JP6096117B2 - 抗ｃｄ４８抗体およびその使用 - Google Patents

抗ｃｄ４８抗体およびその使用 Download PDF

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Publication number
JP6096117B2
JP6096117B2 JP2013530383A JP2013530383A JP6096117B2 JP 6096117 B2 JP6096117 B2 JP 6096117B2 JP 2013530383 A JP2013530383 A JP 2013530383A JP 2013530383 A JP2013530383 A JP 2013530383A JP 6096117 B2 JP6096117 B2 JP 6096117B2
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JP
Japan
Prior art keywords
antibody
human
antigen
seq
antibodies
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Expired - Fee Related
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JP2013530383A
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English (en)
Japanese (ja)
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JP2013542194A (ja
JP2013542194A5 (enExample
Inventor
ブレンダン・ジェイ・クラソン
アナ・コスティク
シュンバオ・デュアン
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of JP2013542194A5 publication Critical patent/JP2013542194A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2013530383A 2010-09-27 2011-09-26 抗ｃｄ４８抗体およびその使用 Expired - Fee Related JP6096117B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US38674610P 2010-09-27 2010-09-27
US61/386,746 2010-09-27
US201161475280P 2011-04-14 2011-04-14
US61/475,280 2011-04-14
US201161515490P 2011-08-05 2011-08-05
US61/515,490 2011-08-05
PCT/US2011/053193 WO2012047567A1 (en) 2010-09-27 2011-09-26 Anti-cd48 antibodies and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016210605A Division JP2017036324A (ja) 2010-09-27 2016-10-27 抗ｃｄ４８抗体およびその使用

Publications (3)

Publication Number Publication Date
JP2013542194A JP2013542194A (ja) 2013-11-21
JP2013542194A5 JP2013542194A5 (enExample) 2014-11-13
JP6096117B2 true JP6096117B2 (ja) 2017-03-15

Family

ID=45870888

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013530383A Expired - Fee Related JP6096117B2 (ja) 2010-09-27 2011-09-26 抗ｃｄ４８抗体およびその使用
JP2016210605A Pending JP2017036324A (ja) 2010-09-27 2016-10-27 抗ｃｄ４８抗体およびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016210605A Pending JP2017036324A (ja) 2010-09-27 2016-10-27 抗ｃｄ４８抗体およびその使用

Country Status (19)

Country Link
US (1) US9228014B2 (enExample)
EP (1) EP2621952A1 (enExample)
JP (2) JP6096117B2 (enExample)
KR (1) KR20140014067A (enExample)
CN (1) CN103261226B (enExample)
AR (1) AR083044A1 (enExample)
AU (1) AU2011312623B2 (enExample)
BR (1) BR112013007314A2 (enExample)
CA (1) CA2812748A1 (enExample)
CL (1) CL2013000843A1 (enExample)
EA (1) EA030437B1 (enExample)
IL (1) IL225484A (enExample)
MX (1) MX348417B (enExample)
MY (1) MY165273A (enExample)
NZ (1) NZ608660A (enExample)
PH (1) PH12013500564A1 (enExample)
SG (1) SG189089A1 (enExample)
TW (1) TWI507416B (enExample)
WO (1) WO2012047567A1 (enExample)

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RS64172B1 (sr) 2012-06-28 2023-05-31 Univ Of Central Florida Research Foundation Incorporated Postupci i kompozicije za ćelije prirodne ubice
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
EP3189077A2 (en) * 2014-09-05 2017-07-12 Aimm Therapeutics B.V. Hepatitis c virus specific antibody
MX382582B (es) * 2015-03-18 2025-03-13 Seagen Inc Anticuerpos contra cúmulo de diferenciación 48 (cd48) y sus conjugados.
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法（一）
WO2018039499A1 (en) 2016-08-24 2018-03-01 Regeneron Pharmaceuticals, Inc. Host cell protein modification
JP6805884B2 (ja) 2017-02-28 2020-12-23 住友ゴム工業株式会社 二輪自動用空気入りタイヤ
EP3649144A4 (en) 2017-07-06 2021-07-21 Regeneron Pharmaceuticals, Inc. CELL CULTURE PROCESS TO PRODUCE GLYCOPROTEIN
BR112020010615A2 (pt) 2017-12-22 2020-10-27 Regeneron Pharmaceuticals, Inc. produto farmacêutico proteico, método e sistema para caracterizar impurezas de produto farmacêutico proteico e de fármaco de baixo peso molecular, método para produzir um anticorpo, anticorpo, e, usos do método e do sistema
SG11202005235WA (en) 2018-01-31 2020-07-29 Regeneron Pharma System and method for characterizing size and charge variant drug product impurities
TWI786265B (zh) 2018-02-02 2022-12-11 美商再生元醫藥公司 用於表徵蛋白質二聚合之系統及方法
KR20200127979A (ko) 2018-02-28 2020-11-11 리제너론 파마슈티칼스 인코포레이티드 바이러스 오염물질을 확인하기 위한 시스템 및 방법
US12259355B2 (en) 2018-03-19 2025-03-25 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
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EA202191841A1 (ru) 2019-01-16 2021-10-07 Ридженерон Фармасьютикалз, Инк. Способы для идентификации свободных тиолов в белках
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Also Published As

Publication number Publication date
MX2013003468A (es) 2013-05-31
MY165273A (en) 2018-03-20
US20120076790A1 (en) 2012-03-29
CL2013000843A1 (es) 2014-03-07
KR20140014067A (ko) 2014-02-05
CN103261226B (zh) 2016-06-15
WO2012047567A1 (en) 2012-04-12
US9228014B2 (en) 2016-01-05
CN103261226A (zh) 2013-08-21
JP2013542194A (ja) 2013-11-21
NZ608660A (en) 2015-03-27
PH12013500564A1 (en) 2021-06-02
IL225484A0 (en) 2013-06-27
CA2812748A1 (en) 2012-04-12
TW201305206A (zh) 2013-02-01
EA201370081A1 (ru) 2013-12-30
AU2011312623B2 (en) 2016-12-15
TWI507416B (zh) 2015-11-11
BR112013007314A2 (pt) 2017-03-21
SG189089A1 (en) 2013-05-31
JP2017036324A (ja) 2017-02-16
AU2011312623A1 (en) 2013-05-02
IL225484A (en) 2017-07-31
EP2621952A1 (en) 2013-08-07
AR083044A1 (es) 2013-01-30
EA030437B1 (ru) 2018-08-31
MX348417B (es) 2017-06-12

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