JO3200B1 - طريقة ونواتج وسيطة لتحضير أجوميلاتين - Google Patents
طريقة ونواتج وسيطة لتحضير أجوميلاتينInfo
- Publication number
- JO3200B1 JO3200B1 JOP/2011/0392A JOP20110392A JO3200B1 JO 3200 B1 JO3200 B1 JO 3200B1 JO P20110392 A JOP20110392 A JO P20110392A JO 3200 B1 JO3200 B1 JO 3200B1
- Authority
- JO
- Jordan
- Prior art keywords
- agomelatine
- preparation
- intermediate products
- products
- compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- YJYPHIXNFHFHND-UHFFFAOYSA-N agomelatine Chemical compound C1=CC=C(CCNC(C)=O)C2=CC(OC)=CC=C21 YJYPHIXNFHFHND-UHFFFAOYSA-N 0.000 title 1
- 229960002629 agomelatine Drugs 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/06—Preparation of carboxylic acid amides from nitriles by transformation of cyano groups into carboxamide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/40—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
عملية تصنيع لمركب الصيغة (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1100024A FR2970000B1 (fr) | 2011-01-05 | 2011-01-05 | Nouveau procede de synthese de l'agomelatine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3200B1 true JO3200B1 (ar) | 2018-03-08 |
Family
ID=44088993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2011/0392A JO3200B1 (ar) | 2011-01-05 | 2011-12-20 | طريقة ونواتج وسيطة لتحضير أجوميلاتين |
Country Status (43)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103058879B (zh) * | 2012-12-20 | 2015-09-09 | 安徽悦康凯悦制药有限公司 | 阿戈美拉汀的制备方法 |
| CN103804232B (zh) * | 2014-01-26 | 2015-08-19 | 江西同和药业股份有限公司 | 一种1-氰基-1-(7-甲氧基-3,4-二氢-1-萘基)甲醇酯类化合物及其制备方法和应用 |
| CN107353229B (zh) * | 2017-08-08 | 2019-04-30 | 许昌恒生制药有限公司 | 一种阿戈美拉汀中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2658818B1 (fr) | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2866334B1 (fr) | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine |
| FR2866335B1 (fr) * | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
| CN101486665B (zh) | 2009-03-03 | 2013-04-17 | 上海医药工业研究院 | 阿戈美拉汀中间体2-(7-甲氧基-1-萘基)乙酰胺的制备方法 |
-
2011
- 2011-01-05 FR FR1100024A patent/FR2970000B1/fr not_active Expired - Fee Related
- 2011-12-20 JO JOP/2011/0392A patent/JO3200B1/ar active
- 2011-12-30 UY UY0001033845A patent/UY33845A/es unknown
-
2012
- 2012-01-03 SA SA112330134A patent/SA112330134B1/ar unknown
- 2012-01-04 US US14/619,284 patent/USRE46218E1/en active Active
- 2012-01-04 HU HUE12703858A patent/HUE028471T2/en unknown
- 2012-01-04 DK DK12703858.6T patent/DK2661422T3/en active
- 2012-01-04 GE GEAP201213180A patent/GEP20156365B/en unknown
- 2012-01-04 EP EP12703858.6A patent/EP2661422B9/fr active Active
- 2012-01-04 SG SG2013046370A patent/SG191733A1/en unknown
- 2012-01-04 RU RU2013136344/04A patent/RU2550812C2/ru not_active IP Right Cessation
- 2012-01-04 ME MEP-2016-99A patent/ME02408B/me unknown
- 2012-01-04 JP JP2013547894A patent/JP5837616B2/ja not_active Expired - Fee Related
- 2012-01-04 MX MX2013007837A patent/MX2013007837A/es active IP Right Grant
- 2012-01-04 TW TW101100368A patent/TWI438180B/zh not_active IP Right Cessation
- 2012-01-04 RS RS20160320A patent/RS54753B9/sr unknown
- 2012-01-04 SI SI201230629A patent/SI2661422T1/sl unknown
- 2012-01-04 CN CN201280004746.9A patent/CN103313965B/zh not_active Expired - Fee Related
- 2012-01-04 AP AP2013007022A patent/AP3609A/xx active
- 2012-01-04 PL PL12703858.6T patent/PL2661422T3/pl unknown
- 2012-01-04 KR KR1020137020469A patent/KR101543432B1/ko not_active Expired - Fee Related
- 2012-01-04 PE PE2013001435A patent/PE20140037A1/es active IP Right Grant
- 2012-01-04 CA CA2823587A patent/CA2823587C/fr active Active
- 2012-01-04 US US13/977,799 patent/US8853449B2/en not_active Ceased
- 2012-01-04 MY MYPI2013701043A patent/MY162977A/en unknown
- 2012-01-04 BR BR112013017307A patent/BR112013017307A2/pt not_active IP Right Cessation
- 2012-01-04 PH PH1/2013/501278A patent/PH12013501278A1/en unknown
- 2012-01-04 AR ARP120100020A patent/AR084780A1/es unknown
- 2012-01-04 WO PCT/FR2012/000005 patent/WO2012113999A1/fr not_active Ceased
- 2012-01-04 HR HRP20160713TT patent/HRP20160713T1/hr unknown
- 2012-01-04 EA EA201300794A patent/EA022077B1/ru unknown
- 2012-01-04 CU CUP2013000092A patent/CU24289B1/xx unknown
- 2012-01-04 ES ES12703858.6T patent/ES2583682T3/es active Active
- 2012-01-04 AU AU2012220474A patent/AU2012220474B2/en not_active Ceased
- 2012-04-01 UA UAA201309590A patent/UA104122C2/uk unknown
-
2013
- 2013-06-19 CR CR20130301A patent/CR20130301A/es unknown
- 2013-06-25 TN TNP2013000274A patent/TN2013000274A1/fr unknown
- 2013-06-25 CL CL2013001882A patent/CL2013001882A1/es unknown
- 2013-07-01 IL IL227281A patent/IL227281A/en active IP Right Grant
- 2013-07-03 CO CO13156552A patent/CO6731101A2/es unknown
- 2013-07-03 NI NI201300062A patent/NI201300062A/es unknown
- 2013-07-04 ZA ZA2013/05027A patent/ZA201305027B/en unknown
- 2013-07-05 EC ECSP13012735 patent/ECSP13012735A/es unknown
-
2016
- 2016-07-11 CY CY20161100655T patent/CY1117774T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1119143T1 (el) | Διεργασια για την παρασκευη παραγωγων και ενδιαμεσων καρβαμουλοπυριδονης | |
| DE112012003312A5 (de) | Modulierbares Universalverfahren zur Herstellung von Syntheseprodukten | |
| BR112013023064A2 (pt) | processo de síntese de derivados de cetobenzofurano | |
| MX350211B (es) | Proceso para la preparacion del etil-ester del acido n- (4-ciclohexil-3-trifluoro-metil-benciloxi) -acetimidico. | |
| IL229647A0 (en) | A new process for the preparation of prostaglandin amides | |
| CO6751286A2 (es) | Síntesis de derivados de 2-carboxamida-cicloamino-urea | |
| UA111333C2 (uk) | Спосіб одержання l-аргінінової солі периндроприлу | |
| IN2014MN00850A (ar) | ||
| MX2016007186A (es) | Nuevo procedimiento de sintesis de la agomelatina. | |
| GB201107985D0 (en) | Process | |
| JO3200B1 (ar) | طريقة ونواتج وسيطة لتحضير أجوميلاتين | |
| UY33879A (es) | Proceso para la preparación de amidas del ácido pirazol carboxílico | |
| MX2014002378A (es) | Proceso para la preparacion de (r)-2-acetamido-n-bencil-3-metoxipr opionamida e intermediarios de la misma. | |
| IN2014DN07498A (ar) | ||
| PH12013501279A1 (en) | New process for the synthesis of agomelatine | |
| EA201400188A1 (ru) | Способ получения кристаллической формы i агомелатина | |
| GEP20186847B (en) | Novel method for synthesis of 7-methoxy-naphthalene-1- carbaldehyde and usage therein synthesis of agomelatine | |
| HUP1100291A2 (en) | Process for the preparation of prostaglandin amides | |
| WO2015082848A3 (fr) | Nouveau procede de synthese du 7-methoxy-naphtalene-1-carbaldehyde et application a la synthese de l'agomelatine |