MX382345B - Métodos para producir molindona y sus sales. - Google Patents

Métodos para producir molindona y sus sales.

Info

Publication number
MX382345B
MX382345B MX2017015076A MX2017015076A MX382345B MX 382345 B MX382345 B MX 382345B MX 2017015076 A MX2017015076 A MX 2017015076A MX 2017015076 A MX2017015076 A MX 2017015076A MX 382345 B MX382345 B MX 382345B
Authority
MX
Mexico
Prior art keywords
molindone
methods
salts
synthesis
producing
Prior art date
Application number
MX2017015076A
Other languages
English (en)
Inventor
Attilia Figini
Likan Liang
Martin Hanbauer
Peter Hildebrand
Tiziano Fumagalli
Zarghun Nazir
Original Assignee
Supernus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Supernus Pharmaceuticals Inc filed Critical Supernus Pharmaceuticals Inc
Publication of MX382345B publication Critical patent/MX382345B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención está dirigida hacia nuevos métodos de síntesis de molindona, síntesis de los intermediarios de molindona y composiciones de alta pureza de molindona. En específico, la invención se relaciona a los métodos de síntesis de molindona a través de la reacción de Mannich.
MX2017015076A 2012-09-14 2013-03-15 Métodos para producir molindona y sus sales. MX382345B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261701007P 2012-09-14 2012-09-14
PCT/US2013/032142 WO2014042688A1 (en) 2012-09-14 2013-03-15 Methods of producing molindone and its salts

Publications (1)

Publication Number Publication Date
MX382345B true MX382345B (es) 2025-03-13

Family

ID=48050289

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2015003237A MX356357B (es) 2012-09-14 2013-03-15 Metodos para producir molindona y sus sales.
MX2017015078A MX379124B (es) 2012-09-14 2013-03-15 Métodos para producir molindona y sus sales.
MX2017015076A MX382345B (es) 2012-09-14 2013-03-15 Métodos para producir molindona y sus sales.
MX2017015070A MX379125B (es) 2012-09-14 2013-03-15 Métodos para producir molindona y sus sales.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2015003237A MX356357B (es) 2012-09-14 2013-03-15 Metodos para producir molindona y sus sales.
MX2017015078A MX379124B (es) 2012-09-14 2013-03-15 Métodos para producir molindona y sus sales.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2017015070A MX379125B (es) 2012-09-14 2013-03-15 Métodos para producir molindona y sus sales.

Country Status (8)

Country Link
US (6) US8957206B2 (es)
EP (3) EP4074691A1 (es)
JP (4) JP6133427B2 (es)
AU (3) AU2013316119B2 (es)
CA (3) CA3111577C (es)
ES (1) ES2643557T3 (es)
MX (4) MX356357B (es)
WO (1) WO2014042688A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8957206B2 (en) * 2012-09-14 2015-02-17 Supernus Pharmaceuticals Inc. Methods of producing molindone and its salts
CN107011237B (zh) * 2016-01-27 2020-04-21 合肥立方制药股份有限公司 一种改进的吗茚酮的合成方法
US10752586B1 (en) 2019-02-16 2020-08-25 Lupin Limited Process for preparation of molindone

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3467755A (en) * 1966-05-11 1969-09-16 Endo Lab Compositions and methods for producing sedation and tranquilization with substituted 4,5,6,7- tetrahydro-4-oxindoles
US3491093A (en) * 1967-11-29 1970-01-20 Endo Lab Derivatives of 5 aminomethyl-4,5,6,7-tetrahydro-4-oxoindoles
US3646042A (en) 1970-02-09 1972-02-29 Velsicol Chemical Corp Certain n-phenyl n-lower-alkyl-pyridine carboxamides and derivatives thereof
US4016281A (en) * 1975-02-22 1977-04-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Tetralone and indanone compounds
US4065453A (en) * 1976-11-01 1977-12-27 Endo Laboratories, Inc. Levorotatory molindone and the use as an antidepressant
US4707484A (en) * 1986-11-25 1987-11-17 Hoffmann-La Roche Inc. Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
US5180834A (en) * 1990-08-23 1993-01-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones
JP2804364B2 (ja) * 1990-10-31 1998-09-24 三井化学株式会社 オキシム類の製造方法
JP4169562B2 (ja) 2002-10-09 2008-10-22 横浜ゴム株式会社 タイヤ成形用金型及び空気入りタイヤ
CA2634846C (en) * 2005-12-29 2013-02-19 Toyama Chemical Co., Ltd. Novel arylamidine derivative, salt thereof and antifungal agent containing those
JP2007217353A (ja) * 2006-02-17 2007-08-30 Sankyo Agro Kk １，２，３，４−テトラヒドロキノリン化合物
US8957206B2 (en) * 2012-09-14 2015-02-17 Supernus Pharmaceuticals Inc. Methods of producing molindone and its salts

Also Published As

Publication number Publication date
AU2013316119A1 (en) 2015-04-02
MX2015003237A (es) 2016-02-05
US20140081020A1 (en) 2014-03-20
US10081595B2 (en) 2018-09-25
EP2895175B1 (en) 2017-07-12
US20170101377A1 (en) 2017-04-13
CA3111577C (en) 2023-01-31
CA2884179A1 (en) 2014-03-20
JP2019108351A (ja) 2019-07-04
US8957206B2 (en) 2015-02-17
MX379124B (es) 2025-03-11
US10676432B2 (en) 2020-06-09
US20190218179A1 (en) 2019-07-18
US20150141645A1 (en) 2015-05-21
JP2018090604A (ja) 2018-06-14
JP6133427B2 (ja) 2017-05-24
AU2013316119B2 (en) 2017-05-04
MX379125B (es) 2025-03-10
AU2017208312B2 (en) 2019-02-14
US9802893B2 (en) 2017-10-31
EP2895175A1 (en) 2015-07-22
JP2017141247A (ja) 2017-08-17
MX356357B (es) 2018-05-25
CA3111577A1 (en) 2014-03-20
AU2017208312A1 (en) 2017-08-17
JP6324567B2 (ja) 2018-05-16
EP3290403A3 (en) 2018-03-21
US20200262789A1 (en) 2020-08-20
ES2643557T3 (es) 2017-11-23
WO2014042688A1 (en) 2014-03-20
CA2884179C (en) 2021-05-04
JP2015534551A (ja) 2015-12-03
EP4074691A1 (en) 2022-10-19
CA3170247A1 (en) 2014-03-20
AU2019203270A1 (en) 2019-05-30
EP3290403A2 (en) 2018-03-07
AU2019203270B2 (en) 2020-07-09
US20180029982A1 (en) 2018-02-01
US9562011B2 (en) 2017-02-07
US11117862B2 (en) 2021-09-14

Similar Documents

Publication Publication Date Title
MX2020009401A (es) Ligadores de nucleótidos modificados.
EA201790916A1 (ru) Новые лиганды rig-i и способы их получения
NZ726859A (en) Synthesis of polycyclic-carbamoylpyridone compounds
BR112013028187A2 (pt) processo para produzir olefinas
CR20140435A (es) Nuevos derivados de tienopirimidina, procesos para su preparacion y sus usos terapeuticos
TR201905217T4 (tr) Kopanlisib ve bunun dihidroklorid tuzunun sentezi.
MX2014014138A (es) Procedimiento nuevo para la preparacion de acido 2-ciclopentil-6-metoxi-isonicotinico.
CO7141402A2 (es) Procesos para producir ciertos 2 (piridin 3 il)tiazoles
CO6751286A2 (es) Síntesis de derivados de 2-carboxamida-cicloamino-urea
UA111333C2 (uk) Спосіб одержання l-аргінінової солі периндроприлу
IN2014KN01062A (es)
NZ720106A (en) A process for the preparation of regadenoson
MX2016007186A (es) Nuevo procedimiento de sintesis de la agomelatina.
MX382345B (es) Métodos para producir molindona y sus sales.
PH12016501201A1 (en) Synthesis of ent-progesterone and intermediates thereof
MX2013008361A (es) Procedimiento para la preparacion de derivados 1-h-pirrolidin-2,4-diona.
IN2013MU01290A (es)
JO3200B1 (ar) طريقة ونواتج وسيطة لتحضير أجوميلاتين
MX2016005511A (es) Intermediarios y metodos para sintetizar derivados de calicheamicina.
MX2015012902A (es) Sintesis de ent-progesterona e intermediarios de la misma.
UY34685A (es) Nuevo procedimiento de síntesis de la ivabradinay de sus sales de adición a un ácido farmacéuticamente aceptable
IN2013MU03379A (es)
CO6680684A2 (es) Proceso para la preparación de intermedios de 1-aril-pirazol -3-ona utiles en la sisntesis de inhibidores de receptores sigma
PH12013501279A1 (en) New process for the synthesis of agomelatine
MX2012013730A (es) Sintesis por electrocarboxilacion para obtener intermedios utiles para la sintesis de derivados de span.