JP6133427B2 - モリンドン及びその塩の製造方法 - Google Patents

モリンドン及びその塩の製造方法 Download PDF

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Publication number
JP6133427B2
JP6133427B2 JP2015531913A JP2015531913A JP6133427B2 JP 6133427 B2 JP6133427 B2 JP 6133427B2 JP 2015531913 A JP2015531913 A JP 2015531913A JP 2015531913 A JP2015531913 A JP 2015531913A JP 6133427 B2 JP6133427 B2 JP 6133427B2
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Japan
Prior art keywords
sumo
molindone
morindon
reaction
acid
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Expired - Fee Related
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JP2015531913A
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English (en)
Japanese (ja)
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JP2015534551A (ja
Inventor
ハンバウアー，マーティン
ナジル，ザーグン
ヒルデブランド，ペーター
フィギーニ，アッティリア
リアン，リカン
フマガッリ，ティズィアーノ
Original Assignee
スパーナス ファーマシューティカルズ インコーポレイテッド
スパーナス ファーマシューティカルズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
JP2015531913A 2012-09-14 2013-03-15 モリンドン及びその塩の製造方法 Expired - Fee Related JP6133427B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261701007P 2012-09-14 2012-09-14
US61/701,007 2012-09-14
PCT/US2013/032142 WO2014042688A1 (en) 2012-09-14 2013-03-15 Methods of producing molindone and its salts

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017047064A Division JP6324567B2 (ja) 2012-09-14 2017-03-13 モリンドン及びその塩の製造方法

Publications (2)

Publication Number Publication Date
JP2015534551A JP2015534551A (ja) 2015-12-03
JP6133427B2 true JP6133427B2 (ja) 2017-05-24

Family

ID=48050289

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2015531913A Expired - Fee Related JP6133427B2 (ja) 2012-09-14 2013-03-15 モリンドン及びその塩の製造方法
JP2017047064A Expired - Fee Related JP6324567B2 (ja) 2012-09-14 2017-03-13 モリンドン及びその塩の製造方法
JP2018021784A Pending JP2018090604A (ja) 2012-09-14 2018-02-09 モリンドン及びその塩の製造方法
JP2019032306A Pending JP2019108351A (ja) 2012-09-14 2019-02-26 モリンドン及びその塩の製造方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2017047064A Expired - Fee Related JP6324567B2 (ja) 2012-09-14 2017-03-13 モリンドン及びその塩の製造方法
JP2018021784A Pending JP2018090604A (ja) 2012-09-14 2018-02-09 モリンドン及びその塩の製造方法
JP2019032306A Pending JP2019108351A (ja) 2012-09-14 2019-02-26 モリンドン及びその塩の製造方法

Country Status (8)

Country Link
US (6) US8957206B2 (https=)
EP (3) EP2895175B1 (https=)
JP (4) JP6133427B2 (https=)
AU (3) AU2013316119B2 (https=)
CA (3) CA3170247A1 (https=)
ES (1) ES2643557T3 (https=)
MX (4) MX379124B (https=)
WO (1) WO2014042688A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6133427B2 (ja) * 2012-09-14 2017-05-24 スパーナス ファーマシューティカルズ インコーポレイテッド モリンドン及びその塩の製造方法
CN107011237B (zh) * 2016-01-27 2020-04-21 合肥立方制药股份有限公司 一种改进的吗茚酮的合成方法
US10752586B1 (en) 2019-02-16 2020-08-25 Lupin Limited Process for preparation of molindone

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3467755A (en) * 1966-05-11 1969-09-16 Endo Lab Compositions and methods for producing sedation and tranquilization with substituted 4,5,6,7- tetrahydro-4-oxindoles
US3491093A (en) * 1967-11-29 1970-01-20 Endo Lab Derivatives of 5 aminomethyl-4,5,6,7-tetrahydro-4-oxoindoles
US3646042A (en) 1970-02-09 1972-02-29 Velsicol Chemical Corp Certain n-phenyl n-lower-alkyl-pyridine carboxamides and derivatives thereof
US4016281A (en) * 1975-02-22 1977-04-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Tetralone and indanone compounds
US4065453A (en) 1976-11-01 1977-12-27 Endo Laboratories, Inc. Levorotatory molindone and the use as an antidepressant
US4707484A (en) * 1986-11-25 1987-11-17 Hoffmann-La Roche Inc. Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
US5180834A (en) * 1990-08-23 1993-01-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones
JP2804364B2 (ja) * 1990-10-31 1998-09-24 三井化学株式会社 オキシム類の製造方法
JP4169562B2 (ja) 2002-10-09 2008-10-22 横浜ゴム株式会社 タイヤ成形用金型及び空気入りタイヤ
NZ569317A (en) * 2005-12-29 2010-08-27 Toyama Chemical Co Ltd Novel arylamidine derivative, salt thereof and antifungal agent containing those
JP2007217353A (ja) * 2006-02-17 2007-08-30 Sankyo Agro Kk １，２，３，４−テトラヒドロキノリン化合物
JP6133427B2 (ja) * 2012-09-14 2017-05-24 スパーナス ファーマシューティカルズ インコーポレイテッド モリンドン及びその塩の製造方法

Also Published As

Publication number Publication date
EP3290403A2 (en) 2018-03-07
AU2013316119B2 (en) 2017-05-04
CA3170247A1 (en) 2014-03-20
US20150141645A1 (en) 2015-05-21
CA2884179C (en) 2021-05-04
WO2014042688A1 (en) 2014-03-20
AU2019203270B2 (en) 2020-07-09
JP2017141247A (ja) 2017-08-17
CA3111577A1 (en) 2014-03-20
EP3290403A3 (en) 2018-03-21
US9562011B2 (en) 2017-02-07
ES2643557T3 (es) 2017-11-23
MX382345B (es) 2025-03-13
AU2017208312A1 (en) 2017-08-17
US10081595B2 (en) 2018-09-25
AU2017208312B2 (en) 2019-02-14
US20200262789A1 (en) 2020-08-20
US10676432B2 (en) 2020-06-09
US20180029982A1 (en) 2018-02-01
US11117862B2 (en) 2021-09-14
MX379125B (es) 2025-03-10
EP2895175B1 (en) 2017-07-12
AU2019203270A1 (en) 2019-05-30
US20190218179A1 (en) 2019-07-18
EP2895175A1 (en) 2015-07-22
US9802893B2 (en) 2017-10-31
US20170101377A1 (en) 2017-04-13
CA2884179A1 (en) 2014-03-20
CA3111577C (en) 2023-01-31
EP4074691A1 (en) 2022-10-19
JP6324567B2 (ja) 2018-05-16
MX2015003237A (es) 2016-02-05
JP2015534551A (ja) 2015-12-03
JP2019108351A (ja) 2019-07-04
US8957206B2 (en) 2015-02-17
US20140081020A1 (en) 2014-03-20
AU2013316119A1 (en) 2015-04-02
MX356357B (es) 2018-05-25
MX379124B (es) 2025-03-11
JP2018090604A (ja) 2018-06-14

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