AU2011312623B2 - Anti-CD48 antibodies and uses thereof - Google Patents
Anti-CD48 antibodies and uses thereof Download PDFInfo
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- AU2011312623B2 AU2011312623B2 AU2011312623A AU2011312623A AU2011312623B2 AU 2011312623 B2 AU2011312623 B2 AU 2011312623B2 AU 2011312623 A AU2011312623 A AU 2011312623A AU 2011312623 A AU2011312623 A AU 2011312623A AU 2011312623 B2 AU2011312623 B2 AU 2011312623B2
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
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- Chemical & Material Sciences (AREA)
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- Mycology (AREA)
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| EP4279579A3 (en) * | 2012-06-28 | 2024-02-21 | University Of Central Florida Research Foundation Incorporated | Methods and compositions for natural killer cells |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| US10435463B2 (en) * | 2014-09-05 | 2019-10-08 | Academisch Medisch Centrum | Hepatitis C virus specific antibody |
| US10722592B2 (en) * | 2015-03-18 | 2020-07-28 | Seattle Genetics, Inc. | CD48 antibodies and conjugates thereof |
| TW202440903A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法（一） |
| EP3504328A1 (en) | 2016-08-24 | 2019-07-03 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| JP6805884B2 (ja) | 2017-02-28 | 2020-12-23 | 住友ゴム工業株式会社 | 二輪自動用空気入りタイヤ |
| AU2018298039B2 (en) | 2017-07-06 | 2023-02-02 | Regeneron Pharmaceuticals, Inc. | Cell culture process for making a glycoprotein |
| SG11202004380QA (en) | 2017-12-22 | 2020-06-29 | Regeneron Pharma | System and method for characterizing drug product impurities |
| CN111655722A (zh) | 2018-01-31 | 2020-09-11 | 瑞泽恩制药公司 | 用于表征药物产品杂质的系统和方法 |
| TW202311746A (zh) | 2018-02-02 | 2023-03-16 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
| BR112020013426A2 (pt) | 2018-02-28 | 2020-12-01 | Regeneron Pharmaceuticals, Inc. | métodos para identificação de um vírus em uma amostra e para detecção de ácidos nucleicos virais em uma amostra de cultura de células |
| EA202092203A1 (ru) | 2018-03-19 | 2020-12-07 | Ридженерон Фармасьютикалз, Инк. | Способы анализа и реагенты для микрочипового капиллярного электрофореза |
| US12259355B2 (en) | 2018-03-19 | 2025-03-25 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| US12253490B2 (en) | 2018-03-19 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
| EA202092684A1 (ru) | 2018-08-27 | 2021-03-11 | Ридженерон Фармасьютикалз, Инк. | Применение рамановской спектроскопии для последующей очистки |
| TWI866924B (zh) | 2018-08-30 | 2024-12-21 | 美商再生元醫藥公司 | 用於將蛋白質複合物定特徵之方法 |
| CN117110492A (zh) | 2019-01-16 | 2023-11-24 | 瑞泽恩制药公司 | 鉴别蛋白质中的游离巯基的方法 |
| SG11202110911RA (en) | 2019-05-13 | 2021-10-28 | Regeneron Pharma | Improved competitive ligand binding assays |
| BR112022004885A2 (pt) | 2019-09-24 | 2022-06-07 | Regeneron Pharma | Sistemas e métodos para uso e regeneração de cromatografia |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| IL293112A (en) | 2019-11-25 | 2022-07-01 | Regeneron Pharma | Sustained release formulations using non-aqueous emulsions |
| BR112022014212B1 (pt) | 2020-01-21 | 2024-01-23 | Regeneron Pharmaceuticals, Inc | Métodos de análise de uma amostra incluindo uma proteína de interesse |
| LT4157876T (lt) * | 2020-05-26 | 2024-10-25 | Boehringer Ingelheim International Gmbh | Anti-pd-1 antikūnai |
| KR20230058094A (ko) | 2020-08-31 | 2023-05-02 | 리제너론 파아마슈티컬스, 인크. | 세포 배양 성능을 개선하고 아스파라긴 서열 변이체를 완화하기 위한 아스파라긴 공급 전략 |
| EP4251648A2 (en) * | 2020-11-24 | 2023-10-04 | Novartis AG | Anti-cd48 antibodies, antibody drug conjugates, and uses thereof |
| WO2022115588A1 (en) | 2020-11-25 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Sustained release formulations using non-aqueous membrane emulsification |
| US12350374B2 (en) | 2020-12-17 | 2025-07-08 | Regeneron Pharmaceuticals, Inc. | Fabrication of protein-encapsulating microgels |
| JP2024503408A (ja) | 2021-01-20 | 2024-01-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 細胞培養におけるタンパク質力価の改善方法 |
| JP2024512299A (ja) | 2021-03-03 | 2024-03-19 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | タンパク質の粘度を定量及び変更するためのシステム及び方法 |
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| US20070212353A1 (en) * | 2006-02-14 | 2007-09-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Novel therapeutic target and diagnostic marker for asthma and related conditions |
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| US4692405A (en) | 1985-03-05 | 1987-09-08 | Dana-Farber Cancer Institute, Inc. | Monoclonal antibodies to antigen on activated human B-cells and assay therefor, protein antigenic determinant therefor and method of making same |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| US5576423A (en) | 1994-12-02 | 1996-11-19 | Schering Corporation | Antibodies to the slam protein expressed on activated T cells |
| WO1997035614A1 (en) | 1996-03-27 | 1997-10-02 | Crc For Biopharmaceutical Research Pty. Ltd. | The use of antibodies against cd48 for the treatment of t and b cell lymphomas and leukemias |
| EP1749538A4 (en) | 2004-03-31 | 2009-11-11 | Kirin Pharma Kk | METHOD FOR DETERMINING THE DIFFERENTIATION OF REGULATORY T CELLS AND THEIR PROLIFERATION WITH GPI ANCHOR PROTEIN AGONISTS AND MEDICINAL COMPOSITION THEREFOR |
| US7850962B2 (en) | 2004-04-20 | 2010-12-14 | Genmab A/S | Human monoclonal antibodies against CD20 |
| PL2374818T3 (pl) | 2006-06-02 | 2013-05-31 | Regeneron Pharma | Przeciwciała o wysokim powinowactwie przeciw ludzkiemu receptorowi IL 6 |
| WO2010117059A1 (ja) | 2009-04-10 | 2010-10-14 | 国立大学法人大阪大学 | 形質細胞の腫瘍性増殖をきたす疾患の治療薬 |
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| US20070212353A1 (en) * | 2006-02-14 | 2007-09-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Novel therapeutic target and diagnostic marker for asthma and related conditions |
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| CN103261226B (zh) | 2016-06-15 |
| IL225484A (en) | 2017-07-31 |
| PH12013500564A1 (en) | 2021-06-02 |
| TW201305206A (zh) | 2013-02-01 |
| AU2011312623A1 (en) | 2013-05-02 |
| IL225484A0 (en) | 2013-06-27 |
| CA2812748A1 (en) | 2012-04-12 |
| WO2012047567A1 (en) | 2012-04-12 |
| CN103261226A (zh) | 2013-08-21 |
| US9228014B2 (en) | 2016-01-05 |
| CL2013000843A1 (es) | 2014-03-07 |
| MX348417B (es) | 2017-06-12 |
| AR083044A1 (es) | 2013-01-30 |
| MX2013003468A (es) | 2013-05-31 |
| EA201370081A1 (ru) | 2013-12-30 |
| JP2013542194A (ja) | 2013-11-21 |
| BR112013007314A2 (pt) | 2017-03-21 |
| JP2017036324A (ja) | 2017-02-16 |
| SG189089A1 (en) | 2013-05-31 |
| MY165273A (en) | 2018-03-20 |
| NZ608660A (en) | 2015-03-27 |
| EP2621952A1 (en) | 2013-08-07 |
| EA030437B1 (ru) | 2018-08-31 |
| KR20140014067A (ko) | 2014-02-05 |
| TWI507416B (zh) | 2015-11-11 |
| US20120076790A1 (en) | 2012-03-29 |
| JP6096117B2 (ja) | 2017-03-15 |
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