JP6144201B2 - 複素環化合物およびグリコーゲンシンターゼキナーゼ−３阻害薬としてのそれの使用 - Google Patents

複素環化合物およびグリコーゲンシンターゼキナーゼ−３阻害薬としてのそれの使用 Download PDF

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JP6144201B2
JP6144201B2 JP2013546715A JP2013546715A JP6144201B2 JP 6144201 B2 JP6144201 B2 JP 6144201B2 JP 2013546715 A JP2013546715 A JP 2013546715A JP 2013546715 A JP2013546715 A JP 2013546715A JP 6144201 B2 JP6144201 B2 JP 6144201B2
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urea
quinolin
pyridin
pyran
group
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JP2014501269A5 (enExample
JP2014501269A (ja
Inventor
ターナー，シヨーン・コルム
マツク，ヘルムート
バツケル，マルガレータ・ヘンリカ・マリア
フアン・ガーレン，マルセル
ホフト，カロリン
ホルンベルガー，ビルフリート
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アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2013546715A 2010-12-30 2011-12-30 複素環化合物およびグリコーゲンシンターゼキナーゼ−３阻害薬としてのそれの使用 Expired - Fee Related JP6144201B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201061428478P 2010-12-30 2010-12-30
US61/428,478 2010-12-30
US201161521868P 2011-08-10 2011-08-10
US61/521,868 2011-08-10
PCT/EP2011/074272 WO2012089828A2 (en) 2010-12-30 2011-12-30 Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors

Related Child Applications (1)

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JP2017011851A Division JP2017122089A (ja) 2010-12-30 2017-01-26 複素環化合物およびグリコーゲンシンターゼキナーゼ−３阻害薬としてのそれの使用

Publications (3)

Publication Number Publication Date
JP2014501269A JP2014501269A (ja) 2014-01-20
JP2014501269A5 JP2014501269A5 (enExample) 2015-02-19
JP6144201B2 true JP6144201B2 (ja) 2017-06-07

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JP2017011851A Pending JP2017122089A (ja) 2010-12-30 2017-01-26 複素環化合物およびグリコーゲンシンターゼキナーゼ−３阻害薬としてのそれの使用

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Country Status (15)

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US (2) US9090592B2 (enExample)
EP (2) EP2658854B1 (enExample)
JP (2) JP6144201B2 (enExample)
KR (1) KR101860297B1 (enExample)
CN (1) CN103476766B (enExample)
AU (1) AU2011351375B2 (enExample)
BR (1) BR112013016928A2 (enExample)
CA (1) CA2821863A1 (enExample)
IL (1) IL226676A (enExample)
MX (1) MX336346B (enExample)
NZ (1) NZ611314A (enExample)
RU (1) RU2623427C2 (enExample)
SG (2) SG191789A1 (enExample)
WO (1) WO2012089828A2 (enExample)
ZA (1) ZA201304756B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017122089A (ja) * 2010-12-30 2017-07-13 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー 複素環化合物およびグリコーゲンシンターゼキナーゼ−３阻害薬としてのそれの使用

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Publication number Priority date Publication date Assignee Title
JP2017122089A (ja) * 2010-12-30 2017-07-13 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー 複素環化合物およびグリコーゲンシンターゼキナーゼ−３阻害薬としてのそれの使用

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EP2658854B1 (en) 2017-12-13
WO2012089828A2 (en) 2012-07-05
JP2017122089A (ja) 2017-07-13
BR112013016928A2 (pt) 2020-10-27
SG10201406098UA (en) 2014-11-27
IL226676A (en) 2015-08-31
AU2011351375A1 (en) 2013-06-20
EP2658854A2 (en) 2013-11-06
WO2012089828A3 (en) 2012-09-20
KR20140003518A (ko) 2014-01-09
RU2013135477A (ru) 2015-02-10
US9540370B2 (en) 2017-01-10
MX2013007702A (es) 2013-11-20
ZA201304756B (en) 2016-07-27
EP3351543A1 (en) 2018-07-25
US9090592B2 (en) 2015-07-28
NZ611314A (en) 2015-06-26
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