ES2743691T3 - Régimen de dosis para sapacitabina y decitabina en combinación para tratar la leucemia mieloide aguda - Google Patents

Régimen de dosis para sapacitabina y decitabina en combinación para tratar la leucemia mieloide aguda Download PDF

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Publication number
ES2743691T3
ES2743691T3 ES12717824T ES12717824T ES2743691T3 ES 2743691 T3 ES2743691 T3 ES 2743691T3 ES 12717824 T ES12717824 T ES 12717824T ES 12717824 T ES12717824 T ES 12717824T ES 2743691 T3 ES2743691 T3 ES 2743691T3
Authority
ES
Spain
Prior art keywords
decitabine
sapacitabine
treatment
metabolite
cndac
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12717824T
Other languages
English (en)
Spanish (es)
Inventor
Judy Chiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cyclacel Ltd
Original Assignee
Cyclacel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1106339.3A external-priority patent/GB201106339D0/en
Priority claimed from GBGB1117693.0A external-priority patent/GB201117693D0/en
Priority claimed from GBGB1121105.9A external-priority patent/GB201121105D0/en
Application filed by Cyclacel Ltd filed Critical Cyclacel Ltd
Application granted granted Critical
Publication of ES2743691T3 publication Critical patent/ES2743691T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES12717824T 2011-04-14 2012-04-13 Régimen de dosis para sapacitabina y decitabina en combinación para tratar la leucemia mieloide aguda Active ES2743691T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1106339.3A GB201106339D0 (en) 2011-04-14 2011-04-14 Combination
GBGB1117693.0A GB201117693D0 (en) 2011-10-13 2011-10-13 Combination
GBGB1121105.9A GB201121105D0 (en) 2011-12-08 2011-12-08 Combination
PCT/GB2012/050815 WO2012140436A1 (en) 2011-04-14 2012-04-13 Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia

Publications (1)

Publication Number Publication Date
ES2743691T3 true ES2743691T3 (es) 2020-02-20

Family

ID=46022492

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12717824T Active ES2743691T3 (es) 2011-04-14 2012-04-13 Régimen de dosis para sapacitabina y decitabina en combinación para tratar la leucemia mieloide aguda

Country Status (7)

Country Link
US (2) US10226478B2 (enExample)
EP (2) EP2696878B1 (enExample)
JP (1) JP6093755B2 (enExample)
ES (1) ES2743691T3 (enExample)
HU (1) HUE046177T2 (enExample)
PL (1) PL2696878T3 (enExample)
WO (1) WO2012140436A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE046177T2 (hu) 2011-04-14 2020-02-28 Cyclacel Ltd Szapacitabin és decitabin kombinációjának adagolási rendje akut mieloid leukémia kezelésére
WO2013171473A1 (en) 2012-05-15 2013-11-21 Cyclacel Limited Dosage regimen for sapacitabine and seliciclib
CN105960239A (zh) 2013-11-27 2016-09-21 翁科埃斯克斯有限公司 利用含有噻吩并三唑并二氮杂*化合物的药物制剂治疗白血病的方法
WO2019081951A1 (en) 2017-10-27 2019-05-02 Cyclacel Limited DOSAGE REGIME
WO2021079129A1 (en) 2019-10-24 2021-04-29 Cyclacel Limited Dosing regimen

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WO2002046182A1 (en) 2000-12-08 2002-06-13 Bristol-Myers Squibb Pharma Company Semicarbazides and their uses as cyclin dependent kinase inhibitors
JP3748536B2 (ja) 2001-02-09 2006-02-22 三共株式会社 ピリミジンヌクレオシド誘導体の結晶
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US20050014716A1 (en) 2003-05-21 2005-01-20 Wang Jin Wei Pancreatic cancer treatment
GB0328180D0 (en) 2003-12-04 2004-01-07 Cyclacel Ltd Combination
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GB0526419D0 (en) 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
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US20090263398A1 (en) 2006-07-14 2009-10-22 Astex Therapeutics Limited Pharmaceutical combinations
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WO2008132443A1 (en) 2007-04-25 2008-11-06 Cyclacel Limited Use of sapacitabine to treat proliferative disease
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CN101185629A (zh) 2007-12-14 2008-05-28 山东蓝金生物工程有限公司 一种治疗实体肿瘤的地西他滨缓释剂
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HUE046177T2 (hu) 2011-04-14 2020-02-28 Cyclacel Ltd Szapacitabin és decitabin kombinációjának adagolási rendje akut mieloid leukémia kezelésére

Also Published As

Publication number Publication date
JP2014510780A (ja) 2014-05-01
EP2696878B1 (en) 2019-07-10
US10226478B2 (en) 2019-03-12
HUE046177T2 (hu) 2020-02-28
JP6093755B2 (ja) 2017-03-08
EP3560501A1 (en) 2019-10-30
US20140094428A1 (en) 2014-04-03
EP2696878A1 (en) 2014-02-19
WO2012140436A1 (en) 2012-10-18
PL2696878T3 (pl) 2020-01-31
US20190314396A1 (en) 2019-10-17

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