HUE046177T2 - Szapacitabin és decitabin kombinációjának adagolási rendje akut mieloid leukémia kezelésére - Google Patents

Szapacitabin és decitabin kombinációjának adagolási rendje akut mieloid leukémia kezelésére

Info

Publication number
HUE046177T2
HUE046177T2 HUE12717824A HUE12717824A HUE046177T2 HU E046177 T2 HUE046177 T2 HU E046177T2 HU E12717824 A HUE12717824 A HU E12717824A HU E12717824 A HUE12717824 A HU E12717824A HU E046177 T2 HUE046177 T2 HU E046177T2
Authority
HU
Hungary
Prior art keywords
sapacitabine
decitabine
combination
myeloid leukemia
acute myeloid
Prior art date
Application number
HUE12717824A
Other languages
English (en)
Hungarian (hu)
Inventor
Judy Chiao
Original Assignee
Cyclacel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1106339.3A external-priority patent/GB201106339D0/en
Priority claimed from GBGB1117693.0A external-priority patent/GB201117693D0/en
Priority claimed from GBGB1121105.9A external-priority patent/GB201121105D0/en
Application filed by Cyclacel Ltd filed Critical Cyclacel Ltd
Publication of HUE046177T2 publication Critical patent/HUE046177T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HUE12717824A 2011-04-14 2012-04-13 Szapacitabin és decitabin kombinációjának adagolási rendje akut mieloid leukémia kezelésére HUE046177T2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1106339.3A GB201106339D0 (en) 2011-04-14 2011-04-14 Combination
GBGB1117693.0A GB201117693D0 (en) 2011-10-13 2011-10-13 Combination
GBGB1121105.9A GB201121105D0 (en) 2011-12-08 2011-12-08 Combination

Publications (1)

Publication Number Publication Date
HUE046177T2 true HUE046177T2 (hu) 2020-02-28

Family

ID=46022492

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12717824A HUE046177T2 (hu) 2011-04-14 2012-04-13 Szapacitabin és decitabin kombinációjának adagolási rendje akut mieloid leukémia kezelésére

Country Status (7)

Country Link
US (2) US10226478B2 (enExample)
EP (2) EP3560501A1 (enExample)
JP (1) JP6093755B2 (enExample)
ES (1) ES2743691T3 (enExample)
HU (1) HUE046177T2 (enExample)
PL (1) PL2696878T3 (enExample)
WO (1) WO2012140436A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10226478B2 (en) 2011-04-14 2019-03-12 Cyclacel Limited Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia
EP2874631A1 (en) 2012-05-15 2015-05-27 Cyclacel Limited Dosage regimen for sapacitabine and seliciclib
EP3074018A1 (en) * 2013-11-27 2016-10-05 Oncoethix GmbH Method of treating leukemia using pharmaceutical formulation containing thienotriazolodiazepine compounds
WO2019081951A1 (en) 2017-10-27 2019-05-02 Cyclacel Limited DOSAGE REGIME
WO2021079129A1 (en) 2019-10-24 2021-04-29 Cyclacel Limited Dosing regimen

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RU2085557C1 (ru) 1991-09-30 1997-07-27 Санкио Компани Лимитед Производные нуклеозидов пиримидина или их фармацевтически приемлемые соли и способ их получения
US5824984A (en) 1997-03-31 1998-10-20 Morrow; John A. Portable electric wire cutter
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MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EA007867B1 (ru) 2000-05-26 2007-02-27 Айденикс (Кайман) Лимитед Композиции для лечения флавивирусных и пестивирусных инфекций и способы их применения
AU2001270134B2 (en) 2000-06-22 2006-06-15 University Of Iowa Research Foundation Methods for enhancing antibody-induced cell lysis and treating cancer
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ES2402597T3 (es) 2000-10-18 2013-05-07 Gilead Pharmasset Llc Nucleósidos modificados para el tratamiento de infecciones víricas y proliferación celular anormal
EP1360325A2 (en) 2000-10-18 2003-11-12 Pharmasset Limited Multiplex quantification of nucleic acids in diseased cells
JP2004538247A (ja) 2000-12-08 2004-12-24 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー セミカルバジド及びサイクリン依存キナーゼ阻害剤
JP3748536B2 (ja) 2001-02-09 2006-02-22 三共株式会社 ピリミジンヌクレオシド誘導体の結晶
US6908906B2 (en) 2001-02-09 2005-06-21 Sankyo Company, Limited Crystalline forms of pyrimidine nucleoside derivative
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JP2004535411A (ja) 2001-05-25 2004-11-25 ブリストルーマイヤーズ スクイブ カンパニー マトリックスメタロプロテナーゼ及び／またはＴＮＦ−α転換酵素（ＴＡＣＥ）の阻害剤としてのヒダントイン及び関連複素環化合物
WO2003039536A1 (en) 2001-11-07 2003-05-15 Yale University Enhancement of taxane-based chemotherapy by a cdk1 antagonist
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GB0328180D0 (en) 2003-12-04 2004-01-07 Cyclacel Ltd Combination
JP5106098B2 (ja) 2005-02-28 2012-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド化合物の抗癌剤との新規併用
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GB0609530D0 (en) 2006-05-12 2006-06-21 Cyclacel Ltd Combination
JP2009543768A (ja) 2006-07-14 2009-12-10 アステックス・セラピューティクス・リミテッド 医薬組み合わせ
GB0625283D0 (en) 2006-12-19 2007-01-24 Cyclacel Ltd Combination
ES2587381T3 (es) * 2007-04-25 2016-10-24 Cyclacel Limited Uso de sapacitabina para tratar una enfermedad proliferativa
US8124593B2 (en) 2007-11-05 2012-02-28 Cyclacel Limited Methods of treatment using sapacitabine
CN101185629A (zh) 2007-12-14 2008-05-28 山东蓝金生物工程有限公司 一种治疗实体肿瘤的地西他滨缓释剂
GB0808357D0 (en) 2008-05-08 2008-06-18 Cyclacel Ltd Process
US8530445B2 (en) 2008-06-09 2013-09-10 Cyclacel Limited Combinations of sapacitabine or CNDAC with DNA methyltransferase inhibitors such as decitabine and procaine
US10226478B2 (en) 2011-04-14 2019-03-12 Cyclacel Limited Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia

Also Published As

Publication number Publication date
WO2012140436A1 (en) 2012-10-18
EP2696878B1 (en) 2019-07-10
EP3560501A1 (en) 2019-10-30
JP6093755B2 (ja) 2017-03-08
US10226478B2 (en) 2019-03-12
US20140094428A1 (en) 2014-04-03
US20190314396A1 (en) 2019-10-17
JP2014510780A (ja) 2014-05-01
EP2696878A1 (en) 2014-02-19
PL2696878T3 (pl) 2020-01-31
ES2743691T3 (es) 2020-02-20

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