JP6032724B2 - 脂質製剤組成物およびEg5遺伝子とVEGF遺伝子の発現を阻害する方法 - Google Patents
脂質製剤組成物およびEg5遺伝子とVEGF遺伝子の発現を阻害する方法 Download PDFInfo
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| AU2005222902B2 (en) | 2004-03-12 | 2010-06-10 | Alnylam Pharmaceuticals, Inc. | iRNA agents targeting VEGF |
| WO2007115168A2 (en) | 2006-03-31 | 2007-10-11 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of eg5 gene |
| US8598333B2 (en) * | 2006-05-26 | 2013-12-03 | Alnylam Pharmaceuticals, Inc. | SiRNA silencing of genes expressed in cancer |
| KR101397407B1 (ko) * | 2008-03-05 | 2014-06-19 | 알닐람 파마슈티칼스 인코포레이티드 | Eg5 및 VEGF 유전자의 발현을 억제하기 위한 조성물 및 방법 |
| US8058069B2 (en) | 2008-04-15 | 2011-11-15 | Protiva Biotherapeutics, Inc. | Lipid formulations for nucleic acid delivery |
| CN105152939A (zh) | 2008-11-10 | 2015-12-16 | 阿尔尼拉姆医药品有限公司 | 用于递送治疗剂的脂质和组合物 |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
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| CA3045126A1 (en) * | 2009-05-05 | 2010-11-11 | Arbutus Biopharma Corporation | Methods of delivering oligonucleotides to immune cells |
| EP2449114B9 (en) | 2009-07-01 | 2017-04-19 | Protiva Biotherapeutics Inc. | Novel lipid formulations for delivery of therapeutic agents to solid tumors |
| CN102639115A (zh) | 2009-09-15 | 2012-08-15 | 阿尔尼拉姆医药品有限公司 | 脂质配制的组合物及抑制eg5和vegf基因的表达的方法 |
| EP3403647A1 (en) | 2009-12-01 | 2018-11-21 | Translate Bio, Inc. | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
| EP3391877A1 (en) | 2010-04-08 | 2018-10-24 | The Trustees of Princeton University | Preparation of lipid nanoparticles |
| WO2012000104A1 (en) | 2010-06-30 | 2012-01-05 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| JP2013545727A (ja) | 2010-10-21 | 2013-12-26 | メルク・シャープ・アンド・ドーム・コーポレーション | オリゴヌクレオチド送達用の新規低分子量カチオン性脂質 |
| DK2635265T3 (en) | 2010-11-05 | 2018-07-16 | Sirna Therapeutics Inc | New low molecular weight cyclic amine-containing cationic lipids for oligonucleotide delivery |
| CN103370054A (zh) | 2010-11-09 | 2013-10-23 | 阿尔尼拉姆医药品有限公司 | 用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法 |
| US8853377B2 (en) | 2010-11-30 | 2014-10-07 | Shire Human Genetic Therapies, Inc. | mRNA for use in treatment of human genetic diseases |
| EP2649182A4 (en) | 2010-12-10 | 2015-05-06 | Alnylam Pharmaceuticals Inc | Compositions and methods for increasing erythropoietin (epo) production |
| US20140206753A1 (en) | 2011-06-08 | 2014-07-24 | Shire Human Genetic Therapies, Inc. | Lipid nanoparticle compositions and methods for mrna delivery |
| EP2859102A4 (en) | 2012-06-08 | 2016-05-11 | Shire Human Genetic Therapies | NUCLEASE RESISTANT POLYNUCLEOTIDES AND USES THEREOF |
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2010
- 2010-03-12 CN CN201080020483.1A patent/CN102421900B/zh active Active
- 2010-03-12 US US12/723,471 patent/US20100267806A1/en not_active Abandoned
- 2010-03-12 AU AU2010223967A patent/AU2010223967B2/en not_active Ceased
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- 2010-03-12 WO PCT/US2010/027210 patent/WO2010105209A1/en not_active Ceased
- 2010-03-12 CA CA2754043A patent/CA2754043A1/en active Pending
- 2010-03-12 CN CN201510338694.4A patent/CN104922699B/zh active Active
- 2010-03-12 EP EP10708686A patent/EP2406376A1/en not_active Withdrawn
- 2010-03-12 JP JP2011554247A patent/JP6032724B2/ja not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| CN102421900A (zh) | 2012-04-18 |
| CN102421900B (zh) | 2015-07-22 |
| CN104922699A (zh) | 2015-09-23 |
| NZ594995A (en) | 2013-06-28 |
| HK1169676A1 (en) | 2013-02-01 |
| JP2012520082A (ja) | 2012-09-06 |
| EP2406376A1 (en) | 2012-01-18 |
| WO2010105209A1 (en) | 2010-09-16 |
| US20100267806A1 (en) | 2010-10-21 |
| CN104922699B (zh) | 2020-07-24 |
| HK1215180A1 (zh) | 2016-08-19 |
| AU2010223967A1 (en) | 2011-09-29 |
| US20140288154A1 (en) | 2014-09-25 |
| CA2754043A1 (en) | 2010-09-16 |
| AU2010223967B2 (en) | 2015-07-30 |
| JP2016168053A (ja) | 2016-09-23 |
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