CA2797787C - Metabolic biomarkers of autism - Google Patents
Metabolic biomarkers of autism Download PDFInfo
- Publication number
- CA2797787C CA2797787C CA2797787A CA2797787A CA2797787C CA 2797787 C CA2797787 C CA 2797787C CA 2797787 A CA2797787 A CA 2797787A CA 2797787 A CA2797787 A CA 2797787A CA 2797787 C CA2797787 C CA 2797787C
- Authority
- CA
- Canada
- Prior art keywords
- metabolites
- autism
- autistic
- cellular metabolites
- cellular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
- G01N33/9426—GABA, i.e. gamma-amino-butyrate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32951510P | 2010-04-29 | 2010-04-29 | |
| US61/329,515 | 2010-04-29 | ||
| PCT/US2011/034654 WO2011139914A1 (en) | 2010-04-29 | 2011-04-29 | Metabolic biomarkers of autism |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2797787A1 CA2797787A1 (en) | 2011-11-10 |
| CA2797787C true CA2797787C (en) | 2019-07-09 |
Family
ID=44533446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2797787A Active CA2797787C (en) | 2010-04-29 | 2011-04-29 | Metabolic biomarkers of autism |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9547013B2 (enExample) |
| EP (1) | EP2564194B1 (enExample) |
| JP (2) | JP6021187B2 (enExample) |
| AU (2) | AU2011248464B2 (enExample) |
| CA (1) | CA2797787C (enExample) |
| WO (1) | WO2011139914A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101322695B1 (ko) * | 2010-08-25 | 2013-10-25 | 주식회사 엘지화학 | 케이블형 이차전지 |
| WO2012048152A2 (en) | 2010-10-07 | 2012-04-12 | Mazmanian Sarkis K | Probiotic therapies for autism |
| CN114949001A (zh) * | 2012-08-29 | 2022-08-30 | 加州理工学院 | 孤独症谱系障碍的诊断和治疗 |
| MX2016000293A (es) | 2013-07-09 | 2016-06-21 | Stemina Biomarker Discovery Inc | Biomarcadores del trastrono del espectro autista. |
| WO2015027116A1 (en) * | 2013-08-21 | 2015-02-26 | The Regents Of The University Of California | Diagnostic and predictive metabolite patterns for disorders affecting the brain and nervous system |
| CN106537145B (zh) * | 2014-04-08 | 2020-08-25 | 麦特博隆股份有限公司 | 用于疾病诊断和健康评估的个体受试者的小分子生物化学特征分析 |
| US9176113B1 (en) * | 2014-04-11 | 2015-11-03 | Synapdx Corporation | Methods and systems for determining autism spectrum disorder risk |
| US20150294081A1 (en) | 2014-04-11 | 2015-10-15 | Synapdx Corporation | Methods and systems for determining autism spectrum disorder risk |
| US10124025B2 (en) | 2014-10-30 | 2018-11-13 | California Institute Of Technology | Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders |
| KR20170086492A (ko) | 2014-10-30 | 2017-07-26 | 캘리포니아 인스티튜트 오브 테크놀로지 | 신경발달 장애에서의 행동을 개선시키기 위한 박테리아를 포함하는 조성물 및 방법 |
| US11282688B2 (en) | 2015-03-06 | 2022-03-22 | Micromass Uk Limited | Spectrometric analysis of microbes |
| EP3570315B1 (en) | 2015-03-06 | 2024-01-31 | Micromass UK Limited | Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of biopsy samples |
| US11289320B2 (en) | 2015-03-06 | 2022-03-29 | Micromass Uk Limited | Tissue analysis by mass spectrometry or ion mobility spectrometry |
| WO2016142674A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Cell population analysis |
| CA2981085A1 (en) * | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Spectrometric analysis |
| JP6421742B2 (ja) | 2015-11-27 | 2018-11-14 | 株式会社デンソー | 車両制御装置 |
| WO2017178833A1 (en) | 2016-04-14 | 2017-10-19 | Micromass Uk Limited | Spectrometric analysis of plants |
| US11707493B2 (en) | 2016-05-23 | 2023-07-25 | California Institute Of Technology | Regulate gut microbiota to treat neurodegenerative disorders |
| CN107064340A (zh) * | 2017-03-13 | 2017-08-18 | 瀚盟测试科技（天津）有限公司 | 一种检测茶叶中gaba含量的方法 |
| WO2018213204A1 (en) | 2017-05-15 | 2018-11-22 | Axial Biotherapeutics, Inc. | Inhibitors of microbially induced amyloid |
| GB201802116D0 (en) | 2018-02-09 | 2018-03-28 | Univ Warwick | Methods for diagnosing an autistic spectrum disorder |
| CN109030665A (zh) * | 2018-10-08 | 2018-12-18 | 黑龙江大学 | 亲水性液相色谱串联质谱法测定红甜菜中甜菜碱含量的检测方法 |
| US12474327B2 (en) | 2018-11-06 | 2025-11-18 | Stalicla Sa | Metabolic profiling for the diagnosis of a subset of idiopathic autism spectrum disorder patients, ADS Phenotype 1 |
| EP4012414A1 (en) | 2020-12-11 | 2022-06-15 | Stalicla S.A. | Diagnosis of autism spectrum disorder phenotype 1 |
| CN113960200B (zh) * | 2021-10-19 | 2023-06-20 | 首都医科大学附属北京儿童医院 | 代谢标志物在诊断儿童adhd合并抽动障碍中的应用 |
| CN114705775B (zh) * | 2022-03-31 | 2023-09-12 | 广东省结核病控制中心 | 一种肺结核评价的血清代谢标志物及其应用 |
| CN115326953A (zh) * | 2022-08-02 | 2022-11-11 | 云谱康(大连)生物科技有限公司 | 一种代谢物组合及应用和检测试剂盒与使用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5686311A (en) * | 1995-06-23 | 1997-11-11 | The Children's Mercy Hospital | Diagnosis of autism and treatment therefor |
| CA2273683A1 (en) * | 1998-06-15 | 1999-12-15 | Ortho-Clinical Diagnostics, Inc. | Diagnostic markers for human disorders |
| JP2006526140A (ja) | 2002-12-24 | 2006-11-16 | バイオサイト インコーポレイテッド | 鑑別診断のためのマーカーおよびその使用方法 |
| GB0504096D0 (en) | 2005-02-28 | 2005-04-06 | Tipogen As | Method |
| WO2006121952A2 (en) | 2005-05-05 | 2006-11-16 | The Regents Of The University Of California | Diagnostic biomarkers for neurodevelopmental disorders |
| JP5421767B2 (ja) * | 2006-04-10 | 2014-02-19 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | ヒト胚性幹細胞を使用して薬学的化合物および他の化学物質の毒性を評価するための試薬および方法 |
| US8670941B2 (en) * | 2006-08-18 | 2014-03-11 | Huntington Medical Research Institutes | Methods of determining levels of free amino acids and dipeptides and diagnosing Alzheimer's disease |
| AU2008280806B2 (en) * | 2007-07-26 | 2014-12-11 | Phenomenome Discoveries Inc. | Methods for the diagnosis, risk assessment, and monitoring of autism spectrum disorders |
| JP5680964B2 (ja) * | 2007-10-04 | 2015-03-04 | ザ ホスピタル フォー シック チルドレン | 自閉症スペクトラム障害のためのバイオマーカー |
| EP2279417B1 (en) * | 2008-05-28 | 2016-07-20 | Georgia Tech Research Corporation | Metabolic biomarkers for ovarian cancer and methods of use thereof |
-
2011
- 2011-04-29 WO PCT/US2011/034654 patent/WO2011139914A1/en not_active Ceased
- 2011-04-29 CA CA2797787A patent/CA2797787C/en active Active
- 2011-04-29 US US13/098,249 patent/US9547013B2/en active Active
- 2011-04-29 EP EP11721395.9A patent/EP2564194B1/en active Active
- 2011-04-29 JP JP2013508294A patent/JP6021187B2/ja not_active Expired - Fee Related
- 2011-04-29 AU AU2011248464A patent/AU2011248464B2/en active Active
-
2015
- 2015-09-28 JP JP2015189529A patent/JP2015231392A/ja active Pending
-
2016
- 2016-07-15 AU AU2016204969A patent/AU2016204969B2/en active Active
- 2016-12-07 US US15/371,692 patent/US10330688B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011248464B2 (en) | 2016-08-11 |
| JP2013525801A (ja) | 2013-06-20 |
| AU2016204969B2 (en) | 2018-05-17 |
| CA2797787A1 (en) | 2011-11-10 |
| US20120190055A1 (en) | 2012-07-26 |
| JP2015231392A (ja) | 2015-12-24 |
| EP2564194A1 (en) | 2013-03-06 |
| US9547013B2 (en) | 2017-01-17 |
| JP6021187B2 (ja) | 2016-11-09 |
| US10330688B2 (en) | 2019-06-25 |
| EP2564194B1 (en) | 2019-07-10 |
| AU2011248464A1 (en) | 2012-11-22 |
| AU2016204969A1 (en) | 2016-08-04 |
| US20170192019A1 (en) | 2017-07-06 |
| WO2011139914A1 (en) | 2011-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160412 |
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| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 14TH ANNIV.) - STANDARD Year of fee payment: 14 |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250422 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250422 |
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| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260610 |