631B2 (en) 2005-02-02 2009-04-28 Patterson Bruce K HPV E6, E7 mRNA assay and methods of use thereof
EP1928560A2 (en) 2005-04-06 2008-06-11 Verenium Corporation Enzymes and formulations for broad-specificity decontamination of chemical and biological warfare agents
US7803541B2 (en) 2005-05-12 2010-09-28 Panomics, Inc. Multiplex branched-chain DNA assays
WO2007130519A2 (en) 2006-05-02 2007-11-15 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Viral nucleic acid microarray and method of use
EP2024520B1 (en) 2006-05-11 2014-03-05 Becton, Dickinson and Company Method of protein extraction from cells
WO2008139938A1 (ja) 2007-05-02 2008-11-20 National University Corporation Tokyo Medical And Dental University ヒトパピローマウイルス16型遺伝子を標的とする二本鎖核酸分子及びそれを含む医薬
WO2008149237A2 (en) 2007-06-08 2008-12-11 Epigenomics Ag Method for methylation analysis
CN101177701B (zh) 2007-09-29 2010-08-18 潮州凯普生物化学有限公司 人乳头状瘤病毒基因分型检测试剂盒及其基因芯片制备方法
JP2009106220A (ja) 2007-10-31 2009-05-21 Genodive Pharma Kk 基板上での等温増幅反応による標的塩基配列の捕捉及び検出方法
HUE029729T2 (en) 2007-11-01 2017-03-28 Self-Screen B V A new method for detecting cervical HPVs
WO2009123996A2 (en) 2008-03-31 2009-10-08 The Ohio State University Research Foundation Hybridization quantitation method for modified micro-rna and -dna based oligonucleotides
WO2010004251A1 (en) 2008-06-16 2010-01-14 Oncomethylome Sciences Sa Dna methylomes
WO2010028382A2 (en) 2008-09-05 2010-03-11 Mayo Foundation For Medical Education And Research Collecting and processing complex macromolecular mixtures
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
WO2010062546A1 (en) * 2008-10-27 2010-06-03 Qiagen Gaithersburg Inc. Fast results hybrid capture assay on an automated platform
EP2184368A1 (en) 2008-11-07 2010-05-12 DKFZ Deutsches Krebsforschungszentrum Diagnostic transcript and splice patterns of HPV16 in different cervical lesions
JP5738278B2 (ja) 2009-05-01 2015-06-24 キアジェン ゲイサーズバーグ インコーポレイテッド 試料中のrnaスプライシング形態を検出するための非標的増幅法

Also Published As

Publication number Publication date
EP2576840B1 (en) 2018-10-17
EP2576840A1 (en) 2013-04-10
US20120004128A1 (en) 2012-01-05
AU2011258501A1 (en) 2013-01-10
CA2799205A1 (en) 2011-12-01
WO2011149897A1 (en) 2011-12-01
AU2011258501B2 (en) 2016-07-07
US9376727B2 (en) 2016-06-28
JP2013534810A (ja) 2013-09-09

Similar Documents

Publication Publication Date Title
TWI417389B (zh) 於自動平台上之快速結果雜交捕捉法
JP6104296B2 (ja) 標的核酸の存在を判別するための合成プローブを用いた組成物、方法、およびキット
US9689047B2 (en) Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
JP2012506705A5 (OSRAM)
EP2529031B1 (en) Method of determining and confirming the presence of hpv in a sample
JP6153866B2 (ja) 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140410

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140415

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150618

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150904

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20160128

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160512

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20160524

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20160729

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170531

R150 Certificate of patent or registration of utility model

Ref document number: 6153866

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees