JP6093755B2 - 急性骨髄性白血病を治療するためのサパシタビンとデシタビンの組合せの投与計画 - Google Patents

急性骨髄性白血病を治療するためのサパシタビンとデシタビンの組合せの投与計画 Download PDF

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Publication number
JP6093755B2
JP6093755B2 JP2014504392A JP2014504392A JP6093755B2 JP 6093755 B2 JP6093755 B2 JP 6093755B2 JP 2014504392 A JP2014504392 A JP 2014504392A JP 2014504392 A JP2014504392 A JP 2014504392A JP 6093755 B2 JP6093755 B2 JP 6093755B2
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Japan
Prior art keywords
treatment
decitabine
sapacitabine
treatment cycle
weeks
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JP2014504392A
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English (en)
Japanese (ja)
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JP2014510780A5 (enExample
JP2014510780A (ja
Inventor
ジュディ チアオ
ジュディ チアオ
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サイクラセル リミテッド
サイクラセル リミテッド
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Priority claimed from GBGB1106339.3A external-priority patent/GB201106339D0/en
Priority claimed from GBGB1117693.0A external-priority patent/GB201117693D0/en
Priority claimed from GBGB1121105.9A external-priority patent/GB201121105D0/en
Application filed by サイクラセル リミテッド, サイクラセル リミテッド filed Critical サイクラセル リミテッド
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Publication of JP2014510780A5 publication Critical patent/JP2014510780A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014504392A 2011-04-14 2012-04-13 急性骨髄性白血病を治療するためのサパシタビンとデシタビンの組合せの投与計画 Expired - Fee Related JP6093755B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1106339.3A GB201106339D0 (en) 2011-04-14 2011-04-14 Combination
GB1106339.3 2011-04-14
GBGB1117693.0A GB201117693D0 (en) 2011-10-13 2011-10-13 Combination
GB1117693.0 2011-10-13
GB1121105.9 2011-12-08
GBGB1121105.9A GB201121105D0 (en) 2011-12-08 2011-12-08 Combination
PCT/GB2012/050815 WO2012140436A1 (en) 2011-04-14 2012-04-13 Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia

Publications (3)

Publication Number Publication Date
JP2014510780A JP2014510780A (ja) 2014-05-01
JP2014510780A5 JP2014510780A5 (enExample) 2015-04-30
JP6093755B2 true JP6093755B2 (ja) 2017-03-08

Family

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JP2014504392A Expired - Fee Related JP6093755B2 (ja) 2011-04-14 2012-04-13 急性骨髄性白血病を治療するためのサパシタビンとデシタビンの組合せの投与計画

Country Status (7)

Country Link
US (2) US10226478B2 (enExample)
EP (2) EP3560501A1 (enExample)
JP (1) JP6093755B2 (enExample)
ES (1) ES2743691T3 (enExample)
HU (1) HUE046177T2 (enExample)
PL (1) PL2696878T3 (enExample)
WO (1) WO2012140436A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10226478B2 (en) 2011-04-14 2019-03-12 Cyclacel Limited Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia
JP6286421B2 (ja) 2012-05-15 2018-02-28 サイクラセル リミテッド サパシタビン及びセリシクリブの投与レジメン
JP2016538310A (ja) * 2013-11-27 2016-12-08 オンコエシックス ゲーエムベーハー チエノトリアゾロジアゼピン化合物を含む医薬製剤を用いる白血病の治療方法
WO2019081951A1 (en) 2017-10-27 2019-05-02 Cyclacel Limited DOSAGE REGIME
WO2021079129A1 (en) 2019-10-24 2021-04-29 Cyclacel Limited Dosing regimen

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GB0609530D0 (en) 2006-05-12 2006-06-21 Cyclacel Ltd Combination
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GB0625283D0 (en) 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US8536188B2 (en) 2007-04-25 2013-09-17 Cyclacel Limited Dosing regimens for treatment of proliferative disorders comprising administration of sapacitabine
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CA2725295C (en) * 2008-06-09 2016-11-08 Cyclacel Limited Combination of sapacitabine (cndac) and dna methyltransferase inhibitors such as decitabine and procaine
US10226478B2 (en) 2011-04-14 2019-03-12 Cyclacel Limited Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia

Also Published As

Publication number Publication date
EP3560501A1 (en) 2019-10-30
US20140094428A1 (en) 2014-04-03
ES2743691T3 (es) 2020-02-20
US10226478B2 (en) 2019-03-12
EP2696878B1 (en) 2019-07-10
WO2012140436A1 (en) 2012-10-18
PL2696878T3 (pl) 2020-01-31
EP2696878A1 (en) 2014-02-19
JP2014510780A (ja) 2014-05-01
US20190314396A1 (en) 2019-10-17
HUE046177T2 (hu) 2020-02-28

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