JP6130391B2 - Ｍｔｏｒ阻害剤を使用する強化された治療レジメン - Google Patents
Ｍｔｏｒ阻害剤を使用する強化された治療レジメン Download PDFInfo
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- JP6130391B2 JP6130391B2 JP2014543592A JP2014543592A JP6130391B2 JP 6130391 B2 JP6130391 B2 JP 6130391B2 JP 2014543592 A JP2014543592 A JP 2014543592A JP 2014543592 A JP2014543592 A JP 2014543592A JP 6130391 B2 JP6130391 B2 JP 6130391B2
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Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
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- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US201161563516P | 2011-11-23 | 2011-11-23 | |
| US61/563,516 | 2011-11-23 | ||
| PCT/US2012/066431 WO2013078440A2 (en) | 2011-11-23 | 2012-11-21 | Enhanced treatment regimens using mtor inhibitors |
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| JP2015500209A JP2015500209A (ja) | 2015-01-05 |
| JP2015500209A5 JP2015500209A5 (enExample) | 2016-01-14 |
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| WO2015050957A2 (en) * | 2013-10-02 | 2015-04-09 | Treatments For Systemic Lupus Erythematosus | Treatments for systemic lupus erythematosus |
| CA2925523A1 (en) * | 2013-10-03 | 2015-04-09 | Millenium Pharmaceuticals, Inc. | Enhanced treatment regimens using pi3k.alpha. inhibitors |
| WO2015148626A1 (en) * | 2014-03-26 | 2015-10-01 | Millennium Pharmaceuticals, Inc. | Treatment of fibrotic disorders |
| WO2015148623A1 (en) * | 2014-03-26 | 2015-10-01 | Millennium Pharmaceuticals, Inc. | Treatment of fibrotic respiratory disorders |
| WO2015148615A1 (en) * | 2014-03-26 | 2015-10-01 | Millennium Pharmaceuticals, Inc. | Treatment of bronchiolitis obliterans syndrome |
| EP3294338A4 (en) * | 2015-05-13 | 2019-07-17 | Memorial Sloan Kettering Cancer Center | MACROPINOCYTOSIS IN CANCER |
| HUE064656T2 (hu) | 2016-03-28 | 2024-04-28 | Incyte Corp | Pirrolotriazin vegyületek mint TAM inhibitorok |
| PL3442535T3 (pl) | 2016-04-15 | 2022-10-24 | Cancer Research Technology Limited | Związki heterocykliczne jako inhibitory kinazy ret |
| RU2742115C2 (ru) | 2016-04-15 | 2021-02-02 | Кэнсер Рисерч Текнолоджи Лимитед | Гетероциклические соединения в качестве ингибиторов киназы RET |
| GB201705971D0 (en) | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
| AR112834A1 (es) | 2017-09-26 | 2019-12-18 | Novartis Ag | Derivados de rapamicina |
| FR3075795A1 (fr) | 2017-12-21 | 2019-06-28 | Galderma Research & Development | Nouveaux composes inhibiteurs de mtor |
| WO2020055761A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
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| HUE067396T2 (hu) | 2019-03-26 | 2024-10-28 | Novartis Ag | Izotiazolidin 1,1-dioxidot és 1,4-bután szultont tartalmazó rapamicinszármazékok és alkalmazásaik |
| US20210205322A1 (en) * | 2020-01-08 | 2021-07-08 | Albert Einstein College Of Medicine | Rictor-targeted therapy in the management of brain metastases |
| IL298760A (en) | 2020-06-05 | 2023-02-01 | Kinnate Biopharma Inc | Fibroblast growth factor receptor kinase inhibitors |
| CN116515988A (zh) * | 2023-03-21 | 2023-08-01 | 中南大学湘雅二医院 | 用于评估长期使用糖皮质激素后t淋巴细胞功能的标志物 |
| WO2024249380A2 (en) * | 2023-05-26 | 2024-12-05 | University Of Vermont And State Agricultural College | 1h-pyrazolo[3,4-d]pyrimidin-4-amines as anti-infectious agents |
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| JP6130391B2 (ja) * | 2011-11-23 | 2017-05-17 | インテリカイン， エルエルシー | Ｍｔｏｒ阻害剤を使用する強化された治療レジメン |
-
2012
- 2012-11-21 JP JP2014543592A patent/JP6130391B2/ja active Active
- 2012-11-21 US US14/360,267 patent/US9174994B2/en active Active
- 2012-11-21 US US13/683,967 patent/US20130209543A1/en not_active Abandoned
- 2012-11-21 EP EP12851154.0A patent/EP2793893A4/en not_active Withdrawn
- 2012-11-21 HK HK15103955.0A patent/HK1203378A1/xx unknown
- 2012-11-21 CA CA2856803A patent/CA2856803A1/en not_active Abandoned
- 2012-11-21 WO PCT/US2012/066431 patent/WO2013078440A2/en not_active Ceased
- 2012-11-21 CN CN201280067718.1A patent/CN104363914A/zh active Pending
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2015
- 2015-10-15 US US14/884,120 patent/US9669032B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2793893A4 (en) | 2015-07-08 |
| US9669032B2 (en) | 2017-06-06 |
| US20140287031A1 (en) | 2014-09-25 |
| EP2793893A2 (en) | 2014-10-29 |
| US9174994B2 (en) | 2015-11-03 |
| CN104363914A (zh) | 2015-02-18 |
| CA2856803A1 (en) | 2013-05-30 |
| US20160038497A1 (en) | 2016-02-11 |
| US20130209543A1 (en) | 2013-08-15 |
| JP2015500209A (ja) | 2015-01-05 |
| WO2013078440A3 (en) | 2014-09-25 |
| HK1203378A1 (en) | 2015-10-30 |
| WO2013078440A2 (en) | 2013-05-30 |
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