JP6021187B2 - 自閉症の代謝バイオマーカー - Google Patents

自閉症の代謝バイオマーカー Download PDF

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JP6021187B2
JP6021187B2 JP2013508294A JP2013508294A JP6021187B2 JP 6021187 B2 JP6021187 B2 JP 6021187B2 JP 2013508294 A JP2013508294 A JP 2013508294A JP 2013508294 A JP2013508294 A JP 2013508294A JP 6021187 B2 JP6021187 B2 JP 6021187B2
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autism
metabolites
brain
autistic
cellular
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Japanese (ja)
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JP2013525801A (ja
JP2013525801A5 (enExample
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ガブリエラ ゲブリン セザー，
ガブリエラ ゲブリン セザー，
アラン エム． スミス，
アラン エム． スミス，
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Wisconsin Alumni Research Foundation
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Wisconsin Alumni Research Foundation
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/9426—GABA, i.e. gamma-amino-butyrate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2013508294A 2010-04-29 2011-04-29 自閉症の代謝バイオマーカー Expired - Fee Related JP6021187B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32951510P 2010-04-29 2010-04-29
US61/329,515 2010-04-29
PCT/US2011/034654 WO2011139914A1 (en) 2010-04-29 2011-04-29 Metabolic biomarkers of autism

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015189529A Division JP2015231392A (ja) 2010-04-29 2015-09-28 自閉症の代謝バイオマーカー

Publications (3)

Publication Number Publication Date
JP2013525801A JP2013525801A (ja) 2013-06-20
JP2013525801A5 JP2013525801A5 (enExample) 2014-05-22
JP6021187B2 true JP6021187B2 (ja) 2016-11-09

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JP2013508294A Expired - Fee Related JP6021187B2 (ja) 2010-04-29 2011-04-29 自閉症の代謝バイオマーカー
JP2015189529A Pending JP2015231392A (ja) 2010-04-29 2015-09-28 自閉症の代謝バイオマーカー

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JP2015189529A Pending JP2015231392A (ja) 2010-04-29 2015-09-28 自閉症の代謝バイオマーカー

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US (2) US9547013B2 (enExample)
EP (1) EP2564194B1 (enExample)
JP (2) JP6021187B2 (enExample)
AU (2) AU2011248464B2 (enExample)
CA (1) CA2797787C (enExample)
WO (1) WO2011139914A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101322695B1 (ko) * 2010-08-25 2013-10-25 주식회사 엘지화학 케이블형 이차전지
WO2012048152A2 (en) 2010-10-07 2012-04-12 Mazmanian Sarkis K Probiotic therapies for autism
CN114949001A (zh) * 2012-08-29 2022-08-30 加州理工学院 孤独症谱系障碍的诊断和治疗
MX2016000293A (es) 2013-07-09 2016-06-21 Stemina Biomarker Discovery Inc Biomarcadores del trastrono del espectro autista.
WO2015027116A1 (en) * 2013-08-21 2015-02-26 The Regents Of The University Of California Diagnostic and predictive metabolite patterns for disorders affecting the brain and nervous system
CN106537145B (zh) * 2014-04-08 2020-08-25 麦特博隆股份有限公司 用于疾病诊断和健康评估的个体受试者的小分子生物化学特征分析
US9176113B1 (en) * 2014-04-11 2015-11-03 Synapdx Corporation Methods and systems for determining autism spectrum disorder risk
US20150294081A1 (en) 2014-04-11 2015-10-15 Synapdx Corporation Methods and systems for determining autism spectrum disorder risk
US10124025B2 (en) 2014-10-30 2018-11-13 California Institute Of Technology Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders
KR20170086492A (ko) 2014-10-30 2017-07-26 캘리포니아 인스티튜트 오브 테크놀로지 신경발달 장애에서의 행동을 개선시키기 위한 박테리아를 포함하는 조성물 및 방법
US11282688B2 (en) 2015-03-06 2022-03-22 Micromass Uk Limited Spectrometric analysis of microbes
EP3570315B1 (en) 2015-03-06 2024-01-31 Micromass UK Limited Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of biopsy samples
US11289320B2 (en) 2015-03-06 2022-03-29 Micromass Uk Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
WO2016142674A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Cell population analysis
CA2981085A1 (en) * 2015-03-06 2016-09-15 Micromass Uk Limited Spectrometric analysis
JP6421742B2 (ja) 2015-11-27 2018-11-14 株式会社デンソー 車両制御装置
WO2017178833A1 (en) 2016-04-14 2017-10-19 Micromass Uk Limited Spectrometric analysis of plants
US11707493B2 (en) 2016-05-23 2023-07-25 California Institute Of Technology Regulate gut microbiota to treat neurodegenerative disorders
CN107064340A (zh) * 2017-03-13 2017-08-18 瀚盟测试科技（天津）有限公司 一种检测茶叶中gaba含量的方法
WO2018213204A1 (en) 2017-05-15 2018-11-22 Axial Biotherapeutics, Inc. Inhibitors of microbially induced amyloid
GB201802116D0 (en) 2018-02-09 2018-03-28 Univ Warwick Methods for diagnosing an autistic spectrum disorder
CN109030665A (zh) * 2018-10-08 2018-12-18 黑龙江大学 亲水性液相色谱串联质谱法测定红甜菜中甜菜碱含量的检测方法
US12474327B2 (en) 2018-11-06 2025-11-18 Stalicla Sa Metabolic profiling for the diagnosis of a subset of idiopathic autism spectrum disorder patients, ADS Phenotype 1
EP4012414A1 (en) 2020-12-11 2022-06-15 Stalicla S.A. Diagnosis of autism spectrum disorder phenotype 1
CN113960200B (zh) * 2021-10-19 2023-06-20 首都医科大学附属北京儿童医院 代谢标志物在诊断儿童adhd合并抽动障碍中的应用
CN114705775B (zh) * 2022-03-31 2023-09-12 广东省结核病控制中心 一种肺结核评价的血清代谢标志物及其应用
CN115326953A (zh) * 2022-08-02 2022-11-11 云谱康(大连)生物科技有限公司 一种代谢物组合及应用和检测试剂盒与使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686311A (en) * 1995-06-23 1997-11-11 The Children's Mercy Hospital Diagnosis of autism and treatment therefor
CA2273683A1 (en) * 1998-06-15 1999-12-15 Ortho-Clinical Diagnostics, Inc. Diagnostic markers for human disorders
JP2006526140A (ja) 2002-12-24 2006-11-16 バイオサイト インコーポレイテッド 鑑別診断のためのマーカーおよびその使用方法
GB0504096D0 (en) 2005-02-28 2005-04-06 Tipogen As Method
WO2006121952A2 (en) 2005-05-05 2006-11-16 The Regents Of The University Of California Diagnostic biomarkers for neurodevelopmental disorders
JP5421767B2 (ja) * 2006-04-10 2014-02-19 ウィスコンシン・アルムニ・リサーチ・ファウンデーション ヒト胚性幹細胞を使用して薬学的化合物および他の化学物質の毒性を評価するための試薬および方法
US8670941B2 (en) * 2006-08-18 2014-03-11 Huntington Medical Research Institutes Methods of determining levels of free amino acids and dipeptides and diagnosing Alzheimer's disease
AU2008280806B2 (en) * 2007-07-26 2014-12-11 Phenomenome Discoveries Inc. Methods for the diagnosis, risk assessment, and monitoring of autism spectrum disorders
JP5680964B2 (ja) * 2007-10-04 2015-03-04 ザ ホスピタル フォー シック チルドレン 自閉症スペクトラム障害のためのバイオマーカー
EP2279417B1 (en) * 2008-05-28 2016-07-20 Georgia Tech Research Corporation Metabolic biomarkers for ovarian cancer and methods of use thereof

Also Published As

Publication number Publication date
AU2011248464B2 (en) 2016-08-11
JP2013525801A (ja) 2013-06-20
AU2016204969B2 (en) 2018-05-17
CA2797787A1 (en) 2011-11-10
US20120190055A1 (en) 2012-07-26
JP2015231392A (ja) 2015-12-24
EP2564194A1 (en) 2013-03-06
CA2797787C (en) 2019-07-09
US9547013B2 (en) 2017-01-17
US10330688B2 (en) 2019-06-25
EP2564194B1 (en) 2019-07-10
AU2011248464A1 (en) 2012-11-22
AU2016204969A1 (en) 2016-08-04
US20170192019A1 (en) 2017-07-06
WO2011139914A1 (en) 2011-11-10

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