JP6073043B2 - 医薬品適用のための熱−動力学的混合 - Google Patents

医薬品適用のための熱−動力学的混合 Download PDF

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JP6073043B2
JP6073043B2 JP2010522038A JP2010522038A JP6073043B2 JP 6073043 B2 JP6073043 B2 JP 6073043B2 JP 2010522038 A JP2010522038 A JP 2010522038A JP 2010522038 A JP2010522038 A JP 2010522038A JP 6073043 B2 JP6073043 B2 JP 6073043B2
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drug
thermodynamic
ktz
poly
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JP2010536877A (ja
Inventor
クリス ブロウ
クリス ブロウ
ジェイムス ダブリュー． マギニティ
ジェイムス ダブリュー． マギニティ
デイブ エー． ミラー
デイブ エー． ミラー
ジェイムス シー． ディヌンツィオ
ジェイムス シー． ディヌンツィオ
ロバート オー．， サード ウィリアムス
ロバート オー．， サード ウィリアムス
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The University of Texas System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2010522038A 2007-08-21 2008-08-21 医薬品適用のための熱−動力学的混合 Active JP6073043B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95704407P 2007-08-21 2007-08-21
US60/957,044 2007-08-21
US5092208P 2008-05-06 2008-05-06
US61/050,922 2008-05-06
PCT/US2008/073913 WO2009026461A2 (en) 2007-08-21 2008-08-21 Thermo-kinetic mixing for pharmaceutical applications

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2014148568A Division JP2014221816A (ja) 2007-08-21 2014-07-22 医薬品適用のための熱−動力学的混合
JP2016076558A Division JP2016121195A (ja) 2007-08-21 2016-04-06 医薬品適用のための熱−動力学的混合

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JP2010536877A JP2010536877A (ja) 2010-12-02
JP6073043B2 true JP6073043B2 (ja) 2017-02-01

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JP2010522038A Active JP6073043B2 (ja) 2007-08-21 2008-08-21 医薬品適用のための熱−動力学的混合
JP2014148568A Withdrawn JP2014221816A (ja) 2007-08-21 2014-07-22 医薬品適用のための熱−動力学的混合
JP2016076558A Withdrawn JP2016121195A (ja) 2007-08-21 2016-04-06 医薬品適用のための熱−動力学的混合
JP2018226362A Withdrawn JP2019052173A (ja) 2007-08-21 2018-12-03 医薬品適用のための熱−動力学的混合

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JP2014148568A Withdrawn JP2014221816A (ja) 2007-08-21 2014-07-22 医薬品適用のための熱−動力学的混合
JP2016076558A Withdrawn JP2016121195A (ja) 2007-08-21 2016-04-06 医薬品適用のための熱−動力学的混合
JP2018226362A Withdrawn JP2019052173A (ja) 2007-08-21 2018-12-03 医薬品適用のための熱−動力学的混合

Country Status (6)

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US (6) US8486423B2 (enExample)
EP (1) EP2187968A4 (enExample)
JP (4) JP6073043B2 (enExample)
CN (1) CN101835492B (enExample)
CA (3) CA3076115C (enExample)
WO (1) WO2009026461A2 (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8821928B2 (en) 2007-06-04 2014-09-02 Egalet Ltd. Controlled release pharmaceutical compositions for prolonged effect
WO2009026461A2 (en) 2007-08-21 2009-02-26 Board Of Regents, The University Of Texas System Thermo-kinetic mixing for pharmaceutical applications
US9545361B1 (en) * 2011-07-25 2017-01-17 Dispersol Technologies, Llc Multiple speed process for preserving heat sensitive portions of a thermokinetically melt blended batch
AU2009268923B2 (en) 2008-06-16 2015-09-17 Pfizer Inc. Drug loaded polymeric nanoparticles and methods of making and using same
WO2010005726A2 (en) 2008-06-16 2010-01-14 Bind Biosciences Inc. Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same
EA020753B1 (ru) 2008-06-16 2015-01-30 Бинд Терапьютикс, Инк. Терапевтические полимерные наночастицы, содержащие алкалоиды vinca, и их применение
US8809261B2 (en) * 2008-10-31 2014-08-19 Elsohly Laboratories, Incorporated Compositions containing delta-9-THC-amino acid esters and process of preparation
WO2010068866A2 (en) 2008-12-12 2010-06-17 Bind Biosciences Therapeutic particles suitable for parenteral administration and methods of making and using same
EA201100765A1 (ru) * 2008-12-15 2012-04-30 Бинд Биосаиэнсис Наночастицы длительной циркуляции для замедленного высвобождения терапевтических средств
NZ594207A (en) 2009-02-06 2013-03-28 Egalet Ltd Immediate release composition resistant to abuse by intake of alcohol
AU2010265213B2 (en) 2009-06-24 2012-08-23 Egalet Ltd. Controlled release formulations
CN102811743B (zh) 2009-12-11 2015-11-25 佰恩德治疗股份有限公司 冻干治疗颗粒的稳定制剂
JP5965844B2 (ja) 2009-12-15 2016-08-10 バインド セラピューティックス インコーポレイテッド 高いガラス転移温度または高分子量のコポリマーを有する治療用ポリマーナノ粒子組成物
US20140039031A1 (en) * 2011-02-23 2014-02-06 Dispersol Technologies. LLC Pharmaceutical formulations of acetyl-11-keto-b-boswellic acid, diindolylmethane, and curcumin for pharmaceutical applications
CN102204868B (zh) * 2011-05-18 2014-01-22 北京化工大学 采用多元辅料制备吲哚美辛速释制剂的热熔挤出工艺
US9821283B1 (en) * 2011-07-25 2017-11-21 Dispersol Technologies, Llc Direct probe sensed temperature method for speed change for heat sensitive portions of a thermokinetically melt blended batch
HUE043998T2 (hu) 2012-09-17 2019-09-30 Pfizer Eljárás terápiás nanorészecskék elõállítására
CN113209024A (zh) 2013-12-31 2021-08-06 阿森迪亚制药有限责任公司 疏水性化合物的药物组合物
EP3116547B1 (en) 2014-03-14 2019-06-05 Pfizer Inc Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
WO2015141662A1 (ja) * 2014-03-18 2015-09-24 武田薬品工業株式会社 固体分散体
AU2014391109B2 (en) * 2014-04-18 2019-01-17 AustinPx, LLC Multiple speed process for preserving heat sensitive portions of a thermokinetically melt blended batch
US20170333404A1 (en) * 2014-11-03 2017-11-23 Dispersol Technologies, Llc Improved formulations of vemurafenib and methods of making the same
CN107205935A (zh) * 2015-01-20 2017-09-26 默克专利股份有限公司 用聚乙烯醇作载体聚合物的化合物固体分散体
JP2018517734A (ja) 2015-06-17 2018-07-05 ディスパーソル テクノロジーズ リミテッド ライアビリティ カンパニー デフェラシロクスの改善された製剤およびその作製方法
TWI799366B (zh) 2015-09-15 2023-04-21 美商建南德克公司 胱胺酸結骨架平臺
CN109069460A (zh) * 2016-05-09 2018-12-21 分散技术有限责任公司 改进的药物制剂
DK3454906T3 (da) 2016-05-13 2025-10-20 Merck Patent Gmbh Partikelstørrelse og fordeling af polymer til smelteekstruderingsanvendelse
JP7376220B2 (ja) * 2017-09-11 2023-11-08 オースティンピーエックス リミテッド ライアビリティ カンパニー 熱動力学的に溶融ブレンドされるバッチの熱感受性部分用の、直接プローブにより感知した温度による、速度変更のための方法
MA50189A (fr) * 2017-09-22 2021-05-19 Dispersol Technologies Llc Formulations pharmaceutiques d'oligomère cyclique et d'abiratérone et procédés de formation et d'administration de celles-ci
CN109663524B (zh) * 2017-10-13 2022-07-15 分散技术有限责任公司 用于热动力学熔体共混批次的热敏部分的速度改变的直接进样探头感测温度方法
HUE052986T2 (hu) 2017-10-13 2021-05-28 Dispersol Technologies Llc Sebességváltoztatási eljárás közvetlen szonda általi hõmérséklet-érzékeléssel egy termokinetikusan ömlesztve kevert töltet hõérzékeny részei számára
WO2019094688A1 (en) * 2017-11-10 2019-05-16 Dispersol Technologies, Llc Improved drug formulations
EP3492070A1 (en) * 2017-11-30 2019-06-05 BIT Pharma GmbH Process and device for preparing a solid dispersion
CN111742041B (zh) * 2017-12-21 2023-06-06 丹尼斯科美国公司 包含耐热干燥剂的含酶的热熔细粒
US20200147032A1 (en) 2018-11-14 2020-05-14 Robert K. Prud'homme Dihydromyricetin hot melt extrusion formulations and methods for forming them
MX2021015457A (es) 2019-06-14 2022-04-06 Univ Princeton Formulaciones de dihidromiricetina y un permeabilizante.
WO2021108022A1 (en) * 2019-11-30 2021-06-03 Dispersol Technologies, Llc Inclusion complexes of pharmaceuticals and cyclic oligomers
KR20220130698A (ko) * 2019-12-20 2022-09-27 에피자임, 인코포레이티드 Ezh2 억제제의 결정질 하이드로브로마이드 염, 이의 제조 및 암의 치료에 유용한 약학적 조성물
JP2023520018A (ja) 2020-04-01 2023-05-15 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム ニクロサミドの薬学的組成物
IL303390A (en) 2020-12-03 2023-08-01 Battelle Memorial Institute Compositions of polymer nanoparticles and DNA nanostructures and methods for non-viral transport
US20240108639A1 (en) * 2020-12-11 2024-04-04 Board Of Regents, The University Of Texas System Compositions and methods of making cocrystals using dielectric heating with dispersive and distributive mixing
AU2022250858A1 (en) * 2021-04-01 2023-11-16 Merck Patent Gmbh Process for continuous hot melt granulation of low soluble pharmaceuticals
WO2022216977A1 (en) 2021-04-07 2022-10-13 Batelle Memorial Institute Rapid design, build, test, and learn technologies for identifying and using non-viral carriers
US20250000794A1 (en) * 2021-07-27 2025-01-02 Board Of Regents, The University Of Texas System Improved drug processing methods to increase drug loading
WO2023034844A1 (en) 2021-08-31 2023-03-09 Board Of Regents, The University Of Texas System Delayed release niclosamide formulation
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
AU2024393766A1 (en) 2023-12-08 2026-06-18 Battelle Memorial Institute Use of dna origami nanostructures for molecular information based data storage systems
AU2025207356A1 (en) 2024-01-11 2026-08-06 Minneamrita Therapeutics Llc Triptolide formulations
CN119453203A (zh) * 2025-01-09 2025-02-18 山东百农思达生物科技有限公司 一种含杀虫单和阿维菌素的复合微乳制剂及其制备工艺

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319478A1 (fr) 1975-07-30 1977-02-25 Gen Electric Extrudeuse et procede d'extrusion de materiaux thermoplastiques
US4230615A (en) * 1978-11-21 1980-10-28 Carlew Chemicals Limited Process for controlled mixing in a high intensity mixer
US4628073A (en) 1984-10-03 1986-12-09 Monsanto Company Soft, rubbery, multiphase matrix material and methods for its production
US4789597A (en) 1987-01-12 1988-12-06 Fetherstonhaugh & Co. Incorporation of chemically reactive agents on resin particles
ES2111065T5 (es) * 1991-04-16 2005-06-16 Nippon Shinyaku Company, Limited Procedimiento para producir una dispersion solida.
JP2516524B2 (ja) * 1992-04-27 1996-07-24 大洋薬品工業株式会社 持続性製剤
JPH07159587A (ja) 1993-12-07 1995-06-23 Hitachi Ltd 樹脂性能モニタ
JPH07187998A (ja) * 1993-12-27 1995-07-25 Kao Corp 錠剤の製造方法
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5895790A (en) 1995-03-14 1999-04-20 Good; Elmer Thermosetting wide range polymer blends
DE19531067A1 (de) 1995-08-23 1997-02-27 Hermann P T Prof Dr Med Ammon Verwendung von Boswelliasäure und ihren Derivaten zur Hemmung der normalen und gesteigerten Leukozytenelastase- oder Plasminaktivität
US6509038B2 (en) * 1996-05-20 2003-01-21 Janssen Pharmaceutica N.V. Antifungal compositions with improved bioavailability
AR028253A1 (es) 2000-03-16 2003-04-30 Pfizer Prod Inc Inhibidores de la glucogeno fosforilasa
US6709146B1 (en) 2000-07-28 2004-03-23 David Little Thermokinetic mixer and method of using
KR100759635B1 (ko) 2001-06-22 2007-09-17 화이자 프로덕츠 인코포레이티드 비정질 약물의 흡착체의 약학 조성물
KR20040011248A (ko) 2002-07-30 2004-02-05 환인제약 주식회사 암로디핀의 고체분산체와 그 제조방법 및 그를 포함하는약학적 조성물
CA2509958A1 (en) 2003-02-03 2004-08-19 Novartis Ag Pharmaceutical formulation
GB0319797D0 (en) * 2003-08-26 2003-09-24 Leuven K U Res & Dev Particle size reduction of poorly soluble drugs
US20050158376A1 (en) * 2003-10-23 2005-07-21 Sardi William F. Dietary supplement and method of processing same
CN100563658C (zh) * 2003-11-14 2009-12-02 味之素株式会社 苯丙氨酸衍生物的固体分散体或固体分散体医药制剂
WO2005053851A1 (en) 2003-11-26 2005-06-16 E.I. Dupont De Nemours And Company High pressure media milling system and process of milling particles
JP2005263758A (ja) * 2004-03-22 2005-09-29 Kirin Brewery Co Ltd 非晶質のｎ−｛２−クロロ−４−［（６，７−ジメトキシ−４−キナゾリニル）オキシ］フェニル｝−ｎ’−プロピルウレア
KR101086254B1 (ko) * 2004-11-04 2011-11-24 에스케이케미칼주식회사 생체이용률이 개선된 프란루카스트 고체분산체 조성물 및그 고체분산체의 제조방법
US20060264497A1 (en) 2005-03-28 2006-11-23 Zeligs Michael A Diindolylmethane-based compositions and methods of use thereof for promoting oral mucosal and bone health
JP2006347939A (ja) * 2005-06-15 2006-12-28 Tokyo Printing Ink Mfg Co Ltd 薬物高分子複合体の製造方法及び薬物高分子複合体
JP4429262B2 (ja) * 2005-12-09 2010-03-10 壽製薬株式会社 フェノフィブラートの固体分散体
US9545361B1 (en) * 2011-07-25 2017-01-17 Dispersol Technologies, Llc Multiple speed process for preserving heat sensitive portions of a thermokinetically melt blended batch
WO2009026461A2 (en) * 2007-08-21 2009-02-26 Board Of Regents, The University Of Texas System Thermo-kinetic mixing for pharmaceutical applications
JP2012047227A (ja) 2010-08-25 2012-03-08 Nippon Steel & Sumikin Metal Products Co Ltd ナット保持部材
US20140039031A1 (en) 2011-02-23 2014-02-06 Dispersol Technologies. LLC Pharmaceutical formulations of acetyl-11-keto-b-boswellic acid, diindolylmethane, and curcumin for pharmaceutical applications
US20170333404A1 (en) 2014-11-03 2017-11-23 Dispersol Technologies, Llc Improved formulations of vemurafenib and methods of making the same

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CA2990445C (en) 2020-05-05
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CA2697099A1 (en) 2009-02-26
US20200261473A1 (en) 2020-08-20
EP2187968A4 (en) 2013-02-20
CA3076115C (en) 2022-06-28
CA2697099C (en) 2018-02-20
CN101835492B (zh) 2012-11-21
WO2009026461A3 (en) 2009-04-30
US10022385B2 (en) 2018-07-17
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US12023343B2 (en) 2024-07-02
CA2990445A1 (en) 2009-02-26
CN101835492A (zh) 2010-09-15
US20160250230A1 (en) 2016-09-01
US8486423B2 (en) 2013-07-16
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US20090053315A1 (en) 2009-02-26
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US11439650B2 (en) 2022-09-13
JP2014221816A (ja) 2014-11-27
JP2010536877A (ja) 2010-12-02
WO2009026461A2 (en) 2009-02-26
US20130303630A1 (en) 2013-11-14
US10668085B2 (en) 2020-06-02

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