JP6091891B2 - ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法 - Google Patents

ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法 Download PDF

Info

Publication number
JP6091891B2
JP6091891B2 JP2012510083A JP2012510083A JP6091891B2 JP 6091891 B2 JP6091891 B2 JP 6091891B2 JP 2012510083 A JP2012510083 A JP 2012510083A JP 2012510083 A JP2012510083 A JP 2012510083A JP 6091891 B2 JP6091891 B2 JP 6091891B2
Authority
JP
Japan
Prior art keywords
human
polypeptide
agent
leukemia
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2012510083A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012526729A (ja
JP2012526729A5 (enExample
Inventor
ウォン，シー・ワイ・ジーン
ディック，ジョン
ダンスカ，ジェイン
ジン，リキン
テオチャリデス，アレクサンドレ
ラジャクマー，スジーサ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hospital for Sick Children HSC
Original Assignee
Hospital for Sick Children HSC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43084582&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP6091891(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hospital for Sick Children HSC filed Critical Hospital for Sick Children HSC
Publication of JP2012526729A publication Critical patent/JP2012526729A/ja
Publication of JP2012526729A5 publication Critical patent/JP2012526729A5/ja
Application granted granted Critical
Publication of JP6091891B2 publication Critical patent/JP6091891B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012510083A 2009-05-15 2010-05-14 ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法 Active JP6091891B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17855309P 2009-05-15 2009-05-15
US61/178,553 2009-05-15
PCT/CA2010/000743 WO2010130053A1 (en) 2009-05-15 2010-05-14 COMPOSITIONS AND METHODS FOR TREATING HEMATOLOGIC CANCERS TARGETING THE SIRPα - CD47 INTERACTION

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015160462A Division JP6254124B2 (ja) 2009-05-15 2015-08-17 ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法

Publications (3)

Publication Number Publication Date
JP2012526729A JP2012526729A (ja) 2012-11-01
JP2012526729A5 JP2012526729A5 (enExample) 2013-06-27
JP6091891B2 true JP6091891B2 (ja) 2017-03-08

Family

ID=43084582

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2012510083A Active JP6091891B2 (ja) 2009-05-15 2010-05-14 ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法
JP2015160462A Active JP6254124B2 (ja) 2009-05-15 2015-08-17 ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法
JP2017218996A Active JP6410911B2 (ja) 2009-05-15 2017-11-14 ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法
JP2018178322A Pending JP2019011347A (ja) 2009-05-15 2018-09-25 ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法
JP2020095230A Pending JP2020143146A (ja) 2009-05-15 2020-06-01 ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法
JP2022148798A Pending JP2022180495A (ja) 2009-05-15 2022-09-20 ＳＩＲＰα－ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2015160462A Active JP6254124B2 (ja) 2009-05-15 2015-08-17 ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法
JP2017218996A Active JP6410911B2 (ja) 2009-05-15 2017-11-14 ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法
JP2018178322A Pending JP2019011347A (ja) 2009-05-15 2018-09-25 ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法
JP2020095230A Pending JP2020143146A (ja) 2009-05-15 2020-06-01 ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法
JP2022148798A Pending JP2022180495A (ja) 2009-05-15 2022-09-20 ＳＩＲＰα－ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法

Country Status (15)

Country Link
US (3) US10907209B2 (enExample)
EP (3) EP4311863A3 (enExample)
JP (6) JP6091891B2 (enExample)
CN (2) CN102596233A (enExample)
AU (1) AU2010246872B2 (enExample)
CA (2) CA2761438C (enExample)
DK (2) DK2429574T3 (enExample)
ES (2) ES2539141T3 (enExample)
FI (1) FI2995315T3 (enExample)
HR (2) HRP20150553T1 (enExample)
HU (1) HUE065432T2 (enExample)
PL (2) PL2429574T3 (enExample)
PT (2) PT2995315T (enExample)
SI (2) SI2995315T1 (enExample)
WO (1) WO2010130053A1 (enExample)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2582340T3 (es) 2008-01-15 2016-09-12 The Board Of Trustees Of The Leland Stanford Junior University Métodos para manipular fagocitosis mediada por CD47
HRP20150553T1 (hr) * 2009-05-15 2015-08-28 University Health Network Sastavi i metode za lijeäśenje hematoloških maligniteta ciljajuä†i sirp - cd47 interakciju
ES2816647T3 (es) * 2012-01-17 2021-04-05 Univ Leland Stanford Junior Reactivos SIRP-alfa de alta afinidad
WO2013112942A1 (en) 2012-01-25 2013-08-01 Dna Trix, Inc. Biomarkers and combination therapies using oncolytic virus and immunomodulation
CN102643347A (zh) * 2012-03-29 2012-08-22 中国人民解放军第四军医大学 一种白血病干细胞靶向可溶性蛋白TrxHis-hSIRPα
CN103804495A (zh) * 2012-11-07 2014-05-21 深圳大学 抗肿瘤基因工程二价类抗体及其制备方法及抗肿瘤基因工程药物
PL3575326T3 (pl) 2012-12-17 2022-07-11 Pf Argentum Ip Holdings Llc Leczenie komórek chorobowych cd47+ z użyciem fuzji sirp alfa-fc
WO2014121093A1 (en) 2013-01-31 2014-08-07 Thomas Jefferson University Fusion proteins that facilitate cancer cell destruction
EP2953633B1 (en) 2013-02-05 2017-10-04 The Board of Trustees of the Leland Stanford Junior University Cd47 targeted therapies for the treatment of infectious disease
CN103665165B (zh) * 2013-08-28 2016-02-24 江苏匡亚生物医药科技有限公司 一种靶向人CD47-SIRPα信号通路的双特异性抗体及其制备方法和用途
JP6355032B2 (ja) * 2014-03-24 2018-07-11 イミューンオンコ バイオファーマシューティカルズ （シャンハイ） カンパニー リミテッド 新規組換え二機能性融合タンパク質、それらの調製および使用
WO2016023040A1 (en) * 2014-08-08 2016-02-11 Alexo Therapeutics International Sirp-alpha variant constructs and uses thereof
PL3180363T3 (pl) 2014-08-15 2020-02-28 Merck Patent Gmbh Białka fuzyjne immunoglobulin sirp-alfa
EP3012271A1 (en) 2014-10-24 2016-04-27 Effimune Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases
CN106146670B (zh) * 2015-04-24 2019-01-15 宜明昂科生物医药技术（上海）有限公司 一种新的重组双功能融合蛋白及其制备和应用
AU2016304794B2 (en) 2015-08-07 2021-07-15 ALX Oncology Inc. Constructs having a SIRP-alpha domain or variant thereof
WO2017053423A1 (en) 2015-09-21 2017-03-30 Erasmus University Medical Center Anti-cd47 antibodies and methods of use
WO2017068164A1 (en) 2015-10-21 2017-04-27 Ose Immunotherapeutics Methods and compositions for modifying macrophage polarization into pro-inflammatory cells to treat cancer
CN107149682B (zh) * 2016-03-04 2022-01-04 复旦大学 一种靶向cd47的免疫检查点抑制剂药物组合物及其制备方法
IL262251B2 (en) 2016-04-14 2023-09-01 Ose Immunotherapeutics New anti-syrap antibodies and their medical applications
AU2017250029C1 (en) * 2016-04-15 2022-03-24 Pfizer Inc. Macrophage stimulation in CD47 blockade therapy
US20190135921A1 (en) * 2016-05-19 2019-05-09 Adaerata, Limited Partnership Methods of preventing or treating slamf7 positive and slamf7 negative cancers
CN117717604A (zh) 2016-07-19 2024-03-19 梯瓦制药澳大利亚股份有限公司 抗cd47联合治疗
CA3042581A1 (en) 2016-11-03 2018-05-11 Trillium Therapeutics Inc. Enhancement of cd47 blockade therapy by proteasome inhibitors
CA3042583A1 (en) 2016-11-03 2018-05-11 Trillium Therapeutics Inc. Improvements in cd47 blockade therapy by hdac inhibitors
AU2017371070B2 (en) 2016-12-09 2025-01-02 Alector Llc Anti-SIRP-alpha antibodies and methods of use thereof
US11566060B2 (en) 2017-01-05 2023-01-31 Kahr Medical Ltd. PD1-CD70 fusion protein and methods of use thereof
CN110536693B (zh) 2017-01-05 2023-12-22 卡尔医学有限公司 Pd1-41bbl融合蛋白及使用其的方法
RU2769769C2 (ru) 2017-01-05 2022-04-05 Кахр Медикал Лтд. СЛИТЫЙ БЕЛОК SIRPα-4-1BBL И СПОСОБЫ ЕГО ПРИМЕНЕНИЯ
US11299530B2 (en) 2017-01-05 2022-04-12 Kahr Medical Ltd. SIRP alpha-CD70 fusion protein and methods of use thereof
BR112020001653A2 (pt) 2017-07-26 2020-07-21 Forty Seven, Inc. anticorpos anti-sirp-alfa e métodos relacionados
JP7262440B2 (ja) 2017-08-02 2023-04-21 フェインズ セラピューティクス，インコーポレーテッド 抗ｃｄ４７抗体及びその使用
EP3694881A1 (en) 2017-10-13 2020-08-19 OSE Immunotherapeutics Modified anti-sirpa antibodies and uses thereof
US11771764B2 (en) 2017-11-06 2023-10-03 Pfizer Inc. CD47 blockade with radiation therapy
CN108484774B (zh) * 2018-03-09 2021-11-05 上海高菲生物科技有限公司 一种SIRPα融合蛋白及其制备方法和用途
JP2021517130A (ja) * 2018-03-13 2021-07-15 オーセ イミュノセラピューティクスＯｓｅ Ｉｍｍｕｎｏｔｈｅｒａｐｅｕｔｉｃｓ 抗ヒトＳＩＲＰａｖ１抗体の使用および抗ｖ１抗体を製造する方法
CN110386984B (zh) * 2018-04-17 2022-04-22 杭州尚健生物技术有限公司 结合cd47蛋白的融合蛋白及其应用
JP7337099B2 (ja) 2018-05-25 2023-09-01 アレクトル エルエルシー 抗ｓｉｒｐａ抗体およびその使用法
CN108872569A (zh) * 2018-06-19 2018-11-23 浠思（上海）生物技术有限公司 利用HTRF一步法筛选CD47/SIRP alpha阻断剂的方法
SG11202012338QA (en) 2018-07-10 2021-01-28 Univ Kobe Nat Univ Corp ANTI-SIRPa ANTIBODY
KR102945860B1 (ko) 2018-07-11 2026-03-31 카 메디컬 리미티드 SIRPalpha-4-1BBL 변이체 융합 단백질 및 이의 사용 방법
EP3820887A4 (en) 2018-07-11 2022-04-20 KAHR Medical Ltd. Pd1-4-1bbl variant fusion protein and methods of use thereof
US20210347848A1 (en) * 2018-08-31 2021-11-11 ALX Oncology Inc. Decoy polypeptides
WO2020107115A1 (en) * 2018-11-29 2020-06-04 Trillium Therapeutics Inc. Biomarkers for cd47 blockade therapy
CN114126648A (zh) 2019-05-31 2022-03-01 Alx肿瘤生物技术公司 用SIRPα Fc融合体组合免疫检查点抑制剂治疗癌症的方法
CN121243368A (zh) 2019-11-27 2026-01-02 Alx肿瘤生物技术公司 用于治疗癌症的组合疗法
JP7538334B2 (ja) * 2020-08-14 2024-08-21 コリア・インスティテュート・オブ・サイエンス・アンド・テクノロジー 抗癌活性を有する免疫調節タンパク質－ｓｉＲＮＡ複合体
KR102557016B1 (ko) * 2020-09-22 2023-07-20 비피진 주식회사 암 치료를 위한 cd47 바인더 및 리포좀 복합체
KR102398032B1 (ko) * 2020-09-22 2022-05-19 비피진 주식회사 암 치료를 위한 5''-뉴클레오티다아제 변이체
EP4262828A1 (en) 2020-12-18 2023-10-25 Instil Bio (Uk) Limited Tumor infiltrating lymphocytes and anti-cd47 therapeutics
JP2024515211A (ja) 2021-04-27 2024-04-05 ファイザー・インク Ｄｈｆｒ阻害剤を用いたｃｄ４７遮断療法の増強
JP2024520902A (ja) 2021-05-13 2024-05-27 エーエルエックス オンコロジー インコーポレイテッド がんを治療するための併用療法
TW202317620A (zh) 2021-06-04 2023-05-01 德商百靈佳殷格翰國際股份有限公司 抗ＳＩＲＰα抗體
CN117915938A (zh) * 2021-06-30 2024-04-19 俄亥俄州国家创新基金会 用于与抗cd47-sirpα治疗剂组合抑制二氢乳清酸脱氢酶的方法和组合物
JP2024530040A (ja) * 2021-08-05 2024-08-14 イムノス セラピューティクス アーゲー Ｈｌａ融合タンパク質を含む併用医薬
US20250235504A1 (en) 2021-10-29 2025-07-24 Pfizer Inc. Enhancement of cd47 blockade with taxanes for cd47+ cancer therapy
US20250367255A1 (en) 2021-11-08 2025-12-04 Pfizer Inc. Enhancement Of CD47 Blockade Therapy With Anti-VEGF Agents
US20250345395A1 (en) 2022-05-25 2025-11-13 Pfizer Inc. Dosing Regimens of SIRP Alpha Fusion Proteins for Treatment of Cancer
WO2024040151A1 (en) 2022-08-18 2024-02-22 Pfizer Inc. Sirp alpha fusion protein and anti-cd38 antibody combination therapies
KR20250116736A (ko) 2022-12-09 2025-08-01 화이자 인코포레이티드 Cd47 차단제 및 항-bcma/항-cd3 이중특이성 항체 병용 요법
WO2024124107A2 (en) 2022-12-09 2024-06-13 Pfizer Inc. Cd47 blocking agent and anti-cd20 / anti-cd3 bispecific antibody combination therapy
KR20250121414A (ko) * 2022-12-15 2025-08-12 칼리버 임뮤노쎄라퓨틱스, 인크. Cd47/sirp-알파 면역 체크포인트 억제제 조성물 및 그의 용도
CN116879560A (zh) * 2023-05-23 2023-10-13 中山大学 SIRPα抑制剂及SIRPα-Fc融合蛋白在制备治疗肿瘤的药物中的用途
WO2026062544A1 (en) 2024-09-23 2026-03-26 Pfizer Inc. Sirp alpha fusion protein formulation

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・２・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US6641809B1 (en) 1990-03-26 2003-11-04 Bristol-Myers Squibb Company Method of regulating cellular processes mediated by B7 and CD28
US5844095A (en) 1991-06-27 1998-12-01 Bristol-Myers Squibb Company CTLA4 Ig fusion proteins
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
EP0914452A2 (en) 1996-06-17 1999-05-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Novel ptp20, pcp-2, bdp1, clk and sirp proteins and related products and methods
US6541615B1 (en) 1996-11-15 2003-04-01 Max-Planck-Gellschaft Zur Foderung Der Wissenschaften E.V. SIRP proteins and uses thereof
CA2226962A1 (en) * 1998-02-16 1999-08-16 Marie Sarfati Use of binding agents to cd47 and its ligands in the treatment or the prophylaxis of various inflammatory, autoimmune and allergic diseases and in the treatment of graft rejection
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
WO2001040307A1 (de) 1999-11-30 2001-06-07 Eberhard-Karls-Universität Tübingen Universitätsklinikum Antikörper gegen signal-regulator-proteine
GB9930706D0 (en) 1999-12-24 2000-02-16 Medical Res Council Composition for inhibiting macrophage activity
WO2002092784A2 (en) 2001-05-15 2002-11-21 Emory University POLYNUCLEOTIDES AND POLYPEPTIDES RELATING TO THE MODULATION OF SIRP α-CD47
EP1369128A1 (en) * 2002-06-07 2003-12-10 Procorde GmbH Inhibitors of glycoprotein VI and their therapeutic use
US20040213792A1 (en) 2003-04-24 2004-10-28 Clemmons David R. Method for inhibiting cellular activation by insulin-like growth factor-1
JP3936673B2 (ja) 2003-06-02 2007-06-27 国立大学法人群馬大学 Ｃｄ４７部分ペプチドと抗ｓｈｐｓ−１モノクロナール抗体
CA2545166A1 (en) 2003-11-11 2005-05-19 Chugai Seiyaku Kabushiki Kaisha Humanized anti-cd47 antibody
JP2007008895A (ja) * 2005-07-04 2007-01-18 Chugai Pharmaceut Co Ltd 抗ｃｄ４７抗体とインテグリンリガンドとの併用
EP2083081A1 (en) 2005-07-22 2009-07-29 Five Prime Therapeutics, Inc. Compositions and methods of treating disease with FGFR fusion proteins
US7514229B2 (en) 2005-09-29 2009-04-07 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosing and evaluating treatment of blood disorders
CA2642516A1 (en) * 2006-02-08 2007-08-16 Targeted Molecular Diagnostics, Llc Bivalent erbb ligand binding molecules and methods for their preparation and use
US8377448B2 (en) * 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
EP2573112A1 (en) * 2007-10-11 2013-03-27 The Hospital For Sick Children Modulation of sirpa - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor
DE102007056623B3 (de) 2007-11-23 2009-05-20 Mtu Friedrichshafen Gmbh Verfahren zur Regelung eines stationären Gasmotors
EP3043181B1 (en) 2008-01-15 2020-04-08 The Board of Trustees of the Leland Stanford Junior University Markers of acute myeloid leukemia stem cells
ES2582340T3 (es) 2008-01-15 2016-09-12 The Board Of Trustees Of The Leland Stanford Junior University Métodos para manipular fagocitosis mediada por CD47
EP2111869A1 (en) 2008-04-23 2009-10-28 Stichting Sanquin Bloedvoorziening Compositions and methods to enhance the immune system
WO2010070047A1 (en) 2008-12-19 2010-06-24 Novartis Ag Soluble polypeptides for use in treating autoimmune and inflammatory disorders
HRP20150553T1 (hr) * 2009-05-15 2015-08-28 University Health Network Sastavi i metode za lijeäśenje hematoloških maligniteta ciljajuä†i sirp - cd47 interakciju
PT2569013T (pt) 2010-05-14 2017-02-08 Univ Leland Stanford Junior Anticorpos monoclonais humanizados e quiméricos para cd47
KR102100388B1 (ko) 2012-02-06 2020-04-13 인히브릭스, 인크. Cd47 항체 및 그 사용 방법
PL3575326T3 (pl) 2012-12-17 2022-07-11 Pf Argentum Ip Holdings Llc Leczenie komórek chorobowych cd47+ z użyciem fuzji sirp alfa-fc

Also Published As

Publication number Publication date
JP6254124B2 (ja) 2017-12-27
PL2995315T3 (pl) 2024-04-22
JP2018065822A (ja) 2018-04-26
EP4311863A3 (en) 2024-04-10
JP2020143146A (ja) 2020-09-10
EP4311863A2 (en) 2024-01-31
EP2995315B1 (en) 2023-12-27
JP2019011347A (ja) 2019-01-24
JP6410911B2 (ja) 2018-10-24
PT2429574E (pt) 2015-07-17
EP2429574A4 (en) 2012-10-03
US20190093174A1 (en) 2019-03-28
US20240084399A1 (en) 2024-03-14
ES2539141T3 (es) 2015-06-26
SI2995315T1 (sl) 2024-05-31
HRP20150553T1 (hr) 2015-08-28
AU2010246872A1 (en) 2011-12-01
CN107252476A (zh) 2017-10-17
US10907209B2 (en) 2021-02-02
EP2429574A1 (en) 2012-03-21
AU2010246872B2 (en) 2015-01-22
DK2429574T3 (da) 2015-06-22
PL2429574T3 (pl) 2015-12-31
ES2973099T3 (es) 2024-06-18
HRP20240362T1 (hr) 2024-06-07
JP2016029043A (ja) 2016-03-03
DK2995315T3 (da) 2024-02-19
JP2012526729A (ja) 2012-11-01
JP2022180495A (ja) 2022-12-06
HUE065432T2 (hu) 2024-05-28
EP2995315A1 (en) 2016-03-16
PT2995315T (pt) 2024-03-14
CA2761438A1 (en) 2010-11-18
CN102596233A (zh) 2012-07-18
CA2983972C (en) 2023-05-02
SI2429574T1 (sl) 2015-10-30
WO2010130053A1 (en) 2010-11-18
US20120189625A1 (en) 2012-07-26
FI2995315T3 (fi) 2024-03-18
CA2983972A1 (en) 2010-11-18
CA2761438C (en) 2017-12-12
EP2429574B1 (en) 2015-05-06

Similar Documents

Publication Publication Date Title
JP6410911B2 (ja) ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法
CN107835820B (zh) 识别癌症特异性IL13Rα2的CAR T细胞
US7090843B1 (en) Recombinant anti-CD30 antibodies and uses thereof
CN103242444A (zh) 调节SIRPα-CD47相互作用以增加造血干细胞植入和用于此的化合物
KR20210094609A (ko) 절제 레짐에 대해 저항성인 유전적으로 변형된 hspc
HU229148B1 (en) Human cytokine as ligand of the zalpha receptor and uses thereof
KR20190109440A (ko) 줄기 세포 이식을 위한 비-유전독성 컨디셔닝 레지멘
US20260108616A1 (en) Methods for treating graft versus host disease
AU2022256193A1 (en) Compositions and methods for treating hematologic cancers targeting the SIRPa-CD47 interaction
WO2026037425A1 (en) Engineered cd9 antibodies and their use
WO2024148235A1 (en) Epitope engineering of kit cell-surface receptors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130513

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130513

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140624

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140922

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140930

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141023

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141030

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141121

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20141121

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150416

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161206

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170208

R150 Certificate of patent or registration of utility model

Ref document number: 6091891

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250