JP6101250B2 - 治療薬としてのイソオキサゾリン類 - Google Patents

治療薬としてのイソオキサゾリン類 Download PDF

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JP6101250B2
JP6101250B2 JP2014509340A JP2014509340A JP6101250B2 JP 6101250 B2 JP6101250 B2 JP 6101250B2 JP 2014509340 A JP2014509340 A JP 2014509340A JP 2014509340 A JP2014509340 A JP 2014509340A JP 6101250 B2 JP6101250 B2 JP 6101250B2
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carboxamide
dihydroisoxazol
methyl
methoxybenzyl
fluoro
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JP2014513122A (ja
JP2014513122A5 (OSRAM
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カルダーウツド，デイビツド・ジエイ
ブレインリンガー，エリツク・シー
スワン，ステイーブン・エル
ムカルジー，スブヘンドウ
チテイ，ベンカタ・シユリーカーント
トウヌグントラ，シバ・サンジーバ・ラーオ
ホサハリ，スブラマニヤ・シータラーマ・シヤストリ
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アッヴィ・インコーポレイテッド
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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014081800A1 (en) * 2012-11-21 2014-05-30 Zoetis Llc Synthesis of spirocyclic isoxazoline derivatives
US20150065724A1 (en) * 2013-09-05 2015-03-05 Abbvie Inc. Diastereoselective methods for synthesizing compounds
EP3325465B1 (en) * 2015-07-17 2022-05-18 Syngenta Participations AG Pesticidally active pyrazole derivatives
EP3145168A1 (en) 2015-09-17 2017-03-22 Thomson Licensing An apparatus and a method for generating data representing a pixel beam
MX2020001724A (es) 2017-08-14 2020-07-29 Boehringer Ingelheim Animal Health Usa Inc Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas.
CN112638908A (zh) * 2018-09-04 2021-04-09 豪夫迈·罗氏有限公司 用于治疗自身免疫性疾病的苯并噻唑类化合物
WO2022056447A1 (en) * 2020-09-14 2022-03-17 Genzyme Corporation Carboxylic acid-containing compounds as modulators of bis-phosphoglycerate mutase for the treatment of sickle cell disease
WO2022233877A1 (en) 2021-05-03 2022-11-10 Katholieke Universiteit Leuven Treatment of pharmacoresistant epilepsy

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
CO5170501A1 (es) 1999-04-14 2002-06-27 Novartis Ag AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO
ECSP003448A (es) 2000-04-27 2000-05-25 Azoles sustituidos
US20040132726A1 (en) 2002-08-09 2004-07-08 Astrazeneca Ab And Nps Pharmaceuticals, Inc. New compounds
US20040067985A1 (en) * 2002-10-04 2004-04-08 Fortuna Haviv Method of inhibiting angiogenesis
ATE388941T1 (de) 2002-11-02 2008-03-15 Sanofi Aventis Deutschland Neue pyrimidin-4,6-dicarbons urediamide zur selektiven inhibierung von kollagenasen
US7166609B2 (en) * 2002-11-02 2007-01-23 Sanofi-Aventis Deutschland Gmbh Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases
WO2004043349A2 (en) 2002-11-06 2004-05-27 Bristol-Myers Squibb Company Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
US20050004111A1 (en) * 2003-01-03 2005-01-06 Aventis Pharma Deutschland Gmbh Selective MMP-13 inhibitors
US20070259874A1 (en) 2003-11-26 2007-11-08 Palle Venkata P Phosphodiesterase Inhibitors
UA86614C2 (ru) 2004-01-23 2009-05-12 Амген Инк Соединение, которое имеет активность ингибитора киназ, фармацевтическая композиция, которая включает указанное соединение, и их применение для приготовления лекарственного препарата
JP4883296B2 (ja) * 2004-03-05 2012-02-22 日産化学工業株式会社 イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
DE102004023635A1 (de) 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
ES2567853T3 (es) * 2005-01-25 2016-04-26 Synta Pharmaceuticals Corporation Compuestos contra la inflamación y utilizaciones relacionadas con el sistema inmunitario
ATE537169T1 (de) 2005-08-15 2011-12-15 Hoffmann La Roche Piperidin- und piperazinderivate als p2x3- antagonisten
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
BRPI0620668A2 (pt) 2005-12-14 2011-11-22 Du Pont composto da fórmula 1, composição que compreende composto, composição de controle de pragas invertebradas, composição de pulverização, composição de isca, dispositivo de armadilha, métodos de controle de pragas invertebradas, método de controle de baratas, formigas ou cupins e método de proteção de sementes contra pragas invertebradas
CN101330828A (zh) * 2005-12-14 2008-12-24 杜邦公司 用于防治无脊椎害虫的异噁唑啉
US20090163549A1 (en) 2005-12-15 2009-06-25 Hiroyuki Kai Pharmaceutical Composition Comprising an Amide Derivative
WO2007079199A2 (en) * 2005-12-30 2007-07-12 Alantos Pharmaceuticals, Holding, Inc. Substituted bis-amide metalloprotease inhibitors
TWI412322B (zh) * 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
KR20090005201A (ko) * 2006-04-20 2009-01-12 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충 방제용 피라졸린
ES2805286T3 (es) 2006-12-26 2021-02-11 Lantheus Medical Imaging Inc Ligandos para la formación de imágenes de la inervación cardíaca
CN101815706A (zh) * 2007-06-13 2010-08-25 杜邦公司 异*唑啉杀昆虫剂
US20090035381A1 (en) 2007-08-01 2009-02-05 Stankus John J Electrospraying method for fabrication of particles and coatings and treatment methods thereof
JP2010535192A (ja) * 2007-08-02 2010-11-18 ファイザー・インク ピリミジンおよびピリジン誘導体ならびにその薬学的な使用および組成物
CA2700598C (en) 2007-08-10 2012-11-20 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and pest control agent
US8168114B2 (en) 2007-09-12 2012-05-01 University Of Washington Through Its Center For Commercialization Methods for blow molding solid-state cellular thermoplastic articles
ES2553412T3 (es) 2007-10-31 2015-12-09 Merck Sharp & Dohme Corp. Antagonistas del receptor P2X3 para el tratamiento del dolor
TWI411395B (zh) * 2007-12-24 2013-10-11 Syngenta Participations Ag 殺蟲化合物
JP2009286773A (ja) 2008-03-14 2009-12-10 Bayer Cropscience Ag 殺虫性縮環式アリール類
ES2421537T3 (es) 2008-05-01 2013-09-03 Vitae Pharmaceuticals Inc Inhibidores cíclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
RS54560B1 (sr) 2008-06-10 2016-06-30 Abbvie Inc. Triciklična jedinjenja
WO2010010187A1 (en) 2008-07-25 2010-01-28 Galapagos Nv Novel compounds useful for the treatment of degenerative and inflammatory diseases
ES2434734T3 (es) 2008-08-22 2013-12-17 Syngenta Participations Ag Compuestos insecticidas
WO2010045191A2 (en) 2008-10-13 2010-04-22 Vuelogic, Llc Methods and systems for customer performance scoring
WO2010045190A1 (en) 2008-10-15 2010-04-22 Boehringer Ingelheim International Gmbh Fused heteroaryl diamide compounds useful as mmp-13 inhibitors
AU2009309019B2 (en) * 2008-10-31 2014-11-13 Merck Sharp & Dohme Llc P2X3, receptor antagonists for treatment of pain
BRPI0923009B1 (pt) * 2008-12-19 2018-07-17 Elanco Tiergesundheit Ag compostos de isoxazolina, composição para o controle de parasitas e uso de compostos de isoxazolina para o preparo de composição para o controle de parasitas
CN102292331A (zh) 2009-01-22 2011-12-21 先正达参股股份有限公司 杀虫化合物
EP2414353A1 (en) 2009-04-01 2012-02-08 Basf Se Isoxazoline compounds for combating invertebrate pests
EP2417121A1 (en) 2009-04-10 2012-02-15 Pfizer Inc. 4, 5-dihydro-1h-pyrazole compounds and their pharmaceutical uses
GB0910003D0 (en) 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
FR2948939B1 (fr) 2009-08-05 2013-03-22 Pf Medicament Derives de 2h pyridazin-3-ones, leur preparation et leur application en therapeutique humaine
TWI487486B (zh) * 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
GB2481118A (en) 2010-06-09 2011-12-14 Syngenta Participations Ag Pesticidal mixtures comprising enantiomerically enriched isoxazoline derivatives
KR20130089232A (ko) 2010-06-15 2013-08-09 바이엘 인텔렉쳐 프로퍼티 게엠베하 안트라닐산 디아미드 유도체
DK178277B1 (da) 2010-06-18 2015-10-26 Novartis Tiergesundheit Ag Diaryloxazolinforbindelser til bekæmpelse af fiskelus
CA2826067A1 (en) 2011-02-10 2012-08-16 Novartis Ag Isoxazoline derivatives for controlling invertebrate pests

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