JP6084924B2 - β−アミロイドパシーまたはα−シヌクレオパシーを治療するための２−（Ｒ２−チオ）−１０−［３−（４−Ｒ１−ピペラジン−１−イル）プロピル］−１０Ｈ−フェノチアジン、およびβ−アミロイドパシーまたはα−シヌクレオパシーの診断または事前診断のための方法 - Google Patents

β−アミロイドパシーまたはα−シヌクレオパシーを治療するための２−（Ｒ２−チオ）−１０−［３−（４−Ｒ１−ピペラジン−１−イル）プロピル］−１０Ｈ−フェノチアジン、およびβ−アミロイドパシーまたはα−シヌクレオパシーの診断または事前診断のための方法 Download PDF

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JP6084924B2
JP6084924B2 JP2013527544A JP2013527544A JP6084924B2 JP 6084924 B2 JP6084924 B2 JP 6084924B2 JP 2013527544 A JP2013527544 A JP 2013527544A JP 2013527544 A JP2013527544 A JP 2013527544A JP 6084924 B2 JP6084924 B2 JP 6084924B2
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パーンケ，イエンス
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イムンゲネテイクス・アーゲー
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    • C—CHEMISTRY; METALLURGY
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    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
    • C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • G01N2333/4709—Amyloid plaque core protein
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    • G01N2800/00—Detection or diagnosis of diseases
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JP2013527544A 2010-09-07 2011-08-30 β−アミロイドパシーまたはα−シヌクレオパシーを治療するための２−（Ｒ２−チオ）−１０−［３−（４−Ｒ１−ピペラジン−１−イル）プロピル］−１０Ｈ−フェノチアジン、およびβ−アミロイドパシーまたはα−シヌクレオパシーの診断または事前診断のための方法 Active JP6084924B2 (ja)

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DE102010044561 2010-09-07
DE102010044561.4 2010-09-07
PCT/EP2011/064893 WO2012031941A2 (de) 2010-09-07 2011-08-30 2-(R²-THIO)-10-[3-(4-R1-PIPERAZIN-1-YL)PROPYL]-10H-PHENOTHIAZINE ZUR BEHANDLUNG EINER β-AMYLOIDOPATHIE ODER ALPHA-SYNUCLEOPATHIE SOWIE VERFAHREN ZU DEREN DIAGNOSE ODER PRÄDIAGNOSE

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JP2016131781A Active JP6426663B2 (ja) 2010-09-07 2016-07-01 β−アミロイドパシーまたはα−シヌクレオパシーを治療するための２−（Ｒ２−チオ）−１０−［３−（４−Ｒ１−ピペラジン−１−イル）プロピル］−１０Ｈ−フェノチアジン、およびβ−アミロイドパシーまたはα−シヌクレオパシーの診断または事前診断のための方法

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US (3) US20130184268A1 (https=)
EP (3) EP2614060B1 (https=)
JP (2) JP6084924B2 (https=)
CN (2) CN106243060A (https=)
BR (1) BR112013005472A2 (https=)
CA (2) CA2870626C (https=)
DE (2) DE102010062810B4 (https=)
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KR102592614B1 (ko) 2016-07-25 2023-10-24 위스타 레보레이토리스 리미티드 디아미노페노티아진 (diaminophenothiazines)의 투여 및 투여량 (dosage)
DK3826639T3 (da) 2018-07-26 2024-09-23 Wista Lab Ltd Optimeret dosering af diaminophenothiaziner i populationer
CN115279915A (zh) * 2020-03-16 2022-11-01 德瑞生物医药股份有限公司 依托泊苷糖苷、其制备方法及其作为抗癌药物的用途
WO2023131606A1 (en) * 2022-01-04 2023-07-13 Immungenetics Ag Specific dosage of phenothiazine compounds for use in treatment or prevention of alzheimer's dementia
CA3268498A1 (en) * 2022-10-18 2024-04-25 Immungenetics Ag IDENTIFICATION OF A SUBJECT SUFFERING FROM ALZHEIMER'S DISEASE OR PRESENTING A RISK OF DEVELOPING ALZHEIMER'S DISEASE

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EP0778773A1 (en) * 1994-08-08 1997-06-18 Albert Einstein College Of Medicine Of Yeshiva University Methods for treating and/or preventing alzheimer's disease using phenothiazines and/or thioxanthenes
DE4430091A1 (de) * 1994-08-25 1996-02-29 Bayer Ag Verwendung von N-substituierten Phenothiazinen
EP1470818B1 (en) * 2003-04-25 2006-07-26 Neuro3D Use of piperazine phenothiazine derivatives in the manufacture of a medicament with neuroprotector and/or neurotrophic effects on cns and/or pns
DE102005014142B4 (de) * 2005-03-23 2006-11-09 Hennig Arzneimittel Gmbh & Co. Kg Pelletförmige Retardzubereitung gegen Schwindel
WO2007062862A2 (en) * 2005-12-02 2007-06-07 Ludwig Maximilians Universität München Use of calmodulin inhibitors for the treatment of neurodegenerative disorders
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EA019571B1 (ru) * 2008-04-29 2014-04-30 Фарнекст Применение сульфизоксазола для лечения болезни альцгеймера
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MX357521B (es) 2018-07-12
ES2605705T3 (es) 2017-03-15
CA2870626A1 (en) 2012-03-15
DE102010062810B4 (de) 2014-03-13
US20150374711A1 (en) 2015-12-31
ES2701453T3 (es) 2019-02-22
DK2614060T3 (da) 2017-01-02
JP6426663B2 (ja) 2018-11-21
JP2013537881A (ja) 2013-10-07
US9370523B2 (en) 2016-06-21
PL2614060T3 (pl) 2017-05-31
RU2587154C2 (ru) 2016-06-20
DE102011053114A1 (de) 2012-03-08
JP2017019776A (ja) 2017-01-26
DK2693216T3 (en) 2019-01-14
CN103237802B (zh) 2017-06-09
US20130184268A1 (en) 2013-07-18
DE102010062810A1 (de) 2012-03-08
EP2693216A1 (de) 2014-02-05
MX2013002612A (es) 2013-08-01
EP3097914A2 (de) 2016-11-30
BR112013005472A2 (pt) 2020-11-10
EP2693216B1 (de) 2018-09-12
CN103237802A (zh) 2013-08-07
RU2016118021A (ru) 2018-11-01
CA2811454C (en) 2017-03-28
RU2016118021A3 (https=) 2020-02-26
WO2012031941A2 (de) 2012-03-15
CN106243060A (zh) 2016-12-21
EP3097914A3 (de) 2016-12-28
RU2013110018A (ru) 2014-10-20
PL2693216T3 (pl) 2019-04-30
US20150024418A1 (en) 2015-01-22
WO2012031941A3 (de) 2012-09-20
CA2811454A1 (en) 2012-03-15
EP2614060B1 (de) 2016-08-31
CA2870626C (en) 2018-08-14
EP2614060A2 (de) 2013-07-17

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