JP6084983B2 - モグロシド化合物の酵素的合成のための方法および材料 - Google Patents

モグロシド化合物の酵素的合成のための方法および材料 Download PDF

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JP6084983B2
JP6084983B2 JP2014542951A JP2014542951A JP6084983B2 JP 6084983 B2 JP6084983 B2 JP 6084983B2 JP 2014542951 A JP2014542951 A JP 2014542951A JP 2014542951 A JP2014542951 A JP 2014542951A JP 6084983 B2 JP6084983 B2 JP 6084983B2
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polypeptide
ugt
mogroside
amino acid
seq
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JP2014533518A (ja
JP2014533518A5 (OSRAM
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リウ，ヤオクァン
ヨプ イ，ジョン
ヨプ イ，ジョン
クハレ，モニカ
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Evolva Holding SA
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Evolva AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/20—Preparation of steroids containing heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2014542951A 2011-11-23 2012-11-19 モグロシド化合物の酵素的合成のための方法および材料 Active JP6084983B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161563303P 2011-11-23 2011-11-23
US61/563,303 2011-11-23
PCT/IB2012/002857 WO2013076577A1 (en) 2011-11-23 2012-11-19 Methods and materials for enzymatic synthesis of mogroside compounds

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JP2014533518A JP2014533518A (ja) 2014-12-15
JP2014533518A5 JP2014533518A5 (OSRAM) 2016-09-29
JP6084983B2 true JP6084983B2 (ja) 2017-02-22

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JP2014542951A Active JP6084983B2 (ja) 2011-11-23 2012-11-19 モグロシド化合物の酵素的合成のための方法および材料

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US (2) US9920349B2 (OSRAM)
EP (1) EP2783009B1 (OSRAM)
JP (1) JP6084983B2 (OSRAM)
KR (1) KR101791597B1 (OSRAM)
CN (1) CN103958693B (OSRAM)
AU (2) AU2012342114B2 (OSRAM)
BR (1) BR112014012543A2 (OSRAM)
CA (1) CA2853677C (OSRAM)
IN (1) IN2014CN03557A (OSRAM)
MX (1) MX342851B (OSRAM)
MY (1) MY170686A (OSRAM)
RU (1) RU2633644C2 (OSRAM)
SG (1) SG11201401927PA (OSRAM)
WO (1) WO2013076577A1 (OSRAM)

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SG11201401927PA (en) 2011-11-23 2014-09-26 Evolva Sa Methods and materials for enzymatic synthesis of mogroside compounds
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MX2015010098A (es) 2013-02-11 2016-04-19 Evolva Sa Producción eficiente de glicosidos de esteviol en huéspedes recombinantes.
SG11201700651RA (en) 2014-08-11 2017-02-27 Evolva Sa Production of steviol glycosides in recombinant hosts
MX2017003130A (es) 2014-09-09 2017-10-24 Evolva Sa Produccion de glucosidos de esteviol en hospederos recombinantes.
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JP6698028B2 (ja) * 2014-10-17 2020-05-27 サントリーホールディングス株式会社 モグロール配糖体化酵素およびそれをコードする遺伝子
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JP2018522569A (ja) 2015-08-07 2018-08-16 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組換え宿主内でのステビオールグリコシドの産生
SG11201803603WA (en) 2015-10-29 2018-05-30 Senomyx Inc High intensity sweeteners
CN106924274B (zh) * 2015-12-29 2019-01-04 成都普睿法药物研发有限公司 葫芦烷型四环三萜类化合物抗肺纤维化应用
BR112018071144B1 (pt) 2016-04-13 2023-04-18 Evolva Sa Célula hospedeira recombinante que produz um ou mais glicosídeos de esteviol ou uma composição de glicosídeo de esteviol em uma cultura de células e métodos para produzir um ou mais glicosídeos de esteviol ou uma composição de glicosídeo de esteviol, bem como cultura de células e lisado celular da dita célula hospedeira recombinante
AU2017267214A1 (en) * 2016-05-16 2018-11-15 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3458599A1 (en) 2016-05-16 2019-03-27 Evolva SA Production of steviol glycosides in recombinant hosts
WO2018016483A1 (ja) * 2016-07-19 2018-01-25 サントリーホールディングス株式会社 モグロールまたはモグロール配糖体の生産方法
CN110100006A (zh) 2016-11-07 2019-08-06 埃沃尔瓦公司 重组宿主中甜菊糖苷的生产
MX2019012940A (es) 2017-05-03 2019-12-16 Firmenich Incorporated Metodos para producir edulcorantes de alta intensidad.
US11653680B2 (en) 2017-05-19 2023-05-23 The Coca-Cola Company Siamenoside I sweetened compositions and uses of the same
WO2021214008A1 (en) 2020-04-20 2021-10-28 Givaudan Sa Compositions
RU2762719C2 (ru) 2017-06-02 2021-12-22 Живодан Са Композиция, модифицирующая сладость
WO2018229283A1 (en) 2017-06-15 2018-12-20 Evolva Sa Production of mogroside compounds in recombinant hosts
CN107189976B (zh) * 2017-07-28 2022-03-11 李华政 促进罗汉果ugt72b21基因表达的方法
WO2020096905A1 (en) 2018-11-07 2020-05-14 Firmenich Incorporated Methods for making high intensity sweeteners
KR20210089717A (ko) 2018-11-07 2021-07-16 피르메니히 인코포레이티드 고강도 감미료의 제조 방법
WO2020097588A1 (en) 2018-11-09 2020-05-14 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
CN110669094B (zh) * 2019-10-14 2021-12-21 上海交通大学 罗汉果新苷及其制备方法
KR102362135B1 (ko) * 2019-10-25 2022-02-14 고려대학교 산학협력단 테르펜 당쇄 부가 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 조성물
WO2021188703A1 (en) * 2020-03-17 2021-09-23 The Coca-Cola Company Novel mogroside production system and methods
GB202007984D0 (en) 2020-05-28 2020-07-15 Givaudan Sa Compositions
CN112063647B (zh) * 2020-09-17 2023-05-02 云南农业大学 酿酒酵母重组菌Cuol01的构建方法、酿酒酵母重组菌Cuol02及应用
CN116064712B (zh) * 2022-10-08 2025-05-06 中国药科大学 一种罗汉果醇的生物合成方法
CN121127603A (zh) 2023-04-20 2025-12-12 帝斯曼知识产权资产管理有限公司 用于产生罗汉果苷的菌株和方法

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SG11201401927PA (en) 2011-11-23 2014-09-26 Evolva Sa Methods and materials for enzymatic synthesis of mogroside compounds
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015536157A (ja) * 2012-12-04 2015-12-21 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． モグロシド化合物の生合成のための方法および材料

Also Published As

Publication number Publication date
MY170686A (en) 2019-08-26
AU2012342114A1 (en) 2014-05-22
KR101791597B1 (ko) 2017-10-30
MX2014006276A (es) 2014-10-13
RU2014125216A (ru) 2015-12-27
CN103958693B (zh) 2016-08-24
CA2853677A1 (en) 2013-05-30
US20180237819A1 (en) 2018-08-23
KR20140099281A (ko) 2014-08-11
EP2783009A1 (en) 2014-10-01
CN103958693A (zh) 2014-07-30
AU2017235907A1 (en) 2017-10-12
RU2633644C2 (ru) 2017-10-16
MX342851B (es) 2016-10-14
WO2013076577A1 (en) 2013-05-30
SG11201401927PA (en) 2014-09-26
AU2012342114B2 (en) 2017-12-21
HK1200494A1 (zh) 2015-08-07
US20140308698A1 (en) 2014-10-16
CA2853677C (en) 2019-01-29
US10738340B2 (en) 2020-08-11
BR112014012543A2 (pt) 2017-06-13
JP2014533518A (ja) 2014-12-15
IN2014CN03557A (OSRAM) 2015-10-09
US9920349B2 (en) 2018-03-20
EP2783009B1 (en) 2016-04-13

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