AU2013316119B2 - Methods of producing molindone and its salts - Google Patents

Methods of producing molindone and its salts Download PDF

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Publication number
AU2013316119B2
AU2013316119B2 AU2013316119A AU2013316119A AU2013316119B2 AU 2013316119 B2 AU2013316119 B2 AU 2013316119B2 AU 2013316119 A AU2013316119 A AU 2013316119A AU 2013316119 A AU2013316119 A AU 2013316119A AU 2013316119 B2 AU2013316119 B2 AU 2013316119B2
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AU
Australia
Prior art keywords
sumo
molindone
reaction
acid
cyclohexanedione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2013316119A
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English (en)
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AU2013316119A1 (en
Inventor
Attilia Figini
Tiziano FUMAGALLI
Martin HANBAUER
Peter Hildebrand
Likan Liang
Zarghun Nazir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Supernus Pharmaceuticals Inc
Original Assignee
Supernus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Supernus Pharmaceuticals Inc filed Critical Supernus Pharmaceuticals Inc
Publication of AU2013316119A1 publication Critical patent/AU2013316119A1/en
Application granted granted Critical
Publication of AU2013316119B2 publication Critical patent/AU2013316119B2/en
Priority to AU2017208312A priority Critical patent/AU2017208312B2/en
Priority to AU2019203270A priority patent/AU2019203270B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
AU2013316119A 2012-09-14 2013-03-15 Methods of producing molindone and its salts Active AU2013316119B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017208312A AU2017208312B2 (en) 2012-09-14 2017-07-27 Methods of producing molindone and its salts
AU2019203270A AU2019203270B2 (en) 2012-09-14 2019-05-09 Methods of producing molindone and its salts

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261701007P 2012-09-14 2012-09-14
US61/701,007 2012-09-14
PCT/US2013/032142 WO2014042688A1 (en) 2012-09-14 2013-03-15 Methods of producing molindone and its salts

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017208312A Division AU2017208312B2 (en) 2012-09-14 2017-07-27 Methods of producing molindone and its salts

Publications (2)

Publication Number Publication Date
AU2013316119A1 AU2013316119A1 (en) 2015-04-02
AU2013316119B2 true AU2013316119B2 (en) 2017-05-04

Family

ID=48050289

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2013316119A Active AU2013316119B2 (en) 2012-09-14 2013-03-15 Methods of producing molindone and its salts
AU2017208312A Active AU2017208312B2 (en) 2012-09-14 2017-07-27 Methods of producing molindone and its salts
AU2019203270A Active AU2019203270B2 (en) 2012-09-14 2019-05-09 Methods of producing molindone and its salts

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2017208312A Active AU2017208312B2 (en) 2012-09-14 2017-07-27 Methods of producing molindone and its salts
AU2019203270A Active AU2019203270B2 (en) 2012-09-14 2019-05-09 Methods of producing molindone and its salts

Country Status (8)

Country Link
US (6) US8957206B2 (https=)
EP (3) EP2895175B1 (https=)
JP (4) JP6133427B2 (https=)
AU (3) AU2013316119B2 (https=)
CA (3) CA3170247A1 (https=)
ES (1) ES2643557T3 (https=)
MX (4) MX379124B (https=)
WO (1) WO2014042688A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6133427B2 (ja) * 2012-09-14 2017-05-24 スパーナス ファーマシューティカルズ インコーポレイテッド モリンドン及びその塩の製造方法
CN107011237B (zh) * 2016-01-27 2020-04-21 合肥立方制药股份有限公司 一种改进的吗茚酮的合成方法
US10752586B1 (en) 2019-02-16 2020-08-25 Lupin Limited Process for preparation of molindone

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3491093A (en) * 1967-11-29 1970-01-20 Endo Lab Derivatives of 5 aminomethyl-4,5,6,7-tetrahydro-4-oxoindoles
US4065453A (en) * 1976-11-01 1977-12-27 Endo Laboratories, Inc. Levorotatory molindone and the use as an antidepressant
US5180834A (en) * 1990-08-23 1993-01-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3467755A (en) * 1966-05-11 1969-09-16 Endo Lab Compositions and methods for producing sedation and tranquilization with substituted 4,5,6,7- tetrahydro-4-oxindoles
US3646042A (en) 1970-02-09 1972-02-29 Velsicol Chemical Corp Certain n-phenyl n-lower-alkyl-pyridine carboxamides and derivatives thereof
US4016281A (en) * 1975-02-22 1977-04-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Tetralone and indanone compounds
US4707484A (en) * 1986-11-25 1987-11-17 Hoffmann-La Roche Inc. Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
JP2804364B2 (ja) * 1990-10-31 1998-09-24 三井化学株式会社 オキシム類の製造方法
JP4169562B2 (ja) 2002-10-09 2008-10-22 横浜ゴム株式会社 タイヤ成形用金型及び空気入りタイヤ
NZ569317A (en) * 2005-12-29 2010-08-27 Toyama Chemical Co Ltd Novel arylamidine derivative, salt thereof and antifungal agent containing those
JP2007217353A (ja) * 2006-02-17 2007-08-30 Sankyo Agro Kk １，２，３，４−テトラヒドロキノリン化合物
JP6133427B2 (ja) * 2012-09-14 2017-05-24 スパーナス ファーマシューティカルズ インコーポレイテッド モリンドン及びその塩の製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3491093A (en) * 1967-11-29 1970-01-20 Endo Lab Derivatives of 5 aminomethyl-4,5,6,7-tetrahydro-4-oxoindoles
US4065453A (en) * 1976-11-01 1977-12-27 Endo Laboratories, Inc. Levorotatory molindone and the use as an antidepressant
US5180834A (en) * 1990-08-23 1993-01-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ACHIM PORZELLE,, "Direct Access to Functionalized Cyclic Enones Using Mannich, Morita-Baylis-Hillman and Elimination Reactions", SYNTHESIS, (2006), vol. 18, pages 3025 - 3030 *

Also Published As

Publication number Publication date
EP3290403A2 (en) 2018-03-07
CA3170247A1 (en) 2014-03-20
US20150141645A1 (en) 2015-05-21
CA2884179C (en) 2021-05-04
WO2014042688A1 (en) 2014-03-20
AU2019203270B2 (en) 2020-07-09
JP2017141247A (ja) 2017-08-17
CA3111577A1 (en) 2014-03-20
EP3290403A3 (en) 2018-03-21
US9562011B2 (en) 2017-02-07
ES2643557T3 (es) 2017-11-23
MX382345B (es) 2025-03-13
AU2017208312A1 (en) 2017-08-17
US10081595B2 (en) 2018-09-25
AU2017208312B2 (en) 2019-02-14
US20200262789A1 (en) 2020-08-20
US10676432B2 (en) 2020-06-09
US20180029982A1 (en) 2018-02-01
US11117862B2 (en) 2021-09-14
MX379125B (es) 2025-03-10
EP2895175B1 (en) 2017-07-12
AU2019203270A1 (en) 2019-05-30
US20190218179A1 (en) 2019-07-18
EP2895175A1 (en) 2015-07-22
US9802893B2 (en) 2017-10-31
US20170101377A1 (en) 2017-04-13
CA2884179A1 (en) 2014-03-20
CA3111577C (en) 2023-01-31
EP4074691A1 (en) 2022-10-19
JP6324567B2 (ja) 2018-05-16
MX2015003237A (es) 2016-02-05
JP2015534551A (ja) 2015-12-03
JP2019108351A (ja) 2019-07-04
US8957206B2 (en) 2015-02-17
US20140081020A1 (en) 2014-03-20
AU2013316119A1 (en) 2015-04-02
MX356357B (es) 2018-05-25
MX379124B (es) 2025-03-11
JP2018090604A (ja) 2018-06-14
JP6133427B2 (ja) 2017-05-24

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