JP6113393B2 - 機能的色素沈着皮膚同等物 - Google Patents

機能的色素沈着皮膚同等物 Download PDF

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Publication number
JP6113393B2
JP6113393B2 JP2009062725A JP2009062725A JP6113393B2 JP 6113393 B2 JP6113393 B2 JP 6113393B2 JP 2009062725 A JP2009062725 A JP 2009062725A JP 2009062725 A JP2009062725 A JP 2009062725A JP 6113393 B2 JP6113393 B2 JP 6113393B2
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Prior art keywords
equivalent
skin
pigmentation
melanocytes
fibroblasts
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Japanese (ja)
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JP2009219491A (ja
JP2009219491A5 (enExample
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クリスティーヌ・デュヴァル
フランソワ・ベルネール
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LOreal SA
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LOreal SA
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Priority claimed from FR0851705A external-priority patent/FR2928654B1/fr
Priority claimed from FR0852886A external-priority patent/FR2930644B1/fr
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Publication of JP2009219491A5 publication Critical patent/JP2009219491A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A61L27/3891—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types as distinct cell layers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/091—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells melanocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2009062725A 2008-03-17 2009-03-16 機能的色素沈着皮膚同等物 Active JP6113393B2 (ja)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
FR0851705 2008-03-17
FR0851705A FR2928654B1 (fr) 2008-03-17 2008-03-17 Equivalent de peau pigmentee fonctionnelle.
US4611908P 2008-04-18 2008-04-18
US61/046,119 2008-04-18
FR0852886A FR2930644B1 (fr) 2008-04-29 2008-04-29 Procede d'evaluation de la pigmentation
FR0852886 2008-04-29
US5389008P 2008-05-16 2008-05-16
US61/053,890 2008-05-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016093687A Division JP6240255B2 (ja) 2008-03-17 2016-05-09 機能的色素沈着皮膚同等物

Publications (3)

Publication Number Publication Date
JP2009219491A JP2009219491A (ja) 2009-10-01
JP2009219491A5 JP2009219491A5 (enExample) 2017-01-26
JP6113393B2 true JP6113393B2 (ja) 2017-04-12

Family

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JP2009062725A Active JP6113393B2 (ja) 2008-03-17 2009-03-16 機能的色素沈着皮膚同等物
JP2016093687A Active JP6240255B2 (ja) 2008-03-17 2016-05-09 機能的色素沈着皮膚同等物

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Country Status (6)

Country Link
US (1) US10612004B2 (enExample)
EP (1) EP2103687B1 (enExample)
JP (2) JP6113393B2 (enExample)
KR (1) KR101132578B1 (enExample)
CA (1) CA2658074C (enExample)
ES (1) ES2596811T3 (enExample)

Families Citing this family (24)

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US8728819B2 (en) 2006-08-29 2014-05-20 Fibrocell Technologies, Inc. Methods for culturing minimally-passaged fibroblasts and uses thereof
FR2957089A1 (fr) * 2010-03-05 2011-09-09 Immunosearch Methode d'evaluation du potentiel sensibilisant d'un compose test
KR101739330B1 (ko) 2010-10-29 2017-05-24 (주)아모레퍼시픽 진피 모사체를 이용한 피부 탄력 증진력 평가법
KR102031161B1 (ko) * 2011-10-18 2019-10-14 (주)아모레퍼시픽 피부 미백 물질 스크리닝 시스템
KR101874790B1 (ko) * 2011-11-23 2018-07-05 (주)아모레퍼시픽 멜라닌형성세포를 함유하는 인공피부 및 이의 제조방법
HK1205707A1 (en) * 2012-03-07 2015-12-24 Fibrocell Technologies, Inc. Topical dermal formulations and methods of personalized treatment of skin
FR3007037B1 (fr) * 2013-06-18 2016-07-29 Clarins Lab Modele d'epiderme reconstruit presentant des caracteristiques des taches de vieillesse
CN105916979A (zh) * 2013-11-14 2016-08-31 德玛奇实验室公司 成纤维细胞混合物及其制备和使用方法
US9554744B2 (en) * 2013-12-19 2017-01-31 International Business Machines Corporation Mining social media for ultraviolet light exposure analysis
WO2016151134A1 (fr) * 2015-03-26 2016-09-29 Université De Bordeaux Équivalent de peau et utilisation
DK3072535T5 (en) 2015-03-26 2017-06-06 Univ Bordeaux METHOD OF RECONSTRUCTION OF SKIN
HK1256840A1 (zh) * 2015-11-30 2019-10-04 德玛福斯控股有限责任公司 含有蛋白的外用皮肤组合物和使用方法
JP6817610B2 (ja) * 2016-04-05 2021-01-20 日本メナード化粧品株式会社 三次元培養表皮モデル及びその製造方法、ならびに三次元培養表皮モデルの使用方法
US10273549B2 (en) 2016-04-21 2019-04-30 Vitrolabs Inc. Engineered skin equivalent, method of manufacture thereof and products derived therefrom
JP6824689B2 (ja) * 2016-10-27 2021-02-03 株式会社ナリス化粧品 真皮シミ予防・改善剤及び／又はマクロファージ誘引剤のスクリーニング方法
KR102540981B1 (ko) * 2017-06-30 2023-06-08 (주)아모레퍼시픽 인공피부 제조방법 및 인공피부
JP7139136B2 (ja) * 2018-04-12 2022-09-20 小林製薬株式会社 メラノサイトの共存下でのケラチノサイトのオートファジー活性を増大又は抑制する物質のスクリーニング方法
JP7495354B2 (ja) 2018-11-30 2024-06-04 株式会社 資生堂 皮膚の色素沈着を治療または予防するための組成物
EP3889247A4 (en) * 2018-11-30 2022-10-19 Shiseido Company, Ltd. SKIN PIGMENTATION MODEL AND METHOD FOR PRODUCTION THEREOF, AND FACTOR EVALUATION METHOD FOR TREATMENT OR PREVENTION OF SKIN PIGMENTATION
JP7650019B2 (ja) * 2020-01-10 2025-03-24 ポーラ化成工業株式会社 真皮の神経線維量の推定方法、肌のシミ濃度及び／又はシミ発生リスクの推定方法
JP6810288B2 (ja) * 2020-01-22 2021-01-06 株式会社ナリス化粧品 真皮シミ予防・改善剤及び／又はマクロファージ誘引剤のスクリーニング方法
CN111337494A (zh) * 2020-03-27 2020-06-26 济南磐升生物技术有限公司 一种人工表皮化妆品检测试剂盒的制备方法及其应用
JP7576821B2 (ja) * 2020-07-16 2024-11-01 学校法人順天堂 再生ヒト皮膚組織の製造法
WO2025100384A1 (ja) * 2023-11-06 2025-05-15 株式会社アンズコーポレーション 三次元皮膚モデル

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Publication number Priority date Publication date Assignee Title
FR2612938B1 (fr) 1987-03-26 1989-06-23 Cird Procede d'obtention d'un equivalent de peau et equivalent de peau correspondant
JP2950519B2 (ja) * 1991-02-28 1999-09-20 アンティキャンサー インコーポレイテッド 皮膚の未変性状態組織培養法
FR2689904B1 (fr) 1992-04-08 1994-12-16 Martin Rosdy Test de bronzage épidermique in vitro.
WO1995010600A1 (fr) 1993-10-08 1995-04-20 Martin Rosdy Test de bronzage epidermique humain in vitro
US6123959A (en) * 1998-04-24 2000-09-26 Univera Pharmaceuticals, Inc. Aqueous composition comprising active ingredients for the de-pigmentation of the skin
US6479072B1 (en) * 1999-02-11 2002-11-12 The General Hospital Corporation Microfabricated membranes and matrices
US6974697B2 (en) * 2001-03-02 2005-12-13 Stratech Corporation Skin substitutes with improved barrier function
US20020192738A1 (en) * 2001-04-27 2002-12-19 Janice Brissette Tyrosinase assay
US7429391B2 (en) * 2004-01-30 2008-09-30 Access Business Group International Llc Holistic composition and method for reducing skin pigmentation
FR2879474B1 (fr) 2004-12-16 2008-06-13 Air Liquide Procede d'epuration d'un melange entrant comportant du dioxyde de carbone (co2) et du monoxyde de carbone (co) en vue de l'elimination du monoxyde de carbone (co) contenu dans ce melange
FR2879747A1 (fr) * 2004-12-16 2006-06-23 Oreal Procede d'evaluation in vitro du potentiel protecteur contre la photoimmunosuppression ou du caractere photosensibilisant de produits ou de compositions.
KR100806695B1 (ko) 2005-11-25 2008-02-27 주식회사 엠씨티티 색소화 질환 치료용 세포치료 약제학적 조성물
FR2903702B1 (fr) 2006-07-13 2012-10-19 Oreal Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation

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Publication number Publication date
CA2658074A1 (fr) 2009-09-17
JP2009219491A (ja) 2009-10-01
US20090239254A1 (en) 2009-09-24
CA2658074C (fr) 2017-11-07
JP6240255B2 (ja) 2017-11-29
KR20090099491A (ko) 2009-09-22
JP2016144472A (ja) 2016-08-12
EP2103687A1 (fr) 2009-09-23
ES2596811T3 (es) 2017-01-12
EP2103687B1 (fr) 2016-07-13
KR101132578B1 (ko) 2012-04-06
US10612004B2 (en) 2020-04-07

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