MX379124B - Métodos para producir molindona y sus sales. - Google Patents
Métodos para producir molindona y sus sales.Info
- Publication number
- MX379124B MX379124B MX2017015078A MX2017015078A MX379124B MX 379124 B MX379124 B MX 379124B MX 2017015078 A MX2017015078 A MX 2017015078A MX 2017015078 A MX2017015078 A MX 2017015078A MX 379124 B MX379124 B MX 379124B
- Authority
- MX
- Mexico
- Prior art keywords
- molindone
- methods
- salts
- synthesis
- producing
- Prior art date
Links
- KLPWJLBORRMFGK-UHFFFAOYSA-N Molindone Chemical compound O=C1C=2C(CC)=C(C)NC=2CCC1CN1CCOCC1 KLPWJLBORRMFGK-UHFFFAOYSA-N 0.000 title abstract 5
- 229960004938 molindone Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 3
- 238000003786 synthesis reaction Methods 0.000 abstract 3
- 238000006683 Mannich reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
- C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente invención está dirigida hacia nuevos métodos de síntesis de molindona, síntesis de los intermediarios de molindona y composiciones de alta pureza de molindona. En específico, la invención se relaciona a los métodos de síntesis de molindona a través de la reacción de Mannich.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261701007P | 2012-09-14 | 2012-09-14 | |
| PCT/US2013/032142 WO2014042688A1 (en) | 2012-09-14 | 2013-03-15 | Methods of producing molindone and its salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX379124B true MX379124B (es) | 2025-03-11 |
Family
ID=48050289
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015003237A MX356357B (es) | 2012-09-14 | 2013-03-15 | Metodos para producir molindona y sus sales. |
| MX2017015078A MX379124B (es) | 2012-09-14 | 2013-03-15 | Métodos para producir molindona y sus sales. |
| MX2017015076A MX382345B (es) | 2012-09-14 | 2013-03-15 | Métodos para producir molindona y sus sales. |
| MX2017015070A MX379125B (es) | 2012-09-14 | 2013-03-15 | Métodos para producir molindona y sus sales. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015003237A MX356357B (es) | 2012-09-14 | 2013-03-15 | Metodos para producir molindona y sus sales. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017015076A MX382345B (es) | 2012-09-14 | 2013-03-15 | Métodos para producir molindona y sus sales. |
| MX2017015070A MX379125B (es) | 2012-09-14 | 2013-03-15 | Métodos para producir molindona y sus sales. |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US8957206B2 (es) |
| EP (3) | EP4074691A1 (es) |
| JP (4) | JP6133427B2 (es) |
| AU (3) | AU2013316119B2 (es) |
| CA (3) | CA3111577C (es) |
| ES (1) | ES2643557T3 (es) |
| MX (4) | MX356357B (es) |
| WO (1) | WO2014042688A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8957206B2 (en) * | 2012-09-14 | 2015-02-17 | Supernus Pharmaceuticals Inc. | Methods of producing molindone and its salts |
| CN107011237B (zh) * | 2016-01-27 | 2020-04-21 | 合肥立方制药股份有限公司 | 一种改进的吗茚酮的合成方法 |
| US10752586B1 (en) | 2019-02-16 | 2020-08-25 | Lupin Limited | Process for preparation of molindone |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3467755A (en) * | 1966-05-11 | 1969-09-16 | Endo Lab | Compositions and methods for producing sedation and tranquilization with substituted 4,5,6,7- tetrahydro-4-oxindoles |
| US3491093A (en) * | 1967-11-29 | 1970-01-20 | Endo Lab | Derivatives of 5 aminomethyl-4,5,6,7-tetrahydro-4-oxoindoles |
| US3646042A (en) | 1970-02-09 | 1972-02-29 | Velsicol Chemical Corp | Certain n-phenyl n-lower-alkyl-pyridine carboxamides and derivatives thereof |
| US4016281A (en) * | 1975-02-22 | 1977-04-05 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Tetralone and indanone compounds |
| US4065453A (en) * | 1976-11-01 | 1977-12-27 | Endo Laboratories, Inc. | Levorotatory molindone and the use as an antidepressant |
| US4707484A (en) * | 1986-11-25 | 1987-11-17 | Hoffmann-La Roche Inc. | Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives |
| US5114936A (en) * | 1990-08-23 | 1992-05-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use |
| US5180834A (en) * | 1990-08-23 | 1993-01-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones |
| JP2804364B2 (ja) * | 1990-10-31 | 1998-09-24 | 三井化学株式会社 | オキシム類の製造方法 |
| JP4169562B2 (ja) | 2002-10-09 | 2008-10-22 | 横浜ゴム株式会社 | タイヤ成形用金型及び空気入りタイヤ |
| CA2634846C (en) * | 2005-12-29 | 2013-02-19 | Toyama Chemical Co., Ltd. | Novel arylamidine derivative, salt thereof and antifungal agent containing those |
| JP2007217353A (ja) * | 2006-02-17 | 2007-08-30 | Sankyo Agro Kk | １，２，３，４−テトラヒドロキノリン化合物 |
| US8957206B2 (en) * | 2012-09-14 | 2015-02-17 | Supernus Pharmaceuticals Inc. | Methods of producing molindone and its salts |
-
2013
- 2013-03-15 US US13/834,097 patent/US8957206B2/en active Active
- 2013-03-15 WO PCT/US2013/032142 patent/WO2014042688A1/en not_active Ceased
- 2013-03-15 CA CA3111577A patent/CA3111577C/en active Active
- 2013-03-15 JP JP2015531913A patent/JP6133427B2/ja not_active Expired - Fee Related
- 2013-03-15 MX MX2015003237A patent/MX356357B/es active IP Right Grant
- 2013-03-15 EP EP22177217.1A patent/EP4074691A1/en not_active Withdrawn
- 2013-03-15 MX MX2017015078A patent/MX379124B/es unknown
- 2013-03-15 CA CA3170247A patent/CA3170247A1/en active Pending
- 2013-03-15 EP EP13714783.1A patent/EP2895175B1/en active Active
- 2013-03-15 EP EP17180165.7A patent/EP3290403A3/en not_active Withdrawn
- 2013-03-15 CA CA2884179A patent/CA2884179C/en active Active
- 2013-03-15 MX MX2017015076A patent/MX382345B/es unknown
- 2013-03-15 ES ES13714783.1T patent/ES2643557T3/es active Active
- 2013-03-15 MX MX2017015070A patent/MX379125B/es unknown
- 2013-03-15 AU AU2013316119A patent/AU2013316119B2/en active Active
-
2015
- 2015-01-29 US US14/608,262 patent/US9562011B2/en active Active
-
2016
- 2016-11-30 US US15/365,566 patent/US9802893B2/en active Active
-
2017
- 2017-03-13 JP JP2017047064A patent/JP6324567B2/ja not_active Expired - Fee Related
- 2017-07-27 AU AU2017208312A patent/AU2017208312B2/en active Active
- 2017-10-03 US US15/723,515 patent/US10081595B2/en active Active
-
2018
- 2018-02-09 JP JP2018021784A patent/JP2018090604A/ja active Pending
- 2018-08-21 US US16/107,836 patent/US10676432B2/en active Active
-
2019
- 2019-02-26 JP JP2019032306A patent/JP2019108351A/ja active Pending
- 2019-05-09 AU AU2019203270A patent/AU2019203270B2/en active Active
-
2020
- 2020-04-30 US US16/863,020 patent/US11117862B2/en active Active
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