JP6133969B2 - 特定の置換基分布を有するエステル化セルロースエーテル - Google Patents

特定の置換基分布を有するエステル化セルロースエーテル Download PDF

Info

Publication number
JP6133969B2
JP6133969B2 JP2015505699A JP2015505699A JP6133969B2 JP 6133969 B2 JP6133969 B2 JP 6133969B2 JP 2015505699 A JP2015505699 A JP 2015505699A JP 2015505699 A JP2015505699 A JP 2015505699A JP 6133969 B2 JP6133969 B2 JP 6133969B2
Authority
JP
Japan
Prior art keywords
cellulose ether
methyl
group
esterified cellulose
hydroxypropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2015505699A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015521209A (ja
JP2015521209A5 (cg-RX-API-DMAC7.html
Inventor
ロバート・エル・シュミット
ロバート・エル・ザムラー
マインオルフ・ブラックハーゲン
オリヴァー・ペーターマン
ローラント・アデン
ニコラス・エス・グラスマン
スティーブン・ジェイ・ギラード
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Global Technologies LLC
Original Assignee
Dow Global Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47146713&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP6133969(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dow Global Technologies LLC filed Critical Dow Global Technologies LLC
Publication of JP2015521209A publication Critical patent/JP2015521209A/ja
Publication of JP2015521209A5 publication Critical patent/JP2015521209A5/ja
Application granted granted Critical
Publication of JP6133969B2 publication Critical patent/JP6133969B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/193—Mixed ethers, i.e. ethers with two or more different etherifying groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B13/00—Preparation of cellulose ether-esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
JP2015505699A 2012-04-11 2012-10-24 特定の置換基分布を有するエステル化セルロースエーテル Expired - Fee Related JP6133969B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261622754P 2012-04-11 2012-04-11
US61/622,754 2012-04-11
PCT/US2012/061586 WO2013154607A1 (en) 2012-04-11 2012-10-24 Esterified cellulose ethers having a specific substituent distribution

Publications (3)

Publication Number Publication Date
JP2015521209A JP2015521209A (ja) 2015-07-27
JP2015521209A5 JP2015521209A5 (cg-RX-API-DMAC7.html) 2015-09-03
JP6133969B2 true JP6133969B2 (ja) 2017-05-24

Family

ID=47146713

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015505699A Expired - Fee Related JP6133969B2 (ja) 2012-04-11 2012-10-24 特定の置換基分布を有するエステル化セルロースエーテル

Country Status (6)

Country Link
US (1) US9320799B2 (cg-RX-API-DMAC7.html)
EP (1) EP2836205B1 (cg-RX-API-DMAC7.html)
JP (1) JP6133969B2 (cg-RX-API-DMAC7.html)
KR (1) KR20140146181A (cg-RX-API-DMAC7.html)
CN (1) CN104427979B (cg-RX-API-DMAC7.html)
WO (1) WO2013154607A1 (cg-RX-API-DMAC7.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX363722B (es) 2013-03-01 2019-03-29 Hercules Inc Composiciones farmaceuticas con rendimiento mejorado y capacidad de procesamiento mejorada.
EP2964204B1 (en) * 2013-03-07 2017-01-04 Dow Global Technologies LLC Novel esterified cellulose ethers of very low viscosity
JP6334574B2 (ja) * 2013-03-07 2018-05-30 ダウ グローバル テクノロジーズ エルエルシー 新規の超高分子量のエステル化セルロースエーテル
CN105164162B (zh) * 2013-05-14 2017-11-28 陶氏环球技术有限责任公司 用二羧酸酯化的纤维素醚
KR102286952B1 (ko) 2013-12-31 2021-08-09 롯데정밀화학 주식회사 입도분포가 조절된 히드록시프로필 메틸셀룰로오스 아세테이트 숙시네이트(hpmcas) 입자의 제조방법 및 hpmcas 분말
EP3107940B1 (en) * 2014-02-20 2019-08-07 Dow Global Technologies LLC Novel esterified cellulose ethers of high molecular weight and homogeneity
US10179110B2 (en) * 2014-05-20 2019-01-15 Dow Global Technologies Llc Dispersion comprising a partially neutralized esterified cellulose ether
MX2017002073A (es) 2014-08-27 2017-05-25 Dow Global Technologies Llc Eteres de celulosa esterificados con bajo contenido insoluble en acetona.
JP6203702B2 (ja) 2014-11-18 2017-09-27 信越化学工業株式会社 ヒプロメロース酢酸エステルコハク酸エステルを用いたスプレードライ用溶液及び固体分散体の製造方法
JP6295380B2 (ja) * 2015-03-16 2018-03-14 ダウ グローバル テクノロジーズ エルエルシー 脂肪族カルボン酸の存在下でエステル化セルロースエーテルを調製するためのプロセス
KR20170128355A (ko) * 2015-03-16 2017-11-22 다우 글로벌 테크놀로지스 엘엘씨 에스테르화 셀룰로오스 에테르의 겔화
JP6356922B2 (ja) * 2015-03-16 2018-07-11 ダウ グローバル テクノロジーズ エルエルシー 低い中和度を有する水溶性エステル化セルロースエーテル
BR112017018232A2 (pt) * 2015-03-16 2018-04-17 Dow Global Technologies Llc éteres de celulose esterificados solúveis em água
JP6371482B2 (ja) * 2015-03-16 2018-08-08 ダウ グローバル テクノロジーズ エルエルシー エステル化セルロースエーテルの水溶液
KR20180008524A (ko) * 2015-05-15 2018-01-24 다우 글로벌 테크놀로지스 엘엘씨 초고분자량 및 저점도의 에스테르화된 셀룰로오스 에테르의 제조 방법
WO2016196153A1 (en) * 2015-06-05 2016-12-08 Dow Global Technologies Llc Cellulose ether powders
CN107636018B (zh) * 2015-06-05 2020-07-10 陶氏环球技术有限责任公司 纤维素醚粉末
WO2017053337A1 (en) * 2015-09-24 2017-03-30 Dow Global Technologies Llc Process for preparing an ester of a cellulose ether in the presence of acetic acid and a reaction catalyst
CN108026184B (zh) * 2015-10-02 2020-09-15 陶氏环球技术有限责任公司 包含分散的酯化纤维素醚的水性组合物
US9884922B2 (en) 2016-03-11 2018-02-06 Shin-Etsu Chemical Co., Ltd. Hypromellose acetate succinate, method for producing the same and composition containing the same
GB201609222D0 (en) 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
KR20190125334A (ko) * 2017-03-17 2019-11-06 다우 글로벌 테크놀로지스 엘엘씨 반응 생성 혼합물로부터 에스테르화 셀룰로스 에테르를 회수하는 공정
KR102719143B1 (ko) * 2017-08-16 2024-10-21 뉴트리션 ＆ 바이오사이언시즈 유에스에이 1, 엘엘씨 저분자량 셀룰로오스 에테르의 제어된 제조 방법
JP7526727B2 (ja) * 2018-12-18 2024-08-01 ニュートリション アンド バイオサイエンシズ ユーエスエー １，リミティド ライアビリティ カンパニー ヒドロキシアルキルメチルセルロースを含む徐放性組成物
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection
JP7128782B2 (ja) * 2019-08-09 2022-08-31 信越化学工業株式会社 エアゾール食品用組成物、ヒドロキシプロピルメチルセルロース及びヒドロキシプロピルメチルセルロースの製造方法
CN112704671B (zh) * 2020-12-28 2022-04-19 普洛药业股份有限公司 一种阿莫西林克拉维酸钾胶囊及其制备方法
WO2023023424A1 (en) 2021-08-19 2023-02-23 Phenom Pharmaceuticals, Inc. Compositions and methods for treatment of sars cov-2
US20240360250A1 (en) * 2021-08-26 2024-10-31 Nutrition & Biosciences Usa 1, Llc Novel hydroxyalkyl methylcellulose and its use
CN114805787B (zh) * 2022-02-24 2023-09-12 南京林业大学 一种纤维素基聚醚多元醇脂肪酸酯增塑剂及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3435027A (en) 1965-12-13 1969-03-25 Hercules Inc Cellulose ether-esters and process
US4226981A (en) 1977-09-28 1980-10-07 Shin-Etsu Chemical Co., Ltd. Ether-ester derivatives of cellulose and their applications
DE2917104A1 (de) 1979-04-27 1980-11-06 Hoechst Ag Verfahren zur viskositaetserniedrigung von celluloseethern durch ozon und seine verwendung
US4365060A (en) 1979-04-28 1982-12-21 Shin-Etsu Chemical Co. Ltd. Enterosoluble capsules
JPS6225101A (ja) 1985-07-24 1987-02-03 Shin Etsu Chem Co Ltd 低重合度セルロ−スエ−テルの製造方法
JPS6281402A (ja) 1985-10-07 1987-04-14 Shin Etsu Chem Co Ltd セルロ−スエ−テル酸性ジカルボン酸エステルの製造方法
JP2916238B2 (ja) * 1990-10-16 1999-07-05 旭化成工業株式会社 アルキルセルロースの製造方法
US5698155A (en) * 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
JP3002916B2 (ja) * 1991-10-29 2000-01-24 ダイセル化学工業株式会社 セルロース混合エーテルの製造法
JP2872951B2 (ja) * 1995-11-07 1999-03-24 第一工業製薬株式会社 カルボキシメチルセルロースナトリウム塩
JP3996653B2 (ja) * 1996-01-26 2007-10-24 信越化学工業株式会社 置換度分布が制御されたヒドロキシプロピルセルロース
US6261218B1 (en) 1998-12-01 2001-07-17 The Dow Chemical Company Process and apparatus for making low molecular weight cellulose ethers
DE10141680B4 (de) 2001-08-25 2004-02-26 Clariant Gmbh Verfahren zur Herstellung niederviskoser Celluloseether durch sauer-oxidativen Abbau von gemahlenen und getrockneten Celluloseethern
DE602005010074D1 (de) * 2004-05-28 2008-11-13 Pfizer Prod Inc Pharmazeutische zusammensetzungen mit verbesserter leistung enthaltend ein hpmca polymer
JP2011074113A (ja) * 2009-09-29 2011-04-14 Toray Ind Inc セルロース混合エステルおよびその製造方法
WO2011159626A1 (en) 2010-06-14 2011-12-22 Bend Research, Inc. Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution
US20160228559A1 (en) 2013-09-25 2016-08-11 Dow Global Technologies Llc Composition for application to a mucosa comprising a cellulose ether

Also Published As

Publication number Publication date
CN104427979B (zh) 2018-02-16
EP2836205B1 (en) 2016-10-19
KR20140146181A (ko) 2014-12-24
US9320799B2 (en) 2016-04-26
WO2013154607A1 (en) 2013-10-17
EP2836205A1 (en) 2015-02-18
CN104427979A (zh) 2015-03-18
JP2015521209A (ja) 2015-07-27
US20150065547A1 (en) 2015-03-05

Similar Documents

Publication Publication Date Title
JP6133969B2 (ja) 特定の置換基分布を有するエステル化セルロースエーテル
CN105899542B (zh) 新颖低粘度酯化纤维素醚
JP6321689B2 (ja) 新規の低粘度及び高分子量のエステル化セルロースエーテル
JP6334574B2 (ja) 新規の超高分子量のエステル化セルロースエーテル
CN105025887B (zh) 新颖极低粘度酯化纤维素醚
JP6185559B2 (ja) 有機希釈剤およびセルロースエーテルを含む組成物
JP6224712B2 (ja) 高分子量および均一性の新規エステル化セルロースエーテル
JP6294323B2 (ja) 脂肪族カルボン酸の存在下でセルロースエーテルのエステルを調製する方法
JP6254593B2 (ja) カルボン酸アルカリ金属塩の存在下でセルロースエーテルのエステルを調製する方法
JP6224711B2 (ja) 部分架橋結合型エステル化セルロースエーテル
JP6420520B2 (ja) 新規の高分子量及び高均一性のエステル化セルロースエーテル
CN104602673B (zh) 包含高度取代的羟基烷基甲基纤维素的固体分散体
KR20180008524A (ko) 초고분자량 및 저점도의 에스테르화된 셀룰로오스 에테르의 제조 방법

Legal Events

Date Code Title Description
RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20150511

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151023

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161108

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170116

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170321

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170420

R150 Certificate of patent or registration of utility model

Ref document number: 6133969

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees